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1-naphthyl acetate + H2O
1-naphthol + acetate
1-Naphthyl methylcarbonate + H2O
1-Naphthol + methylcarbonate
-
6% of the activity with juvenile hormone I
-
-
?
4-nitrophenyl acetate + H2O
4-nitrophenol + acetate
-
69% of the activity with juvenile hormone I, slightly more active than with juvenile hormone III
-
-
?
4-Nitrophenyl methylcarbonate + H2O
4-Nitrophenol + methylcarbonate
-
5% of the activity with juvenile hormone I
-
-
?
alpha-naphthyl acetate + H2O
?
-
artificial substrate
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
alpha-naphthyl hexanoate + H2O
alpha-naphthol + hexanoate
alpha-naphthyl octanoate + H2O
alpha-naphthol + octanoate
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
ethyl acetate + H2O
ethanol + acetate
-
-
-
-
?
ethyl butanoate + H2O
ethanol + butanoate
-
-
-
-
?
ethyl propionate + H2O
ethanol + propionate
-
-
-
-
?
HEPTAT + H2O
?
synthetic juvenile hormone analog
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
juvenile hormone I + H2O
juvenile hormone I acid + methanol
juvenile hormone II + H2O
juvenile hormone II acid + methanol
juvenile hormone III + H2O
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
juvenile hormone III bisepoxide + H2O
?
juvenile hormone III diol + H2O
?
although hydrogen bonding appears not to occur between juvenile hormone III diol and Thr-314, the hydroxyls of the diol (at C10 and C11) are within hydrogen bonding distance of the main chain carbonyl oxygen atoms of Phe-259 and Phe-311
-
-
?
methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O
(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol
juvenile hormone esterase plays an important role in regulating juvenile hormone titers
-
-
?
methyl 1-heptylthioacetothioate + H2O
?
HEPTAT
-
-
?
methyl farnesoate + H2O
methanol + farnesoic acid
-
-
-
?
methyl heptylthioacetothioate + H2O
?
methyl hexylthio acetothioate + H2O
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
p-nitrophenyl valerate + H2O
p-nitrophenol + valerate
saturated juvenile hormone III + H2O
saturated juvenile hormone III acid + methanol
alpha,beta-saturated methyl ester
-
-
?
additional information
?
-
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
-
-
-
?
1-naphthyl acetate + H2O
1-naphthol + acetate
-
13% of the activity with juvenile hormone I
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
lower activity than with alpha-naphthyl propionate
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
specific activities of several developmental stages
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
lower activity than with alpha-naphthyl propionate
-
?
alpha-naphthyl acetate + H2O
alpha-naphthol + acetate
-
-
-
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
-
activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
-
activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
-
?
alpha-naphthyl butyrate + H2O
alpha-naphthol + butyrate
-
activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl hexanoate + H2O
alpha-naphthol + hexanoate
-
activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl hexanoate + H2O
alpha-naphthol + hexanoate
-
activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
-
?
alpha-naphthyl hexanoate + H2O
alpha-naphthol + hexanoate
-
activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl octanoate + H2O
alpha-naphthol + octanoate
-
activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl octanoate + H2O
alpha-naphthol + octanoate
-
activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
-
?
alpha-naphthyl octanoate + H2O
alpha-naphthol + octanoate
-
activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
-
higher activity than with alpha-naphthyl acetate, activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
-
activity decreases with increasing the chain length of the alpha-naphthyl substrates from acetate to octanoate
-
?
alpha-naphthyl propionate + H2O
alpha-naphthol + propionate
-
higher activity than with alpha-naphthyl acetate, activity decreases with increasing the chain length of the alpha-naphthyl substrates from propionate to octanoate
-
?
juvenile hormone + H2O
?
-
-
-
-
?
juvenile hormone + H2O
?
-
juvenile hormone esterase activity
-
?
juvenile hormone + H2O
?
-
endocrine regulator, degrades and inactivates a key developmental and reproductive hormone, juvenile hormone
-
?
juvenile hormone + H2O
?
-
juvenile hormone degradation
-
?
juvenile hormone + H2O
?
-
-
-
?
juvenile hormone + H2O
?
-
-
-
?
juvenile hormone + H2O
?
-
selective enzyme, hydrolyzes the methyl ester of juvenile hormone
-
?
juvenile hormone + H2O
?
-
plays an important role in the regulation of metamorphosis in caterpillars, JHE is implicated in additional roles in development and reproduction
-
?
juvenile hormone + H2O
?
-
-
-
?
juvenile hormone + H2O
?
-
-
-
?
juvenile hormone + H2O
?
selective enzyme, juvenile hormone metabolism, alters the activity of juvenile hormone, which regulates development and reproduction
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
key enzyme in the regulation of juvenile hormone level
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
juvenile hormone I
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
JHE catabolizes juvenile hormone
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
juvenile hormone III
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
juvenile hormone III
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
key enzyme in the regulation of juvenile hormone level, degradation of juvenile hormone is required for proper insect development
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
C16 juvenile hormone-23H
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
juvenile hormone II
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
juvenile hormone III
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
juvenile hormone I
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
key enzyme in the regulation of juvenile hormone level
-
-
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
-
-
-
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
-
-
-
-
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
-
-
-
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
-
-
-
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
-
-
-
?
juvenile hormone I + H2O
juvenile hormone I acid + methanol
-
-
-
-
?
juvenile hormone II + H2O
juvenile hormone II acid + methanol
-
-
-
?
juvenile hormone II + H2O
juvenile hormone II acid + methanol
-
-
-
-
?
juvenile hormone III + H2O
?
-
-
-
?
juvenile hormone III + H2O
?
BmJHE is a juvenile hormone-selective esterase. Of the CCEs containing a GQSAG motif only BmJHE can function as a JH-specific degradation enzyme in the silkworm
-
-
?
juvenile hormone III + H2O
?
BmCCE-5 has the ability to degrade juvenile hormone, however, the protein might not function as a JH-specific esterase in vivo as it has a high Km value for juvenile hormone
-
-
?
juvenile hormone III + H2O
?
-
JHE is highly selective for JHIII and JHIII bisepoxide
-
?
juvenile hormone III + H2O
?
-
JHE is highly selective for JHIII and JHIII bisepoxide, both may be in vivo substrates
-
?
juvenile hormone III + H2O
?
-
racemic
-
?
juvenile hormone III + H2O
?
-
high affinity for juvenile hormone III
-
?
juvenile hormone III + H2O
?
hydrolyzes the methyl ester of juvenile hormone, highest specificity for juvenile hormone III
-
?
juvenile hormone III + H2O
?
D7US45
-
-
-
?
juvenile hormone III + H2O
?
D7US45
degradation
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
JH esterase hydrolyzes the methyl ester to produce juvenile hormone acid
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
10R-juvenile hormone III is the natural isomer
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
racemic
juvenile hormone acid is the sole product
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
specific activities of several developmental stages, highest specific activity
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
juvenile hormone III fits very tightly within the substrate binding pocket of JHE. This tight fit places two noncatalytic amino acid residues, Phe-259 and Thr-314, within the appropriate distance and geometry to potentially interact with the R,beta-unsaturated ester and epoxide, respectively, of juvenile hormone III. Neither nucleophilic attack of the resonance-stabilized ester by the catalytic serine nor the availability of a water molecule for attack of the acyl-enzyme intermediate appears to be a rate-determining step in the hydrolysis. Release of the juvenile hormone III acid metabolite from the substrate binding pocket limits the catalytic cycle. Chemical bond strength does not necessarily correlate with how reactive the bond will be to metabolism
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
highest specific activity
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
-
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
-
-
?
juvenile hormone III bisepoxide + H2O
?
-
JHE is highly selective for JHIII and JHIII bisepoxide
-
?
juvenile hormone III bisepoxide + H2O
?
-
JHE is highly selective for JHIII and JHIII bisepoxide, both may be in vivo substrates
-
?
methyl heptylthioacetothioate + H2O
?
a synthetic substrate
-
-
?
methyl heptylthioacetothioate + H2O
?
D7US45
the recombinant JHE has a strong ability to degrade methyl hepthylthioacetothioate, HEPTAT, as a synthetic substrate
-
-
?
methyl hexylthio acetothioate + H2O
?
-
putative surrogate substrate for juvenile hormone, specific activities of several developmental stages
-
?
methyl hexylthio acetothioate + H2O
?
-
putative surrogate substrate for juvenile hormone
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
higher specific activity than for p-nitrophenyl valerate
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
higher specific activity than for p-nitrophenyl valerate
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
higher specific activity than for p-nitrophenyl valerate
-
?
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
-
-
-
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valerate
-
lower specific activity than for p-nitrophenyl acetate
-
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valerate
-
lower specific activity than for p-nitrophenyl acetate
-
?
p-nitrophenyl valerate + H2O
p-nitrophenol + valerate
-
lower specific activity than for p-nitrophenyl acetate
-
?
additional information
?
-
clearance of juvenile hormone during larval-pupal metamorphosis
-
-
?
additional information
?
-
-
clearance of juvenile hormone during larval-pupal metamorphosis
-
-
?
additional information
?
-
deficiency in Amjhe-like results in 6fold increase in juvenile hormone titer (adult, 4 day-old worker bee)
-
-
?
additional information
?
-
-
deficiency in Amjhe-like results in 6fold increase in juvenile hormone titer (adult, 4 day-old worker bee)
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
the enzymes encoded by genes Bmcce-1-4 are not active on juvenile hormone
-
-
?
additional information
?
-
the enzymes encoded by genes Bmcce-1-4 are not active on juvenile hormone
-
-
?
additional information
?
-
-
hormonal regulation of enzyme
-
?
additional information
?
-
-
structural features promoting substrate binding at the active site of JHE
-
?
additional information
?
-
there is probably only one physiologically functional JHE in Drosophila melanogaster but multiple esterases with JH esterase activity
-
-
?
additional information
?
-
-
there is probably only one physiologically functional JHE in Drosophila melanogaster but multiple esterases with JH esterase activity
-
-
?
additional information
?
-
no activity with juvenile hormone II
-
-
?
additional information
?
-
-
no activity with juvenile hormone II
-
-
?
additional information
?
-
-
the enzyme plays a profound role in metamorphosis and reproduction
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
the enzyme is also active on alpha-naphthyl propionate, alpha-naphthyl butyrate, and 2-carbon substrate alpha-naphthyl acetate
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
effectiveness of thioester compounds as surrogate substrates
-
-
?
additional information
?
-
-
low activity with hydroprene and methoprene
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, but does not hydrolyze the analogous ethyl or isopropyl esters
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
juvenile hormone + H2O
Juvenile hormone acid + methanol
juvenile hormone III + H2O
?
juvenile hormone III + H2O
juvenile hormone III acid + methanol
-
JH esterase hydrolyzes the methyl ester to produce juvenile hormone acid
-
-
?
juvenile hormone III bisepoxide + H2O
?
-
JHE is highly selective for JHIII and JHIII bisepoxide, both may be in vivo substrates
-
?
methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O
(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol
juvenile hormone esterase plays an important role in regulating juvenile hormone titers
-
-
?
additional information
?
-
juvenile hormone + H2O
?
-
-
-
-
?
juvenile hormone + H2O
?
-
endocrine regulator, degrades and inactivates a key developmental and reproductive hormone, juvenile hormone
-
?
juvenile hormone + H2O
?
-
juvenile hormone degradation
-
?
juvenile hormone + H2O
?
-
-
-
?
juvenile hormone + H2O
?
-
plays an important role in the regulation of metamorphosis in caterpillars, JHE is implicated in additional roles in development and reproduction
-
?
juvenile hormone + H2O
?
-
-
-
?
juvenile hormone + H2O
?
selective enzyme, juvenile hormone metabolism, alters the activity of juvenile hormone, which regulates development and reproduction
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
key enzyme in the regulation of juvenile hormone level
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
JHE catabolizes juvenile hormone
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
key enzyme in the regulation of juvenile hormone level, degradation of juvenile hormone is required for proper insect development
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
-
-
?
juvenile hormone + H2O
Juvenile hormone acid + methanol
-
key enzyme in the regulation of juvenile hormone level
-
-
?
juvenile hormone III + H2O
?
BmJHE is a juvenile hormone-selective esterase. Of the CCEs containing a GQSAG motif only BmJHE can function as a JH-specific degradation enzyme in the silkworm
-
-
?
juvenile hormone III + H2O
?
-
JHE is highly selective for JHIII and JHIII bisepoxide, both may be in vivo substrates
-
?
juvenile hormone III + H2O
?
D7US45
degradation
-
-
?
additional information
?
-
clearance of juvenile hormone during larval-pupal metamorphosis
-
-
?
additional information
?
-
-
clearance of juvenile hormone during larval-pupal metamorphosis
-
-
?
additional information
?
-
deficiency in Amjhe-like results in 6fold increase in juvenile hormone titer (adult, 4 day-old worker bee)
-
-
?
additional information
?
-
-
deficiency in Amjhe-like results in 6fold increase in juvenile hormone titer (adult, 4 day-old worker bee)
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
hormonal regulation of enzyme
-
?
additional information
?
-
there is probably only one physiologically functional JHE in Drosophila melanogaster but multiple esterases with JH esterase activity
-
-
?
additional information
?
-
-
there is probably only one physiologically functional JHE in Drosophila melanogaster but multiple esterases with JH esterase activity
-
-
?
additional information
?
-
-
the enzyme plays a profound role in metamorphosis and reproduction
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
additional information
?
-
-
likely to be involved in elimination of intracellular juvenile hormone from the target tissues in the preparation for metamorphosis
-
-
?
additional information
?
-
-
demethylates the insect juvenile hormones, JH1 and JH3, major role in regulation of juvenile hormone titer and may be necessary for the removal of all traces of juvenile hormone at periods critical to further development
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,1,1-trifluoro-3-(octane-1-sulfonyl)propan-2,2-diol
IC50: 0.0016 mM
1,1,1-trifluoro-3-(octylsulfanyl)propan-2-one
-
-
1,1,1-trifluoro-3-decylsulfanyl-propan-2-one
1,1,1-trifluoro-3-dodecylsulfanyl-propan-2-one
1,1,1-trifluoro-3-hexylsulfanyl-propan-2-one
1,1,1-trifluoro-3-octylsulfanyl-propan-2-one
1,1,1-trifluoro-3-phenethylsulfanyl-propan-2-one
1-octyl (1-(3,3,3-trifluoropropan-2,2-dihydroxy))sulfone
-
potent, specific inhibitor
3-(4'-Butylphenylthio)-1,1,1-trifluoropropan-2-one
-
-
3-octylthio-1,1,1-trifluoro-2-propanone
3-Octylthio-1,1,1-trifluoropropan-2-one
3-pentylthio-1,1,1-trifluoro-2-propanone
3-Substituted 1,1,1-trifluoropropanone sulfides
3-[(4'-Mercapto)butylthio]-1,1,1-trifluoropropan-2-one
-
-
Alkylthiotrifluoropropanones
bis-(4-nitrophenyl) phosphate
-
-
Carbaryl
weak, IC50: above 0.1 mM
chlorpromazine
-
octopamine antagonist, reduces JHE activity, when applied in diet at 10-100 ppm
diisopropyl fluorophosphate
eserine
-
IC50: 3.9-4.2, high- and low-selected JHE activity lines
gramine
-
octopamine antagonist, reduces JHE activity, when applied in diet at 10-100 ppm
hydroprene
50% inhibition at 8 mM
JHE binding protein
-
DmP29, induces anti-juvenile hormone effects
-
Juvenile hormone
-
juvenile hormone I, II or III
kinoprene
50% inhibition at 2 mM
methamidophos
weak, IC50: above 1 mM
methoprene
50% inhibition at 2 mM
O,O-Dialkyl-O-4-nitrophenyl phosphates
-
O,O-dialkyl-O-4-nitrophenyl analog provides the greatest inhibition
O,O-diethyl-p-nitrophenyl phosphate
O,O-diisopropyl phosphofluoridate
-
pI50: 5-5.7, high- and low-selected JHE activity lines
O-ethyl-S-phenyl-phosphoramidothiolate
IC50: 0.0084 mM
O-Ethyl-S-phosphoramidothiolate
octylthiotrifluoropropanone
50% inhibition below 1 nM
Phenylmethylsulfonylfluoride
phosphoramidothiolate
-
JHE is highly sensitive to certain phosphoramidothiolates
trifluoroketone inhibitor
-
JHE is highly sensitive
-
trifluoromethylketone
-
with chain lengths of 8, 10 or 12 carbons, highly effective inhibitors
Tris-butylphosphorotrithiolate
-
-
ZR-448
-
a methyl ester dienoate juvenoid, competitive
1,1,1-trifluoro-3-decylsulfanyl-propan-2-one
-
IC50: 0.99 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-decylsulfanyl-propan-2-one
-
IC50: 2.8 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-decylsulfanyl-propan-2-one
-
IC50: 3.6 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-decylsulfanyl-propan-2-one
potent inhibitor, IC50: 3.6 nm
1,1,1-trifluoro-3-dodecylsulfanyl-propan-2-one
-
IC50: 2.2 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-dodecylsulfanyl-propan-2-one
-
IC50: 4.4 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-dodecylsulfanyl-propan-2-one
-
IC50: 12 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-hexylsulfanyl-propan-2-one
-
IC50: 1100 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-hexylsulfanyl-propan-2-one
-
IC50: 1700 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-hexylsulfanyl-propan-2-one
-
IC50: 14 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-octylsulfanyl-propan-2-one
-
IC50: 5.8 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-octylsulfanyl-propan-2-one
-
IC50: 9.1 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-octylsulfanyl-propan-2-one
-
IC50: 4.6 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-octylsulfanyl-propan-2-one
potent inhibitor, IC50: 4.6 nm
1,1,1-trifluoro-3-phenethylsulfanyl-propan-2-one
-
IC50: 75 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-phenethylsulfanyl-propan-2-one
-
IC50: 400 nM, juvenile hormone III hydrolysis
1,1,1-trifluoro-3-phenethylsulfanyl-propan-2-one
-
IC50: 36 nM, juvenile hormone III hydrolysis
3-octylthio-1,1,1-trifluoro-2-propanone
-
specific inhibitor, 95-100% inhibition at 2 mM in hemolymph and fat body
3-octylthio-1,1,1-trifluoro-2-propanone
-
potent inhibitor, pI50: 7.3-7.8, high- and low-selected JHE activity lines
3-octylthio-1,1,1-trifluoro-2-propanone
-
more inhibitory than 3-pentylthio-1,1,1-trifluoro-2-propanone and diisopropyl fluorophosphate, moderately potent inhibitor
3-octylthio-1,1,1-trifluoro-2-propanone
-
very potent inhibitor
3-Octylthio-1,1,1-trifluoropropan-2-one
-
-
3-Octylthio-1,1,1-trifluoropropan-2-one
transition state analogue inhibitor; transition state analogue inhibitor, IC50 (wild type): 22 nM, IC50 (F259I mutant): 330 nM
3-Octylthio-1,1,1-trifluoropropan-2-one
-
high affinity and slow binding inhibitor
3-pentylthio-1,1,1-trifluoro-2-propanone
-
less inhibitory than 3-octylthio-1,1,1-trifluoro-2-propanone, more inhibitory than diisopropyl fluorophosphate
3-pentylthio-1,1,1-trifluoro-2-propanone
-
less inhibitory than 3-octylthio-1,1,1-trifluoro-2-propanone, more inhibitory than diisopropyl fluorophosphate
3-Substituted 1,1,1-trifluoropropanone sulfides
-
-
3-Substituted 1,1,1-trifluoropropanone sulfides
-
-
3-Substituted 1,1,1-trifluoropropanone sulfides
-
3-Substituted 1,1,1-trifluoropropanone sulfides
-
-
Alkylthiotrifluoropropanones
-
-
Alkylthiotrifluoropropanones
-
diisopropyl fluorophosphate
50% inhibition at 0.002 mM
diisopropyl fluorophosphate
-
less inhibitory than 3-octylthio-1,1,1-trifluoro-2-propanone and 3-pentylthio-1,1,1-trifluoro-2-propanone, poor inhibitor
diisopropyl fluorophosphate
-
less inhibitory than 3-octylthio-1,1,1-trifluoro-2-propanone and 3-pentylthio-1,1,1-trifluoro-2-propanone, poor inhibitor
O,O-diethyl-p-nitrophenyl phosphate
-
poor inhibitor
O,O-diethyl-p-nitrophenyl phosphate
-
poor inhibitor
O-Ethyl-S-phosphoramidothiolate
-
Galleria mellonella enzyme inhibited, Tenebrio molitor enzyme not
O-Ethyl-S-phosphoramidothiolate
-
-
O-Ethyl-S-phosphoramidothiolate
-
irreversible
O-Ethyl-S-phosphoramidothiolate
-
-
paraoxon
-
irreversible
Phenylmethylsulfonylfluoride
-
moderate inhibitor
Phenylmethylsulfonylfluoride
-
weak inhibitor
Phenylmethylsulfonylfluoride
mediocre inhibitor, IC50: 0.24 mM
Triton X-100
-
-
Triton X-100
-
inhibits at low concentrations
additional information
-
ethanol leaf extract of Clerodendrum inerme significantly inhibits hemolymph JH esterase activity and affects insect growth and normal development
-
additional information
-
lipophorin might modulate juvenile hormone hydrolysis by competition for binding of juvenile hormone
-
additional information
-
highly resistant to diisopropyl fluorophosphate
-
additional information
-
highly resistant to diisopropyl fluorophosphate
-
additional information
-
highly resistant to diisopropyl fluorophosphate
-
additional information
-
not inhibited by 1% Triton X-100, IC50-values for several inhibitors
-
additional information
-
highly resistant to diisopropyl fluorophosphate
-
additional information
-
highly resistant to diisopropyl fluorophosphate; phenylmethylsulfonyl fluoride
-
additional information
activity of the juvenile hormone degrading enzyme JH-esterase is significantly lower in the hemolymph of larvae infected with the microsporidium Vairimorpha disparis than in hemolymph of uninfected larvae, the difference becomes larger during development. The disturbance of juvenile hormone metabolism is rather due to generally impaired fat body functions than an active manipulation of the host by the pathogen, overview
-
additional information
-
activity of the juvenile hormone degrading enzyme JH-esterase is significantly lower in the hemolymph of larvae infected with the microsporidium Vairimorpha disparis than in hemolymph of uninfected larvae, the difference becomes larger during development. The disturbance of juvenile hormone metabolism is rather due to generally impaired fat body functions than an active manipulation of the host by the pathogen, overview
-
additional information
-
highly resistant to diisopropyl fluorophosphate
-
additional information
-
highly resistant to diisopropyl fluorophosphate
-
additional information
-
highly resistant to diisopropyl fluorophosphate; iodoacetate
-
additional information
-
highly resistant to diisopropyl fluorophosphate
-
additional information
-
highly resistant to diisopropyl fluorophosphate
-
additional information
-
highly resistant to diisopropyl fluorophosphate
-
additional information
-
highly resistant to diisopropyl fluorophosphate
-
additional information
-
IC50-values for several inhibitors
-
additional information
-
-
-
additional information
-
highly resistant to diisopropyl fluorophosphate (very little effect)
-
additional information
-
insects treated with different substances, trans-stilbene oxide do not alter JH esterase levels when topically applied, but oral administration reduces activity to 70%, cholesterol 5alpha,6alpha-epoxide reduces the JH esterase activity to 6080% of the control, 3-octylthio-1,1,1-trifluoropropan-2-one strongly reduces JH esterase activity
-
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0.0016
1,1,1-trifluoro-3-(octane-1-sulfonyl)propan-2,2-diol
Tenebrio molitor
IC50: 0.0016 mM
0.00000099 - 0.0000036
1,1,1-trifluoro-3-decylsulfanyl-propan-2-one
0.0000022 - 0.000012
1,1,1-trifluoro-3-dodecylsulfanyl-propan-2-one
0.000014 - 0.0017
1,1,1-trifluoro-3-hexylsulfanyl-propan-2-one
0.0000046 - 0.0000091
1,1,1-trifluoro-3-octylsulfanyl-propan-2-one
0.000036 - 0.0004
1,1,1-trifluoro-3-phenethylsulfanyl-propan-2-one
0.000022 - 0.00033
3-Octylthio-1,1,1-trifluoropropan-2-one
0.1
Carbaryl
Tenebrio molitor
weak, IC50: above 0.1 mM
1
methamidophos
Tenebrio molitor
weak, IC50: above 1 mM
0.0084
O-ethyl-S-phenyl-phosphoramidothiolate
Tenebrio molitor
IC50: 0.0084 mM
0.24
Phenylmethylsulfonylfluoride
Tenebrio molitor
mediocre inhibitor, IC50: 0.24 mM
0.00000099
1,1,1-trifluoro-3-decylsulfanyl-propan-2-one
Heliothis virescens
-
IC50: 0.99 nM, juvenile hormone III hydrolysis
0.0000028
1,1,1-trifluoro-3-decylsulfanyl-propan-2-one
Manduca sexta
-
IC50: 2.8 nM, juvenile hormone III hydrolysis
0.0000036
1,1,1-trifluoro-3-decylsulfanyl-propan-2-one
Tenebrio molitor
-
IC50: 3.6 nM, juvenile hormone III hydrolysis
0.0000036
1,1,1-trifluoro-3-decylsulfanyl-propan-2-one
Tenebrio molitor
potent inhibitor, IC50: 3.6 nm
0.0000022
1,1,1-trifluoro-3-dodecylsulfanyl-propan-2-one
Heliothis virescens
-
IC50: 2.2 nM, juvenile hormone III hydrolysis
0.0000044
1,1,1-trifluoro-3-dodecylsulfanyl-propan-2-one
Manduca sexta
-
IC50: 4.4 nM, juvenile hormone III hydrolysis
0.000012
1,1,1-trifluoro-3-dodecylsulfanyl-propan-2-one
Tenebrio molitor
-
IC50: 12 nM, juvenile hormone III hydrolysis
0.000014
1,1,1-trifluoro-3-hexylsulfanyl-propan-2-one
Tenebrio molitor
-
IC50: 14 nM, juvenile hormone III hydrolysis
0.0011
1,1,1-trifluoro-3-hexylsulfanyl-propan-2-one
Heliothis virescens
-
IC50: 1100 nM, juvenile hormone III hydrolysis
0.0017
1,1,1-trifluoro-3-hexylsulfanyl-propan-2-one
Manduca sexta
-
IC50: 1700 nM, juvenile hormone III hydrolysis
0.0000046
1,1,1-trifluoro-3-octylsulfanyl-propan-2-one
Tenebrio molitor
-
IC50: 4.6 nM, juvenile hormone III hydrolysis
0.0000046
1,1,1-trifluoro-3-octylsulfanyl-propan-2-one
Tenebrio molitor
potent inhibitor, IC50: 4.6 nm
0.0000058
1,1,1-trifluoro-3-octylsulfanyl-propan-2-one
Heliothis virescens
-
IC50: 5.8 nM, juvenile hormone III hydrolysis
0.0000091
1,1,1-trifluoro-3-octylsulfanyl-propan-2-one
Manduca sexta
-
IC50: 9.1 nM, juvenile hormone III hydrolysis
0.000036
1,1,1-trifluoro-3-phenethylsulfanyl-propan-2-one
Tenebrio molitor
-
IC50: 36 nM, juvenile hormone III hydrolysis
0.000075
1,1,1-trifluoro-3-phenethylsulfanyl-propan-2-one
Heliothis virescens
-
IC50: 75 nM, juvenile hormone III hydrolysis
0.0004
1,1,1-trifluoro-3-phenethylsulfanyl-propan-2-one
Manduca sexta
-
IC50: 400 nM, juvenile hormone III hydrolysis
0.000022
3-Octylthio-1,1,1-trifluoropropan-2-one
Manduca sexta
transition state analogue inhibitor, IC50 (wild type): 22 nM
0.00033
3-Octylthio-1,1,1-trifluoropropan-2-one
Manduca sexta
IC50 (F259I mutant): 330 nM
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De Kort, C.A.D.; Granger, N.A.
Regulation of the juvenile hormone titer
Ann. Rev. Entomol.
26
1-28
1981
Galleria mellonella, insecta, Lymantria dispar, Manduca sexta, Sarcophaga bullata, Periplaneta brunnea, Samia cynthia, Schistocerca nitens, Trichoplusia ni
-
brenda
Mitsui, T.; Riddiford, L.M.; Bellamy, G.
Metabolism of juvenile hormone by the epidermis of the tobacco hornworm, Manduca sexta
Insect Biochem.
9
637-643
1979
Manduca sexta
-
brenda
Hammock, B.D.; Roe, R.M.
Analysis of juvenile hormone esterase activity
Methods Enzymol.
111
487-494
1985
Manduca sexta, Trichoplusia ni
brenda
Shiotsuki, T.; Huang, T.L.; Uematsu, T.; Bonning, B.C.; Ward, V.K.; Hammock, B.D.
Juvenile hormone esterase purified by affinity chromatography with 8-mercapto-1,1,1-trifluoro-2-octanone as a rationally designed ligand
Protein Expr. Purif.
5
296-306
1994
Heliothis virescens (P12992), Heliothis virescens
brenda
Valaitis, A.P.
Characterization of hemolymph juvenile hormone esterase from Lymantria dispar
Insect Biochem.
21
583-595
1991
Lymantria dispar
-
brenda
Abdel-Aal, Y.A.I.; Hanzlik, T.N.; Hammock, B.D.; Harshman, L.G.; Prestwich, G.
Juvenile hormone esterases in two heliothines: kinetic, biochemical and immunogenic characterization
Comp. Biochem. Physiol. B
90
117-124
1988
Helicoverpa zea, Heliothis virescens (P12992)
-
brenda
Rudnicka, M.; Jones, D.
Characterization of homogeneous juvenile hormone esterase from larvae of Trichoplusia ni
Insect Biochem.
17
373-382
1987
Trichoplusia ni
-
brenda
Abdel-Aal, Y.A.I.; Hammock, B.D.
3-Octylthio-1,1,1-trifluoro-2-propanone, a high affinity and slow binding inhibitor of juvenile hormone esterase from Trichoplusia ni (Huebner)
Insect Biochem.
15
111-122
1985
Trichoplusia ni
-
brenda
Rudnicka, M.; Kochman, M.
Purification of the juvenile hormone esterase from the hemolymph of the wax moth Galleria mellonella (Lepidoptera)
Insect Biochem.
14
189-198
1984
Galleria mellonella
-
brenda
Sparks, T.C.; Rose, R.L.
Inhibition and substrate specificity of the hemolymph juvenile hormone esterase of the cabbage looper, Trichoplusia ni (Huebner)
Insect Biochem.
13
633-640
1983
Trichoplusia ni
-
brenda
Mai, M.S.; Kramer, K.J.
Properties of esterases from pharate pupal moulting fluid of the tobacco hornworm, Manduca sexta
Comp. Biochem. Physiol. B
74
769-773
1983
Manduca sexta
-
brenda
Yuhas, D.A.; Roe, R.M.; Sparks, T.C.; Hammond, A.M.
Purification and kinetics of juvenile hormone esterase from the cabbage looper, Trichoplusia ni (Hubner)
Insect Biochem.
13
129-136
1983
Trichoplusia ni
-
brenda
Coudron, T.A.; Dunn, P.E.; Seballos, H.L.; Wharen, R.E.; Sanburg, L.L.; Law, J.H.
Preparation of homogeneous juvenile hormone specific esterase from the hemolymph of the tobacco hornworm, Manduca sexta
Insect Biochem.
11
453-461
1981
Manduca sexta
-
brenda
McCaleb, D.C.; Reddy, G.; Kumaran, A.K.
Some properties of the hemolymph juvenile hormone esterases in Galleria mellonella larvae and Tenebrio molitor pupae
Insect Biochem.
10
273-277
1980
Galleria mellonella, Tenebrio molitor
-
brenda
Sparks, T.C.; Hammock, B.D.
A comparison of the induced and naturally occurring juvenile hormone esterases from last instar larvae of Trichoplusia ni
Insect Biochem.
9
411-421
1979
Trichoplusia ni
-
brenda
Pratt, G.E.
Inhibition of juvenile hormone carboxyesterase of locust hemolymph by organophosphates in vitro
Insect Biochem.
5
595-607
1975
Schistocerca gregaria
-
brenda
Wozniak, M.; Jones, G.; Hiremath, S.; Jones, D.
Biochemical and immunological properties of different electrophoretic forms of juvenile hormone esterase from Trichoplusia ni (Hubner)
Biochim. Biophys. Acta
926
26-39
1987
Trichoplusia ni
brenda
Hanzlik, T.N.; Hammock, B.D.
Characterization of affinity-purified juvenile hormone esterase from Trichoplusia ni
J. Biol. Chem.
28
13584-13591
1987
Trichoplusia ni
brenda
Hanzlik, T.N.; Abdel-Aal, Y.A.I.; Harshman, L.G.; Hammock, B.D.
Isolation and sequencing of cDNA clones coding for juvenile hormone esterase from Heliothis virescens. Evidence for a catalytic mechanism for the serine carboxylesterases different from that of the serine proteases
J. Biol. Chem.
264
12419-12425
1989
Heliothis virescens (P12992), Heliothis virescens
brenda
Venkatesh, K.; Abdel-Aal, Y.A.I.; Armstrong, F.B.; Roe, R.M.
Characterization of affinity-purified juvenile hormone esterase from the plasma of the tobacco hornworm, Manduca sexta
J. Biol. Chem.
265
21727-21732
1990
Manduca sexta
brenda
Jones, G.; Manczak, M.; Wozniak, M.; Ko'rrati, R.
Characterization of two major isoforms of juvenile hormone esterase from Trichoplusia ni (Lepidoptera)
Biochim. Biophys. Acta
1161
235-243
1993
Trichoplusia ni
brenda
McCutchen, B.F.; Uematsu, T.; Szekacs, A.; Huang, T.L.; Shiotsuki, T.; Lucas, A.; Hammock, B.D.
Development of surrogate substrates for juvenile hormone esterase
Arch. Biochem. Biophys.
307
231-241
1993
Spodoptera frugiperda
brenda
Abdel-Aal, Y.A.I.; Hammock, B.D.
Transition state analogs as ligands for affinity purification of juvenile hormone esterase
Science
233
1073-1076
1986
Bombyx mori, Helicoverpa zea, Manduca sexta, Trichoplusia ni, Heliothis virescens (P12992)
brenda
Wozniak, M.; Jones, D.
Immunochemical characterization of juvenile hormone esterase from different species of Lepidoptera
Biochem. Biophys. Res. Commun.
144
1281-1286
1987
Hyphantria cunea, Isia isabella, Spodoptera exigua, Trichoplusia ni
brenda
Abdel-Aal, Y.A.I.; Hammock, B.D.
Apparent multiple catalytic sites involved in the ester hydrolysis of juvenile hormones by the hemolymph and by an affinity-purified esterase from Manduca sexta Johannson (Lepidoptera: Sphingidae)
Arch. Biochem. Biophys.
243
206-219
1985
Manduca sexta
brenda
Hammock, B.D.; Sparks, T.C.
A rapid assay for insect juvenile hormone esterase activity
Anal. Biochem.
82
573-579
1977
Trichoplusia ni
brenda
Stauffer, C.; Shiotsuki, T.; Chan, W.; Hammock, B.D.
Characterization of the esterase isoenzymes of Ips typographus (Coleoptera, Scolytidae)
Arch. Insect Biochem. Physiol.
34
203-221
1997
Tenebrio molitor, Ips typographus
-
brenda
Vermunt, A.M.W.; Vermeesch, A.M.G.; de Kort, C.A.D.
Purification and characterization of juvenile hormone esterase from hemolymph of the Colorado potato beetle
Arch. Insect Biochem. Physiol.
35
261-277
1997
Leptinotarsa decemlineata
brenda
Zera, A.J.; Zeisset, M.
Biochemical characterization of juvenile hormone esterases from lines selected for high or low enzyme activity in Gryllus assimilis
Biochem. Genet.
34
421-435
1996
Gryllus assimilis
brenda
Hirashima, A.; Suetsugu, E.; Hirokado, S.; Kuwano, E.; Taniguchi, E.; Eto, M.
Effect of octopamine on the activity of juvenile-hormone esterase in the silkworm Bombyx mori and the red flour beetle Tribolium freemani
Gen. Comp. Endocrinol.
116
373-381
1999
Bombyx mori, Tribolium freemani, Bombyx mori Shogetu-Shunrei
brenda
Campbell, P.M.; Oakeshott, J.G.; Healy, M.J.
Purification and kinetic characterisation of juvenile hormone esterase from Drosophila melanogaster
Insect Biochem. Mol. Biol.
28
501-515
1998
Drosophila melanogaster
brenda
Nussbaumer, C.; Hinton, A.C.; Schopf, A.; Stradner, A.; Hammock, B.D.
Isolation and characterization of juvenile hormone esterase from hemolymph of Lymantria dispar by affinity- and by anion-exchange chromatography
Insect Biochem. Mol. Biol.
30
307-314
2000
Lymantria dispar
brenda
Engelmann, F.; Mala, J.
The interactions between juvenile hormone (JH), lipophorin, vitellogenin, and JH esterases in two cockroach species
Insect Biochem. Mol. Biol.
30
793-803
2000
Rhyparobia maderae
brenda
Kamita, S.G.; Hinton, A.C.; Wheelock, C.E.; Wogulis, M.D.; Wilson, D.K.; Wolf, N.M.; Stok, J.E.; Hock, B.; Hammock, B.D.
Juvenile hormone (JH) esterase: why are you so JH specific?
Insect Biochem. Mol. Biol.
33
1261-1273
2003
Heliothis virescens, Manduca sexta, Tenebrio molitor, Trichoplusia ni
brenda
Hinton, A.C.; Hammock, B.D.
In vitro expression and biochemical characterization of juvenile hormone esterase from Manduca sexta
Insect Biochem. Mol. Biol.
33
317-329
2003
Manduca sexta
brenda
Hinton, A.C.; Hammock, B.D.
Juvenile hormone esterase (JHE) from Tenebrio molitor: full-length cDNA sequence, in vitro expression, and characterization of the recombinant protein
Insect Biochem. Mol. Biol.
33
477-487
2003
Tenebrio molitor (Q8WRD8), Tenebrio molitor
brenda
Feng, Q.L.; Ladd, T.R.; Tomkins, B.L.; Sundaram, M.; Sohi, S.S.; Retnakaran, A.; Davey, K.G.; Palli, S.R.
Spruce budworm (Choristoneura fumiferana) juvenile hormone esterase: hormonal regulation, developmental expression and cDNA cloning
Mol. Cell. Endocrinol.
148
95-108
1999
Choristoneura fumiferana
brenda
Wogulis, M.; Wheelock, C.E.; Kamita, S.G.; Hinton, A.C.; Whetstone, P.A.; Hammock, B.D.; Wilson, D.K.
Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta
Biochemistry
45
4045-4057
2006
Manduca sexta (P19985), Manduca sexta (Q9GPG0), Manduca sexta
brenda
Anspaugh, D.D.; Roe, R.M.
Regulation of JH epoxide hydrolase versus JH esterase activity in the cabbage looper, Trichoplusia ni, by juvenile hormone and xenobiotics
J. Insect Physiol.
51
523-535
2005
Trichoplusia ni
brenda
Tan, A.; Tanaka, H.; Tamura, T.; Shiotsuki, T.
Precocious metamorphosis in transgenic silkworms overexpressing juvenile hormone esterase
Proc. Natl. Acad. Sci. USA
102
11751-11756
2005
Bombyx mori
brenda
Kamimura, M.; Takahashi, M.; Kikuchi, K.; Reza, A.M.; Kiuchi, M.
Tissue-specific regulation of juvenile hormone esterase gene expression by 20-hydroxyecdysone and juvenile hormone in Bombyx mori
Arch. Insect Biochem. Physiol.
65
143-151
2007
Bombyx mori (Q6RVD1), Bombyx mori
brenda
Elayidam, U.G.; Muraleedharan, D.
Juvenile hormone activity in Dysdercus cingulatus Fabr by juvenile hormone esterase inhibitor, OTFP
Indian J. Exp. Biol.
45
901-906
2007
Dysdercus cingulatus
brenda
Crone, E.J.; Zera, A.J.; Anand, A.; Oakeshott, J.G.; Sutherland, T.D.; Russell, R.J.; Harshman, L.G.; Hoffmann, F.G.; Claudianos, C.
Jhe in Gryllus assimilis: cloning, sequence-activity associations and phylogeny
Insect Biochem. Mol. Biol.
37
1359-1365
2007
Gryllus assimilis (A5HSI6), Gryllus assimilis
brenda
Munyiri, F.N.; Ishikawa, Y.
Molecular cloning and developmental expression of the gene encoding juvenile hormone esterase in the yellow-spotted longicorn beetle, Psacothea hilaris
Insect Biochem. Mol. Biol.
37
497-505
2007
Psacothea hilaris (Q1HA48), Psacothea hilaris
brenda
Crone, E.J.; Sutherland, T.D.; Campbell, P.M.; Coppin, C.W.; Russell, R.J.; Oakeshott, J.G.
Only one esterase of Drosophila melanogaster is likely to degrade juvenile hormone in vivo
Insect Biochem. Mol. Biol.
37
540-549
2007
Drosophila melanogaster (A1ZA98), Drosophila melanogaster
brenda
Bai, H.; Ramaseshadri, P.; Palli, S.R.
Identification and characterization of juvenile hormone esterase gene from the yellow fever mosquito, Aedes aegypti
Insect Biochem. Mol. Biol.
37
829-837
2007
Aedes aegypti (Q17AV1), Aedes aegypti
brenda
Khalil, S.M.; Anspaugh, D.D.; Michael Roe, R.
Role of juvenile hormone esterase and epoxide hydrolase in reproduction of the cotton bollworm, Helicoverpa zea
J. Insect Physiol.
52
669-678
2006
Helicoverpa zea
brenda
Schafellner, C.; Marktl, R.C.; Schopf, A.
Inhibition of juvenile hormone esterase activity in Lymantria dispar (Lepidoptera, Lymantriidae) larvae parasitized by Glyptapanteles liparidis (Hymenoptera, Braconidae)
J. Insect Physiol.
53
858-868
2007
Lymantria dispar (Q7M4I4), Lymantria dispar
brenda
Mackert, A.; do Nascimento, A.M.; Bitondi, M.M.; Hartfelder, K.; Simoes, Z.L.
Identification of a juvenile hormone esterase-like gene in the honey bee, Apis mellifera L.--expression analysis and functional assays
Comp. Biochem. Physiol. B
150
33-44
2008
Apis mellifera (Q76LA5), Apis mellifera
brenda
Liu, Z.; Li, X.; Prasifka, J.R.; Jurenka, R.; Bonning, B.C.
Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone abundance
Gen. Comp. Endocrinol.
156
164-172
2008
Drosophila melanogaster
brenda
Kamita, S.G.; Wogulis, M.D.; Law, C.S.; Morisseau, C.; Tanaka, H.; Huang, H.; Wilson, D.K.; Hammock, B.D.
Function of phenylalanine 259 and threonine 314 within the substrate binding pocket of the juvenile hormone esterase of Manduca sexta
Biochemistry
49
3733-3742
2010
Manduca sexta (Q9GPG0), Manduca sexta
brenda
Elayidam, U.G.; Muraleedharen, D.
Identification and partial characterization of juvenile hormone esterase from cotton pest Dysdercus cingulatus
Indian J. Biochem. Biophys.
45
121-125
2008
Dysdercus cingulatus
brenda
Wheeler, M.; Tarver, M.; Coy, M.; Scharf, M.
Characterization of four esterase genes and esterase activity from the gut of the termite Reticulitermes flavipes
Arch. Insect Biochem. Physiol.
73
30-48
2010
Reticulitermes flavipes (D8UUL2)
brenda
Tsubota, T.; Shimomura, M.; Ogura, T.; Seino, A.; Nakakura, T.; Mita, K.; Shinoda, T.; Shiotsuki, T.
Molecular characterization and functional analysis of novel carboxyl/cholinesterases with GQSAG motif in the silkworm Bombyx mori
Insect Biochem. Mol. Biol.
40
100-112
2010
Bombyx mori, Bombyx mori (D2KWC2)
brenda
Tsubota, T.; Minakuchi, C.; Nakakura, T.; Shinoda, T.; Shiotsuki, T.
Molecular characterization of a gene encoding juvenile hormone esterase in the red flour beetle, Tribolium castaneum
Insect Mol. Biol.
19
527-535
2010
Tribolium castaneum (D7US45), Tribolium castaneum
brenda
Mackert, A.; Hartfelder, K.; Bitondi, M.M.; Simoes, Z.L.
The juvenile hormone (JH) epoxide hydrolase gene in the honey bee (Apis mellifera) genome encodes a protein which has negligible participation in JH degradation
J. Insect Physiol.
56
1139-1146
2010
Apis mellifera
brenda
Karlhofer, J.; Schafellner, C.; Hoch, G.
Reduced activity of juvenile hormone esterase in microsporidia-infected Lymantria dispar larvae
J. Invertebr. Pathol.
110
126-128
2012
Lymantria dispar (Q7M4I4), Lymantria dispar
brenda
Kontogiannatos, D.; Swevers, L.; Maenaka, K.; Park, E.Y.; Iatrou, K.; Kourti, A.
Functional characterization of a juvenile hormone esterase related gene in the moth Sesamia nonagrioides through RNA interference
PLoS ONE
8
e73834
2013
Sesamia nonagrioides (A8VJM0), Sesamia nonagrioides
brenda
Bomtorin, A.D.; Mackert, A.; Rosa, G.C.; Moda, L.M.; Martins, J.R.; Bitondi, M.M.; Hartfelder, K.; Simoes, Z.L.
Juvenile hormone biosynthesis gene expression in the corpora allata of honey bee (Apis mellifera L.) female castes
PLoS ONE
9
e86923
2014
Apis mellifera
brenda
Yankanchi, S.; Kallapur, V.; Holihosur, S.
In vitro and in vivo inhibition of haemolymph juvenile hormone esterase activity by the ethanol extract of Clerodendrum inerme in fifth instar larva of castor semilooper, Achaea janata (L.)
Curr. Sci.
108
1516-1520
2015
Achaea janata
-
brenda
El-Sheikh, E.
Characterization and kinetics of juvenile hormone esterase from Spodoptera littoralis (Boisd.) and S. frugiperda (J. E. Smith) (Lepidoptera Noctuidae)
Egypt. J. Biol. Pest Control
25
625-630
2015
Spodoptera frugiperda, Spodoptera littoralis
-
brenda
Saito, Y.; Kamita, S.G.; Hammock, B.D.; Kunimi, Y.; Inoue, M.N.; Nakai, M.
Juvenile hormone (JH) esterase activity but not JH epoxide hydrolase activity is downregulated in larval Adoxophyes honmai following nucleopolyhedroviruses infection
J. Insect Physiol.
80
71-80
2015
Adoxophyes honmai (A0A0G4DCW7), Adoxophyes honmai
brenda
Gu, X.; Kumar, S.; Kim, E.; Kim, Y.
A whole genome screening and RNA interference identify a juvenile hormone esterase-like gene of the diamondback moth, Plutella xylostella
J. Insect Physiol.
80
81-87
2015
Plutella xylostella
brenda
Steiner, C.; Bozzolan, F.; Montagne, N.; Maibeche, M.; Chertemps, T.
Neofunctionalization of "Juvenile Hormone Esterase Duplication" in Drosophila as an odorant-degrading enzyme towards food odorants
Sci. Rep.
7
12629
2017
Drosophila melanogaster
brenda