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EC Tree
The taxonomic range for the selected organisms is: Plasmodium falciparum The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
6-phosphogluconolactonase, 6pgl, phosphogluconolactonase, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, g6pd-6pgl, 6-pgl, xoo2316, og1rf_11582, 6-phosphogluconolactonase 3, 6-phosphoglucono-gamma-lactonase,
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6-phosphogluconolactonase
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6-phospho-D-glucose-delta-lactone hydrolase
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6-phosphoglucono-gamma-lactonase
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glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
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lactonase, phosphoglucono-
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phosphogluconolactonase
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6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
PfGluPho functions on the basis of a rapid equilibrium random Bi Bi mechanism, where the binding of the second substrate depends on the first substrate
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hydrolysis of carboxylic ester
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6-phospho-D-glucono-1,5-lactone lactonohydrolase
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6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
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6-phospho-D-glucono-1,4-lactone + H2O
6-phospho-D-gluconate
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the gamma-lactone is more stable than the natural delta-lactone substrate. It contains a five-membered heterocyclic ring, whereas the delta-lactone contains a six-membered heterocyclic ring
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6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
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6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
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6-phospho-D-glucono-1,5-lactone + H2O
6-phospho-D-gluconate
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ellagic acid
mixed type inhibitor of glucose 6-phosphate activity
glutathione
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PfGluPho is inhibited by S-glutathionylation
additional information
presence of H2O2 only slightly alters enzyme activity or expression
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additional information
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presence of H2O2 only slightly alters enzyme activity or expression
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additional information
additional information
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detailed kinetic analysis of the bifunctional glucose-6-phosphate dehydrogenase/6-phosphogluconolactonase indicates that PfGluPho functions on the basis of a rapid equilibrium random Bi Bi mechanism, where the binding of the second substrate depends on the first substrate
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46
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recombinant PfGluPho, substrate is 6-phosphoglucono-gamma-lactone, pH 7.0, 25°C
60
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recombinant PfGluPho, substrate is 6-phosphoglucono-delta-lactone, pH 7.0, 25°C
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bifunctional enzyme having both glucose-6-phosphate dehydrogenase and 6-phosphogluconolactonase activity
SwissProt
brenda
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brenda
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metabolism
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in Plasmodium falciparum, glucose-6-phosphate dehydrogenase is combined with the second enzyme of the pentose phosphate pathway to create a unique bifunctional enzyme named GluPho, glucose-6-phosphate dehydrogenase/6-phosphogluconolactonase. The G6PD activity is not largely influenced by the 6PGL part
physiological function
the enzyme is essential for the growth of blood stage parasites
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Q27741_PLAFA
910
0
106987
TrEMBL
Chloroplast (Reliability: 4 )
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107000
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one subunit, determined by size exclusion chromatography
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x * 109000, calculated from sequence, x * 100000, SDS-PAGE
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expression of lactonase domain Pf6PGL in Escherichia coli, low recovery of soluble Pf6PGL
cloning of the gene encoding PfGluPho from chromosome 14 of the 3D7 gametocyte cDNA library, heterologous overexpression of PfGluPho using vector pQE30 in Escherichia coli strain M15
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no significant upregulation of expression in presence of artemisinin, chloroquine or methylene blue
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Miclet, E.; Stoven, V.; Michels, P.A.M.; Opperdoes, F.R.; Lallemand, J.Y.; Duffieux, F.
NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase
J. Biol. Chem.
276
34840-34846
2001
Homo sapiens (O95336), Homo sapiens, Plasmodium falciparum (Q27741), Plasmodium falciparum, Trypanosoma brucei (Q9GRG6), Trypanosoma brucei
brenda
Crooke, A.; Diez, A.; Mason, P.J.; Bautista, J.M.
Transient silencing of Plasmodium falciparum bifunctional glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
FEBS J.
273
1537-1546
2006
Plasmodium falciparum
brenda
Jortzik, E.; Mailu, B.M.; Preuss, J.; Fischer, M.; Bode, L.; Rahlfs, S.; Becker, K.
Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum
Biochem. J.
436
641-650
2011
Plasmodium falciparum, Homo sapiens (O95336), Homo sapiens
brenda
Allen, S.M.; Lim, E.E.; Jortzik, E.; Preuss, J.; Chua, H.H.; MacRae, J.I.; Rahlfs, S.; Haeussler, K.; Downton, M.T.; McConville, M.J.; Becker, K.; Ralph, S.A.
Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target
FEBS J.
282
3808-3823
2015
Plasmodium falciparum (Q8IKU0), Plasmodium falciparum
brenda