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Information on EC 3.1.1.4 - phospholipase A2

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.4 phospholipase A2
IUBMB Comments
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
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This record set is specific for:
UNIPROT: P03135
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
phospholipase a2, cpla2, spla2, spla(2), prdx6, cytosolic phospholipase a2, crotoxin, pla2s, ipla2, spla2-iia, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
secreted phospholipase A2
-
14 kDa phospholipase A2
-
-
-
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Agkistrotoxin
-
-
-
-
amdI1
-
-
-
-
Ammodytin I2
-
-
-
-
APLA
-
-
-
-
APP-D-49
-
-
-
-
ASPLA1
-
-
-
-
ASPLA10
-
-
-
-
ASPLA11
-
-
-
-
ASPLA12
-
-
-
-
ASPLA13
-
-
-
-
ASPLA14
-
-
-
-
ASPLA15
-
-
-
-
ASPLA16
-
-
-
-
ASPLA17
-
-
-
-
ASPLA2
-
-
-
-
ASPLA3
-
-
-
-
ASPLA4
-
-
-
-
ASPLA5
-
-
-
-
ASPLA6
-
-
-
-
ASPLA7
-
-
-
-
ASPLA8
-
-
-
-
ASPLA9
-
-
-
-
ATX
-
-
-
-
Basic protein I/II
-
-
-
-
BJ-PLA2
-
-
-
-
BJUPLA2
-
-
-
-
BPI/BPII
-
-
-
-
CaI-PLA2
-
-
-
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Caudoxin
-
-
-
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cPm09
-
-
-
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Enhancing factor
-
-
-
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GIIC sPLA2
-
-
-
-
GIID sPLA2
-
-
-
-
GIIE sPLA2
-
-
-
-
GIIF sPLA2
-
-
-
-
GIII sPLA2
-
-
-
-
Group IB phospholipase A2
-
-
-
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Group IIA phospholipase A2
-
-
-
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Group V phospholipase A2
-
-
-
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Group VI phospholipase A2
-
-
-
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GVI PLA2
-
-
-
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GX sPLA2
-
-
-
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GXII sPLA2
-
-
-
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GXIII sPLA2
-
-
-
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iPLA2
-
-
-
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lecithinase A
-
-
-
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MP-III 4R
-
-
-
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Muscarinic inhibitor
-
-
-
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Myotoxin
-
-
-
-
NAJPLA-2A
-
-
-
-
NAJPLA-2B
-
-
-
-
NAJPLA-2C
-
-
-
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Nigexine
-
-
-
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Non-pancreatic secretory phospholipase A2
-
-
-
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Notechis 11'2
-
-
-
-
Notexin
-
-
-
-
NPLA
-
-
-
-
NPS-PLA2
-
-
-
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OHV A-PLA2
-
-
-
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OHV-APLA2
-
-
-
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pgPLA 1a/pgPLA 2a
-
-
-
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phosphatidase
-
-
-
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phosphatide 2-acylhydrolase
-
-
-
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phosphatidolipase
-
-
-
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Phosphatidylcholine 2-acylhydrolase
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-
-
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Phosphatidylcholine 2-acylhydrolase GIIC
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-
-
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Phosphatidylcholine 2-acylhydrolase GIID
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-
-
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Phosphatidylcholine 2-acylhydrolase GIIE
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-
-
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Phosphatidylcholine 2-acylhydrolase GIIF
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-
-
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Phosphatidylcholine 2-acylhydrolase GIII
-
-
-
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Phosphatidylcholine 2-acylhydrolase GX
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-
-
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Phosphatidylcholine 2-acylhydrolase GXII
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-
-
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Phosphatidylcholine 2-acylhydrolase GXIII
-
-
-
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phospholipase A
-
-
-
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Phospholipase A2 inhibitor
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-
-
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pkP5
-
-
-
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PLA2-10
-
-
-
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PLA2-VI
-
-
-
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PLA2-VII
-
-
-
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PLA2IID
-
-
-
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platelet activating factor acetyl hydrolase
-
-
-
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Pt-PLA1
-
-
-
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Pt-PLA2
-
-
-
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Secretory-type PLA, stroma-associated homolog
-
-
-
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sPLA(2)-IID
-
-
-
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sPLA(2)-IIE
-
-
-
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sPLA(2)-IIF
-
-
-
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TMV-K49
-
-
-
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Toxin VI
-
-
-
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Toxin VI:5
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine 2-acylhydrolase
Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-84-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CAPSD_AAV2S
735
0
81945
Swiss-Prot
other Location (Reliability: 1)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H75A/D76N
the secretory phospholipase A2 defect in H75A/D76N severely impairs adeno-associated virus' infectivity
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stahnke, S.; Lux, K.; Uhrig, S.; Kreppel, F.; Hoesel, M.; Coutelle, O.; Ogris, M.; Hallek, M.; Buening, H.
Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles
Virology
409
77-83
2011
Adeno-associated virus (P03135), Adeno-associated virus
Manually annotated by BRENDA team