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(+)-7-deoxy-O6-buxafurandiene
-
isolated from Buxus hyrcana
(+)-benzoylbuxidienine
-
isolated from Buxus hyrcana
(+)-buxapapillinine
-
isolated from Buxus hyrcana
(+)-buxaquamarine
-
isolated from Buxus hyrcana
(+)-debromoflustramine B
-
-
(+)-irehine
-
isolated from Buxus hyrcana
(+)-limonene
-
identified compound of Pimpinella anisodes, IC50: 456.2 microgram/ml
(+)-O6-buxafurandiene
-
isolated from Buxus hyrcana
(+)-sabinene
-
identified compound of Pimpinella anisodes, IC50: 218.6 microgram/ml
(+/-)-6-bromo-N-((1-(2,3-dihydro-1H-inden-2-yl)-piperidin-3-yl)methyl)-N-(2-methoxyethyl)-2-naphthamide
-
(+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-1-naphthamide
-
(+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-(dimethylamino)ethyl)-2-naphthamide
(+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(3-methoxypropyl)-2-naphthamide
-
(+/-)-N-((1-(benzo[d]thiazol-2-ylmethyl)piperidin-3-yl)methyl)-2-naphthamide
-
(+/-)-N-((1-benzylpiperidin-3-yl)methyl)-2-naphthamide
-
(+/-)-N-((1-benzylpiperidin-3-yl)methyl)-N-(2-methoxyethyl)-2-naphthamide
-
(-)-10,10-dimethylhuperzine A
-
-
(-)-3-O-acetyl-spectaline
-
isolated from flowers of Senna spectabilis
(-)-Carvone
-
62.4% inhibition at 1 mM
(-)-debromoflustramine B
-
-
(-)-galanthamine
-
isolated from Galanthus woronowii
(-)-N1-phenethylnorcymserine
-
-
(-)-N1-phenethylnorphenserine
-
-
(-)-N1-phenethylnorphysostigmine
-
-
(-)-spectaline
-
isolated from flowers of Senna spectabilis
(13E,13'Z)-N,N'-hexane-1,6-diylbis(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-imine)
-
-
(13Z,13'Z)-N,N'-heptane-1,7-diylbis(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-imine)
-
-
(1alpha,3beta,22R)-stigmast-5-ene-1,3,22-triol
-
i.e. haloxysterol A, isolated from Haloxylon recurvum
(1alpha,3beta,22R)-stigmasta-4,6-diene-1,3,22-triol
-
i.e. haloxysterol B, isolated from Haloxylon recurvum
(1alpha,3beta,5alpha,6beta,22R)-stigmastane-1,3,5,6,22-pentol
-
i.e. haloxysterol D, isolated from Haloxylon recurvum
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,3,4,4a,5,6,11b-octahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
-
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,4a,5,6,11b-hexahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
-
(2,6,6-trimethylcyclohex-1-en-1-yl)methyl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
-
-
(2-((ethoxy(hydroxy)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium methanesulfonate
(2-((ethoxy(methyl)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium
(2-mercaptoethyl)trimethylammonium iodide O,O-diethyl phosphorothioate
-
0.2 mM, 21% inhibition; i.e. echothiophate
(22R)-22-hydroxystigmasta-4,9(11)-dien-3-one
-
i.e. haloxysterol , isolated from Haloxylon recurvum
(24S)-ethylcholesta-7,9(11),22(E)-triene-3beta-ol
-
isolated from Haloxylon recurvum
(2E)-1,3-diphenylprop-2-en-1-one
-
-
(2E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one
-
-
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
-
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
-
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
-
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
-
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
-
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
-
(2E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(3,4-dimethoxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(3-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2x)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-([[(2E)-3-phenylprop-2-enoyl]oxy]carbonyl)-D-arabino-hexitol
96% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(2-methylbutanoyl)-D-arabino-hexitol
99% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(biphenyl-4-ylcarbonyl)-D-arabino-hexitol
99% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(carboxycarbamoyl)-D-arabino-hexitol
92% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(cyclopentylcarbonyl)-D-arabino-hexitol
99% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(cyclopropylcarbonyl)-D-arabino-hexitol
97% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(phenoxycarbonyl)-D-arabino-hexitol
99% inhibition at 0.1 mM, highly selective for BuChE, with about 50000fold selectivity over human erythrocyte acetylcholinesterase. Competitive, and slowly reversible inhibition by active site carbamylation
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-([[(4-methylphenyl)sulfonyl]oxy]carbonyl)-D-arabino-hexitol
25% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-([[(trifluoromethyl)sulfonyl]oxy]carbonyl)-D-arabino-hexitol
85% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(2H-chromen-2-yloxy)carbonyl]-D-arabino-hexitol
100% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(3,4-dihydroxyphenyl)carbonyl]-D-arabino-hexitol
38% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(pentanoyloxy)carbonyl]-D-arabino-hexitol
95% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(propanoyloxy)carbonyl]-D-arabino-hexitol
97% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[([[4-(heptyloxy)phenyl]carbonyl]oxy)carbonyl]-D-arabino-hexitol
80% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(methylsulfonyl)oxy]carbonyl]-D-arabino-hexitol
9.8% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(naphthalen-2-ylcarbonyl)oxy]carbonyl]-D-arabino-hexitol
100% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(pyridin-3-ylcarbonyl)oxy]carbonyl]-D-arabino-hexitol
99% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(pyridin-4-ylcarbonyl)oxy]carbonyl]-D-arabino-hexitol
97% inhibition at 0.1 mM
(2xi)-1,4:3,6-dianhydro-2-O-([2-[(carbamoyloxy)methyl]-5-hydroxybenzyl]carbamoyl)-D-arabino-hexitol
95% inhibition at 0.1 mM
(2xi)-5-O-[(acetyloxy)carbonyl]-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-D-arabino-hexitol
97% inhibition at 0.1 mM
(2Z)-4-[(2-aminophenyl)amino]-4-oxobut-2-enoic acid
-
one of the best inhibitors
(2Z)-4-[(4-nitrophenyl)amino]-4-oxobut-2-enoic acid
-
weak inhibition
(3,4-dimethoxyphenyl)(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methanol
-
-
(3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
-
-
(3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
-
-
(3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
-
-
(3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
-
-
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 1950 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 50 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl ethylcarbamate
-
50% inhibition at 4 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl methylcarbamate
-
50% inhibition at 16 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 1560 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 17 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl ethylcarbamate
-
50% inhibition at 2 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl methylcarbamate
-
50% inhibition at 4 nM
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-phenylethyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3,4-dimethoxyphenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-acetylphenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-butylphenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-chlorophenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-methoxyphenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-nitrophenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-phenoxyphenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-tert-butylphenyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (cyclohexylmethyl)carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl 1,3-benzodioxol-5-ylcarbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl benzylcarbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl biphenyl-4-ylcarbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl cyclohexylcarbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl hexylcarbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl naphthalen-2-ylcarbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl [4-(dimethylamino)phenyl]carbamate
-
-
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl [4-(hexyloxy)phenyl]carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,3-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4,6-trimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,5-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,6-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-ethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3,4-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3-methylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-methylphenyl)carbamate
-
-
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-1,26-dioxo-5,6:22,26-diepoxyergost-24-en-19-oic acid
-
isolated from Withania somnifera, noncompetitive inhibition
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-5,6:22,26-diepoxyergost-24-ene-1,26-dione
-
isolated from Withania somnifera, noncompetitive inhibition
(3beta,4beta,6beta,8xi,9xi,14xi,17xi,22R)-4,6,27-trihydroxy-3-methoxy-22,26-epoxyergost-24-ene-1,26-dione
-
isolated from Withania somnifera, noncompetitive inhibition
(3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3R,4aS,9bS)-9-(chloromethyl)-9b-[2-[(ethoxycarbonyl)(methyl)amino]ethyl]-6-methoxy-3,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-yl ethyl carbonate
-
-
(4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
-
-
(4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,10,11,13,14-hexahydro-4aH,9H-[1]benzofuro[3a,3,2-gh][3,4]benzoxazonin-6-ol
-
-
(4aS,6R,8aS)-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol
-
-
(4aS,6R,8aS)-3-[[12-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)dodecyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-3-[[8-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[10-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(10-phenyldecyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(8-phenyloctyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,27-dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione
-
isolated from Ajuga bracteosa, noncompetitive inhibition
(5alpha,6alpha,7alpha,8xi,9xi,14xi,17xi,22R)-5-hydroxy-20-methyl-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione
-
isolated from Ajuga bracteosa, noncompetitive inhibition
(6,7-dimethoxyisoquinolin-1-yl)(2-methoxyphenyl)methanol
-
-
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanol
-
-
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanone
-
-
(6R,7S)-6-(acetyloxy)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2Z)-2-methylbut-2-enoate
mixed-type inhibition
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2E)-2-methylbut-2-enoate
mixed-type inhibition
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate
noncompetitive inhibition
(6R,7S)-6-methoxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate
noncompetitive inhibition
(6R,7S)-7-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-yl 4-methylpent-3-enoate
mixed-type inhibition
(7R,11R)-huprine 19
binding structure from analysis of the crystal structure
(7S,11S)-huprine W
binding structure from analysis of the crystal structure
(8Z)-5,6-dihydro-8H-isoquino[1,2b]quinazolin-8-imine
-
-
(9E,9'E)-N,N'-hexane-1,6-diylbis(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine)
-
-
(9E,9'Z)-N,N'-heptane-1,7-diylbis(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine)
-
-
(dibutyl phosphoric) hypochlorous anhydride
-
(E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene
-
(R)-bambuterol monocarbamate
(R)-[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
(RS)-[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
(S)-3-benzoyloxy-1-benzylquinuclidinium bromide
-
inhibition at 0.01 mM and 0.02 mM
(S)-bambuterol monocarbamate
(S)-[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
(Z)-N1-methyl-N4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylidene)-N1-(3-((E)-8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-butane-1,4-diamine
-
-
1,1'-(2E)-but-2-ene-1,4-diyldipyridinium dibromide
-
-
1,1'-(2Z)-but-2-ene-1,4-diyldipyridinium dichloride
-
-
1,1'-(benzene-1,2-diyldimethanediyl)dipyridinium dibromide
-
-
1,1'-(benzene-1,3-diyldimethanediyl)dipyridinium dibromide
-
-
1,1'-(benzene-1,4-diyldimethanediyl)dipyridinium dibromide
-
-
1,1'-(naphthalene-2,7-diyldimethanediyl)dipyridinium dibromide
-
-
1,1'-(oxydiethane-2,1-diyl)dipyridinium dibromide
-
-
1,1'-(oxydimethanediyl)dipyridinium dichloride
-
-
1,1'-butane-1,4-diyldipyridinium dibromide
-
-
1,1'-decane-1,10-diyldipyridinium dibromide
-
-
1,1'-heptane-1,7-diyldipyridinium dibromide
-
-
1,1'-hexane-1,6-diyldipyridinium dibromide
-
-
1,1'-nonane-1,9-diyldipyridinium dibromide
-
-
1,1'-octane-1,8-diyldipyridinium dibromide
-
-
1,1'-pentane-1,5-diyldipyridinium dibromide
-
-
1,1'-undecane-1,11-diyldipyridinium dibromide
-
-
1,2,11,12-tetramethoxy-7-methyl-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
-
1,2,2-triethyl-2,3-dihydro-1H-quinazolin-4-one
-
1,2,3,10,11-pentamethoxy-7-(methoxycarbonyl)-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
-
1,2,3,4,9,9a-hexahydroacridin-9-amine
-
-
1,2,3,4-tetrahydroacridin-9-amine
-
1,2-di(berberine-9-O-yl)ethane dibromide
-
-
1,2-diethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1,2-dimethyl-beta-carbolin-2-ium iodide
-
noncompetitive inhibition
1,3-bis[5(diethyl-o-nitrobenzylammonium)pentyl]-6-methyluracil dibromide
compound C547, a fast-binding reversible inhibitor of mixed-type on human BChE. The inhibitor shows a high level of pharmacological selectivity in inhibiting acetylcholinesterase (AChE, EC 3.1.1.7) as compared to butyrylcholinesterase
1,3-di(berberine-9-O-yl)propane dibromide
-
-
1,3a,8-tris(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
1,4-dichlorobenzene
-
reversible
1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-nitro-D-threo-hexitol
96% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-(butylcarbamoyl)-5-O-nitro-D-threo-hexitol
92% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-(cyclohexylcarbamoyl)-5-O-nitro-D-threo-hexitol
99% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-(ethylcarbamoyl)-5-O-nitro-D-threo-hexitol
73% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-(methylcarbamoyl)-5-O-nitro-D-threo-hexitol
82% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-nitro-5-O-(phenylcarbamoyl)-D-threo-hexitol
37% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-nitro-5-O-(propylcarbamoyl)-D-threo-hexitol
93% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-nitro-5-O-[[4-(trifluoromethyl)phenyl]carbamoyl]-D-threo-hexitol
10% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-[(2-chlorophenyl)carbamoyl]-5-O-nitro-D-threo-hexitol
11% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-[(3,4-dichlorophenyl)carbamoyl]-5-O-nitro-D-threo-hexitol
28% inhibition at 0.1 mM
1,4:3,6-dianhydro-2-O-[(3-chlorophenyl)carbamoyl]-5-O-nitro-D-threo-hexitol
11% inhibition at 0.1 mM
1,5,6-trimethyl-9-oxo-7H,9H-pyrano[3,4,5-ij]isoquinolin-1-ium
-
-
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one
1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
1-(2-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1Hquinazolin-4-one
-
1-(2-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-fluorobenzyl)-N-[6-(1H-indol-1-yl)hexyl]piperidin-4-amine
-
1-(2-fluorobenzyl)-N-[8-(1H-indol-1-yl)octyl]piperidin-4-amine
-
1-(2-nitrophenyl)-1H-pyrrole-2,5-dione
-
weak inhibition
1-(2-nitrophenyl)pyrrolidine-2,5-dione
-
weak inhibition
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
-
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium
-
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
-
-
1-(3-aminophenyl)pyrrolidine-2,5-dione
-
one of the best inhibitors
1-(3-chlorobenzyl)-N-[6-(1H-indol-1-yl)hexyl]piperidin-4-amine
-
1-(3-chlorobenzyl)-N-[8-(1H-indol-1-yl)octyl]piperidin-4-amine
-
1-(4-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane
-
1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)propane
-
1-(hydroxymethyl)-5-methyloctahydro-2H-quinolizinium
1--(4-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2,2-diisobutyl-2,3-dihydro-1Hquinazolin-4-one
-
1-benzyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-5-methoxy-3a,8-bis(3-methylbut-2-enyl)-1,2,3,3a,8,8ahexahydropyrrolo[2,3-b]indole
-
-
1-benzyl-N-[3-(2,3-dihydro-1H-indol-1-yl)propyl]piperidin-4-amine
-
1-benzyl-N-[5-(2,3-dihydro-1H-indol-1-yl)pentyl]piperidin-4-amine
-
1-benzyl-N-[6-(1H-indol-1-yl)hexyl]piperidin-4-amine
-
1-benzyl-N-[8-(1H-indol-1-yl)octyl]piperidin-4-amine
-
1-butanoyl-3-(2,6-dimethylphenyl) thiourea
-
1-butanoyl-3-(3-methoxyphenyl)thiourea
-
1-butanoyl-3-(4-chlorophenyl)thiourea
-
1-butanoyl-3-benzylthiourea
-
1-dehydrotestosterone
-
-
1-epideacetylbowdensine
-
-
1-ethyl-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
-
1-ethyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
-
1-ethyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-ethyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
1-ethyl-2-methyl-2-propyl -2,3-dihydro-1H-quinazolin-4-one
-
1-methyl-1-[2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propyl]pyrrolidinium
-
-
1-methyl-1-[3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butyl]pyrrolidinium
-
-
1-methyl-1-[4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentyl]pyrrolidinium
-
-
1-methyl-3-(3-(methylamino)cyclohexyl)pyridinium
1-methyl-4,5-dihydro[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-6-ium-2-olate
-
-
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (2-methylphenyl)carbamate
-
50% inhibition above 0.030 mM
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 22 nM
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl ethylcarbamate
-
50% inhibition at 24 nM
1-methylcarbamoyloxy-naphthalene
-
0.2 mM, 19% inhibition; i.e. sevin
1-naphthyl methyl carbamate
1-naphthyl phenothiazine carbamate
-
-
1-p-menthanol, 2-dimethylamino-, 2,5-dimethylbenzyl chloride
-
Q 80, growth retardant, 0.1 mM, 32% inhibition
1-[2-(4-carboxyphenyl)-5-(ethoxycarbonyl)-1H-benzimidazol-1-yl]-4-ethylmorpholin-1-ium
-
-
10-(2,2-dimethylpropanoyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 4.7
10-(2-ethylbutanoyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(3,3-dimethylbutanoyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(3-methylbutanoyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(chloroacetyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 7.3
10-(cyclobutylcarbonyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 11.6
10-(cycloheptylcarbonyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(cyclohexylacetyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(cyclohexylcarbonyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(cyclopentylacetyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(cyclopentylcarbonyl)-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-(cyclopropylcarbonyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 1.9
10-(methoxyacetyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 0.8
10-acetyl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 1.1
10-butyryl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 1.9
10-heptanoyl-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-hexanoyl-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-isobutyryl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 2.7
10-methoxy-9-(4-phenoxybutoxy)-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium bromide
-
-
10-N-demethyl-10-N-(10-(4-(piperidin-1-ylmethyl)-phenoxy)decan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(12-(4-(piperidin-1-ylmethyl)-phenoxy)dodecan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(2-(4-(piperidin-1-ylmethyl)phenoxy)ethan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(1-benzylpiperidin-4-yloxy)-butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(3-(1-morpholinoethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-((diethylamino)methyl)-phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(morpholinomethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(piperidin-1-ylmethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(pyrrolidine-1-carbonyl)-phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(5-(4-(piperidin-1-ylmethyl)phenoxy)pentan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(1-benzylpiperidin-4-yloxy)-hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(3-(1-morpholinoethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-((diethylamino)methyl)-phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(morpholinomethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(piperidin-1-ylmethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(pyrrolidine-1-carbonyl)-phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(8-(4-(piperidin-1-ylmethyl)phenoxy)octan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(9-(4-(piperidin-1-ylmethyl)phenoxy)nonan-1-yl)-galanthamine
-
-
10-pentanoyl-10H-phenothiazine
-
not inhibitory to EC 3.1.1.7
10-propionyl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC 3.1.1.7 is 1.8
10-[4-[(diethylamino)methyl]phenoxy]-N,N-diethyldecan-1-amine
-
-
10-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropyldecan-1-amine
-
-
11alpha,17beta-dihydroxyandrost-1,4-dien-3-one
-
-
11alpha-hydroxyandrost-1,4-dien-3,17-dione
-
-
11alpha-hydroxyandrost-4-en-3,17-dione
-
-
11alpha-hydroxytestolactone
-
-
11alpha-hydroxytestosterone
-
-
12-n-butoxy-demethoxykesselringine
-
-
13-methyl-5,8-dihydro-6H isoquino[1,2b]quinazolin-13-ium chloride
-
-
13-methyl-5,8-dihydro-6H-isoquino[1,2b]quinazolin-13-ium chloride
-
-
14-ethoxy-14-oxogalanthamine
-
-
15alpha,16alpha-epoxy-17-hydroxy-ent-kauran-19-oic acid
-
-
16 alpha-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic acid
-
-
16alpha,17-dihydroxy-ent-kauran-19-oic acid
-
-
17-hydroxy-ent-kaur-15-en-19-oic acid
-
-
17beta-hydroxy-5alpha-androstan-3,6-dione
-
-
18-nor-ent-Kaur-16-ene-4 beta-ol
-
-
18-nor-ent-pimara-8(14),15-diene-4 beta-ol
-
-
19,20-dihydroervahanin A
-
-
19,20-dihydrotabernamine
-
-
2'-ethylphenylgeneserine N-oxide
-
50% inhibition at 1700 nM
2,2,-dichlorvinyl dimethyl phosphate
-
irreversible inhibition
2,2-dichlorovinyl dimethyl phosphate
-
i.e. DDVP, reversible, detailed kinetic analysis and comparison with acetylcholinesterase EC 3.1.1.7
2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
2,3-dihydroquinazolin-4(1H)-one
-
2,3-dimethoxy-6-methyl-9H-xanthen-9-one
-
-
2-((Z)-(hydroxyimino)methyl)-1-methylpyridinium chloride
-
i.e. 2-PAM, reversible, detailed kinetic analysis and comparison with acetylcholinesterase EC 3.1.1.7
2-(1-piperidinyl)ethyl phenothiazine carbamate
-
-
2-(1-pyrrolidinyl)ethyl phenothiazine carbamate
-
-
2-(3-methylphenyl)-4H-chromen-4-one
-
-
2-(3-[[1-(2-fluorobenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
-
2-(3-[[1-(3-chlorobenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
-
2-(3-[[1-(4-hydroxybenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
-
2-(3-[[1-(4-methoxybenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
-
2-(4-(((7-(diethylamino)-2,4-dioxo-2H-chromen-3(4H)-ylidene)methyl)amino)phenyl)-N'-1,2,3,4-tetrahydroacridin-9-ylacetohydrazide
-
-
2-(4-chloro-phenyl)-1-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
-
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
-
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
neuroprotective effect of K3-2 against H2O2-induced toxicity
2-(4-hydroxybenzyl)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
-
2-(4-hydroxybenzyl)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
-
2-(4-hydroxybenzyl)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
-
2-(4-methylphenyl)-4H-chromen-4-one
-
-
2-(4-morpholino)ethyl phenothiazine carbamate
-
-
2-(6-oxo-7,11-diazatricyclo(7.3.1.0 2,7)tridec-11-yl)ethyl acetate
2-(6-[[1-(2-fluorobenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
-
2-(6-[[1-(3-chlorobenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
-
2-(6-[[1-(4-hydroxybenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
-
2-(6-[[1-(4-methoxybenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
-
2-(8-[[1-(2-fluorobenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
-
2-(8-[[1-(3-chlorobenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
a selective BChE inhibitor
2-(8-[[1-(4-hydroxybenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
-
2-(8-[[1-(4-methoxybenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
-
2-(benzylaminocarbonyloxy)-5-(phenylcarbonyloxyimino-)-1,4 3,6-dianhydro-D-glucitol
-
9% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-deoxy, 5-dehydro-((ethyloxycarbonyl)ene-)-1,4 3,6-dianhydro-D-glucitol
-
4.9% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-deoxy-5-phenylcarbonylamino-1,4 3,6-dianhydro-D-glucitol
-
46% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-deoxy-L-xylohex-6-enitol
-
9.8% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-keto-1,4 3,6-dianhydro-D-glucitol
-
10% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-ketoxime-1,4 3,6-dianhydro-D-glucitol
-
83% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-O-(phenylpropyloxy)-1,4 3,6-dianhydro-D-glucitol
-
55% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy)-5-O-benzyl-1,4 3,6-dianhydro-D-glucitol
-
55% inhibition at 0.1 mM
2-(benzylaminocarbonyloxy-)-5-O-(1-naphthoyl)-1,4:3,6-dianhydro-D-glucitol
99% inhibition at 0.1 mM
2-(diethylamino)ethyl 10H-phenothiazine-10-carboxylate
-
-
2-(dimethylamino)ethyl (2Z)-2-[[(2-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
2-(dimethylamino)ethyl (2Z)-2-[[(2-chlorophenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
2-(dimethylamino)ethyl (2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
2-(dimethylamino)ethyl (2Z)-2-[[(3-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
2-(dimethylamino)ethyl (2Z)-2-[[(4-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
2-(dimethylamino)ethyl (2Z)-2-[[(4-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoate
-
2-(dimethylamino)ethyl (2Z)-3-phenyl-2-[(phenylcarbonyl)amino]prop-2-enoate
-
2-(dimethylamino)ethyl 10H-phenothiazine-10-carboxylate
-
-
2-(trifluoromethyl)phenyl butylcarbamate
-
-
2-acetamido-N,N,N-trimethylethen-1-aminium
2-acetamido-N-(4-(8,9,10,11-tetrahydro-6H-azocino-[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,-11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)acetamide
-
-
2-amino-3-((1R)-1-cyclohexyl-2-[(cyclohexylcarbonyl)amino]ethyl)-6-phenoxyquinazolin-3-ium
-
2-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
2-chlorophenyl 1-methylhydrazinecarboxylate
-
-
2-chlorophenyl butylcarbamate
-
-
2-chlorophenyl phenothiazine carbamate
-
-
2-decanol
-
42,0% inhibition at 1 mM
2-dimethylaminoethyl esters of N-substituted alpha,beta-dehydrophenylalanine
inhibition potencies, overview
-
2-ethyl-1-methyl-beta-carbolin-2-ium iodide
-
noncompetitive inhibition
2-ethylphenyl butylcarbamate
-
-
2-methoxyphenyl butylcarbamate
-
-
2-methoxyphenyl phenothiazine carbamate
-
-
2-methylphenyl butylcarbamate
-
-
2-methylphenyl phenothiazine carbamate
-
-
2-naphthyl phenothiazine carbamate
-
-
2-nitrophenyl butylcarbamate
-
-
2-t-butylphenyl phenothiazine carbamate
-
-
2-tert-butoxyphenyl butylcarbamate
-
-
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
2-[(5-acetyl-6-methyl-4-phenyl-1,4-dihydropyrimidin-2-yl)sulfanyl]-N-phenylacetamide
-
2-[3-[(1-benzylpiperidin-4-yl)amino]propyl]-1H-isoindole-1,3(2H)-dione
-
2-[5-[(1-benzylpiperidin-4-yl)amino]pentyl]-1H-isoindole-1,3(2H)-dione
-
2-[6-[(1-benzylpiperidin-4-yl)amino]hexyl]-1H-isoindole-1,3(2H)-dione
-
2-[8-[(1-benzylpiperidin-4-yl)amino]octyl]-1H-isoindole-1,3(2H)-dione
-
2-[acetyl(methyl)amino]-N,N,N-trimethylethen-1-aminium
2-[cyano(3-indolyl)methylene]-3-indolone
-
an alkaloid isolated from Isatis tinctoria
2-[[(2Z)-2-[[(2-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
2-[[(2Z)-2-[[(2-chlorophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
2-[[(2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium
i.e. compound IIIf, a choline ester of dehydrophenylalanine, the amine group of the amino acid is derivatized with a benzoyl group containing a methoxy in the 2-position, binding structure and modelling, overview
2-[[(2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
2-[[(2Z)-2-[[(3-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
2-[[(2Z)-2-[[(4-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
2-[[(2Z)-2-[[(4-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
-
2-[[2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
-
2-[[2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
-
2-[[5-acetyl-6-methyl-4-(4-phenoxyphenyl)-1,4-dihydropyrimidin-2-yl]sulfanyl]-N-phenylacetamide
-
24-ethyl-cholest-7-ene-3,5,6-triol
-
isolated from Haloxylon recurvum
24-ethylcholest-6-ene-3,5-diol
-
isolated from Haloxylon recurvum
2alpha,11alpha-dihydroxyfawcettiine
-
-
2beta-hydroxyepipachysamine D
-
-
3'-hydroxyepiglucoisatisin
-
an alkaloid isolated from Isatis tinctoria
3,3'-((1,5-dioxopentane-1,5-diyl)bis(iminocyclohexane-3,1-diyl))bis(1-methylpyridinium)
3,3'-[butane-1,4-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
-
-
3,3'-[butane-1,4-diylbis(oxy)]bis(7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine)
-
-
3,3'-[butane-1,4-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
-
-
3,3'-[dodecane-1,12-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
-
-
3,3'-[dodecane-1,12-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
-
-
3,3'-[hexane-1,6-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
-
-
3,3'-[hexane-1,6-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
-
-
3,3'-[octane-1,8-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
-
-
3,3'-[octane-1,8-diylbis(oxy)]bis(7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine)
-
-
3,3'-[octane-1,8-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
-
-
3,3'-[pentane-1,5-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
-
-
3,3'-[pentane-1,5-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
-
-
3,3'-[propane-1,3-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
-
-
3,3'-[propane-1,3-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
-
-
3,5,7,3',4'-pentamethoxyflavone
-
3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid
-
one of the best inhibitors
3-(3-methylphenyl)-2H-chromen-2-one
-
-
3-(4-methylphenyl)-2H-chromen-2-one
-
-
3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(6-oxo-6-(8-oxooctahydro-2H-2,6-methanopyrido(1,2-a)(1,5)diazocin-3(4H)-yl)hexanoyl)decahydro-8H-1,5-methanopyrido(1,2-a)(1,5)diazocin-8-one
3-(9-hydroxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
-
3-(9-methoxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
-
3-(diethylamino)propyl 10H-phenothiazine-10-carboxylate
-
-
3-(N,N-dimethylamino) phenyl phenothiazine carbamate
-
binding by residues F329 and Y332, structure, overview
3-([7-[methyl(3-[[(methylamino)oxy]carbonyl]benzyl)amino]heptyl]oxy)-9H-xanthen-9-one
-
-
3-carene
-
50% inhibition at 2 mM
3-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
3-chlorophenyl 1-methylhydrazinecarboxylate
-
-
3-chlorophenyl phenothiazine carbamate
-
-
3-hydroxy-2,2,6-trimethyl-3,4,5,6-tetrahydro-2H-pyrano[3,2c] quinoline 5-one
-
isolated from Skimmia laureola
3-methoxy-6-methyl-9H-xanthen-9-one
-
-
3-methoxy-7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium iodide
-
micromolar non-selective inhibitor
3-methoxyphenyl phenothiazine carbamate
-
-
3-methyl-2-(4-methylphenyl)-4H-chromen-4-one
-
-
3-methyl-N-(4-(8,9,10,11-tetrahydro-6H-azocino-[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,-10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)butanamide
-
-
3-methylphenyl phenothiazine carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-alkyl) carbamates
-
inhibit quickly by carbamoylation
3-N,N-diethylaminophenyl-N'-(1-butyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-ethyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-hexyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-octyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-propyl) carbamate
-
-
3-oxo-N-[(1,2,3,4-tetrahydroacridin-9-ylamino)methyl]butanamide
-
3-oxo-N-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]butanamide
-
3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
-
3-oxo-N-[5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyl]butanamide
-
3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate
-
3-[(methyl[7-[(9-oxo-9H-xanthen-3-yl)oxy]heptyl]amino)methyl]phenyl methylcarbamate
-
-
3-[10-(benzylmethylamino)decyloxy]xanthen-9-one
-
-
3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one
-
-
3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one
-
-
3-[2-(4-carboxyphenyl)-5-(ethoxycarbonyl)-1H-benzimidazol-1-yl]-1-propyl-1H-imidazol-3-ium
-
-
3-[3-(benzylmethylamino)propoxy]xanthen-9-one
-
-
3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one
-
-
3-[4-(benzylmethylamino)butoxy]xanthen-9-one
-
-
3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one
-
-
3-[5-(ethoxycarbonyl)-2-(4-hydroxyphenyl)-1H-benzimidazol-1-yl]-1-propyl-1H-imidazol-3-ium
-
-
3-[5-(ethoxycarbonyl)-2-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-1-yl]-1-propyl-1H-imidazol-3-ium
-
-
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one
-
-
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one
-
-
3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one
-
-
3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
-
3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
-
3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one
-
-
3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one
-
-
3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one
-
-
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one
-
-
3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one
-
-
3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones
-
structure-activity relationships, overview, inhibition with high selectivity toward BuChE
3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
3a,8-dibenzyl-5-methoxy-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (2-methylphenyl)carbamate
-
50% inhibition above 0.030 mM
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 27 nM
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl ethylcarbamate
-
50% inhibition at 6 nM
4,4'-(3-oxopentane-1,5-diyl)bis(N,N-dimethyl-N-prop-2-en-1-ylanilinium) dibromide
-
i.e. BW284c51, cholinesterase from large fish is more sensitive to inhibition
4,4'-Bipyridine
-
competitive, reversible
4,5-diethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-(aminocarbonyl)-1-(((2-((Z)-(hydroxyimino)methyl)pyridinium-1-yl)methoxy)methyl)pyridinium dichloride
-
i.e. HI-6, reversible, detailed kinetic analysis and comparison with acetylcholinesterase EC 3.1.1.7
4-acetyl-1,1-dimethylpiperazin-1-ium
4-biphenyl phenothiazine carbamate
-
-
4-carbamoyl-1-(3-(3-chloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)propyl)pyridinium
-
4-carbamoyl-1-(4-(3,5-dichloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)butyl)pyridinium
-
4-carbamoyl-1-(4-(3,5-dichloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)propyl)pyridinium
-
4-carbamoyl-1-(4-(3-chloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)butyl)pyridinium
-
4-carbamoyl-1-[(2E)-4-(3,5-dichloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)but-2-en-1-yl]pyridinium
-
4-carbamoyl-1-[(2E)-4-(3-chloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)but-2-en-1-yl]pyridinium
-
4-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
4-chlorophenyl 1-methylhydrazinecarboxylate
-
-
4-chlorophenyl phenothiazine carbamate
-
-
4-cymene
-
isolated from Melaleuca atlernifolia
4-ethenyl-5-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine hydrobromide
-
-
4-ethyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-N-methyl-dihydrophenanthridine
-
-
4-isopropyl benzaldehyde
-
30.4% inhibition at 1 mM
4-methoxyphenyl phenothiazine carbamate
-
-
4-methyl-N-(4-(8,9,10,11-tetrahydro-6H-azocino-[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,-10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)pentanamide
-
-
4-methylphenyl phenothiazine carbamate
-
-
4-Methylumbelliferone
-
80.9% inhibition at 1 mM
4-t-butylphenyl phenothiazine carbamate
-
-
4-[(2-aminophenyl)amino]-4-oxobutanoic acid
-
one of the best inhibitors
4-[(3-aminophenyl)amino]-4-oxobutanoic acid
-
weak inhibition
4-[(4-[[6-(1H-indol-1-yl)hexyl]amino]piperidin-1-yl)methyl]phenol
-
4-[(4-[[8-(1H-indol-1-yl)octyl]amino]piperidin-1-yl)methyl]phenol
-
4-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylbutan-1-amine
-
-
4-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylbutan-1-amine
-
-
5,6-dimethoxy-9-prop-2-en-1-yl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-ol
-
-
5,7,8,13-tetrahydroindolo [2',3':3,4]pyrido[2,1-b]quinazoline
-
-
5,8-dihydro-6H isoquino[1,2b]quinazoline
-
-
5-(1,2-dithiolan-3-yl)-N-[8-(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-ylideneamino)-octyl]pentanamide
-
-
5-butyl-4-ethenyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
5-butyl-4-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
5-deoxy-5-azido-1,4 3,6-dianhydro-D-glucitol
-
5% inhibition at 0.1 mM
5-ethoxy-3,4-dihydro-2H-pyrrole
-
-
5-hydroxy-5,6-seco-dihydrolycorine
-
-
5-hydroxy-5,6-secolycorine
-
-
5-methoxy-1-methyl-3a,8-bis(3-methylbut-2-en-1-yl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
5-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylpentan-1-amine
-
-
5-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylpentan-1-amine
-
-
5alpha,8alpha-epidioxy-(24S)-ethylcholesta-6,9(11),22(E)-triene-3beta-ol
-
isolated from Haloxylon recurvum
6,7-dimethoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
6,7-dimethoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
6,7-dimethoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
6,8-dibromo-2-(4-chlorophenyl)-2-methyl-2,3-dihydroquinazolin-4(1H)-one
-
6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
6-chloro-2-methyl-9H-beta-carbolin-2-ium iodide
-
-
6-formylumbelliferone
isolated from Angelica decursiva, noncompetitive inhibition
6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium iodide
-
-
6-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
6-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
-
-
6-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
6-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
6-O-demethylgalanthamine
-
-
6-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylhexan-1-amine
-
-
6-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylhexan-1-amine
-
-
6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one
-
-
7(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
-
7-bromo-6-methyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-one
-
-
7-exo-(benzylaminocarbonyloxy)-3-oxo-2,5,9-trioxabicyclo [4.3.0] nonane
-
10% inhibition at 0.1 mM
7-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
7-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
-
-
7-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
7-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
7-methoxy-N-nonyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride (1:1)
-
-
7-methoxy-N-octyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
-
7-methoxy-N-pentyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
-
7-methoxy-N-propyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
-
7-methyloctahydro-2H-quinolizin-1-yl (7-methyloctahydro-2H-quinolizin-1-yl)methyl butanedioate
7-O-galloyl-D-sedoheptulose
a mixed-type inhibitor, enzyme interacting residues, overview
7-oxo-ent-pimara-8(14),15-diene-19-oic acid
-
-
7-[(diethoxyphosphoryl)oxy]-1-methylquinolinium iodide
-
an irreversible inhibitor
8-alpha-ethoxyprecriwelline
-
-
8-benzyl-1-methyl-3a-(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
8-benzyl-5-methoxy-1-methyl-3a-(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
-
-
8-formylumbelliferone
noncompetitive inhibition
8-methoxypsoralen
-
67.1% inhibition at 1 mM
8-[4-[(diethylamino)methyl]phenoxy]-N,N-diethyloctan-1-amine
-
-
8-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropyloctan-1-amine
-
-
9,10-dimethoxy-1,2,3,12,15,16-hexadehydrogalanthan
-
-
9-(2-oxo-3-pyrrolidin-1-ylpropyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(2-oxo-4-pyrrolidin-1-ylbutyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(2-oxo-5-pyrrolidin-1-ylpentyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(4-[[2-(dimethylamino)ethyl]amino]-2-oxobutyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-amino-7-methoxy-1,2,3,4-tetrahydroacridine
-
-
9-O-[(2-(3-methyl)pyridinium bromide)ethyl]-berberine bromide
-
-
9-O-[(2-pyridinium)bromide ethyl]-berberine bromide
-
-
9-O-[(3-o xo-3-p-chlorophenylamino)propyl]-berberine bromide
-
-
9-O-[(3-oxo-3-p-methoxyamino)propyl]-berberine bromide
-
-
9-O-[(3-oxo-3-p-nitrophenylamino)propyl]-berberine bromide
-
-
9-O-[(3-oxo-3-p-tolylamino)propyl]-berberine bromide
-
-
9-O-[(3-oxo-3-phenylamino)propyl]-berberine bromide
-
-
9-O-[(3-pyridinium bromide)propyl]-berberine bromide
-
-
9-O-[3-(2-pyridinoxyl)butyl]-berberine bromide
-
-
9-O-[3-(3-methyl pyridinium bromide)propyl]-berberine bromide
-
-
9-O-[3-(4-bromo-phenoxyl)butyl]-berberine bromide
-
-
9-O-[3-(4-bromo-phenoxyl)propyl]-berberine bromide
-
-
9-O-[3-(4-chloro-phenoxyl) butyl]-berberine bromide
-
-
9-O-[3-(4-chloro-phenoxyl)propyl]-berberine bromide
-
-
9-O-[3-(4-methoxy-phenoxyl)-propyl]-berberine bromide
-
-
9-O-[3-(4-methoxy-phenoxyl)butyl]-berberine bromide
-
-
9-O-[3-(4-methyl-phenoxyl) propyl]-berberine bromide
-
-
9-O-[3-(4-nitro-phenoxyl)butyl]-berberine bromide
-
-
9-O-[3-(4-nitro-phenoxyl)propyl]-berberine bromide
-
-
9-O-[3-(N-methyl-phenylamino)propyl]-berberine bromide
-
-
9-O-[3-(naphthalen-2-yloxy)butyl]-berberine bromide
-
-
9-O-[3-(naphthalen-2-yloxy)propyl]-berberine bromide
-
-
9-O-[3-(naphthalene-2-ylthio)butyl]-berberine bromide
-
most potent BuChE inhibito
9-O-[3-(naphthalene-2-ylthio)propyl]-berberine bromide
-
-
9-O-[3-(phenylamino)propyl]-berberine bromide
-
-
9-[3-(dimethylamino)-2-oxopropyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-(diethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-(dimethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-[(2-hydroxyethyl)amino]-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[5-(dimethylamino)-2-oxopentyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
abamectin
-
is a potent inhibitor of horse serum butyrylcholinesterase which interacts with the enzyme in a reversible, competitive manner predictively to block the mouth of the active-site gorge of the enzyme and to bind to several critical residues that normally bind/hydrolyze choline esters. Abamectin is a blend of natural avermectins B1a and B1b. Avermectins potentiate the ability of certain neurotransmitters (GABA and/or glutamate) to trigger an influx of Cl- ions carried by neurotransmitter-gated chloride channels in target organisms. Competitive versus butyrylthiocholine. Docking study, BChE-avermectin docking and interaction profiling, overview
alpha-pinene
-
23.5% inhibition at 1 mM
alpha-terpinen
-
isolated from Melaleuca atlernifolia
ambenonium
-
1 mM, 18% inhibition, 10 mM 50% inhibition
amberboin
a sesquiterpene lactone from extract of Volutaria abyssinica, inhibition mechanism
ammonium(5-hydroxycarvacryl) trimethyl chloride piperidine carboxylate
androst-1,4-dien-3,17-dione
-
-
androst-4-en-3,7-dione
-
-
Anethum graveolens essential oil
-
90.9% inhibition
-
avermectin B1a
-
engagement of avermectin B1a in a hydrogen-bonding interaction with the catalytic serine
baicalein
-
an alkaloid isolated from Isatis tinctoria
Benzoylcholine
-
competitive
benzoylthiocholine
-
substrate inhibition
benzyl di-n-butyl phosphate
-
beta-pinene
-
31.3% inhibition at 1 mM
biphenyl-2-yl butylcarbamate
-
-
bulbocapnine
-
isolated from Corydalis cava
butyl ethyl phenyl phosphate
-
Butyrylcholine
-
competitive to butyrylthiocholine
buxabenzacinine
-
isolated from Buxus hyrcana
buxandrine
-
isolated from Buxus hyrcana
buxidin
-
isolated from Buxus hyrcana
buxippine-K
-
isolated from Buxus hyrcana
buxoviricine
-
isolated from Buxus hyrcana
chlorobenzene
-
reversible
chlorogenic acid
-
30.8% inhibition at 1 mM
chlorpromazine
-
not inhibitory to EC 3.1.1.7
chlorpyriphos-oxon
-
irreversible inhibitor
citral
-
32.6% inhibition at 1 mM
citronellal
-
60.6% inhibition at 1 mM
citronellol
-
55.4% inhibition at 1 mM
clomipramine
-
competitive inhibition
corydine
-
specific for BChE
cryptotanshinone
uncompetitive inhibitor
cuminyl alcohol
-
18.1% inhibition at 1 mM
cyclopentyl phenothiazine carbamate
-
-
D-borneol
-
12.1% inhibition at 1 mM
dec-N-dimethylregeline
-
-
decursidin
competitive inhibition
dehydroevodiamine hydrochloride
-
isolated from Evodia rutaecarpa
demethyldebromoflustramine B
-
-
di-n-butyl 2-chlorophenyl phosphate
irreversible inhibition
di-n-butyl 2-methylbenzyl phosphate
-
di-n-butyl 2-methylphenyl phosphate
reversible inhibition
di-n-butyl 2-naphthyl phosphate
-
di-n-butyl 2-phenylethyl phosphate
-
di-n-butyl 3,4,5-trimethylphenyl phosphate
-
di-n-butyl 3,4-dimethylphenyl phosphate
-
di-n-butyl 3,5-dimethylphenyl phosphate
-
di-n-butyl 3-methylbenzyl phosphate
-
di-n-butyl 3-methylphenyl phosphate
reversible inhibition
di-n-butyl 4-methylbenzyl phosphate
-
di-n-butyl 4-methylphenyl phosphate
reversible inhibition
di-n-butyl naphthalen-1-yl phosphate
-
di-n-butyl phenyl phosphate
-
di-n-pentyl phenyl phosphate
-
diazinon oxon
-
high inhibition, irreversible inhibitor
diazoxon
-
second order rate constant for inhibition is 77000000 per M and min
dicyclohexyl phenyl phosphate
-
diethyl 2-naphthyl phosphate
-
diethyl 3,5-dimethylphenyl phosphate
-
Diethyl p-nitrophenyl phosphate
diethyl phenyl phosphate
-
diethylphosphochloridate
-
-
diethylphosphofluoridate
-
-
dihydrobenzodioxepine cymserine
-
i.e. DHBDC
dihydrocarvone
-
66.5% inhibition at 1 mM
dihydrotanshinone
uncompetitive inhibitor
diisopropyl fluorophosphate
diisopropyl phosphorofluoridate
-
rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon
diisopropylfluorophosphate
diisopropylphosphofluoridate
dimethyl phenyl phosphate
-
dipropan-2-yl phosphorofluoridate
EDTA
-
inhibitory above 1 mM
ent-kaur-16-en-19-oic-acid
-
-
ent-pimar-15-en-8 alpha, 19-diol
-
-
ent-pimara-8(14),15-diene-19-oic acid
-
-
ent-pimara-8(14),15-diene-19-ol
-
-
epiglucoisatisin
-
an alkaloid isolated from Isatis tinctoria
ethanolic extract from Pimpinella anisodes
-
IC50: 362.1 microgram/ml
-
ethopropazine hydrochloride
ethyl 1-(3-(1H-imidazol-1-yl)propyl)-2-(4-nitrophenyl)-1H-benzo[d]imidazole-5-carboxylate
-
best inhibitor
ethyl carbamoyl
-
native enzyme, 50% inhibition at 10 nM, recombinant enzyme, 50% inhibition at 5 nM
ethyl [2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl]methylcarbamate
-
-
ethyl [2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl]methylcarbamate
-
-
ethylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
eugenol
-
45.4% inhibition at 1 mM
farnesol
-
33.0% inhibition at 1 mM
fenobucarb
-
an insecticide toxic to the fish via inhibition of brain cholinesterase
fluoride
-
reversible inhibitor, forms a complex with the enzyme
Foeniculum vulgare essential oil
-
flowering, 65.4% inhibition; fully-mature, 71.6% inhibition
-
FP-biotin
-
i.e. 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide, second order rate constant for inhibition is 160000000 per M and min, binding affinity is about 5.8 nM
gallic acid
-
48.8% inhibition at 1 mM
gamma-terpinen
-
isolated from Melaleuca atlernifolia
genistein
-
65.7% inhibition at 1 mM
geraniol
-
21.1% inhibition at 1 mM
geranyl ester
-
59.1% inhibition at 1 mM
Harmane
-
noncompetitive inhibition
HI 6
-
competitive, reversible
homatropine
-
competitive
huperzine
-
50% inhibition at 0.03 mM
hyrcamine
-
isolated from Buxus hyrcana
hyrcanone
-
isolated from Buxus hyrcana
hyrcatrienine
-
isolated from Buxus hyrcana
imipramine
-
competitive inhibition
iodine methylated 2-dimethylaminoethyl esters of N-substituted alpha,beta-dehydrophenylalanine
inhibition potencies, overview
-
iolantamine iodomethylate
-
-
iprobenfos
-
i.e. IBP or kitazin
isatan A
-
an alkaloid isolated from Isatis tinctoria
isatan B
-
an alkaloid isolated from Isatis tinctoria
iso-butylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
iso-menthone
-
64.7% inhibition at 1 mM
iso-pulegol
-
44.7% inhibition at 1 mM
isolariin A
-
isolated from Linaria reflexa
isolariin B
-
isolated from Linaria reflexa
isoquinolin-1-yl(2-methoxyphenyl)methanol
-
-
isosorbide-di-(4-nitrophenyl carbamate)
-
-
isosorbide-di-(benzylcarbamate)
-
77% inhibition at 0.1 mM
isosorbide-di-(butylcarbamate)
-
13% inhibition at 0.1 mM
isosorbide-di-(ethylcarbamate)
-
-
isosorbide-di-(propylcarbamate)
-
28% inhibition at 0.1 mM
isosorbide-di-phenylcarbamate
-
77% inhibition at 0.1 mM
K074
-
a bispyridinium para-aldoxime with butane linker, reversible inhibition
K075
-
a bispyridinium para-aldoxime with but-2-ene linker, reversible inhibition
K114
-
a bispyridinium para-aldoxime with xylene-like linker, reversible, noncompetitive inhibition
kesselridine iodomethylate
-
-
Lavandula officinalis essential oil
-
chemical fertilizer, 95.0% inhibition; organic fertilizer, 92.9% inhibition
-
lawsaritol
-
isolated from Haloxylon recurvum
leufolin A
-
isolated from Leucas urticifolia
leufolin B
-
isolated from Leucas urticifolia
linalyl ester
-
35.8% inhibition at 1 mM
linalyl oxide
-
29.0% inhibition at 1 mM
loganin
a mixed-type inhibitor, enzyme interacting residues, overview
luteidine iodomethylate
-
-
luteolin 7-O-rutinoside
-
54.9% inhibition at 1 mM
lysivane
-
0.1 mM, complete inhibition; i.e. Lysivane
Melissa officinalis essential oil
-
chemical fertilizer, 66.5% inhibition; organic fertilizer, 73.3% inhibition
-
Mentha piperita essential oil
-
organic fertilizer, 93.5% inhibition
-
Mentha spicata essential oil
-
organic fertilizer, 91.0% inhibition
-
menthofurane
-
55.4% inhibition at 1 mM
menthol
-
70.0% inhibition at 1 mM
methanolic exrtact of Dictyota dichotoma
-
methanolic extract, noncompetitive type inhibition, , Ki: 0.9 mg/ml
-
methanolic exrtact of Enteromorpha intestinalis
-
methanolic extract, mixed-type inhibition, Ki: 0.95 mg/ml
-
methanolic exrtact of Hypnea valentine
-
methanolic extract, mixed-type inhibition, Ki: 0.75 mg/ml
-
methanolic exrtact of Ulva reticulate
-
methanolic extract, mixed-type inhibition, Ki: 0.6 mg/ml
-
methyl isoplatydesmine
-
specific for BChE
methylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
metoclopramide
-
0.001-0.0019 mM, 50% competitive inhibition
metrifonate
-
50% inhibition at 0.018 mM
morphine
-
0.0013 mM, 6% inhibition
morroniside
a mixed-type inhibitor, enzyme interacting residues, overview
N,N'-bis(3-pyridin-3-ylcyclohexyl)pentanediamide
N,N'-diisopropylphosphorodiamidic fluoride
-
Mipafox, irreversible, covalente inhibition
N,N'-[(1,1,3,3,5,5,7,7,9,9-decamethylpentasiloxane-1,9-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
N,N'-[(1,1,3,3,5,5,7,7-octamethyltetrasiloxane-1,7-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
N,N'-[(1,1,3,3,5,5-hexamethyltrisiloxane-1,5-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
N,N'-[(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
N,N,N',N'-tetramethyl-1,6-hexane diamine
-
-
N,N,N,N',N',N'-hexamethylbutane-1,4-diaminium
N,N,N-triethylethanaminium
N,N,N-trimethyl-2-([(2Z)-3-phenyl-2-[(phenylcarbonyl)amino]prop-2-enoyl]oxy)ethanaminium iodide
-
N,N,N-trimethyl-2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propan-1-aminium
-
-
N,N,N-trimethyl-3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butan-1-aminium
-
-
N,N,N-trimethyl-4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentan-1-aminium
-
-
N,N,N-trimethylmethanaminium
N,N-bis(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl) acetamide
-
-
N,N-bis(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)acetamide
-
-
N,N-di-sec-butyl-2-(1,3-dioxoisoindolin-2-yl)acetamide
-
N,N-dibutyl-10-[4-[(diethylamino)methyl]phenoxy]decan-1-amine
-
-
N,N-dibutyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
-
N,N-dibutyl-4-[4-[(diethylamino)methyl]phenoxy]butan-1-amine
-
-
N,N-dibutyl-5-[4-[(diethylamino)methyl]phenoxy]pentan-1-amine
-
-
N,N-dibutyl-6-[4-[(diethylamino)methyl]phenoxy]hexan-1-amine
-
-
N,N-dibutyl-8-[4-[(diethylamino)methyl]phenoxy]octan-1-amine
-
-
N,N-dicyclohexyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
-
N-((1-benzylpiperidin-4-yl)methyl)-N-(2-methoxyethyl)-2-naphthamide
-
N-(1,3-thiazol-5-ylcarbamothioyl)butanamide
-
N-(2-phenylethyl)-N-[(12Z)-7,8,9,10-tetrahydroazepino [2,1b]quinazolin-12(6H)-ylidene]amine
-
-
N-(3-([6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]amino)propyl)-5-(1,2-dithiolan-3-yl)pentanamide
-
-
N-(3-ferrocenylphenyl)-2-chlorobenzamide
-
N-(3-ferrocenylphenyl)-2-fluorobenzamide
-
N-(3-ferrocenylphenyl)-2-methoxybenzamide
-
N-(3-ferrocenylphenyl)-2-methylbenzamide
-
N-(3-ferrocenylphenyl)-3-chlorobenzamide
-
N-(3-ferrocenylphenyl)-3-fluorobenzamide
-
N-(3-ferrocenylphenyl)-3-methoxybenzamide
-
N-(3-ferrocenylphenyl)-3-methylbenzamide
-
N-(3-ferrocenylphenyl)-4-chlorobenzamide
-
N-(3-ferrocenylphenyl)-4-fluorobenzamide
-
N-(3-ferrocenylphenyl)-4-methoxybenzamide
-
N-(3-ferrocenylphenyl)-4-methylbenzamide
-
N-(3-ferrocenylphenyl)benzamide
-
N-(4-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)butyl)-N-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl) methacrylamide
-
-
N-(4-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)butyl)-N-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl) propionamide
-
-
N-(4-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)butyl)-N-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl)acetamide
-
-
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro--6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-acetamide
-
-
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-methacrylamide
-
-
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-pentanamide
-
-
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-pivalamide
-
-
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-propionamide
-
-
N-(4-ferrocenylphenyl)-2-chlorobenzamide
-
N-(4-ferrocenylphenyl)-2-fluorobenzamide
-
N-(4-ferrocenylphenyl)-2-methoxybenzamide
-
N-(4-ferrocenylphenyl)-2-methylbenzamide
-
N-(4-ferrocenylphenyl)-3-chlorobenzamide
-
N-(4-ferrocenylphenyl)-3-fluorobenzamide
-
N-(4-ferrocenylphenyl)-3-methoxybenzamide
-
N-(4-ferrocenylphenyl)-3-methylbenzamide
-
N-(4-ferrocenylphenyl)-4-chlorobenzamide
-
N-(4-ferrocenylphenyl)-4-fluorobenzamide
-
N-(4-ferrocenylphenyl)-4-methoxybenzamide
-
N-(4-ferrocenylphenyl)-4-methylbenzamide
-
N-(4-ferrocenylphenyl)benzamide
-
N-(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-ylidene)octane-1,8-diamine
-
-
N-(8-([6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]amino)octyl)-5-(1,2-dithiolan-3-yl)-pentanamide
-
-
N-(cyclohexyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide
-
N-butyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
-
n-butylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
N-desmethyl-8alpha-ethoxypretazzettine
-
-
N-desmethyl-8beta-ethoxypretazzettine
-
-
N-ethyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
-
N-ethyl-N-(4-[[10-(4-ethylpiperazin-1-yl)decyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[10-(4-methylpiperazin-1-yl)decyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[10-(piperidin-1-yl)decyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[10-(pyrrolidin-1-yl)decyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[5-(4-ethylpiperazin-1-yl)pentyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[5-(4-methylpiperazin-1-yl)pentyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[5-(piperidin-1-yl)pentyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[5-(pyrrolidin-1-yl)pentyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[6-(4-ethylpiperazin-1-yl)hexyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[6-(4-methylpiperazin-1-yl)hexyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[6-(piperidin-1-yl)hexyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[6-(pyrrolidin-1-yl)hexyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[8-(4-ethylpiperazin-1-yl)octyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[8-(4-methylpiperazin-1-yl)octyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[8-(piperidin-1-yl)octyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-(4-[[8-(pyrrolidin-1-yl)octyl]oxy]benzyl)ethanamine
-
-
N-ethyl-N-[4-[2-(4-methylpiperazin-1-yl)ethoxy]benzyl]ethanamine
-
-
N-ethyl-N-[4-[2-(piperidin-1-yl)ethoxy]benzyl]ethanamine
-
-
N-ethyl-N-[4-[4-(4-methylpiperazin-1-yl)butoxy]benzyl]ethanamine
-
-
N-ethyl-N-[4-[4-(piperidin-1-yl)butoxy]benzyl]ethanamine
-
-
N-ethyl-N-[4-[4-(pyrrolidin-1-yl)butoxy]benzyl]ethanamine
-
-
N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine
-
-
N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
-
N-methyl, N-alkyl carbamates
-
inhibition of human BChE by divers derivatives of phenylethylamines and aminoindans is less influenced by the size of the alkyl group and more dependent on the structure of the leaving group, overview
-
N-methyl-3-pyridin-3-ylcyclohexanamine
N-methyl-7-exo-(benzylaminocarbonyloxy-)-3-oxo-5,9-dioxa-2-azabicyclo[4.3.0] nonane
-
6.5% inhibition at 0.1 mM
N-methyl-N-(3-carbamoyloxyphenyl)methyl-amino inhibitor
-
-
N-methylphenothiazine
-
not inhibitory to EC 3.1.1.7
n-propylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
N-[(1-benzylpiperidin-3-yl)methyl]-N-(2-methoxyethyl)naphthalene-2-sulfonamide
the inhibitor is highly selective for BChE versus acetylcholinesterase, AChE
N-[(2,3-dichlorophenyl)carbamothioyl]butanamide
-
N-[(2,4,6-trimethylphenyl)carbamothioyl]butanamide
-
N-[(2,4-dichlorophenyl)carbamothioyl]butanamide
-
N-[(2,6-dichloro-4-fluorophenyl)carbamothioyl]butanamide
-
N-[(2-methoxyphenyl)carbamothioyl]butanamide
-
N-[(3-nitrophenyl)carbamothioyl]butanamide
-
N-[(4-methoxyphenyl)carbamothioyl]butanamide
-
N-[(4-methylphenyl)carbamothioyl]butanamide
-
N-[(4-nitrophenyl)carbamothioyl]butanamide
-
N-[4-[4-(1,3-benzothiazol-2-yl)phenoxy]butyl]-6-chloro-1,2,3,4-tetrahydroacridin-9-amine
-
N-[6-(1H-indol-1-yl)hexyl]-1-(4-methoxybenzyl)piperidin-4-amine
-
N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]-1-butanamine
-
-
N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]hexane-1,6-diamine
-
-
N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]octane-1,8-diamine
-
-
N-[8-(1H-indol-1-yl)octyl]-1-(4-methoxybenzyl)piperidin-4-amine
-
N-[[1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl]methyl]-N-(2-methoxyethyl)naphthalene-2-carboxamide
the inhibitor is highly selective for BChE versus acetylcholinesterase, AChE. It is a potent, selective, and reversible slow tight-binding inhibitor of human BChE
N1-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene)-N3-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl)-N3-methylpropane-1,3-diamine
-
-
N1-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene)-N4-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl)-N4-methylbutane-1,4-diamine
-
-
N1-methyl-N3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylidene)-N1-(3-(8,9,10,11-tetrahydro-6Hazocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)propane-1,3-diamine
-
-
N3-demethylsaracodine
-
-
naringin
-
13.7% inhibition at 1 mM
Nb-dimethylcycloxobuxoviricine
-
isolated from Buxus hyrcana
nerol
-
30.8% inhibition at 1 mM
O,O-diethyl S-hexyl phosphorothioate
O,O-diethyl-4-nitrophenylphosphate
-
syn: paraoxon, rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon
O,O-diethyl-S-(2-N,N,N-trimethylammonioethyl) phosphorothiolate iodide
-
syn: echothiophate, rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon
O-(4-bromo-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
-
-
O-(4-bromo-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
-
least effective inhibitor
O-(4-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
-
-
O-(4-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
-
-
O-(5-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
-
-
O-(5-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
-
-
O-butyl S-(2-(ethylthio)ethyl) methylphosphonothioate
O-ethyl S-(2-(ethylthio)ethyl) methylphosphonothioate
O-ethyl S-2-diisopropylaminoethyl methyl phosphonothiolate
VX, a highly toxic chemical warfare agent, inhibition of butyrylcholinesterase (BChE) activity by VX is due to formation of a phosphorylated BChE adduct
O-ethyl S-heptyl methylphosphonothioate
O-ethyl S-hexyl methylphosphonothioate
O-ethyl S-neopentyl methylphosphonothioate
O-ethyl S-pentyl methylphosphonothioate
O-ethyl S-[2-(diisopropylamino)ethyl]methylphosphonothioate
nerve agent VX
O-ethyl-S-2-diisopropylaminoethylmethylphosphonothiolate
O-ethyl-S-3,3-dimethylbutyl methylthiophosphonate
O-ethyl-S-ethyl methylthiophosphonate
-
-
O-ethyl-S-n-heptyl methylthiophosphonate
O-ethyl-S-n-hexyl methylthiophosphonate
O-ethyl-S-n-pentyl methylthiophosphonate
O-ethyl-S-pentyl methylthiophosphonate
-
LG-64
O-hexyl-S-ethyl methylthiophosphonate
-
-
O-isopropyl methylphosphonofluoridate
-
syn: sarin, rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon
O-isopropyl S-(diisopropylaminoethyl) methyl thiophosphonate
-
-
O-pinacolyl methylphosphonofluoridate
-
syn: soman, rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon
O-[2-[(3-bromophenyl)carbamoyl]-4-chlorophenyl] O,O-diethyl phosphorothioate
-
-
O-[2-[(3-bromophenyl)carbamoyl]-5-chlorophenyl] O,O-diethyl phosphorothioate
-
-
O-[2-[(4-bromophenyl)carbamoyl]-4-chlorophenyl] O,O-diethyl phosphorothioate
-
-
O-[2-[(4-bromophenyl)carbamoyl]-5-chlorophenyl] O,O-diethyl phosphorothioate
-
-
O-[4-bromo-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[4-bromo-2-[(3-bromophenyl)carbamoyl]phenyl] diethyl phosphate
-
-
O-[4-bromo-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[4-bromo-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[4-bromo-2-[(4-bromophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[4-bromo-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[4-bromo-2-[(4-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[4-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[4-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[4-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[4-chloro-2-[(4-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[5-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[5-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
second best inhibitor
O-[5-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
-
O-[5-chloro-2-[(4-fluorophenyl)-carbamoyl]phenyl] O,O-diethyl phosphorothioate
-
most efficient inhibitor
Ocimum basilicum essential oil
-
green variety, 74.1% inhibition; purple variety, 79.1% inhibition
-
octahydro-2H-quinolizin-1-yl octahydro-2H-quinolizin-1-ylmethyl butanedioate
octahydro-2H-quinolizin-1-ylmethanol
organophosphorus compounds
-
determination of reactivation efficiency with oxims, e.g. obixime, 2-PAM, HI 6, HLö 7, and MMB-4, reactivation kinetics, overview, structure-activity relationship for inhibition and spontaneous reactivation, overview
-
Origanum majorana essential oil
-
organic fertilizer, 94.4% inhibition
-
Origanum munitiflorum essential oil
-
organic fertilizer, 94.7% inhibition
-
Origanum onites essential oil
-
organic fertilizer, 92.9% inhibition
-
Origanum vulgare essential oil
-
organic fertilizer, 88.4% inhibition
-
oxazaphenalene lactone
-
-
p-chloromercuribenzoate
-
-
p-hydroxybenzoic acid
-
-
PAM-2
-
competitive, reversible
paroxetine
-
mixed-type inhibition
phenethyl cymserine
-
native enzyme, 50% inhibition at 7 nM, recombinant enzyme, 50% inhibition at 50 nM
phenyl 1,2-dimethylhydrazinecarboxylate
-
-
phenyl 1-methylhydrazinecarboxylate
-
-
phenyl butylcarbamate
-
-
phenyl dipropyl phosphate
-
phenyl phenothiazine carbamate
-
-
phenyl trimethyl ammonium
-
specific inhibitor
phenylethylcymserine
-
inhibition in the nanomolar range
phosphostigmine
-
competitive, reversible
piperitone
-
76.1% inhibition at 1 mM
procainamide
-
specific inhibitor
propyl phenothiazine carbamate
-
-
pyridostigmine bromide
-
native enzyme, 50% inhibition at 300 nM, recombinant enzyme, 50% inhibition at 500 nM
R-DEPP
O,R-diethylphenylphosphonothioate, stereospecific inhibition kinetics and stereospecificity of the chiral nerve agent derivative O,R-diethylphenylphosphonothioate. Chemical modification by DEPP, a measurable amount of the enzyme-phosphonate adduct does not undergo aging
rac-bambuterol monocarbamate
regeline iodomethylate
-
-
Ro 02-0683
-
progressive inhibitor
RP-3,3-dimethylbutyl-methylphosphonyl thiocholine
-
phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
RP-cycloheptyl-methylphosphonyl thiocholine
-
phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
RP-isopropyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
S-(3,3-dimethylbutyl) O,O-diethyl phosphorothioate
S-DEPP
O,S-diethylphenylphosphonothioate, stereospecific inhibition kinetics and stereospecificity of the chiral nerve agent derivative O,S-diethylphenylphosphonothioate. Chemical modification by DEPP, a measurable amount of the enzyme-phosphonate adduct does not undergo aging. Pralidoxime, a common rescue agent, affects a modest recovery of eqBChE from treatment with S-DEPP. S-DEPP inhibition is practically irreversible. Kinetic analysis of S-DEPP with cholinesterases
salignarine-C
-
isolated from Sarcococca saligna
Salvia officinalis essential oil
-
organic fertilizer, 66.3% inhibition
-
Salvia sclarea essential oil
-
chemical fertilizer, 45.1% inhibition; organic fertilizer, 76.0% inhibition
-
sarcovagenine-C
-
isolated from Sarcococca saligna
Satureja cuneifolia essential oil
-
organic fertilizer, 98.4% inhibition
-
Scopolamine
-
competitive
scopoletin
-
73.5% inhibition at 1 mM
serine
-
selective ChE inhibitor, 93.1-99.2% inhibition at 0.0005 mM
sertraline
-
mixed-type inhibition
silibinin
-
51.4% inhibition at 1 mM
silymarin
-
43.2% inhibition at 1 mM
slavin A
-
isolated from Salvia santolinifolia
slavin B
-
isolated from Salvia santolinifolia
SP-3,3-dimethylbutyl-methylphosphonyl thiocholine
-
phosphonylates the enzyme, enzyme can be reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
SP-cycloheptyl-methylphosphonyl thiocholine
-
phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
SP-isopropyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, enzyme can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
sulfoglucobrassicin
-
an alkaloid isolated from Isatis tinctoria
tacrine-caffeic acid hybrid
-
taspine
-
isolated from Thymus vulgaris essential oil
terpinen-4-ol
-
isolated from Melaleuca atlernifolia
tert-butyl 10H-phenothiazine-10-carboxylate
-
-
tetra monoisopropyl pyrophosphomide
-
50% inhibition at 0.055 mM
tetra(monoisopropyl) diphosphortetramide
-
i.e. iso-OMPA
tetra(monoisopropyl)diphosphortetramide
tetra(monoisopropyl)diphosphotetramide
-
isoOMPA
tetrabutylammonium
-
competitive
tetraisopropyl diphosphoramide
tetraisopropyl phosphoramide
tetraisopropyl pyrophosphoramide
-
irreversible inhibition
tetraisopropyldiphosphoramide
-
iso-OMPA, 98% inhibition at 0.04 mM after 10 min
tetraisopropylpyrophosphoramide
-
iso-OMPA, enzyme BChE is selectively and completely inhibited
thioflavin T
binding structure from analysis of the crystal structure, PDB ID 6ESY, inhibition kinetics and thermodynamics, overview
thioridazine
-
0.0054 mM, 10% inhibition
thymohydroquinone
-
isolated from Thymus vulgaris essential oil
thymoquinone
-
isolated from Thymus vulgaris essential oil
tolserine N-dimethyl ammonium bromide
-
native enzyme, 50% inhibition at 44 nM, recombinant enzyme, 50% inhibition at 45 nM
trans-anethole
-
identified compound of Pimpinella anisodes, IC50: 209.6 microgram/ml
Vanillin
-
8.5% inhibition at 1 mM
VX (nerve agent)
-
a nerve agent
(+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-(dimethylamino)ethyl)-2-naphthamide
the inhibitor is highly selective for BChE versus acetylcholinesterase, AChE, and shows selective reversible huBChE inhibition in the picomolar concentration range. Enzyme-binding crystal structure determination and analysis, overview. The compound has a picomolar inhibition constant versus BChE due to strong cation-Pi interactions, as revealed by the solved crystal structure of its complex with human BChE. Additionally, the inhibitor inhibits BChE ex vivo and is noncytotoxic. In vitro pharmacokinetic experiments show that (+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-(dimethylamino)ethyl)-2-naphthamide is highly protein-bound, highly permeable, and metabolically stable. (+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-(dimethylamino)ethyl)-2-naphthamide crosses the blood-brain barrier and improves memory, cognitive functions, and learning abilities of mice in a scopolamine model of dementia. (+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-(dimethylamino)ethyl)-2-naphthamide is thus a promising advanced lead compound for the development of drugs for alleviating symptoms of cholinergic hypofunction in patients with advanced Alzheimer's disease
(+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-(dimethylamino)ethyl)-2-naphthamide
inhibition of BChE in rat brain slices, low cytotoxicity, favorable in vitro pharmacokinetics, and proven penetration into the brain. The brain-to-blood plasma ratio of (+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-(dimethylamino)ethyl)-2-naphthamide is 1.47
(-)-huperzine A
-
(2-((ethoxy(hydroxy)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium methanesulfonate
-
-
(2-((ethoxy(hydroxy)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium methanesulfonate
-
-
(2-((ethoxy(methyl)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium
-
-
(2-((ethoxy(methyl)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium
-
-
(R)-bambuterol monocarbamate
inhibition kinetics of human and dog plasma butyrylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(R)-bambuterol monocarbamate
inhibition kinetics of human and dog plasma butyrylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(R)-[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
i.e. (R)-bambuterol, inhibition kinetics of human and dog plasma butyrylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(R)-[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
i.e. (R)-bambuterol, inhibition kinetics of human and dog plasma butyrylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
E2020, acetylcholinesterase inhibitor used in treatment of Alzheimer's disease, interacts with the active site and the peripheral anionic site of the enzyme
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
E2020, acetylcholinesterase inhibitor used in treatment of Alzheimer's diaease, inhibition kinetics
(RS)-[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
i.e. rac-bambuterol, inhibition kinetics of human and dog plasma butyrylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(RS)-[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
i.e. rac-bambuterol, inhibition kinetics of human and dog plasma butyrylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(S)-bambuterol monocarbamate
inhibition kinetics of human and dog plasma butyrylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(S)-bambuterol monocarbamate
inhibition kinetics of human and dog plasma butyrylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(S)-[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
i.e. (S)-bambuterol, inhibition kinetics of human and dog plasma butyrylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(S)-[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
i.e. (S)-bambuterol, inhibition kinetics of human and dog plasma butyrylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one
-
1 mM, 12% inhibition; i.e. B.W 284 C51 dibromide
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one
-
i.e. B.W 284 C51 dibromide
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one
-
1 mM, 20% inhibition, 10 mM, 65% inhibition; i.e. B.W 284 C51 dibromide
1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
-
BW284c51
1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
i.e. BW284c51
1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
i.e. BW284c51
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
-
BW284c51
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, cholinesterase from male fish is more sensitive to inhibition
1,8-cineole
-
isolated from Melaleuca atlernifolia
1,8-cineole
-
48.2% inhibition at 1 mM
1-(hydroxymethyl)-5-methyloctahydro-2H-quinolizinium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
1-(hydroxymethyl)-5-methyloctahydro-2H-quinolizinium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
1-methyl-3-(3-(methylamino)cyclohexyl)pyridinium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
1-methyl-3-(3-(methylamino)cyclohexyl)pyridinium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
1-naphthyl methyl carbamate
-
the effects of sublethal concentrations of 1-naphthyl methyl carbamate on the ChE activities present in the oligochaete Lumbriculus variegatus and in the pigmented Biomphalaria glabrata gastropod are investigated. ChE activity from both species are inhibited, with EC50 and IC50 values 20times lower for the oligochaete than for the gastropod the recovery process in uncontaminated media is more efficient in oligochaetes than in snails. In 2 h the oligochaetes show no inhibition with respect to control values whereas the snails do not reach control values even after 48 h of being in pesticide-free water
1-naphthyl methyl carbamate
-
the effects of sublethal concentrations of 1-naphthyl methyl carbamate on the ChE activities present in the oligochaete Lumbriculus variegatus and in the pigmented Biomphalaria glabrata gastropod are investigated. ChE activity from both species are inhibited, with EC50 and IC50 values 20times lower for the oligochaete than for the gastropod the recovery process in uncontaminated media is more efficient in oligochaetes than in snails. In 2 h the oligochaetes show no inhibition with respect to control values whereas the snails do not reach control values even after 48 h of being in pesticide-free water
2-(6-oxo-7,11-diazatricyclo(7.3.1.0 2,7)tridec-11-yl)ethyl acetate
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
2-(6-oxo-7,11-diazatricyclo(7.3.1.0 2,7)tridec-11-yl)ethyl acetate
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
2-acetamido-N,N,N-trimethylethen-1-aminium
-
reversible inhibitor
2-acetamido-N,N,N-trimethylethen-1-aminium
-
reversible inhibitor
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
-
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
2-[acetyl(methyl)amino]-N,N,N-trimethylethen-1-aminium
-
reversible inhibitor
2-[acetyl(methyl)amino]-N,N,N-trimethylethen-1-aminium
-
reversible inhibitor
3,3'-((1,5-dioxopentane-1,5-diyl)bis(iminocyclohexane-3,1-diyl))bis(1-methylpyridinium)
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
3,3'-((1,5-dioxopentane-1,5-diyl)bis(iminocyclohexane-3,1-diyl))bis(1-methylpyridinium)
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
3-(6-oxo-6-(8-oxooctahydro-2H-2,6-methanopyrido(1,2-a)(1,5)diazocin-3(4H)-yl)hexanoyl)decahydro-8H-1,5-methanopyrido(1,2-a)(1,5)diazocin-8-one
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
3-(6-oxo-6-(8-oxooctahydro-2H-2,6-methanopyrido(1,2-a)(1,5)diazocin-3(4H)-yl)hexanoyl)decahydro-8H-1,5-methanopyrido(1,2-a)(1,5)diazocin-8-one
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
4-acetyl-1,1-dimethylpiperazin-1-ium
-
reversible inhibitor
4-acetyl-1,1-dimethylpiperazin-1-ium
-
reversible inhibitor
7-methyloctahydro-2H-quinolizin-1-yl (7-methyloctahydro-2H-quinolizin-1-yl)methyl butanedioate
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
7-methyloctahydro-2H-quinolizin-1-yl (7-methyloctahydro-2H-quinolizin-1-yl)methyl butanedioate
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
acetylthiocholine
-
substrate inhibition
acetylthiocholine
slight substrate inhibition
Aldicarb
-
-
Aldicarb
-
cholinesterase from small fish is more sensitive to inhibition
Aldicarb
-
cholinesterase from male fish is more sensitive to pesticide inhibition
amlodipine besylate
-
reversible mixed-type inhibition
ammonium(5-hydroxycarvacryl) trimethyl chloride piperidine carboxylate
-
10 mM, 74% inhibition
ammonium(5-hydroxycarvacryl) trimethyl chloride piperidine carboxylate
-
i.e. AMO-1618, growth retardant, 1 mM, 85% inhibition
azinphos-methyl
-
formation of the oxon derivative by the enzyme
azinphos-methyl
-
formation of the oxon derivative by the enzyme
bambuterol
-
inhibition in the nanomolar range
bambuterol
a selective BChE inhibitor, causing 98% inhibition of BChE
bambuterol
-
a specific and stereoselective inhibitor of butyrylcholinesterase, which is about 8000times faster inhibited than acetylcholinesterase. Leucine 295 and alanine 337 are crucial residues in BChE for high bambuterol selectivity, preferred inhibition by the R- over the S-bambuterol
Berberine
-
-
bisnorcymserine
-
-
bisnorcymserine
-
inhibition in the nanomolar range
butyrylthiocholine
-
substrate inhibition above 10 mM
butyrylthiocholine
-
competitive to butyrylcholine
butyrylthiocholine
-
substrate inhibition
butyrylthiocholine
-
competitive
butyrylthiocholine
slight substrate inhibition
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide, seletive inhibition of acetylthiocholine esterase activity
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide, seletive inhibition of acetylthiocholine esterase activity
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide, seletive inhibition of acetylthiocholine esterase activity
BW284c51
-
reversible inhibitor
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide, seletive inhibition of acetylthiocholine esterase activity
BW284c51
-
specific inhibition of acetylthiocholinesterase activity
BW284c51
-
i.e. bis(4-allyl dimethyl ammoniumphenyl) pentane-3-one dibromide
BW284c51
-
irreversible inhibitor
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide, seletive inhibition of acetylthiocholine esterase activity
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide, seletive inhibition of acetylthiocholine esterase activity
BW284c51
-
67.4-88.4% inhibition at 0.001 mM
BW284c51
-
inhibits acetylthiocholinesterase and propionylthiocholinesterase activities, but not butyrylthiocholineesterase activity
BW284c51
-
inhibits acetylthiocholinesterase, propionylthiocholinesterase and butyrylthiocholineesterase activities
Carbaryl
-
-
Carbaryl
-
low inhibition, irreversible inhibitor
Carbaryl
-
selectively inhibits isozyme E1
carvacrol
-
isolated from Thymus vulgaris essential oil
carvacrol
-
54.6%inhibition at 1 mM
chlordiazepoxide HCl
-
reversible mixed-type inhibition
chlorpyrifos
an anticholinesterase organophosphate insecticide used in the production of food derived from animal, fruit and horticultural origin. The therapeutic treatment of castrated male bovines treated with chlorpyrifos does not cause changes in the variables evaluated, i.e. total proteins, liver enzymes, urea, and creatinine
chlorpyrifos
-
inhibits the enzyme and is toxic and lethal to the earthworm when exposed to the organohosphorus insecticide
chlorpyrifos
-
the enzyme activity is significantly decreased by environmental realistic chlorpyrifos concentrations of 2.86 and 14.2 nM after seven days of contact
chlorpyrifos oxon
90% inhibition at 50 nM, recombinant bovine BChE (rBoBChE) expressed in serum-free culture medium spontaneously reactivates from inhibition by chlorpyrifos oxon at a rate of 0.0023/min and ages at a rate of 0.0138/min, reactivation by dilution, overview
chlorpyrifos oxon
-
irreversible inhibitor
chlorpyrifos oxon
-
Michaelis-Menten kinetics, ki: 3048 nM/h, KD: 2.02 nM
CuSO4
-
-
cyclosarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
cyclosarin
-
strongest inhibitor
cymserine
-
-
cymserine
-
BChE selective inhibitor
cymserine
-
inhibition in the nanomolar range
cymserine
-
50% inhibition at 53 - 100 nM at substrate concentrations 0.025 - 0.8 mM, detailed kinetic analysis
decamethonium
binding structure from analysis of the crystal structure determined at 2.3 A resolution, overview. Decamethonium spans the gorge of BChE
diazepam
-
reversible mixed-type inhibition
diazinon
-
an insecticide toxic to the fish via inhibition of brain cholinesterase
dichlorvos
-
irreversible inhibitor
dichlorvos
-
enzyme activity can be restored by incubation with pyridine-2-aldoxime methochloride
dichlorvos
-
organophosphate insecticide
Diethyl p-nitrophenyl phosphate
-
i.e. paraoxon
Diethyl p-nitrophenyl phosphate
-
0.001 mM, 71% inhibition; i.e. paraoxon
diisopropyl fluorophosphate
-
comparison with inhibitory potency in brain tissue of different Salmonidae
diisopropyl fluorophosphate
inhibition, aging, and reactivation kinetics
diisopropyl fluorophosphate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
diisopropyl fluorophosphate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
diisopropyl fluorophosphate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
diisopropyl fluorophosphate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
diisopropyl fluorophosphate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
diisopropyl fluorophosphate
inhibition, aging, and reactivation kinetics
diisopropylfluorophosphate
-
DFP, selective inhibitor
diisopropylfluorophosphate
-
-
diisopropylphosphofluoridate
-
diisopropyl fluorophosphate
diisopropylphosphofluoridate
-
irreversible inhibition
diisopropylphosphofluoridate
-
-
diisopropylphosphofluoridate
-
-
diisopropylphosphofluoridate
-
DFP, irreversible, covalent inhibition
dipropan-2-yl phosphorofluoridate
-
-
dipropan-2-yl phosphorofluoridate
-
-
donepezil
-
reversible inhibitor
donepezil
-
50% inhibition at 0.004 mM
donepezil
-
50% inhibition at 4150 nM
donepezil
-
standard drug against Alzheimer's disease, mixed type inhibition, Ki: 1.41 mg/ml
Echothiophate
-
an organophosphorous compound, inhibition kinetics, overview
Echothiophate
-
enzyme spontaneously reactivates with a half-life of 4.3 h
edrophonium
-
reversible inhibitor
edrophonium
lower inhibition
eptastigmine
-
inhibition in the nanomolar range
eptastigmine
-
50% inhibition at 5 nM
eserine
-
non-selective cholinesterase inhibitor, more than 90% inhibition at 0.1 mM
eserine
-
i.e. physostigmine, as hemisulfate salt, 82% inhibition at 1 mM, 72% at 0.05 mM
eserine
-
native enzyme, 50% inhibition at 5 nM, recombinant enzyme, 50% inhibition at 5 nM
eserine
-
i.e. physostigmine, as hemisulfate salt, 94% inhibition at 0.001 mM, 88% at 0.01 mM
eserine
-
cholinesterase from female fish is more sensitive to pesticide inhibition
ethopropazine
-
ethopropazine
-
reversible inhibitor
ethopropazine
-
inhibits at low substrate concentrations, inhibition mechanism
ethopropazine
-
inhibition in the nanomolar range
ethopropazine
-
not inhibitory to EC 3.1.1.7
ethopropazine
-
specific inhibitor
ethopropazine
ethopropazine is a substituted phenothiazine with a marked specificity for BChE. The 9000fold difference in Ki between hAChE and hBChE reflects this specificity, structure from analysis of the crystal structure determined at 2.35 A resolution, overview
ethopropazine
-
selective inhibition
ethopropazine hydrochloride
-
0.1 mM, complete inhibition
ethopropazine hydrochloride
-
-
ethopropazine hydrochloride
-
1 mM, 28% inhibition
galantamine
-
-
galantamine
-
50% inhibition at 0.0073 mM
galantamine
-
slight reversible inhibition
galanthamine
-
an alkaloid isolated from Isatis tinctoria
galanthamine
-
80.3% inhibition at 1 mM
galanthamine
-
50% inhibition at 7300 nM
galanthamine
-
80.3% inhibition at 1 mM
HgCl2
-
-
HgCl2
-
following Palaemon serratus exposure to HgCl2, no effect on ChE activity is observed. By contrast, following 24 h exposure to dichlorvos, decrease of ChE activity is observed until 30 to 40% basal activity
huperzine A
-
-
huperzine A
-
50% inhibition above 10000 nM
huprine X
-
-
hydralazine HCl
-
reversible mixed-type inhibition
iso-ompa
-
i.e. tetra-(monoisopropyl)diphosphor-tetramide, selective inhibition of butyrylthiocholine esterase activity
iso-ompa
-
i.e. tetra-(monoisopropyl)diphosphor-tetramide, selective inhibition of butyrylthiocholine esterase activity
iso-ompa
-
i.e. tetra-(monoisopropyl)diphosphor-tetramide, selective inhibition of butyrylthiocholine esterase activity
iso-ompa
-
i.e. tetraisopropyl diphosphoramide, inhibits the butyrylthiocholine esterase activity
iso-ompa
-
i.e. tetra-(monoisopropyl)diphosphor-tetramide, selective inhibition of butyrylthiocholine esterase activity
iso-ompa
-
inhibition in the nanomolar range
iso-ompa
-
i.e. tetaisopropyl diphosphoramide
iso-ompa
specific inhibition of BChE
iso-ompa
-
i.e. tetraisopropyl diphosphoramide, inhibits the butyrylthiocholine esterase activity
iso-ompa
-
i.e. tetra-(monoisopropyl)diphosphor-tetramide, selective inhibition of butyrylthiocholine esterase activity
iso-ompa
-
i.e. tetra-(monoisopropyl)diphosphor-tetramide, selective inhibition of butyrylthiocholine esterase activity
iso-ompa
-
i.e. tetra-isopropyl-diphosphatamide
iso-ompa
-
specific for BuChE
iso-ompa
-
specific inhibitor of BuChE
iso-ompa
-
inhibits butyrylthiocholineesterase activity
linalool
-
isolated from Thymus vulgaris essential oil
linalool
-
15.7% inhibition at 1 mM
lovastatin
-
reversible mixed-type inhibition
malachite green
-
-
malachite green
-
linear mixed inhibition
malaoxon
-
low inhibition, irreversible inhibitor
methyl green
-
-
methyl green
-
competitive
N,N'-bis(3-pyridin-3-ylcyclohexyl)pentanediamide
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
N,N'-bis(3-pyridin-3-ylcyclohexyl)pentanediamide
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N,N'-[(1,1,3,3,5,5,7,7,9,9-decamethylpentasiloxane-1,9-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3,5,5,7,7,9,9-decamethylpentasiloxane-1,9-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3,5,5,7,7-octamethyltetrasiloxane-1,7-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3,5,5,7,7-octamethyltetrasiloxane-1,7-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3,5,5-hexamethyltrisiloxane-1,5-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3,5,5-hexamethyltrisiloxane-1,5-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N,N,N',N',N'-hexamethylbutane-1,4-diaminium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
N,N,N,N',N',N'-hexamethylbutane-1,4-diaminium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N,N,N-triethylethanaminium
-
reversible inhibitor
N,N,N-triethylethanaminium
-
reversible inhibitor
N,N,N-trimethylmethanaminium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
N,N,N-trimethylmethanaminium
-
reversible inhibitor
N,N,N-trimethylmethanaminium
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N,N,N-trimethylmethanaminium
-
reversible inhibitor
N-methyl-3-pyridin-3-ylcyclohexanamine
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
N-methyl-3-pyridin-3-ylcyclohexanamine
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
NaCl
-
-
neostigmine
-
high inhibition, irreversible inhibitor
neostigmine
-
0.008 mM neostigmine bromide, complete inhibition
neostigmine
-
0.0006 mM, 50% inhibition
nifedipine
-
reversible mixed-type inhibition
O,O-diethyl S-hexyl phosphorothioate
-
-
O,O-diethyl S-hexyl phosphorothioate
-
-
O-butyl S-(2-(ethylthio)ethyl) methylphosphonothioate
-
-
O-butyl S-(2-(ethylthio)ethyl) methylphosphonothioate
-
-
O-ethyl S-(2-(ethylthio)ethyl) methylphosphonothioate
-
-
O-ethyl S-(2-(ethylthio)ethyl) methylphosphonothioate
-
-
O-ethyl S-heptyl methylphosphonothioate
-
-
O-ethyl S-heptyl methylphosphonothioate
-
-
O-ethyl S-hexyl methylphosphonothioate
-
-
O-ethyl S-hexyl methylphosphonothioate
-
-
O-ethyl S-neopentyl methylphosphonothioate
-
-
O-ethyl S-neopentyl methylphosphonothioate
-
-
O-ethyl S-pentyl methylphosphonothioate
-
-
O-ethyl S-pentyl methylphosphonothioate
-
-
O-ethyl-S-2-diisopropylaminoethylmethylphosphonothiolate
-
O-ethyl-S-2-diisopropylaminoethylmethylphosphonothiolate
-
VX
O-ethyl-S-3,3-dimethylbutyl methylthiophosphonate
-
comparison with inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-3,3-dimethylbutyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-3,3-dimethylbutyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-3,3-dimethylbutyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-3,3-dimethylbutyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-3,3-dimethylbutyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-heptyl methylthiophosphonate
-
comparison with inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-heptyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-heptyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-heptyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-heptyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-heptyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-hexyl methylthiophosphonate
-
comparison with inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-hexyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-hexyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-hexyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-hexyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-hexyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-pentyl methylthiophosphonate
-
comparison with inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-pentyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-pentyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-pentyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-pentyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
O-ethyl-S-n-pentyl methylthiophosphonate
-
comparison of inhibitory potency in brain tissue of different Salmonidae
octahydro-2H-quinolizin-1-yl octahydro-2H-quinolizin-1-ylmethyl butanedioate
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
octahydro-2H-quinolizin-1-yl octahydro-2H-quinolizin-1-ylmethyl butanedioate
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
octahydro-2H-quinolizin-1-ylmethanol
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and horse butyrylcholinesterase EC3.1.1.8
octahydro-2H-quinolizin-1-ylmethanol
-
pKi-values and comparison with inhibitory effect on human acetylcholinesterase EC 3.1.1.7 and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
paraoxon
-
irreversible inhibitor
paraoxon
-
paraoxon binds to both the enzyme and acyl-enzyme, but with weak affinities. A slight activation is observed at the lowest paraoxon concentrations and is attributed to the binding of the substrate to the enzyme-inhibitor complex
paraoxon
-
enzyme activity can be restored by incubation with pyridine-2-aldoxime methochloride
paraoxon
-
50% inhibition at 0.0028 mM
paraoxon
-
activity of cholinesterase reactivators pralidoxime, obidoxime, trimedoxime, methoxime and H-oxime HI-6, i.e. 1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane dichloride, in reactivation of plasma BuChE inhibited by pesticide paraoxon, efficacies, none of tested oximes surpassed 12.5% of BuChE reactivation, overview
paraoxon
similar sensitivity to in vitro inhibition of BChE activity is noted with the free enzyme and various copolymer-rhBChE complexes (C-BCs)
paraoxon
-
i.e. diethyl-4-nitrophenylphosphate, irreversible inhibition
paraoxon
-
cholinesterase from small fish is more sensitive to inhibition
paraoxon
-
cholinesterase from male fish is more sensitive to pesticide inhibition
pararosaniline
-
-
pararosaniline
-
linear mixed inhibition
parathion
-
50% inhibition at 0.022 mM
phenothiazine
-
not inhibitory to EC 3.1.1.7
phenserine
-
50% inhibition at 0.0015 mM
phenserine
-
native enzyme, 50% inhibition at 500 nM, recombinant enzyme, 50% inhibition at 500 nM
phenserine
-
50% inhibition at 1560 nM
physostigmine
-
irreversible inhibitor
physostigmine
-
identified compound of Pimpinella anisodes, IC50: 0.17 microgram/ml
physostigmine
-
i.e. eserine
physostigmine
-
inhibition in the nanomolar range
physostigmine
-
i.e. eserine; irreversible inhibition
physostigmine
-
i.e. eserine
physostigmine
-
0.7 mM physostigmine sulfate, 90% inhibition; i.e. eserine
physostigmine
-
i.e. eserine
physostigmine
-
0.42 mM, 50% inhibition; i.e. eserine
pralidoxime
-
pralidoxime
-
significally decreases organophosphate induced mortality of a LD75 dose of paraoxon
propidium
-
reversible inhibitor
propidium
propidium binds very differently to BChE and mostlly fills the gorge due to absence of a blocking Trp residue. The phenanthridinium ring is slotted into the groove of the acyl-binding pocket, with the amino group at interaction distance from Trp231 (2.8 A to the center of the 6-carbon ring) and Ser198-O (3.3 A), and T-stacked to Phe329. The alkyldiethylmethylammonium moiety extends to Trp82 of the A-site at cation-Pi interaction distance (3.1 A between the 6-carbon ring indole center and C5). The second ethyl group of the quaternary center docks against the propidium phenyl group (4 A to aromatic plane), suggesting an intramolecular cation-Pi interaction. The propidium phenyl group is oriented toward the P-site residues Tyr332 and Asp70
propionylthiocholine
-
substrate inhibition above 10 mM
propionylthiocholine
slight substrate inhibition
proserine
-
comparison with inhibitory potency in brain tissue of different Salmonidae
proserine
-
comparison of inhibitory potency in brain tissue of different Salmonidae
proserine
-
comparison of inhibitory potency in brain tissue of different Salmonidae
proserine
-
comparison of inhibitory potency in brain tissue of different Salmonidae
proserine
-
comparison of inhibitory potency in brain tissue of different Salmonidae
proserine
-
comparison of inhibitory potency in brain tissue of different Salmonidae
prostigmin
-
-
pyridostigmine
-
irreversible inhibitor
pyridostigmine
a non-selective inhibitor of cholinesterases (ChEs)
pyridostigmine
-
significally decreases organophosphate induced mortality of a LD75 dose of paraoxon
quercetin
-
48.8% inhibition at 1 mM
quinidine
-
0.007 mM, 5.7% inhibition
rac-bambuterol monocarbamate
inhibition kinetics of human and dog plasma butyrylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
rac-bambuterol monocarbamate
inhibition kinetics of human and dog plasma butyrylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
rivastigmine
-
-
rivastigmine
-
trade name: Exelon, carbamylates the enzyme
rivastigmine
-
50% inhibition at 0.054 mM
rivastigmine
-
50% inhibition at 37 nM
S-(3,3-dimethylbutyl) O,O-diethyl phosphorothioate
-
-
S-(3,3-dimethylbutyl) O,O-diethyl phosphorothioate
-
-
sarin
-
-
sarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
simvastatin
-
reversible mixed-type inhibition
soman
-
soman
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
Tabun
-
Tabun
-
tabun-inhibited enzymes are reactivated by K074, K075, and K114, kinetics, overview
Tabun
the most potent reactivators of tabun-inhibited BChE are 1,1'-(2,2'-oxybis(ethane-2,1-diyl))bis(4-hydroxyiminomethyl pyridinium) bromide and 4-carbamoyl-1-(2-(2-(4-(hydroxyiminomethyl)pyridinium-1-yl)ethoxy)ethyl)pyridinium bromide. Reactivation by these oximes (1 mM) reaches about 50% of control activity after 20 min, however, reactivation stops at 70%
Tabun
i.e. N,N-dimethylamido-O-ethyl cyanophosphate
tacrine
-
reversible inhibitor
tacrine
-
inhibition in the nanomolar range
tacrine
-
50% inhibition at 47 nM
tacrine
-
tacrine has similar inhibition potencies against BChE and AChE
tetra(monoisopropyl)diphosphortetramide
irreversible
tetra(monoisopropyl)diphosphortetramide
irreversible
tetraisopropyl diphosphoramide
-
-
tetraisopropyl diphosphoramide
-
i.e. iso-OMPA
tetraisopropyl diphosphoramide
-
complete inhibition at 0.02 mM
tetraisopropyl diphosphoramide
-
complete inhibition at 0.02 mM
tetraisopropyl diphosphoramide
-
i.e. iso-OMPA
tetraisopropyl diphosphoramide
-
i.e. iso-OMPA, cholinesterase from large fish is more sensitive to inhibition
tetraisopropyl diphosphoramide
-
i.e. iso-OMPA, cholinesterase from male fish is more sensitive to inhibition
tetraisopropyl phosphoramide
-
iso Ompa
tetraisopropyl phosphoramide
-
iso Ompa
Thymol
-
isolated from Thymus vulgaris essential oil
Thymol
-
27.6% inhibition at 1 mM
tolserine
-
-
tolserine
-
native enzyme, 50% inhibition at 50 nM, recombinant enzyme, 50% inhibition at 80 nM
Triton X-100
-
competitive inhibition
Triton X-100
-
inhibition above 0.01 mM
umbelliferone
-
54.3% inhibition at 1 mM
umbelliferone
isolated from Angelica decursiva
xanthostigmine
-
-
xanthostigmine
-
three-dimensional model of the quaternary complex between BuChE and xanthostigmine
Zn2+
-
1-2 mM, 10% activation, inhibitory above
additional information
-
not inhibited by tetraisopropyl diphosphoramide
-
additional information
-
specificity of diverse reversible sulfonium inhibitors, overview
-
additional information
-
organophosphoric enzyme inhibitors and inhibition potencies, comparison to the human enzyme from plasma, overview. The sensitivity of ChE to the siloxane reversible inhibitors is lower in Todarodes pacificus and much lower in commander squid Berryteuthis magister compared to mammals. Substrate-inhibitor binding analysis of homogeneity of visual ganglion activity in individuals, reversible onium ChE inhibitors reveal an inverse relationship
-
additional information
-
inhibition of ChE is not lethal
-
additional information
enzyme BChE is not inhibited by high concentrations of substrate
-
additional information
-
enzyme BChE is not inhibited by high concentrations of substrate
-
additional information
-
-
-
additional information
the inhibition of cholinesterases (ChEs) by carbamates includes a carbamylation (inhibition) step, in which the drug transfers its carbamate moiety to the active site of the enzyme and a decarbamylation (activity recovery) step, in which the carbamyl group is hydrolyzed from the enzyme. The carbamylation and decarbamylation kinetics decide the extent and the duration of the inhibition, thus the full characterization of candidate carbamate inhibitors requires the measurement of the kinetic constants describing both steps. By the analysis of the area under the inhibition-time curve of cholinesterases inhibited by carbamates it is possible to calculate the decarbamylation rate constant from the same data traditionally used to characterize only the carbamylation kinetics, therefore it is possible to obtain a full characterization of the inhibition with a single set of experiments, method validation, a simple and useful approach to reduce the time required for the characterization of carbamate inhibitors, overview
-
additional information
-
the inhibition of cholinesterases (ChEs) by carbamates includes a carbamylation (inhibition) step, in which the drug transfers its carbamate moiety to the active site of the enzyme and a decarbamylation (activity recovery) step, in which the carbamyl group is hydrolyzed from the enzyme. The carbamylation and decarbamylation kinetics decide the extent and the duration of the inhibition, thus the full characterization of candidate carbamate inhibitors requires the measurement of the kinetic constants describing both steps. By the analysis of the area under the inhibition-time curve of cholinesterases inhibited by carbamates it is possible to calculate the decarbamylation rate constant from the same data traditionally used to characterize only the carbamylation kinetics, therefore it is possible to obtain a full characterization of the inhibition with a single set of experiments, method validation, a simple and useful approach to reduce the time required for the characterization of carbamate inhibitors, overview
-
additional information
-
the quaternary pyridinium aldoximes, pralidoxime (2-PAM) and a lead zwitterionic oxime (RS194B), are both able to reactivate DjChE ATCh hydrolyzing activity at concentrations of 4 mM. Also NaF can reactivate DjChE activity, and the rate of reactivation shows a linear dependence on fluoride concentration. Reactivation of DjChE is significantly more rapid with 10 mM NaF than with 4 mM 2-PAM
-
additional information
-
inhibition of DjChE activity by exposing animals to either an organophosphorus pesticides (e.g. diazinon) or carbamates (e.g. physostigmine). At high doses, organophosphorus pesticides are lethal to both insects and humans due to inhibition of AChE and subsequent cholinergic toxicity
-
additional information
-
no inhibition by iso-OMPA
-
additional information
-
ortho electron domating substitutents of the inhibitors accelerate inhibition of enzyme by ortho polar effects
-
additional information
-
specificity of diverse reversible sulfonium inhibitors, overview
-
additional information
-
some inhibitors fullfill the competitive inhibition model with irreversible reaction between enzyme and inhibitor, but e.g. not galantamin
-
additional information
-
selectivity and inhibitory potency of isaindigotone derivatives for inhibition of BuChE
-
additional information
-
potency and mechanism of diverse enzyme inhibitors, corydaline and ribalinine, isolated from Skimmia laureola, are specific for acetylcholinesterase, overview
-
additional information
-
molecular docking analysis of inhibitors, overview
-
additional information
-
76% inhibition by a furanocoumarin mixture obtained from Heracleum crenatifolium, no inhibition by rhapontin, rhein, 4-hydroxycoumarin, aloe-emodine, bergapten and iso-bergapten
-
additional information
-
no inhibition by gamma-terpinene, 4-allyl anisole, cumol, trans-anethole, camphene, iso-borneol, l-bornyl acetate, and 2-heptanol
-
additional information
-
not inhibited by 3-methoxy-5,8,9,13b-tetrahydro-6H-isoquino-[1,2-a]isoquinoline and 3-methoxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine
-
additional information
evaluation of the potential of six dihydroxanthyletin-type coumarins, isolated from Angelica decursiva, to inhibit acetylcholinesterase (AChE, EC 3.1.1.7), butyrylcholinesterase (BChE), and beta-site amyloid precursor protein cleaving enzyme 1 (BACE1, EC 3.4.23.46), overview
-
additional information
substrate inhibition with formylthiocholine does not occur
-
additional information
synthesis, crystal structure determination, biological screening, and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases, structure-activity relationships, overview
-
additional information
evaluation of a combination of both anticholinesterase and beta-amyloid anti-aggregation activities in one molecule, and therapeutic potential in vivo. Design and synthesis of 28 compounds as derivatives of donepezil that contain the N-benzylpiperidine moiety combined with the phthalimide or indole moieties. No or poor inhibition by 2-[5-[(1-benzylpiperidin-4-yl)amino]pentyl]-1H-isoindole-1,3(2H)-dione
-
additional information
design, synthesis, and biological evaluation of multifunctional tacrine-curcumin hybrids as cholinesterase inhibitors with metal ions-chelating and neuroprotective properties, overview. The hybrid compounds show good cholinesterase inhibitory activity, some of the compounds exhibit different selectivity on acetylcholinesterase (EC 3.1.1.7) or butyrylcholinesterase due to the structural difference. Structure-activity relationships, molecular modelling, overview
-
additional information
synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors, overview. Analysis of enzyme binding structure, structure-function analysis, modeling
-
additional information
in-vitro evaluation and in-silico studies on amide derivatives of N-phthaloylglycine as butyrylcholinesterase (BChE) inhibitors. The compounds dock into the binding pocket of butyrylcholinesterase enzyme showing interactive amino acid residues of the binding gorge, docking study, overview
-
additional information
molecular docking, modelling, overview
-
additional information
-
-
-
additional information
-
no substrate inhibition up to 50 mM butyrylthiocholine iodide
-
additional information
-
enzyme variants usual, fluoride resistant, and atypical differ in rates of inhibition by the charged organophosphates and carbamates
-
additional information
-
not inhibitory: acetaminophen, chlordiazepoxide, chlorpromazine, desipramine, doxepin, imipramine, methamphetamine, nortryptiline, phenobarbital, phenytoin, procainamide, salicylic acid, theophyline, valproic acid
-
additional information
-
comparison of reaction rates with human acetylcholinesterase EC 3.1.1.7 and butyrylcholinesterase EC 3.1.1.8 for several organophosphate inhibitors
-
additional information
-
comparison of 50% inhibitory concentration for various inhibitors of EC 3.1.1.7 and EC 3.1.1.8
-
additional information
-
mo product inhibition with aryl acetylamides
-
additional information
-
the engineered recombinant BChE mutant A328W/Y332A displays increased affinity to the organophosphate pesticides paraoxon and malaoxon compared to the wild-type enzyme, overview
-
additional information
-
inhibitor structure-activity relationships, simulation of pseudo-irreversible BuChE covalent inhibitors, overview
-
additional information
-
design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors, structure-based drug design, overview
-
additional information
-
inhibitor molecular mechanics calculations, general mechanism of pseudoirreversible cholinesterase inhibition by carbamates. Enzyme deactivation is initiated by nucleophilic attack of the catalytic triad serine oxygen on the carbonyl group of the carbamate, structure-activity relationships of wild-type and mutant enzymes, overview
-
additional information
-
structure-activity studies of debromoflustramine B analogues as selective BChE inhibitors, molecular modeling, overview
-
additional information
modeling, stability, and binding structure of isosorbide-2-carbamate ester inhibitors, overview
-
additional information
-
modeling, stability, and binding structure of isosorbide-2-carbamate ester inhibitors, overview
-
additional information
-
no inhibition of BChE by caffeic, gallic, and quinic acids, and biochanin A, apigenin, kaempferol-3-O-galactoside, and diosmin
-
additional information
-
organophosphate and N-methyl-carbamate insecticides inhibit enzyme activity
-
additional information
docking study show that flavonoids bind to the BChE active site by forming multiple hydrogen bonds and pi-pi interactions
-
additional information
-
docking study show that flavonoids bind to the BChE active site by forming multiple hydrogen bonds and pi-pi interactions
-
additional information
determination and analysis of the crystal structures of enzyme-bound ligands
-
additional information
kinetics and molecular docking studies of loganin, morroniside, and 7-O-galloyl-D-sedoheptulose derived from Cornus officinalis fruits (Corni fructus) as cholinesterase and beta-secretase 1 inhibitors, overview
-
additional information
-
donepezil is a specific AChE inhibitor
-
additional information
ferrocene-based anilides: synthesis, structural characterization and inhibition of butyrylcholinesterase, overview. Ferrocene derivatives with the conformation of meta amide substituents engage in intermolecular H-bonding, which stabilizes the meta derivatives over their para analogues. The H-bonding takes place when the conformation of the ferrocene changes by rotation around the C-N bond, favoring interactions between two molecules in adjacent layers in the solid state. Limited effects of the H-bonding in the presence and absence of water in the active site of butyrylcholinesterase, supporting the importance of hydrophobicity for inhibitors of the enzyme. Molecular docking
-
additional information
structure-activity relationships, kinetics and molecular docking studies of 1-butanoyl-3-arylthiourea derivatives, overview
-
additional information
pyridinium oximes with ortho-positioned chlorine moiety provide efficient reactivation of human acetylcholinesterase inhibited by several nerve agents, overview. The most potent is the dichlorinated analogue of oxime 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)propane with significantly improved ability to reactivate the conjugated enzyme due to improved binding affinity and molecular recognition. Among the standard oximes, trimedoxime (TMB-4) is the superior reactivator of tabun-inhibited acetylcholinesterase (AChE, EC 3.1.1.7), but it is also the most toxic, which prevents its use in therapy, while asoxime (HI-6) has no reactivation potency (below 20%). Reversible inhibition of recombinant human AChE and purified human plasma butyrylcholinesterase with oximes. The parent compounds and the commercial standards pralidoxime and asoxime are predicted to have minimal CNS penetrability. 1-(4-Hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)propane, 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane, and (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene oximes show low cytotoxic potential in different cell lines, fibroblasts and hepatic, kidney, blood, and ovary cells
-
additional information
structure-based drug discovery approach is used to develop potent, selective, and reversible human butyrylcholinesterase (BChE) inhibitors, crystal structure-based inhibitor optimization. Synthesis of class VIII Inhibitors. Competitive single-step inhibition mechanism with slow association. In vitro permeability assay with Caco-2 cells
-
additional information
-
structure-based drug discovery approach is used to develop potent, selective, and reversible human butyrylcholinesterase (BChE) inhibitors, crystal structure-based inhibitor optimization. Synthesis of class VIII Inhibitors. Competitive single-step inhibition mechanism with slow association. In vitro permeability assay with Caco-2 cells
-
additional information
the inhibition of cholinesterases (ChEs) by carbamates includes a carbamylation (inhibition) step, in which the drug transfers its carbamate moiety to the active site of the enzyme and a decarbamylation (activity recovery) step, in which the carbamyl group is hydrolyzed from the enzyme. The carbamylation and decarbamylation kinetics decide the extent and the duration of the inhibition, thus the full characterization of candidate carbamate inhibitors requires the measurement of the kinetic constants describing both steps. By the analysis of the area under the inhibition-time curve of cholinesterases inhibited by carbamates it is possible to calculate the decarbamylation rate constant from the same data traditionally used to characterize only the carbamylation kinetics, therefore it is possible to obtain a full characterization of the inhibition with a single set of experiments, method validation, a simple and useful approach to reduce the time required for the characterization of carbamate inhibitors, overview
-
additional information
-
the inhibition of cholinesterases (ChEs) by carbamates includes a carbamylation (inhibition) step, in which the drug transfers its carbamate moiety to the active site of the enzyme and a decarbamylation (activity recovery) step, in which the carbamyl group is hydrolyzed from the enzyme. The carbamylation and decarbamylation kinetics decide the extent and the duration of the inhibition, thus the full characterization of candidate carbamate inhibitors requires the measurement of the kinetic constants describing both steps. By the analysis of the area under the inhibition-time curve of cholinesterases inhibited by carbamates it is possible to calculate the decarbamylation rate constant from the same data traditionally used to characterize only the carbamylation kinetics, therefore it is possible to obtain a full characterization of the inhibition with a single set of experiments, method validation, a simple and useful approach to reduce the time required for the characterization of carbamate inhibitors, overview
-
additional information
enzyme-inhibitor binding structure from the crystal structure analysis, molecular docking and modelling, overview. No inhibition by sesquiterpene lactone lipidiol from extract of Volutaria abyssinica
-
additional information
-
-
-
additional information
-
inhibition of ChE is not lethal
-
additional information
-
not inhibited by propionylthiocholine and acetyl-beta-metylthiocholine
-
additional information
-
design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties exhibiting competitive and reversible inhibition, overview
-
additional information
-
not inhibited by 1 mM tetraisopropyl diphosphoramide
-
additional information
-
selectivity of inhibition of different cholinesterase activities in different tissues, in vitro effects of environmental contaminants, overview
-
additional information
-
enzyme is inhibited by quaternary ammonium salts. The effect is influenced by the size of the quaternary ammonium ion
-
additional information
-
-
-
additional information
-
design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors, overview
-
additional information
-
in vitro sensitivity of cholinesterases from gilthead seabream (Sparus aurata) to organophosphate pesticides, overview. Muscle BChE is found to be several orders of magnitude (from 2 to 4) more sensitive than brain and muscle acetylcholinesterase (AChE, EC 3.1.1.7) inhibition by dichlorvos and omethoate. Enzyme BChE does not show excess substrate inhibition
-
additional information
PoBChE is sensitive to BChE-specific inhibitors, but shows only slight substrate inhibition
-
additional information
-
PoBChE is sensitive to BChE-specific inhibitors, but shows only slight substrate inhibition
-
additional information
-
organophosphoric enzyme inhibitors and inhibition potencies, comparison to the human enzyme from plasma, overview. The sensitivity of ChE to the siloxane reversible inhibitors is lower in Todarodes pacificus and much lower in commander squid Berryteuthis magister compared to mammals. Substrate-inhibitor binding analysis of homogeneity of visual ganglion activity in individuals, reversible onium ChE inhibitors reveal an inverse relationship
-
additional information
-
no inhibition by chlorpyrifos
-
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10
(+)-debromoflustramine B
Homo sapiens
-
-
0.00041
(+/-)-6-bromo-N-((1-(2,3-dihydro-1H-inden-2-yl)-piperidin-3-yl)methyl)-N-(2-methoxyethyl)-2-naphthamide
Homo sapiens
pH 8.0, 25°C
0.000067
(+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-1-naphthamide
Homo sapiens
pH 8.0, 25°C
0.00000103
(+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-(dimethylamino)ethyl)-2-naphthamide
Homo sapiens
pH 8.0, 25°C
0.00003824
(+/-)-N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(3-methoxypropyl)-2-naphthamide
Homo sapiens
pH 8.0, 25°C
0.000632
(+/-)-N-((1-(benzo[d]thiazol-2-ylmethyl)piperidin-3-yl)methyl)-2-naphthamide
Homo sapiens
pH 8.0, 25°C
0.001437
(+/-)-N-((1-benzylpiperidin-3-yl)methyl)-2-naphthamide
Homo sapiens
pH 8.0, 25°C
0.00023
(+/-)-N-((1-benzylpiperidin-3-yl)methyl)-N-(2-methoxyethyl)-2-naphthamide
Homo sapiens
pH 8.0, 25°C
0.00137
(-)-debromoflustramine B
Homo sapiens
-
-
0.0186
(-)-galanthamine
Equus caballus
-
-
0.00054
(-)-N1-phenethylnorcymserine
Mus musculus
-
pH not specified in the publication, at 37°C
0.00034
(-)-N1-phenethylnorphenserine
Mus musculus
-
pH not specified in the publication, at 37°C
0.00001
(-)-N1-phenethylnorphysostigmine
Mus musculus
-
pH not specified in the publication, at 37°C
0.000027
(13E,13'Z)-N,N'-hexane-1,6-diylbis(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-imine)
Equus caballus
-
pH and temperature not specified in the publication
0.000076
(13Z,13'Z)-N,N'-heptane-1,7-diylbis(6,7,8,9,10,11-hexahydro-13H-azocino[2,1-b]quinazolin-13-imine)
Equus caballus
-
pH and temperature not specified in the publication
0.0045
(1alpha,3beta,22R)-stigmast-5-ene-1,3,22-triol
Equus caballus
-
-
0.083
(2,6,6-trimethylcyclohex-1-en-1-yl)methyl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
Equus caballus
-
-
0.00187
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
Equus caballus
pH 8.0, 37°C
0.00211
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
Equus caballus
pH 8.0, 37°C
0.0015
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
Equus caballus
pH 8.0, 37°C
0.0016
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
Equus caballus
pH 8.0, 37°C
0.00477
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
Equus caballus
pH 8.0, 37°C
0.00224
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
Equus caballus
pH 8.0, 37°C
0.000137
(2x)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-([[(2E)-3-phenylprop-2-enoyl]oxy]carbonyl)-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.000072
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(2-methylbutanoyl)-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.000012
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(biphenyl-4-ylcarbonyl)-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.000006
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(cyclopentylcarbonyl)-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.000334
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(cyclopropylcarbonyl)-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.0000043
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-(phenoxycarbonyl)-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.00036
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-([[(trifluoromethyl)sulfonyl]oxy]carbonyl)-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.000073
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(2H-chromen-2-yloxy)carbonyl]-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.000669
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(3,4-dihydroxyphenyl)carbonyl]-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.0007
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(pentanoyloxy)carbonyl]-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.00098
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[(propanoyloxy)carbonyl]-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.0028
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[([[4-(heptyloxy)phenyl]carbonyl]oxy)carbonyl]-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.000032
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(naphthalen-2-ylcarbonyl)oxy]carbonyl]-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.00057
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(pyridin-3-ylcarbonyl)oxy]carbonyl]-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.000088
(2xi)-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-[[(pyridin-4-ylcarbonyl)oxy]carbonyl]-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.0037
(2xi)-1,4:3,6-dianhydro-2-O-([2-[(carbamoyloxy)methyl]-5-hydroxybenzyl]carbamoyl)-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.0041
(2xi)-5-O-[(acetyloxy)carbonyl]-1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-D-arabino-hexitol
Homo sapiens
pH 7.4, 37°C
0.0888
(3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
Homo sapiens
-
pH 8.0, 37°C
0.0162
(3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
Homo sapiens
-
pH 8.0, 37°C
0.125
(3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.1
(3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
Homo sapiens
-
above, pH 8.0, 37°C
0.000016
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-phenylethyl)carbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.000097
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3,4-dimethoxyphenyl)carbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.0059
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-acetylphenyl)carbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.00098
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-butylphenyl)carbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.00037
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-chlorophenyl)carbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.000083
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-methoxyphenyl)carbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.0067
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-nitrophenyl)carbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.002
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-phenoxyphenyl)carbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.00043
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-tert-butylphenyl)carbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.0000018
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (cyclohexylmethyl)carbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.0001
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl 1,3-benzodioxol-5-ylcarbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.0000066
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl benzylcarbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.0011
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl biphenyl-4-ylcarbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.000022
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl cyclohexylcarbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.000014
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl hexylcarbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.00058
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl naphthalen-2-ylcarbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.000079
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl [4-(dimethylamino)phenyl]carbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.0014
(3aS)-3a,8-dimethyl-1-(2-phenylethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl [4-(hexyloxy)phenyl]carbamate
Mus musculus
-
pH not specified in the publication, at 37°C
0.0127
(3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Equus caballus
-
-
0.0071
(3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Equus caballus
-
-
0.003
(3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Equus caballus
-
-
0.0017
(3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Equus caballus
-
-
0.0332
(4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.172
(4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.0715
(4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.0607
(4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.1
(4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.1
(4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
Homo sapiens
-
above, pH 8.0, 37°C
0.044
(4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
Homo sapiens
-
above, pH 8.0, 37°C
0.00918
(6R,7S)-6-(acetyloxy)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2Z)-2-methylbut-2-enoate
Equus caballus
pH 8.0, 22°C
0.00578
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2E)-2-methylbut-2-enoate
Equus caballus
pH 8.0, 22°C
0.00734
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate
Equus caballus
pH 8.0, 22°C
0.00886
(6R,7S)-6-methoxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate
Equus caballus
pH 8.0, 22°C
0.01391
(6R,7S)-7-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-yl 4-methylpent-3-enoate
Equus caballus
pH 8.0, 22°C
0.000088
(9E,9'E)-N,N'-hexane-1,6-diylbis(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine)
Equus caballus
-
pH and temperature not specified in the publication
0.0000048
(9E,9'Z)-N,N'-heptane-1,7-diylbis(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine)
Equus caballus
-
pH and temperature not specified in the publication
0.0000514
(Z)-N1-methyl-N4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylidene)-N1-(3-((E)-8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-butane-1,4-diamine
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.541
1,1'-(2E)-but-2-ene-1,4-diyldipyridinium dibromide
Homo sapiens
-
-
1.27
1,1'-(2Z)-but-2-ene-1,4-diyldipyridinium dichloride
Homo sapiens
-
-
0.345
1,1'-(benzene-1,2-diyldimethanediyl)dipyridinium dibromide
Homo sapiens
-
-
1.38
1,1'-(benzene-1,3-diyldimethanediyl)dipyridinium dibromide
Homo sapiens
-
-
0.529
1,1'-(benzene-1,4-diyldimethanediyl)dipyridinium dibromide
Homo sapiens
-
-
0.0008
1,1'-(naphthalene-2,7-diyldimethanediyl)dipyridinium dibromide
Homo sapiens
-
-
2.36
1,1'-(oxydiethane-2,1-diyl)dipyridinium dibromide
Homo sapiens
-
-
0.583
1,1'-(oxydimethanediyl)dipyridinium dichloride
Homo sapiens
-
-
9.8
1,1'-butane-1,4-diyldipyridinium dibromide
Homo sapiens
-
-
0.005
1,1'-decane-1,10-diyldipyridinium dibromide
Homo sapiens
-
-
0.078
1,1'-heptane-1,7-diyldipyridinium dibromide
Homo sapiens
-
-
0.13
1,1'-hexane-1,6-diyldipyridinium dibromide
Homo sapiens
-
-
0.006
1,1'-nonane-1,9-diyldipyridinium dibromide
Homo sapiens
-
-
0.029
1,1'-octane-1,8-diyldipyridinium dibromide
Homo sapiens
-
-
0.12
1,1'-pentane-1,5-diyldipyridinium dibromide
Homo sapiens
-
-
0.007
1,1'-undecane-1,11-diyldipyridinium dibromide
Homo sapiens
-
-
0.1072
1,2,2-triethyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.000531
1,2-di(berberine-9-O-yl)ethane dibromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.1069
1,2-diethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.00023
1,2-dimethyl-beta-carbolin-2-ium iodide
Equus caballus
-
pH and temperature not specified in the publication
0.000231
1,3-di(berberine-9-O-yl)propane dibromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00172
1,3a,8-tris(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
Homo sapiens
-
-
0.000051
1,4:3,6-dianhydro-2-O-(benzylcarbamoyl)-5-O-nitro-D-threo-hexitol
Homo sapiens
pH 7.4, 37°C
0.000894
1,4:3,6-dianhydro-2-O-(butylcarbamoyl)-5-O-nitro-D-threo-hexitol
Homo sapiens
pH 7.4, 37°C
0.0025
1,4:3,6-dianhydro-2-O-(cyclohexylcarbamoyl)-5-O-nitro-D-threo-hexitol
Homo sapiens
pH 7.4, 37°C
0.0039
1,4:3,6-dianhydro-2-O-(ethylcarbamoyl)-5-O-nitro-D-threo-hexitol
Homo sapiens
pH 7.4, 37°C
0.0051
1,4:3,6-dianhydro-2-O-(methylcarbamoyl)-5-O-nitro-D-threo-hexitol
Homo sapiens
pH 7.4, 37°C
0.000639
1,4:3,6-dianhydro-2-O-nitro-5-O-(propylcarbamoyl)-D-threo-hexitol
Homo sapiens
pH 7.4, 37°C
0.00000947 - 0.00037
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
0.01102
1-(2-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.01056
1-(2-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0502
1-(2-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1Hquinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0196
1-(2-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0332
1-(2-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.046
1-(2-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0196
1-(2-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0065
1-(2-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.00083
1-(2-fluorobenzyl)-N-[6-(1H-indol-1-yl)hexyl]piperidin-4-amine
Equus caballus
pH 8.0, 25°C
0.00075
1-(2-fluorobenzyl)-N-[8-(1H-indol-1-yl)octyl]piperidin-4-amine
Equus caballus
pH 8.0, 25°C
0.00178
1-(3-chlorobenzyl)-N-[6-(1H-indol-1-yl)hexyl]piperidin-4-amine
Equus caballus
pH 8.0, 25°C
0.00133
1-(3-chlorobenzyl)-N-[8-(1H-indol-1-yl)octyl]piperidin-4-amine
Equus caballus
pH 8.0, 25°C
0.0237
1-(4-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.00156
1-(4-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.00448
1-(4-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0189
1-(4-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0115
1-(4-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0205
1-(4-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0046
1-(4-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0165
1--(4-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0045
1-benzyl-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.00248
1-benzyl-2,2-diisobutyl-2,3-dihydro-1Hquinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0224
1-benzyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.00376
1-benzyl-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0354
1-benzyl-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.00357
1-benzyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0217
1-benzyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0445
1-benzyl-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.04998
1-benzyl-5-methoxy-3a,8-bis(3-methylbut-2-enyl)-1,2,3,3a,8,8ahexahydropyrrolo[2,3-b]indole
Homo sapiens
-
-
0.0153
1-benzyl-N-[3-(2,3-dihydro-1H-indol-1-yl)propyl]piperidin-4-amine
Equus caballus
pH 8.0, 25°C
0.00108
1-benzyl-N-[5-(2,3-dihydro-1H-indol-1-yl)pentyl]piperidin-4-amine
Equus caballus
pH 8.0, 25°C
0.00341
1-benzyl-N-[6-(1H-indol-1-yl)hexyl]piperidin-4-amine
Equus caballus
pH 8.0, 25°C
0.00093
1-benzyl-N-[8-(1H-indol-1-yl)octyl]piperidin-4-amine
Equus caballus
pH 8.0, 25°C
0.121
1-butanoyl-3-(2,6-dimethylphenyl) thiourea
Homo sapiens
pH 7.7, 37°C
0.00696
1-butanoyl-3-(3-methoxyphenyl)thiourea
Homo sapiens
pH 7.7, 37°C
0.0162
1-butanoyl-3-(4-chlorophenyl)thiourea
Homo sapiens
pH 7.7, 37°C
0.113
1-butanoyl-3-benzylthiourea
Homo sapiens
pH 7.7, 37°C
0.0209
1-dehydrotestosterone
Equus caballus
-
-
0.0418
1-ethyl-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0709
1-ethyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0998
1-ethyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.0614
1-ethyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.1261
1-ethyl-2-methyl-2-propyl -2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.01808
1-[2-(4-carboxyphenyl)-5-(ethoxycarbonyl)-1H-benzimidazol-1-yl]-4-ethylmorpholin-1-ium
Homo sapiens
-
at pH 8.0, temperature not specified in the publication
0.00489
10-methoxy-9-(4-phenoxybutoxy)-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.093
10-N-demethyl-10-N-(10-(4-(piperidin-1-ylmethyl)-phenoxy)decan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0012
10-N-demethyl-10-N-(12-(4-(piperidin-1-ylmethyl)-phenoxy)dodecan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.021
10-N-demethyl-10-N-(2-(4-(piperidin-1-ylmethyl)phenoxy)ethan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.024
10-N-demethyl-10-N-(3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0043
10-N-demethyl-10-N-(4-(1-benzylpiperidin-4-yloxy)-butan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0071
10-N-demethyl-10-N-(4-(3-(1-morpholinoethyl)phenoxy)butan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.034
10-N-demethyl-10-N-(4-(4-((diethylamino)methyl)-phenoxy)butan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0033
10-N-demethyl-10-N-(4-(4-(morpholinomethyl)phenoxy)butan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.028
10-N-demethyl-10-N-(4-(4-(piperidin-1-ylmethyl)phenoxy)butan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0056
10-N-demethyl-10-N-(4-(4-(pyrrolidine-1-carbonyl)-phenoxy)butan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.029
10-N-demethyl-10-N-(5-(4-(piperidin-1-ylmethyl)phenoxy)pentan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0055
10-N-demethyl-10-N-(6-(1-benzylpiperidin-4-yloxy)-hexan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0058
10-N-demethyl-10-N-(6-(3-(1-morpholinoethyl)phenoxy)hexan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.041
10-N-demethyl-10-N-(6-(4-((diethylamino)methyl)-phenoxy)hexan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0039
10-N-demethyl-10-N-(6-(4-(morpholinomethyl)phenoxy)hexan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.033
10-N-demethyl-10-N-(6-(4-(piperidin-1-ylmethyl)phenoxy)hexan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0094
10-N-demethyl-10-N-(6-(4-(pyrrolidine-1-carbonyl)-phenoxy)hexan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.053
10-N-demethyl-10-N-(8-(4-(piperidin-1-ylmethyl)phenoxy)octan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.064
10-N-demethyl-10-N-(9-(4-(piperidin-1-ylmethyl)phenoxy)nonan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.000027
10-[4-[(diethylamino)methyl]phenoxy]-N,N-diethyldecan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.000026
10-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropyldecan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.0615
11alpha,17beta-dihydroxyandrost-1,4-dien-3-one
Equus caballus
-
-
0.1647
11alpha-hydroxyandrost-1,4-dien-3,17-dione
Equus caballus
-
-
0.1413
11alpha-hydroxyandrost-4-en-3,17-dione
Equus caballus
-
-
0.284
11alpha-hydroxytestolactone
Equus caballus
-
-
0.089
11alpha-hydroxytestosterone
Equus caballus
-
-
0.047
15alpha,16alpha-epoxy-17-hydroxy-ent-kauran-19-oic acid
Equus caballus
-
-
0.025
16 alpha-hydroxy-17-isovaleroyloxy-ent-kauran-19-oic acid
Equus caballus
-
-
0.017
16alpha,17-dihydroxy-ent-kauran-19-oic acid
Equus caballus
-
-
0.019
17-hydroxy-ent-kaur-15-en-19-oic acid
Equus caballus
-
-
0.0959
17beta-hydroxy-5alpha-androstan-3,6-dione
Equus caballus
-
-
0.072
18-nor-ent-Kaur-16-ene-4 beta-ol
Equus caballus
-
-
0.0178
18-nor-ent-pimara-8(14),15-diene-4 beta-ol
Equus caballus
-
-
0.000113
2,3-dimethoxy-6-methyl-9H-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.0000637
2-(3-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.01052
2-(3-[[1-(2-fluorobenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.00453
2-(3-[[1-(3-chlorobenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.00937
2-(3-[[1-(4-hydroxybenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.0268
2-(3-[[1-(4-methoxybenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.000016
2-(4-(((7-(diethylamino)-2,4-dioxo-2H-chromen-3(4H)-ylidene)methyl)amino)phenyl)-N'-1,2,3,4-tetrahydroacridin-9-ylacetohydrazide
Homo sapiens
-
-
0.0974
2-(4-chloro-phenyl)-1-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Equus caballus
pH and temperature not specified in the publication
0.00131
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
Equus caballus
pH 8.0, 37°C
0.00338
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
Equus caballus
pH 8.0, 37°C
0.00022
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
Equus caballus
pH 8.0, 37°C
0.00083
2-(4-hydroxybenzyl)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
Equus caballus
pH 8.0, 37°C
0.00039
2-(4-hydroxybenzyl)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
Equus caballus
pH 8.0, 37°C
0.0002
2-(4-hydroxybenzyl)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
Equus caballus
pH 8.0, 37°C
0.0000702
2-(4-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.004
2-(6-[[1-(2-fluorobenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.00273
2-(6-[[1-(3-chlorobenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.00232
2-(6-[[1-(4-hydroxybenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.00739
2-(6-[[1-(4-methoxybenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.00187
2-(8-[[1-(2-fluorobenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.00072
2-(8-[[1-(3-chlorobenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.00081
2-(8-[[1-(4-hydroxybenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.00565
2-(8-[[1-(4-methoxybenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.000028
2-(benzylaminocarbonyloxy-)-5-O-(1-naphthoyl)-1,4:3,6-dianhydro-D-glucitol
Homo sapiens
pH 7.4, 37°C
0.0011
2-(dimethylamino)ethyl (2Z)-2-[[(2-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
Homo sapiens
pH 7.6, 25°C
0.00414
2-(dimethylamino)ethyl (2Z)-2-[[(2-chlorophenyl)carbonyl]amino]-3-phenylprop-2-enoate
Homo sapiens
pH 7.6, 25°C
0.0006
2-(dimethylamino)ethyl (2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoate
Homo sapiens
pH 7.6, 25°C
0.0025
2-(dimethylamino)ethyl (2Z)-2-[[(3-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
Homo sapiens
pH 7.6, 25°C
0.0138
2-(dimethylamino)ethyl (2Z)-2-[[(4-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoate
Homo sapiens
pH 7.6, 25°C
0.0402
2-(dimethylamino)ethyl (2Z)-2-[[(4-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoate
Homo sapiens
pH 7.6, 25°C
0.0028
2-(dimethylamino)ethyl (2Z)-3-phenyl-2-[(phenylcarbonyl)amino]prop-2-enoate
Homo sapiens
pH 7.6, 25°C
0.0001221
2-acetamido-N-(4-(8,9,10,11-tetrahydro-6H-azocino-[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,-11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)acetamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.000637
2-ethyl-1-methyl-beta-carbolin-2-ium iodide
Equus caballus
-
pH and temperature not specified in the publication
0.00017
2-[(5-acetyl-6-methyl-4-phenyl-1,4-dihydropyrimidin-2-yl)sulfanyl]-N-phenylacetamide
Equus caballus
pH and temperature not specified in the publication
0.0518
2-[3-[(1-benzylpiperidin-4-yl)amino]propyl]-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.01285
2-[6-[(1-benzylpiperidin-4-yl)amino]hexyl]-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.00198
2-[8-[(1-benzylpiperidin-4-yl)amino]octyl]-1H-isoindole-1,3(2H)-dione
Equus caballus
pH 8.0, 25°C
0.0235
2-[cyano(3-indolyl)methylene]-3-indolone
Equus caballus
-
pH 8.0, 25°C
0.0009
2-[[(2Z)-2-[[(2-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
Homo sapiens
pH 7.6, 25°C
0.0013
2-[[(2Z)-2-[[(2-chlorophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
Homo sapiens
pH 7.6, 25°C
0.00008
2-[[(2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium
Homo sapiens
pH 7.6, 25°C
0.00015
2-[[(2Z)-2-[[(2-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
Homo sapiens
pH 7.6, 25°C
0.0017
2-[[(2Z)-2-[[(3-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
Homo sapiens
pH 7.6, 25°C
0.0146
2-[[(2Z)-2-[[(4-bromophenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
Homo sapiens
pH 7.6, 25°C
0.0327
2-[[(2Z)-2-[[(4-methoxyphenyl)carbonyl]amino]-3-phenylprop-2-enoyl]oxy]-N,N,N-trimethylethanaminium iodide
Homo sapiens
pH 7.6, 25°C
0.00039
2-[[5-acetyl-6-methyl-4-(4-phenoxyphenyl)-1,4-dihydropyrimidin-2-yl]sulfanyl]-N-phenylacetamide
Equus caballus
pH and temperature not specified in the publication
0.0163
3'-hydroxyepiglucoisatisin
Equus caballus
-
pH 8.0, 25°C
0.000017
3,3'-[butane-1,4-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
Equus caballus
-
pH and temperature not specified in the publication
0.00014
3,3'-[butane-1,4-diylbis(oxy)]bis(7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine)
Equus caballus
-
pH and temperature not specified in the publication
0.000051
3,3'-[butane-1,4-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
Equus caballus
-
pH and temperature not specified in the publication
0.00092
3,3'-[dodecane-1,12-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
Equus caballus
-
pH and temperature not specified in the publication
0.000036
3,3'-[dodecane-1,12-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
Equus caballus
-
pH and temperature not specified in the publication
0.000014
3,3'-[hexane-1,6-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
Equus caballus
-
pH and temperature not specified in the publication
0.000027
3,3'-[hexane-1,6-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
Equus caballus
-
pH and temperature not specified in the publication
0.00068
3,3'-[octane-1,8-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
Equus caballus
-
pH and temperature not specified in the publication
0.00021
3,3'-[octane-1,8-diylbis(oxy)]bis(7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine)
Equus caballus
-
pH and temperature not specified in the publication
0.00011
3,3'-[octane-1,8-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
Equus caballus
-
pH and temperature not specified in the publication
0.000017
3,3'-[pentane-1,5-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
Equus caballus
-
pH and temperature not specified in the publication
0.000047
3,3'-[pentane-1,5-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
Equus caballus
-
pH and temperature not specified in the publication
0.00015
3,3'-[propane-1,3-diylbis(oxy)]bis(5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinoline)
Equus caballus
-
pH and temperature not specified in the publication
0.00016
3,3'-[propane-1,3-diylbis(oxy)]bis(7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium) diiodide
Equus caballus
-
pH and temperature not specified in the publication
0.0000807
3-(3-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.0000594
3-(4-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.02
3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Equus caballus
-
above
0.0083
3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Equus caballus
-
-
0.0057
3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Equus caballus
-
-
0.0000165
3-([7-[methyl(3-[[(methylamino)oxy]carbonyl]benzyl)amino]heptyl]oxy)-9H-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.0000762
3-methoxy-6-methyl-9H-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.0064
3-methoxy-7-methyl-5,8,9,13b-tetrahydro-6H-isoquinolino[1,2-a]isoquinolinium iodide
Equus caballus
-
pH and temperature not specified in the publication
0.0000793
3-methyl-2-(4-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.0000081
3-methyl-N-(4-(8,9,10,11-tetrahydro-6H-azocino-[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,-10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)butanamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.00031
3-oxo-N-[(1,2,3,4-tetrahydroacridin-9-ylamino)methyl]butanamide
Equus caballus
pH 8.0, 37°C
0.00006
3-oxo-N-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]butanamide
Equus caballus
pH 8.0, 37°C
0.00016
3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
Equus caballus
pH 8.0, 37°C
0.00022
3-oxo-N-[5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyl]butanamide
Equus caballus
pH 8.0, 37°C
0.0165
3-[(methyl[7-[(9-oxo-9H-xanthen-3-yl)oxy]heptyl]amino)methyl]phenyl methylcarbamate
Homo sapiens
-
-
0.0001
3-[10-(benzylmethylamino)decyloxy]xanthen-9-one
Homo sapiens
-
-
0.00012
3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one
Homo sapiens
-
-
0.00015
3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one
Homo sapiens
-
-
0.01144
3-[2-(4-carboxyphenyl)-5-(ethoxycarbonyl)-1H-benzimidazol-1-yl]-1-propyl-1H-imidazol-3-ium
Homo sapiens
-
at pH 8.0, temperature not specified in the publication
0.00833
3-[3-(benzylmethylamino)propoxy]xanthen-9-one
Homo sapiens
-
-
0.00191
3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one
Homo sapiens
-
-
0.00265
3-[4-(benzylmethylamino)butoxy]xanthen-9-one
Homo sapiens
-
-
0.02
3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Equus caballus
-
above
0.00249
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one
Homo sapiens
-
-
0.00681
3-[5-(ethoxycarbonyl)-2-(4-hydroxyphenyl)-1H-benzimidazol-1-yl]-1-propyl-1H-imidazol-3-ium
Homo sapiens
-
at pH 8.0, temperature not specified in the publication
0.00659
3-[5-(ethoxycarbonyl)-2-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-1-yl]-1-propyl-1H-imidazol-3-ium
Homo sapiens
-
at pH 8.0, temperature not specified in the publication
0.00143
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one
Homo sapiens
-
-
0.0008
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one
Homo sapiens
-
-
0.0461
3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one
Homo sapiens
-
-
0.00201
3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
Homo sapiens
-
-
0.00127
3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
Homo sapiens
-
-
0.269
3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
Homo sapiens
-
-
0.00093
3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
Homo sapiens
-
-
0.0638
3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
Homo sapiens
-
-
0.00185
3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
Homo sapiens
-
-
0.127
3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
Homo sapiens
-
-
0.00211
3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
Homo sapiens
-
-
0.00032
3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one
Homo sapiens
-
-
0.001
3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one
Homo sapiens
-
-
0.0295
3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one
Homo sapiens
-
-
0.014
3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one
Homo sapiens
-
-
0.00008
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one
Homo sapiens
-
-
0.0001
3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one
Homo sapiens
-
-
0.0221
3a,8-dibenzyl-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
Homo sapiens
-
-
0.00589
3a,8-dibenzyl-5-methoxy-1-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
Homo sapiens
-
-
0.0000397 - 0.00097
4,4'-(3-oxopentane-1,5-diyl)bis(N,N-dimethyl-N-prop-2-en-1-ylanilinium) dibromide
0.000003
4-methyl-N-(4-(8,9,10,11-tetrahydro-6H-azocino-[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,-10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)pentanamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.00052
4-[(4-[[6-(1H-indol-1-yl)hexyl]amino]piperidin-1-yl)methyl]phenol
Equus caballus
pH 8.0, 25°C
0.00034
4-[(4-[[8-(1H-indol-1-yl)octyl]amino]piperidin-1-yl)methyl]phenol
Equus caballus
pH 8.0, 25°C
0.00274
4-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylbutan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.01169
4-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylbutan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.1
5'-O-Methyladenosine
Equus caballus
-
value above 0.1
0.0005
5,7,8,13-tetrahydroindolo [2',3':3,4]pyrido[2,1-b]quinazoline
Equus caballus
-
-
0.0044
5,8-dihydro-6H isoquino[1,2b]quinazoline
Equus caballus
-
-
0.00459
5-methoxy-1-methyl-3a,8-bis(3-methylbut-2-en-1-yl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
Homo sapiens
-
-
0.00442
5-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylpentan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.00178
5-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylpentan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.000072
6,7-dimethoxy-2-(3-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.0000448
6,7-dimethoxy-3-(3-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.000295
6,7-dimethoxy-3-(4-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.0016
6,8-dibromo-2-(4-chlorophenyl)-2-methyl-2,3-dihydroquinazolin-4(1H)-one
Equus caballus
pH and temperature not specified in the publication
0.0132
6-chloro-2-methyl-9H-beta-carbolin-2-ium iodide
Equus caballus
-
pH and temperature not specified in the publication
0.0279
6-formylumbelliferone
Equus caballus
pH 8.0, 22°C
0.0012
6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium iodide
Equus caballus
-
pH and temperature not specified in the publication
0.0000652
6-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.000091
6-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.0000815
6-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.0000383
6-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.00166
6-[4-[(diethylamino)methyl]phenoxy]-N,N-diethylhexan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.00134
6-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropylhexan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.00308
6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one
Homo sapiens
-
-
0.0000574
7-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.000107
7-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.0000415
7-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.0000723
7-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.00036
7-methoxy-N-nonyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride (1:1)
Homo sapiens
-
pH and temperature not specified in the publication
0.00012
7-methoxy-N-octyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
Homo sapiens
-
pH and temperature not specified in the publication
0.016
7-methoxy-N-pentyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
Homo sapiens
-
pH and temperature not specified in the publication
0.07
7-methoxy-N-propyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
Homo sapiens
-
pH and temperature not specified in the publication
0.08794
7-O-galloyl-D-sedoheptulose
Homo sapiens
pH and temperature not specified in the publication
0.094
7-oxo-ent-pimara-8(14),15-diene-19-oic acid
Equus caballus
-
-
0.01
8-benzyl-1-methyl-3a-(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
Homo sapiens
-
-
0.00754
8-benzyl-5-methoxy-1-methyl-3a-(3-methylbut-2-enyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
Homo sapiens
-
-
0.08767
8-formylumbelliferone
Equus caballus
pH 8.0, 22°C
0.000048
8-[4-[(diethylamino)methyl]phenoxy]-N,N-diethyloctan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.0000091
8-[4-[(diethylamino)methyl]phenoxy]-N,N-dipropyloctan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.021
9-amino-7-methoxy-1,2,3,4-tetrahydroacridine
Homo sapiens
-
pH and temperature not specified in the publication
0.0158
9-O-[(2-(3-methyl)pyridinium bromide)ethyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00282
9-O-[(2-pyridinium)bromide ethyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00168
9-O-[(3-o xo-3-p-chlorophenylamino)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00101
9-O-[(3-oxo-3-p-methoxyamino)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00553
9-O-[(3-oxo-3-p-nitrophenylamino)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00131
9-O-[(3-oxo-3-p-tolylamino)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00218
9-O-[(3-oxo-3-phenylamino)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.0133
9-O-[(3-pyridinium bromide)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00416
9-O-[3-(2-pyridinoxyl)butyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00111
9-O-[3-(3-methyl pyridinium bromide)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00544
9-O-[3-(4-bromo-phenoxyl)butyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00424
9-O-[3-(4-bromo-phenoxyl)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.0022
9-O-[3-(4-chloro-phenoxyl) butyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.0018
9-O-[3-(4-chloro-phenoxyl)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00286
9-O-[3-(4-methoxy-phenoxyl)-propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00229
9-O-[3-(4-methoxy-phenoxyl)butyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00181
9-O-[3-(4-methyl-phenoxyl) propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00205
9-O-[3-(4-nitro-phenoxyl)butyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00283
9-O-[3-(4-nitro-phenoxyl)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00217
9-O-[3-(N-methyl-phenylamino)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.0011
9-O-[3-(naphthalen-2-yloxy)butyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.0022
9-O-[3-(naphthalen-2-yloxy)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.000078
9-O-[3-(naphthalene-2-ylthio)butyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.000548
9-O-[3-(naphthalene-2-ylthio)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00176
9-O-[3-(phenylamino)propyl]-berberine bromide
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.0106
abamectin
Equus caballus
-
pH 7.5, 37°C
0.00058
amberboin
Homo sapiens
pH and temperature not specified in the publication
0.1027
androst-1,4-dien-3,17-dione
Equus caballus
-
-
0.00155
androst-4-en-3,7-dione
Equus caballus
-
-
0.0655
atricarpan B
Equus caballus
-
-
0.0195
atricarpan C
Equus caballus
-
-
0.0305
atricarpan D
Equus caballus
-
-
0.00685 - 0.00981
Berberine
0.083
bulbocapnine
Equus caballus
-
-
0.0011
buxoviricine
Equus caballus
-
-
0.0000058
carbaril
Eisenia andrei
-
versus acetylthiocholine
0.00000479 - 0.00312
Carbaryl
0.00027
carbofuran
Diopatra neapolitana
-
inhibition of propionylthiocholine esterase activity, pH 8.0, 25°C
0.052
corydine
Equus caballus
-
-
0.00666
cryptotanshinone
Homo sapiens
pH and temperature not specified in the publication
0.01393
Cycloartenol
Equus caballus
-
-
0.00937
decursidin
Equus caballus
pH 8.0, 22°C
0.00026
demethyldebromoflustramine B
Homo sapiens
-
-
0.00551
dihydrotanshinone
Homo sapiens
pH and temperature not specified in the publication
0.00714 - 0.00795
donepezil
0.02239
ent-kaur-16-en-19-oic-acid
Equus caballus
-
-
0.00758
ent-pimar-15-en-8 alpha, 19-diol
Equus caballus
-
-
0.107
ent-pimara-8(14),15-diene-19-oic acid
Equus caballus
-
-
0.042
ent-pimara-8(14),15-diene-19-ol
Equus caballus
-
-
0.0197
epiglucoisatisin
Equus caballus
-
pH 8.0, 25°C
0.0000034 - 0.00868
eserine
0.091 - 0.22
ethopropazine
0.00512
ethyl 1-(3-(1H-imidazol-1-yl)propyl)-2-(4-nitrophenyl)-1H-benzo[d]imidazole-5-carboxylate
Homo sapiens
-
at pH 8.0, temperature not specified in the publication
0.0059 - 0.0157
galanthamine
0.019
haloxyline A
Equus caballus
-
-
0.0147
haloxyline B
Equus caballus
-
-
0.09
Harmane
Equus caballus
-
pH and temperature not specified in the publication
0.00099
huprine 19
Homo sapiens
pH 7.0, 25°C, recombinant enzyme
0.02
hyrcanone
Equus caballus
-
-
0.0434
isatan A
Equus caballus
-
pH 8.0, 25°C
0.0476
isatan B
Equus caballus
-
pH 8.0, 25°C
0.0054
isosorbide-di-(4-nitrophenyl carbamate)
Homo sapiens
-
-
0.0065
isosorbide-di-(ethylcarbamate)
Homo sapiens
-
-
0.0016
leufolin A
Equus caballus
-
-
0.0036
leufolin B
Equus caballus
-
-
0.03302
loganin
Homo sapiens
pH and temperature not specified in the publication
0.00023
methomyl
Diopatra neapolitana
-
inhibition of propionylthiocholine esterase activity, pH 8.0, 25°C
0.03778
morroniside
Homo sapiens
pH and temperature not specified in the publication
0.0031
N,N,N-trimethyl-2-([(2Z)-3-phenyl-2-[(phenylcarbonyl)amino]prop-2-enoyl]oxy)ethanaminium iodide
Homo sapiens
pH 7.6, 25°C
0.000267
N,N-bis(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl) acetamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.0000727
N,N-bis(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)acetamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
7.4
N,N-di-sec-butyl-2-(1,3-dioxoisoindolin-2-yl)acetamide
Equus caballus
pH 8.0, 25°C
0.000015
N,N-dibutyl-10-[4-[(diethylamino)methyl]phenoxy]decan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
6.5
N,N-dibutyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
Equus caballus
pH 8.0, 25°C
0.00252
N,N-dibutyl-4-[4-[(diethylamino)methyl]phenoxy]butan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.0019
N,N-dibutyl-5-[4-[(diethylamino)methyl]phenoxy]pentan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.00023
N,N-dibutyl-6-[4-[(diethylamino)methyl]phenoxy]hexan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
0.000017
N,N-dibutyl-8-[4-[(diethylamino)methyl]phenoxy]octan-1-amine
Equus caballus
-
pH and temperature not specified in the publication
17.2
N,N-dicyclohexyl-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
Equus caballus
pH 8.0, 25°C
0.000702
N-((1-benzylpiperidin-4-yl)methyl)-N-(2-methoxyethyl)-2-naphthamide
Homo sapiens
pH 8.0, 25°C
0.0365
N-(1,3-thiazol-5-ylcarbamothioyl)butanamide
Homo sapiens
pH 7.7, 37°C
0.015
N-(3-ferrocenylphenyl)-2-chlorobenzamide
Homo sapiens
pH 7.6, 37°C
0.009
N-(3-ferrocenylphenyl)-2-fluorobenzamide
Homo sapiens
pH 7.6, 37°C
0.014
N-(3-ferrocenylphenyl)-2-methoxybenzamide
Homo sapiens
pH 7.6, 37°C
0.013
N-(3-ferrocenylphenyl)-2-methylbenzamide
Homo sapiens
pH 7.6, 37°C
0.015
N-(3-ferrocenylphenyl)-3-chlorobenzamide
Homo sapiens
pH 7.6, 37°C
0.014
N-(3-ferrocenylphenyl)-3-fluorobenzamide
Homo sapiens
pH 7.6, 37°C
0.009
N-(3-ferrocenylphenyl)-3-methoxybenzamide
Homo sapiens
pH 7.6, 37°C
0.012
N-(3-ferrocenylphenyl)-3-methylbenzamide
Homo sapiens
pH 7.6, 37°C
0.014
N-(3-ferrocenylphenyl)-4-chlorobenzamide
Homo sapiens
pH 7.6, 37°C
0.014
N-(3-ferrocenylphenyl)-4-fluorobenzamide
Homo sapiens
pH 7.6, 37°C
0.013
N-(3-ferrocenylphenyl)-4-methoxybenzamide
Homo sapiens
pH 7.6, 37°C
0.01
N-(3-ferrocenylphenyl)-4-methylbenzamide
Homo sapiens
pH 7.6, 37°C
0.013
N-(3-ferrocenylphenyl)benzamide
Homo sapiens
pH 7.6, 37°C
0.0000106
N-(4-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)butyl)-N-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl) methacrylamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.0000059
N-(4-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)butyl)-N-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl) propionamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.000004
N-(4-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)butyl)-N-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl)acetamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.0000431
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro--6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-acetamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.0000377
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-methacrylamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.0000129
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-pentanamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.0000255
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-pivalamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.0000463
N-(4-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)-propionamide
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.016
N-(4-ferrocenylphenyl)-2-chlorobenzamide
Homo sapiens
pH 7.6, 37°C
0.015
N-(4-ferrocenylphenyl)-2-fluorobenzamide
Homo sapiens
pH 7.6, 37°C
0.021
N-(4-ferrocenylphenyl)-2-methoxybenzamide
Homo sapiens
pH 7.6, 37°C
0.016
N-(4-ferrocenylphenyl)-2-methylbenzamide
Homo sapiens
pH 7.6, 37°C
0.025
N-(4-ferrocenylphenyl)-3-chlorobenzamide
Homo sapiens
pH 7.6, 37°C
0.024
N-(4-ferrocenylphenyl)-3-fluorobenzamide
Homo sapiens
pH 7.6, 37°C
0.024
N-(4-ferrocenylphenyl)-3-methoxybenzamide
Homo sapiens
pH 7.6, 37°C
0.021
N-(4-ferrocenylphenyl)-3-methylbenzamide
Homo sapiens
pH 7.6, 37°C
0.021
N-(4-ferrocenylphenyl)-4-chlorobenzamide
Homo sapiens
pH 7.6, 37°C
0.021
N-(4-ferrocenylphenyl)-4-fluorobenzamide
Homo sapiens
pH 7.6, 37°C
0.016
N-(4-ferrocenylphenyl)-4-methoxybenzamide
Homo sapiens
pH 7.6, 37°C
0.024
N-(4-ferrocenylphenyl)-4-methylbenzamide
Homo sapiens
pH 7.6, 37°C
0.017
N-(4-ferrocenylphenyl)benzamide
Homo sapiens
pH 7.6, 37°C
136
N-(cyclohexyl)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide
Equus caballus
pH 8.0, 25°C
0.064
N-butyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
Homo sapiens
-
pH and temperature not specified in the publication
0.097
N-ethyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
Homo sapiens
-
pH and temperature not specified in the publication
0.00019
N-ethyl-N-(4-[[10-(4-ethylpiperazin-1-yl)decyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.000033
N-ethyl-N-(4-[[10-(4-methylpiperazin-1-yl)decyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.000078
N-ethyl-N-(4-[[10-(piperidin-1-yl)decyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.000068
N-ethyl-N-(4-[[10-(pyrrolidin-1-yl)decyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.00308
N-ethyl-N-(4-[[5-(4-ethylpiperazin-1-yl)pentyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.00935
N-ethyl-N-(4-[[5-(4-methylpiperazin-1-yl)pentyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.00067
N-ethyl-N-(4-[[5-(piperidin-1-yl)pentyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.00154
N-ethyl-N-(4-[[5-(pyrrolidin-1-yl)pentyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.0022
N-ethyl-N-(4-[[6-(4-ethylpiperazin-1-yl)hexyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.00376
N-ethyl-N-(4-[[6-(4-methylpiperazin-1-yl)hexyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.00137
N-ethyl-N-(4-[[6-(piperidin-1-yl)hexyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.00128
N-ethyl-N-(4-[[6-(pyrrolidin-1-yl)hexyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.000014
N-ethyl-N-(4-[[8-(4-ethylpiperazin-1-yl)octyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.000011
N-ethyl-N-(4-[[8-(4-methylpiperazin-1-yl)octyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.0000073
N-ethyl-N-(4-[[8-(piperidin-1-yl)octyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.000015
N-ethyl-N-(4-[[8-(pyrrolidin-1-yl)octyl]oxy]benzyl)ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.02027
N-ethyl-N-[4-[2-(4-methylpiperazin-1-yl)ethoxy]benzyl]ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.0101
N-ethyl-N-[4-[2-(piperidin-1-yl)ethoxy]benzyl]ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.00973
N-ethyl-N-[4-[4-(4-methylpiperazin-1-yl)butoxy]benzyl]ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.00071
N-ethyl-N-[4-[4-(piperidin-1-yl)butoxy]benzyl]ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.0014
N-ethyl-N-[4-[4-(pyrrolidin-1-yl)butoxy]benzyl]ethanamine
Equus caballus
-
pH and temperature not specified in the publication
0.001
N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00004
N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
Homo sapiens
-
pH and temperature not specified in the publication
0.00000491
N-[(1-benzylpiperidin-3-yl)methyl]-N-(2-methoxyethyl)naphthalene-2-sulfonamide
Homo sapiens
pH 8.0, 25°C
0.15
N-[(2,3-dichlorophenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0439
N-[(2,4,6-trimethylphenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0155
N-[(2,4-dichlorophenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0231
N-[(2,6-dichloro-4-fluorophenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0758
N-[(2-methoxyphenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0645
N-[(3-nitrophenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0741
N-[(4-methoxyphenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0366
N-[(4-methylphenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0681
N-[(4-nitrophenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.00813
N-[6-(1H-indol-1-yl)hexyl]-1-(4-methoxybenzyl)piperidin-4-amine
Equus caballus
pH 8.0, 25°C
0.0023
N-[6-chloro-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene]-1-butanamine
Mus musculus
-
-
0.00446
N-[8-(1H-indol-1-yl)octyl]-1-(4-methoxybenzyl)piperidin-4-amine
Equus caballus
pH 8.0, 25°C
0.0000213
N-[[1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl]methyl]-N-(2-methoxyethyl)naphthalene-2-carboxamide
Homo sapiens
pH 8.0, 25°C
0.0005471
N1-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene)-N3-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl)-N3-methylpropane-1,3-diamine
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.0000813
N1-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylidene)-N4-(3-(2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ylideneamino)propyl)-N4-methylbutane-1,4-diamine
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.000197
N1-methyl-N3-(8,9,10,11-tetrahydro-6H-azocino[2,1-b]quinazolin-13(7H)-ylidene)-N1-(3-(8,9,10,11-tetrahydro-6Hazocino[2,1-b]quinazolin-13(7H)-ylideneamino)propyl)propane-1,3-diamine
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.0008 - 0.0496
neostigmine
0.02
O-(4-bromo-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0202
O-(4-bromo-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0199
O-(4-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0156
O-(4-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.015
O-(5-chloro-2-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0183
O-(5-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl) O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0151
O-[2-[(3-bromophenyl)carbamoyl]-4-chlorophenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0149
O-[2-[(3-bromophenyl)carbamoyl]-5-chlorophenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0151
O-[2-[(4-bromophenyl)carbamoyl]-4-chlorophenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0164
O-[2-[(4-bromophenyl)carbamoyl]-5-chlorophenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0188
O-[4-bromo-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.02
O-[4-bromo-2-[(3-bromophenyl)carbamoyl]phenyl] diethyl phosphate
Equus caballus
-
pH and temperature not specified in the publication
0.0139
O-[4-bromo-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0122
O-[4-bromo-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0189
O-[4-bromo-2-[(4-bromophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0135
O-[4-bromo-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0126
O-[4-bromo-2-[(4-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0174
O-[4-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0148
O-[4-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0118
O-[4-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0127
O-[4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0149
O-[4-chloro-2-[(4-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0147
O-[5-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0125
O-[5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.00868
O-[5-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.0138
O-[5-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.00867
O-[5-chloro-2-[(4-fluorophenyl)-carbamoyl]phenyl] O,O-diethyl phosphorothioate
Equus caballus
-
pH and temperature not specified in the publication
0.062
p-hydroxybenzoic acid
Equus caballus
-
-
0.00033 - 0.00712
paraoxon
0.00028 - 0.0037
physostigmine
16
pyridostigmine
Homo sapiens
-
-
0.00259
rac debromoflustramine B
Homo sapiens
-
-
0.00037 - 0.022
rivastigmine
0.00125
salignarine-C
Equus caballus
-
-
0.0015
sarcovagenine-C
Equus caballus
-
-
0.0125
slavin A
Equus caballus
-
-
0.0655
slavin B
Equus caballus
-
-
0.0248
sulfoglucobrassicin
Equus caballus
-
pH 8.0, 25°C
0.0000064 - 0.0182
tacrine
0.1425
testolactone
Equus caballus
-
-
0.0535
testosterone
Equus caballus
-
-
0.00102 - 0.0139
tetraisopropyl diphosphoramide
0.09014
umbelliferone
Equus caballus
pH 8.0, 22°C
0.205
vanilloloside
Equus caballus
-
-
0.000048 - 0.048
xanthostigmine
additional information
additional information
-
0.00000947
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
Pleuronichthys verticalis
-
pH 7.4, 22°C, male fish
0.00014
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
Gambusia yucatana
-
muscle enzyme, pH 7.4, temperature not specified in the publication
0.000159
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
Pleuronichthys verticalis
-
pH 7.4, 22°C, female fish
0.00037
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
Gambusia yucatana
-
head enzyme, pH 7.4, temperature not specified in the publication
0.0000397
4,4'-(3-oxopentane-1,5-diyl)bis(N,N-dimethyl-N-prop-2-en-1-ylanilinium) dibromide
Parophrys vetulus
-
pH 7.4, 22°C, large fish
0.00097
4,4'-(3-oxopentane-1,5-diyl)bis(N,N-dimethyl-N-prop-2-en-1-ylanilinium) dibromide
Parophrys vetulus
-
pH 7.4, 22°C, small fish
0.00011
Aldicarb
Diopatra neapolitana
-
inhibition of propionylthiocholine esterase activity, pH 8.0, 25°C
0.00048
Aldicarb
Parophrys vetulus
-
pH 7.4, 22°C, small fish
0.001
Aldicarb
Pleuronichthys verticalis
-
pH 7.4, 22°C, male fish
0.0064
Aldicarb
Pleuronichthys verticalis
-
pH 7.4, 22°C, female fish
0.007
Aldicarb
Parophrys vetulus
-
pH 7.4, 22°C, large fish
0.00685
Berberine
Homo sapiens
pH and temperature not specified in the publication
0.00744
Berberine
Equus caballus
pH 8.0, 22°C
0.00981
Berberine
Equus caballus
pH 8.0, 22°C
0.023
BW284c51
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate butyrylcholine
0.089
BW284c51
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 1 mM substrate butyrylcholine
0.15
BW284c51
Valvata piscinalis
-
pH 7.8, versus acetylthiocholine
0.262
BW284c51
Valvata piscinalis
-
pH 7.8, versus propionylthiocholine
0.29
BW284c51
Potamopyrgus antipodarum
-
pH 7.8, versus acetylthiocholine
0.387
BW284c51
Potamopyrgus antipodarum
-
pH 7.8, versus propionylthiocholine
0.00000479
Carbaryl
Eisenia andrei
-
pH 7.4, 25°C, versus propionylthiocholine
0.0000048
Carbaryl
Eisenia andrei
-
versus propionylthiocholine
0.00000575
Carbaryl
Eisenia andrei
-
pH 7.4, 25°C, versus acetylthiocholine
0.00312
Carbaryl
Diopatra neapolitana
-
inhibition of propionylthiocholine esterase activity, pH 8.0, 25°C
0.00714
donepezil
Homo sapiens
pH 8.0, 25°C
0.0074
donepezil
Homo sapiens
-
-
0.00795
donepezil
Homo sapiens
-
at pH 8.0, temperature not specified in the publication
0.0000034
eserine
Parophrys vetulus
-
pH 7.4, 22°C
0.000012
eserine
Eisenia andrei
-
pH 7.4, 25°C, versus propionylthiocholine
0.000012
eserine
Eisenia andrei
-
versus propionylthiocholine
0.0000142
eserine
Eisenia andrei
-
versus acetylthiocholine
0.0000144
eserine
Eisenia andrei
-
pH 7.4, 25°C, versus acetylthiocholine
0.000024
eserine
Potamopyrgus antipodarum
-
pH 7.8, versus butyrylthiocholine
0.000034
eserine
Potamopyrgus antipodarum
-
pH 7.8, versus acetylthiocholine
0.00007
eserine
Gambusia yucatana
-
head enzyme, pH 7.4, temperature not specified in the publication
0.00009
eserine
Gambusia yucatana
-
muscle enzyme, pH 7.4, temperature not specified in the publication
0.0001
eserine
Pleuronichthys verticalis
-
pH 7.4, 22°C, female fish
0.0002
eserine
Diopatra neapolitana
-
inhibition of propionylthiocholine esterase activity, pH 8.0, 25°C
0.0007
eserine
Pleuronichthys verticalis
-
pH 7.4, 22°C, male fish
0.00139
eserine
Valvata piscinalis
-
pH 7.8, versus acetylthiocholine
0.0014
eserine
Valvata piscinalis
-
pH 7.8, versus butyrylthiocholine
0.00529
eserine
Potamopyrgus antipodarum
-
pH 7.8, versus propionylthiocholine
0.00868
eserine
Valvata piscinalis
-
pH 7.8, versus propionylthiocholine
0.091
ethopropazine
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate butyrylcholine
0.22
ethopropazine
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 1 mM substrate butyrylcholine
0.008
galantamine
Homo sapiens
pH 7.6, 37°C
0.0191
galantamine
Homo sapiens
pH 8.0, 25°C
6.6
galantamine
Homo sapiens
pH 8.0, 25°C
0.0059
galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.00796
galanthamine
Equus caballus
-
pH and temperature not specified in the publication
0.0084
galanthamine
Equus caballus
-
pH and temperature not specified in the publication
0.0085
galanthamine
Equus caballus
-
-
0.0085
galanthamine
Equus caballus
-
pH 8.0, 25°C
0.0157
galanthamine
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.0008
neostigmine
Homo sapiens
-
-
0.0496
neostigmine
Homo sapiens
pH 7.7, 37°C
0.00033
paraoxon
Parophrys vetulus
-
pH 7.4, 22°C, small fish
0.00389
paraoxon
Pleuronichthys verticalis
-
pH 7.4, 22°C, male fish
0.006
paraoxon
Parophrys vetulus
-
pH 7.4, 22°C, large fish
0.00712
paraoxon
Pleuronichthys verticalis
-
pH 7.4, 22°C, female fish
0.00028
physostigmine
Mus musculus
-
pH not specified in the publication, at 37°C
0.0037
physostigmine
Equus caballus
-
pH and temperature not specified in the publication
0.00037
rivastigmine
Homo sapiens
pH 8.0, 25°C
0.01995
rivastigmine
Equus caballus
-
pH and temperature not specified in the publication
0.022
rivastigmine
Homo sapiens
-
at pH 8.0, temperature not specified in the publication
0.0000064
tacrine
Equus caballus
-
in 100 mM potassium dihydrogen phosphate buffer, pH 8.0, at 25°C
0.00001
tacrine
Equus caballus
-
-
0.000012
tacrine
Homo sapiens
pH 8.0, 25°C
0.000023
tacrine
Homo sapiens
-
pH and temperature not specified in the publication
0.00005
tacrine
Equus caballus
pH 8.0, 37°C
0.0182
tacrine
Equus caballus
-
in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C
0.00102
tetraisopropyl diphosphoramide
Parophrys vetulus
-
pH 7.4, 22°C, large fish
0.006
tetraisopropyl diphosphoramide
Pleuronichthys verticalis
-
pH 7.4, 22°C, male fish
0.0133
tetraisopropyl diphosphoramide
Pleuronichthys verticalis
-
pH 7.4, 22°C, female fish
0.0139
tetraisopropyl diphosphoramide
Parophrys vetulus
-
pH 7.4, 22°C, small fish
0.000048
xanthostigmine
Homo sapiens
-
-
0.048
xanthostigmine
Homo sapiens
-
-
additional information
additional information
Equus caballus
-
-
-
additional information
additional information
Biomphalaria glabrata
-
-
-
additional information
additional information
Lumbriculus variegatus
-
-
-
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