Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.1.1.7 - acetylcholinesterase and Organism(s) Danio rerio and UniProt Accession Q9DDE3

for references in articles please use BRENDA:EC3.1.1.7
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.7 acetylcholinesterase
IUBMB Comments
Acts on a variety of acetic esters; also catalyses transacetylations.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Danio rerio
UNIPROT: Q9DDE3
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Danio rerio
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
ache, acetylcholinesterase, acetylcholine esterase, acetyl cholinesterase, hache, eeache, ache1, huache, tcache, membrane-bound acetylcholinesterase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
AcCholE
-
-
-
-
acetyl beta-methylcholinesterase
-
-
-
-
acetylcholine esterase
-
-
-
-
acetylcholine hydrolase
-
-
-
-
acetylthiocholinesterase
-
-
-
-
choline esterase I
-
-
-
-
cholinesterase
-
-
-
-
esterase, acetyl choline
-
-
-
-
true cholinesterase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
transacetylation
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
acetylcholine acetylhydrolase
Acts on a variety of acetic esters; also catalyses transacetylations.
CAS REGISTRY NUMBER
COMMENTARY hide
9000-81-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
?
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetylcholine + H2O
choline + acetate
show the reaction diagram
-
-
-
-
?
acetylthiocholine + H2O
thiocholine + acetate
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Iron
-
in vitro, iron promotes a significant increase in AChE activity in brain (52%) and liver (53%) at the higher concentration (2.6 mM). In vivo, a significant increase in enzyme activity is observed in the presence of 15 mg/l in both, brain (62%) and liver tissue (70%)
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetaldehyde
-
additional information
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
assay at
7.5
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
assay at
25
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
expression analysis
Manually annotated by BRENDA team
expression analysis
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ACES_DANRE
634
0
71998
Swiss-Prot
Secretory Pathway (Reliability: 1)
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme transcript levels do not significantly change in the presence of iron
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Senger, M.R.; Rosemberg, D.B.; Rico, E.P.; de Bem Arizi, M.; Dias, R.D.; Bogo, M.R.; Bonan, C.D.
In vitro effect of zinc and cadmium on acetylcholinesterase and ectonucleotidase activities in zebrafish (Danio rerio) brain
Toxicol. In Vitro
20
954-958
2006
Danio rerio
Manually annotated by BRENDA team
Rico, E.P.; Rosemberg, D.B.; Dias, R.D.; Bogo, M.R.; Bonan, C.D.
Ethanol alters acetylcholinesterase activity and gene expression in zebrafish brain
Toxicol. Lett.
174
25-30
2007
Danio rerio (Q9DDE3), Danio rerio
Manually annotated by BRENDA team
SantAnna, M.C.; Soares, V.d.e..M.; Seibt, K.J.; Ghisleni, G.; Rico, E.P.; Rosemberg, D.B.; de Oliveira, J.R.; Schroeder, N.; Bonan, C.D.; Bogo, M.R.
Iron exposure modifies acetylcholinesterase activity in zebrafish (Danio rerio) tissues: distinct susceptibility of tissues to iron overload
Fish Physiol. Biochem.
37
573-581
2011
Danio rerio
Manually annotated by BRENDA team