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Information on EC 3.1.1.4 - phospholipase A2 and Organism(s) Bungarus caeruleus and UniProt Accession Q6SLM1

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.4 phospholipase A2
IUBMB Comments
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
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This record set is specific for:
Bungarus caeruleus
UNIPROT: Q6SLM1
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Word Map
The taxonomic range for the selected organisms is: Bungarus caeruleus
The enzyme appears in selected viruses and cellular organisms
Synonyms
phospholipase a2, cpla2, spla2, spla(2), prdx6, cytosolic phospholipase a2, crotoxin, pla2s, ipla2, spla2-iia, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
14 kDa phospholipase A2
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Agkistrotoxin
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amdI1
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Ammodytin I2
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APLA
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APP-D-49
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ASPLA1
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ASPLA10
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ASPLA11
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ASPLA12
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ASPLA13
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ASPLA14
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ASPLA15
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ASPLA16
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ASPLA17
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ASPLA2
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ASPLA3
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ASPLA4
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ASPLA5
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ASPLA6
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ASPLA7
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ASPLA8
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ASPLA9
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ATX
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Basic protein I/II
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BJ-PLA2
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BJUPLA2
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BPI/BPII
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CaI-PLA2
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Caudoxin
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cPm09
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Enhancing factor
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GIIC sPLA2
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GIID sPLA2
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GIIE sPLA2
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GIIF sPLA2
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GIII sPLA2
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Group IB phospholipase A2
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Group IIA phospholipase A2
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Group V phospholipase A2
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Group VI phospholipase A2
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GVI PLA2
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GX sPLA2
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GXII sPLA2
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GXIII sPLA2
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iPLA2
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lecithinase A
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MP-III 4R
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Muscarinic inhibitor
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Myotoxin
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NAJPLA-2A
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NAJPLA-2B
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NAJPLA-2C
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Nigexine
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Non-pancreatic secretory phospholipase A2
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Notechis 11'2
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Notexin
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NPLA
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NPS-PLA2
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OHV A-PLA2
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OHV-APLA2
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pgPLA 1a/pgPLA 2a
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phosphatidase
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phosphatide 2-acylhydrolase
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phosphatidolipase
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Phosphatidylcholine 2-acylhydrolase
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Phosphatidylcholine 2-acylhydrolase GIIC
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Phosphatidylcholine 2-acylhydrolase GIID
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Phosphatidylcholine 2-acylhydrolase GIIE
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Phosphatidylcholine 2-acylhydrolase GIIF
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Phosphatidylcholine 2-acylhydrolase GIII
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Phosphatidylcholine 2-acylhydrolase GX
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Phosphatidylcholine 2-acylhydrolase GXII
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Phosphatidylcholine 2-acylhydrolase GXIII
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phospholipase A
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Phospholipase A2 inhibitor
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pkP5
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PLA2-10
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PLA2-VI
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PLA2-VII
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PLA2IID
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platelet activating factor acetyl hydrolase
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Pt-PLA1
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Pt-PLA2
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Secretory-type PLA, stroma-associated homolog
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sPLA(2)-IID
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sPLA(2)-IIE
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sPLA(2)-IIF
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TMV-K49
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Toxin VI
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Toxin VI:5
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
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SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine 2-acylhydrolase
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-84-7
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K+
located in Ca2+-binding loop with sevenfold coordination
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PA2B5_BUNCE
137
0
14827
Swiss-Prot
other Location (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
13198
2 * 13198, MALDI-TOF
26280
MALDI-TOF, dimer
29000
sedimentation velocity data of dimer
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
trimer
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crystal structure, isozyme structure modeling, overview
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
endogenous complex of two PLA2 molecules and two mannoses
in complex with n-tridecanoic acid
four isozymes, for isozyme 1 the protein solution contains 10 mg/ml protein, 50 mM Tris-HCl, pH 8.5, and 3.5 M NaCl, for isozyme 2 7 mg/ml protein, 50 mM Tris-HCl, pH 8.5, and 2.8 M NaCl, for isozyme 3 5 mg/ml protein, 50 mM Tris-HCl, pH 8.5, and 2.8 M NaCl, and for isozyme 4 20 mg/ml protein, 50 mM Tris–HCl, pH 8.5, and 2.4 M NaCl, X-ray diffraction structure determination and analysis at 2.5 A resolution, structure modeling
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Singh, G.; Gourinath, S.; Sarvanan, K.; Sharma, S.; Bhanumathi, S.; Betzel, C.; Yadav, S.; Srinivasan, A.; Singh, T.P.
Crystal structure of a carbohydrate induced homodimer of phospholipase A2 from Bungarus caeruleus at 2.1A resolution
J. Struct. Biol.
149
264-272
2005
Bungarus caeruleus (Q6SLM1), Bungarus caeruleus
Manually annotated by BRENDA team
Singh, G.; Jasti, J.; Saravanan, K.; Sharma, S.; Kaur, P.; Srinivasan, A.; Singh, T.P.
Crystal structure of the complex formed between a group I phospholipase A2 and a naturally occurring fatty acid at 2.7 A resolution
Protein Sci.
14
395-400
2005
Bungarus caeruleus (Q6SLM1), Bungarus caeruleus
Manually annotated by BRENDA team
Le Trong, I.; Stenkamp, R.E.
An alternate description of two crystal structures of phospholipase A2 from Bungarus caeruleus
Acta Crystallogr. Sect. D
63
548-549
2007
Bungarus caeruleus
Manually annotated by BRENDA team