Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Synonyms
lp-pla2, lipoprotein-associated phospholipase a2, paf acetylhydrolase, acetylhydrolase, plasma paf-ah, platelet-activating factor acetylhydrolase, paf-acetylhydrolase, pla2g7, lppla2, pafah,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase
-
-
-
-
1-alkyl-2-acetylglycerophosphocholine esterase
-
-
-
-
1-alkyl-2-acetyllecithin deacetylase
-
-
-
-
2-acetyl-1-alkylglycerophosphocholine esterase
-
-
-
-
alkylacetyl-GPC:acetylhydrolase
-
-
-
-
blood platelet-activating factor-acetyl hydrolase
-
-
-
-
deacetylase, 1-alkyl-2-acetyllecithin
-
-
-
-
LDL-associated phospholipase A2
-
-
-
-
lipoprotein-associated phospholipase A2
-
-
Lissencephaly-1 protein
-
-
-
-
PAF 2-acylhydrolase
-
-
-
-
phosphatide 2-acylhydrolase
-
-
-
-
plasma PAF acetylhydrolase
-
-
plasma platelet-activating factor acetylhydrolase
-
-
platelet-activating factor acetyl-hydrolase
-
-
platelet-activating factor acetylhydrolase
platelet-activating factor acetylhydrolyase
-
-
-
-
Serine dependent phospholipase A2
-
-
-
-
type I platelet-activating factor acetylhydrolase
-
-
PAF acetylhydrolase
-
-
-
-
PAF-acetylhydrolase
-
-
-
-
PAF-AH
-
-
-
-
platelet-activating factor acetylhydrolase
-
-
-
-
platelet-activating factor acetylhydrolase
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the substrate is a potent lipid mediator, involved in pathological responses, particularly in inflammation and allergy. Its level is regulated by hydrolysis
-
-
?
1-O-hexadecyl-2-N-methylcarbamoyl-sn-glycero-3-phospho(N,N,N-trimethyl)hexanolamine
?
-
-
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
-
-
-
-
?
platelet-activating factor + H2O
?
-
-
-
-
?
additional information
?
-
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. PAF
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, a mediator of several vascular and inflammatory diseases
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes
-
?
additional information
?
-
-
enzyme of melanoma cell line inhibits neoangiogenesis and endothelial tubulogenesis in vitro, overview
-
?
additional information
?
-
-
substrate specificity of the enzyme forms and isoenzyme types
-
?
additional information
?
-
-
substrate specificity, mammalian isozyme II possesses transacetylase activity as well
-
?
additional information
?
-
-
physiological functions of isozymes, overview
-
?
additional information
?
-
PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F2alpha and protects tissue from oxidative stress-induced injury
-
-
?
additional information
?
-
-
PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F2alpha and protects tissue from oxidative stress-induced injury
-
-
?
additional information
?
-
-
the PAF-AH (I) catalytic subunits induces centrosomal amplification and microtubule disorganization by disturbing intracellular localization of LIS1 (a causative gene product for type I lissencephaly)
-
-
?
additional information
?
-
-
PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
1-O-alkyl-sn-glycero-3-phosphocholine + acetate
-
regulation of platelet-activating factor
-
-
?
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
?
-
the substrate is a potent lipid mediator, involved in pathological responses, particularly in inflammation and allergy. Its level is regulated by hydrolysis
-
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
2-acetyl-1-O-alkyl-sn-glycero-3-phosphoric acid + H2O
1-O-alkyl-sn-glycero-3-phosphoric acid + acetate
-
-
-
?
3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine + H2O
3-O-hexadecyl-sn-glycero-1-phosphocholine + acetate
-
-
-
-
?
platelet-activating factor + H2O
?
-
-
-
-
?
additional information
?
-
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, a mediator of several vascular and inflammatory diseases
-
?
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O
1-alkyl-sn-glycero-3-phosphocholine + acetate
-
i.e. platelet-activation factor, reaction leads to inactivation of the factor and therefore inhibitsthe initiation of inflammation processes
-
?
additional information
?
-
-
substrate specificity, mammalian isozyme II possesses transacetylase activity as well
-
?
additional information
?
-
-
physiological functions of isozymes, overview
-
?
additional information
?
-
PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F2alpha and protects tissue from oxidative stress-induced injury
-
-
?
additional information
?
-
-
PAF-AH (II) is involved in the metabolism of esterified 8-isoprostaglandin F2alpha and protects tissue from oxidative stress-induced injury
-
-
?
additional information
?
-
-
the PAF-AH (I) catalytic subunits induces centrosomal amplification and microtubule disorganization by disturbing intracellular localization of LIS1 (a causative gene product for type I lissencephaly)
-
-
?
additional information
?
-
-
PAF-AH catalyzes the hydrolysis of the acetyl group esterifying the sn-2 position of PAF, thereby abolishing its biological activity
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
malfunction
-
deletion of the plasma form of PAF-AH abolishes expression of serum and intestinal activities. Mortality rates are significantly lower in enzyme-deficient PAF-AH-/- pups compared to wild-type controls before 24 hours of life but surviving PAF-AH-/- animals are more susceptible to necrotizing enterocolitis, NEC, development compared to wild-type controls
metabolism
-
reducing the role for circulating, although perhaps not intracellular, PLA2G7 in in vivo PAF catabolism. In vivo PAF clearance is independent of the PAF receptor
additional information
-
higher expression of mouse compared with human PAF-AH is not due to variations in catalytic efficiency. A region located at the N-terminal end of PAF-AH regulates expression levels, the degree of hydrophobicity and polarity of the N-terminal region correlates with the level of PAF-AH expression
physiological function
-
PAF is cleared from murine circulation in seconds as an intact molecule through saturable uptake by endothelium. This disappearance is faster than PAF hydrolysis in human or murine blood, and ablation of PLA2G7 has no immediate effect on PAF clearance
physiological function
-
the enzyme inactivates platelet-activating factor, PAF. Protective role for endogenous PAF-AH in the development of necrotizing enterocolitis, NEC, and endogenous PAF-AH deficiency may place them at increased risk for disease
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
N59Q
-
site-directed mutagenesis, the mutant and wild-type mouse PAFAH expression levels are similar
N75Q
-
site-directed mutagenesis, the mutant and wild-type mouse PAFAH expression levels are similar
S61P/P63S
-
site-directed mutagenesis, the mutant and wild-type mouse PAFAH expression levels are similar
additional information
the murine form of PAF-AH is more resistant to inactivation than the human ortholog: studies on chimeric constructs
additional information
-
different human-mouse chimeric constructs are generated
additional information
-
generation of enzyme-deficient PAF-AH-/- mice by targeted disruption of the mouse PAF-AH gene. Mortality rates are significantly lower in PAF-AH-/- pups compared to wild-type controls before 24 hours of life but surviving PAF-AH-/- animals are more susceptible to necrotizing enterocolitis, NEC, development compared to wild-type controls
additional information
-
replacement of human PAF-AH residues 42-100 with mouse PAF-AH amino acids 41-99, resulting in construct m41-99H, dramatically increases protein and enzymatic activity expression. Conversely, when mouse cDNA N-terminal residues are replaced with the equivalent human sequences, resulting in construct h42-100M, the levels of expression are significantly decreased
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Tsaoussis, V.; Vakirtzi-Lemonias, C.
The mouse plasma PAF acetylhydrolase: I. Characterization and properties
J. Lipid Mediat. Cell Signal.
9
301-315
1994
Mus musculus
brenda
Tjoelker, L.W.; Stafforini, D.M.
Platelet-activating factor acetylhydrolases in health and disease
Biochim. Biophys. Acta
1488
102-123
2000
Oryctolagus cuniculus, Cricetinae, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Biancone, L.; Cantaluppi, V.; Del Sorbo, L.; Russo, S.; Tjoelker, L.W.; Camussi, G.
Platelet-activating factor inactivation by local expression of platelet-activating factor acetyl-hydrolase modifies tumor vascularization and growth
Clin. Cancer Res.
9
4214-4220
2003
Homo sapiens, Mus musculus
brenda
Arai, H.; Koizumi, H.; Aoki, J.; Inoue, K.
Platelet-activating factor acetylhydrolase (PAF-AH)
J. Biochem.
131
635-640
2002
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Quistad, G.B.; Fisher, K.J.; Owen, S.C.; Klintenberg, R.; Casida, J.E.
Platelet-activating factor acetylhydrolase: selective inhibition by potent n-alkyl methylphosphonofluoridates
Toxicol. Appl. Pharmacol.
205
149-156
2005
Homo sapiens, Mus musculus
brenda
MacRitchie, A.N.; Gardner, A.A.; Prescott, S.M.; Stafforini, D.M.
Molecular basis for susceptibility of plasma platelet-activating factor acetylhydrolase to oxidative inactivation
FASEB J.
21
1164-1176
2007
Homo sapiens, Mus musculus (A0JNU3 and Q61206 and Q61205)
brenda
Yamaguchi, N.; Koizumi, H.; Aoki, J.; Natori, Y.; Nishikawa, K.; Natori, Y.; Takanezawa, Y.; Arai, H.
Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification
Genes Cells
12
1153-1161
2007
Mus musculus
brenda
Kono, N.; Inoue, T.; Yoshida, Y.; Sato, H.; Matsusue, T.; Itabe, H.; Niki, E.; Aoki, J.; Arai, H.
Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo
J. Biol. Chem.
283
1628-1636
2008
Mus musculus (Q8VDG7), Mus musculus
brenda
Gardner, A.A.; Reichert, E.C.; Topham, M.K.; Stafforini, D.M.
Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein
J. Biol. Chem.
283
17099-17106
2008
Homo sapiens, Mus musculus
brenda
Gardner, A.A.; Reichert, E.C.; Alexander, T.S.; Topham, M.K.; Stafforini, D.M.
Novel mechanism for regulation of plasma platelet-activating factor acetylhydrolase expression in mammalian cells
Biochem. J.
428
269-279
2010
Homo sapiens, Mus musculus
brenda
Liu, J.; Chen, R.; Marathe, G.K.; Febbraio, M.; Zou, W.; McIntyre, T.M.
Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/PAF acetylhydrolase
Circ. Res.
108
469-477
2011
Mus musculus, Mus musculus BL6
brenda
Lu, J.; Pierce, M.; Franklin, A.; Jilling, T.; Stafforini, D.M.; Caplan, M.
Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis
Pediatr. Res.
68
225-230
2010
Mus musculus, Mus musculus C57/BL6J
brenda