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14 kDa phospholipase A2
-
-
-
-
Basic protein I/II
-
-
-
-
Ca2+-independent iPLA2
-
-
Group IB phospholipase A2
-
-
-
-
Group IIA phospholipase A2
-
-
-
-
Group V phospholipase A2
-
-
-
-
Group VI phospholipase A2
-
-
-
-
lipoprotein-associated PLA2
-
-
Muscarinic inhibitor
-
-
-
-
Non-pancreatic secretory phospholipase A2
-
-
-
-
pgPLA 1a/pgPLA 2a
-
-
-
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phosphatide 2-acylhydrolase
-
-
-
-
phosphatidolipase
-
-
-
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Phosphatidylcholine 2-acylhydrolase
-
-
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Phosphatidylcholine 2-acylhydrolase GIIC
-
-
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Phosphatidylcholine 2-acylhydrolase GIID
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-
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Phosphatidylcholine 2-acylhydrolase GIIE
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-
-
-
Phosphatidylcholine 2-acylhydrolase GIIF
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-
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-
Phosphatidylcholine 2-acylhydrolase GIII
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-
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-
Phosphatidylcholine 2-acylhydrolase GX
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-
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Phosphatidylcholine 2-acylhydrolase GXII
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Phosphatidylcholine 2-acylhydrolase GXIII
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-
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Phospholipase A2 inhibitor
-
-
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platelet activating factor acetyl hydrolase
-
-
-
-
Secretory-type PLA, stroma-associated homolog
-
-
-
-
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1,2-diheptanoyl-sn-glycero-3-phophorylcholine + H2O
1-heptanoyl-sn-glycero-3-phophorylcholine + heptanoate
-
-
-
?
1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O
1-octanoyl-sn-glycero-3-phosphocholine + octanoate
-
-
-
?
1,2-dipalmitoyl-phosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + palmitic acid
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + palmitic acid
-
-
-
?
1,2-dipalmitoyl-sn-phosphatidylcholine + H2O
1-palmitoyl-sn-phosphatidylcholine + palmitate
the catalytic site for aiPLA2 activity is an S32-H26-D140 triad
-
-
?
1-O-hexadecyl-2-arachidonyl-glycero-3-phosphocholine + H2O
1-O-hexadecyl-glycero-3-phosphocholine + arachidonic acid
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine + H2O
1-palmitoyl-sn-glycero-3-phosphocholine + linolic acid
-
-
-
?
1-palmitoyl-2-oleoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphocholine + oleic acid
-
-
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoethanolamine + H2O
1-stearoyl-sn-glycero-3-phosphoethanolamine + arachidonic acid
-
-
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol + H2O
1-stearoyl-sn-glycero-3-phosphoinositol + arachidonic acid
-
-
-
?
DBPA + H2O
?
-
fluorogenic Dabcyl- and BODIPY-containing phospholipd-analogue
-
-
?
DBPC + H2O
?
-
fluorogenic Dabcyl- and BODIPY-containing phospholipd-analogue
-
-
?
DBPE + H2O
?
-
fluorogenic Dabcyl- and BODIPY-containing phospholipd-analogue
-
-
?
DBPG + H2O
?
-
fluorogenic Dabcyl- and BODIPY-containing phospholipd-analogue
-
-
?
ethanolamine plasmalogen + H2O
lysoplasmalogen + fatty acid
-
-
-
?
oxidized phosphatidylcholines + H2O
1-acylglycerophosphocholine + oxidized fatty acids
-
oxidized 1-palmitoyl-2-arachidonoylphosphatidylcholine for substrate
-
?
phosphatidylcholine + H2O
1-acylglycerophosphocholine + fatty acid
-
-
-
?
plasmalogen + H2O
?
-
-
-
-
?
additional information
?
-
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
-
-
-
?
1-palmitoyl-2-arachidonoylphosphatidylcholine + H2O
1-palmitoyl-glycerophosphorylcholine + arachidonic acid
-
-
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid
-
preferred substrate
-
?
1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine + H2O
1-stearoyl-sn-glycero-3-phosphocholine + arachidonic acid
-
good substrate
-
?
phospholipids + H2O
?
-
-
-
-
?
phospholipids + H2O
?
-
influence on platelet aggregation
-
-
?
phospholipids + H2O
?
-
eicosanoids
-
-
?
phospholipids + H2O
?
-
inflammatory diseases
-
-
?
phospholipids + H2O
?
-
release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins
-
-
?
additional information
?
-
phospholipase A2 hydrolyzes phospholipids at the sn-2 position to cleave the fatty-acid ester bond of L-glycerophospholipids. The catalytic dyad, formed by residues Asp99 and His48, along with a nucleophilic water molecule is responsible for enzyme hydrolysis
-
-
?
additional information
?
-
the secretory isozyme has a catalytic dyad formed by Asp99 and His48
-
-
?
additional information
?
-
-
enzyme is responsible for Ca2+-dependent release of arachidonic acid from red blood cells
-
?
additional information
?
-
-
preference of substrates in decreasing order: phosphatidylglycerols, phosphatidylethanolamines, phosphatidylcholines, phosphatidic acids
-
-
?
additional information
?
-
-
the phospholipase A2 superfamily consists of many different groups of enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different phospholipids, products of the hydrolysis of the sn-2 ester bond of phospholipid are a free fatty acid and lysophospholipid
-
-
?
additional information
?
-
-
the lysosomal isozyme PLA2 contains a Ser-His-Asp catalytic triad
-
-
?
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acalyphin
from Acalypha indica, shows interaction with the amino acids at the active site of PLA2, interacts also with the Ca2+ ion in the active site of PLA2
aplysulphurin A
from Aplysilla sp., shows interaction with the amino acids at the active site of PLA2, interacts also with the Ca2+ ion in the active site of PLA2
chlorogenic acid
from Achillea millefolium, shows interaction with the amino acids at the active site of PLA2
curcumin
from Curcuma longa, shows interaction with the amino acids at the active site of PLA2
gracilin A
from Aplysilla sp., shows interaction with the amino acids at the active site of PLA2, interacts also with the Ca2+ ion in the active site of PLA2
stigmasterol
from Achillea millefolium, shows interaction with the amino acids at the active site of PLA2
tectoridin
from Belamcanda chinensis, shows interaction with the amino acids at the active site of PLA2
1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol
-
MJ33, competitive inhibitor
3,4-dichloroisocoumarin
-
-
5,5'-dithiobis-(2-nitrobenzoic acid)
-
can be reversed by dithiothreitol
7-chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione
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competitive inhibitor
Ag+
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plasmalogen-specific PLA2
anti-peptide antibody
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-
-
arachidonoyl trifluoromethyl ketone
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-
ATP
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plasmalogen-specific PLA2
chondroitin sulfate
-
plasmalogen-specific PLA2
citrate
-
plasmalogen-specific PLA2
Cowper's gland mucin
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plasmalogen-specific PLA2
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diethyl 4-nitrophenyl phosphate
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Diethyl p-nitrophenyl phosphate
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-
diisopropyl fluorophosphate
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-
DTNB
-
plasmalogen-specific PLA2
Fe3+
-
plasmalogen-specific PLA2
fetuin
-
plasmalogen-specific PLA2
-
ganglioside GM1
-
plasmalogen-specific PLA2
ganglioside GM3
-
plasmalogen-specific PLA2
heparan sulfate
-
plasmalogen-specific PLA2
heparin
-
plasmalogen-specific PLA2
Hg2+
-
plasmalogen-specific PLA2
hyaluronic acid
-
plasmalogen-specific PLA2
iodoacetamide
-
can be reversed by dithiothreitol
iodoacetate
-
plasmalogen-specific PLA2
methyl arachidonyl fluorophosphonate
-
-
mucin
-
plasmalogen-specific PLA2
-
N-acetylneuraminic acid
-
plasmalogen-specific PLA2
N-ethylmaleimide
-
plasmalogen-specific PLA2
octylglucoside
-
plasmalogen-specific PLA2
phenylmethylsulfonyl fluoride
-
-
phosphate
-
plasmalogen-specific PLA2
sodium deoxycholate
-
plasmalogen-specific PLA2
sulfate
-
plasmalogen-specific PLA2
taurocholate
-
plasmalogen-specific PLA2
additional information
no inhibition by bromoenol lactone
-
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0.0000115
-
particulate associated hormonally regulated PLA2, substrate: 1-palmitoyl-2-arachidonylphosphatidylcholine, mixed micelles with Triton X-100
0.0000538
-
particulate associated hormonally regulated PLA2, substrate: micellar 1-palmitoyl-2-arachidonylphosphatidylcholine
0.027
-
acidic iPLA2, substrate: 1-O-hexadecyl-2-arachidonoyl-glycero-3-phosphocholine
0.064
-
acidic iPLA2, substrate: 1-palmitoyl-2-arachidonylphosphatidylcholine or 1,2-dipalmitoyl-phosphatidylcholine
0.065
-
acidic iPLA2, substrate: oxidized 1-palmitoyl-2-arachidonylphosphatidylcholine
0.08
-
acidic iPLA2, pH 4.0, Ca2+-free medium, substrate: 1,2-dipalmitoyl-phosphatidylcholine
2725
-
pH8, micellar 1,2-dioctanoyl-sn-glycero-3-phosphocholine, 2.0 mM Ca2+
2910
-
pH6, micellar 1,2-dioctanoyl-sn-glycero-3-phosphocholine, 8.1 mM Ca2+
additional information
-
synthesis of fluorogenic substrate analogues for rapid determination of head group modification on cell signaling
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Akiba, S.; Dodia, C.; Chen, X.; Fisher, A.B.
Characterization of acidic Ca2+-independent phospholipase A2 of bovine lung
Comp. Biochem. Physiol. B
120
393-404
1998
Bos taurus, Homo sapiens
brenda
Yang, H.C.; Farooqui, A.A.; Horrocks, L.A.
Characterization of plasmalogen-selective phospholipase A2 from bovine brain
Adv. Exp. Med. Biol.
416
309-313
1996
Bos taurus, Homo sapiens
brenda
Hada, S.; Fujii, S.; Inoue, S.; Ikeda, K.; Teshima, K.
Hydrolysis of micellar diheptanoylphosphatidylcholine catalyzed by bovine pancreatic phospholipase A2: Kinetic characterization of group I and II enzymes
J. Biochem.
113
13-18
1993
Bos taurus
brenda
Paglin, S.; Roy, R.; Polgar, P.
Characterization of hormonally regulated and particulate-associated phospholipase A2 from bovine endothelial cells
J. Biol. Chem.
268
11697-11702
1993
Bos taurus
brenda
Hanasaki, K.; Arita, H.
Purification and characterization of a high-affinity binding protein for pancreatic-type phospholipase A2
Biochim. Biophys. Acta
1127
233-241
1992
Bos taurus
brenda
Donne-Op den Kelder, G.M.; de Haas, G.H.; Egmond, M.R.
Localization of the second calcium ion binding site in porcine and equine phospholipase A2
Biochemistry
22
2470-2478
1983
Bos taurus, Equus caballus, Homo sapiens, Sus scrofa
brenda
Shin, H.S.; Chin, M.R.; Kim, J.S.; Chung, J.H.; Ryu, C.K.; Jung, S.Y.; Kim, D.K.
Purification and characterization of a cytosolic, 42-kDa and Ca2+-dependent phospholipase A2 from bovine red blood cells: its involvement in Ca2+-dependent release of arachidonic acid from mammalian red blood cells
J. Biol. Chem.
277
21086-21094
2002
Bos taurus, Homo sapiens
brenda
Sekar, K.; Vaijayanthi Mala, S.; Yogavel, M.; Velmurugan, D.; Poi, M.J.; Vishwanath, B.S.; Gowda, T.V.; Jeyaprakash, A.A.; Tsai, M.D.
Crystal structures of the free and anisic acid bound triple mutant of phospholipase A2
J. Mol. Biol.
333
367-376
2003
Bos taurus (P00593), Bos taurus
brenda
Farooqui, A.A.; Ong, W.Y.; Horrocks, L.A.; Farooqui, T.
Brain cytosolic phospholipase A2: localization, role, and involvement in neurological diseases
Neuroscientist
6
169-180
2000
Bos taurus, Homo sapiens, Mammalia, Rattus norvegicus
-
brenda
Rose, T.M.; Prestwich, G.D.
Fluorogenic phospholipids as head group-selective reporters of phospholipase A activity
ACS Chem. Biol.
1
83-92
2006
Streptomyces violaceoruber, Apis mellifera, Bos taurus, Homo sapiens, Naja mossambica
brenda
Kanaujia, S.P.; Sekar, K.
Structures and molecular-dynamics studies of three active-site mutants of bovine pancreatic phospholipase A2
Acta Crystallogr. Sect. D
64
1003-1011
2008
Bos taurus (P00593)
brenda
Burke, J.E.; Dennis, E.A.
Phospholipase A2 biochemistry
Cardiovasc. Drugs Ther.
23
49-59
2009
Apis mellifera, Bitis gabonica, Bos taurus, Crotalus sp., Homo sapiens, Mus musculus, Naja naja, Oryza sativa, Rattus norvegicus, Sus scrofa, Protoparvovirus
brenda
Nirmal, N.; Praba, G.O.; Velmurugan, D.
Modeling studies on phospholipase A2-inhibitor complexes
Indian J. Biochem. Biophys.
45
256-262
2008
Bos taurus (P00593), Bos taurus, Daboia russelii (P59071), Daboia russelii
brenda
Fisher, A.B.
The phospholipase A2 activity of peroxiredoxin 6
J. Lipid Res.
59
1132-1147
2018
Trematomus bernacchii, Xenopus tropicalis (B1WAZ6), Mus musculus (O08709), Rattus norvegicus (O35244), Bos taurus (O77834), Homo sapiens (P30041), Gallus gallus (Q5ZJF4), Arabidopsis thaliana (Q8S8N6)
brenda
Seroussi, E.; Blum, S.E.; Krifucks, O.; Lavon, Y.; Leitner, G.
Application of pancreatic phospholipase A2 for treatment of bovine mastitis
PLoS ONE
13
e0203132
2018
Bos taurus (P00593), Bos taurus
brenda