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Information on EC 3.1.1.1 - carboxylesterase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.1 carboxylesterase
IUBMB Comments
Wide specificity. The enzymes from microsomes also catalyse the reactions of EC 3.1.1.2 (arylesterase), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.6 (acetylesterase), EC 3.1.1.23 (acylglycerol lipase), EC 3.1.1.28 (acylcarnitine hydrolase), EC 3.1.2.2 (palmitoyl-CoA hydrolase), EC 3.5.1.4 (amidase) and EC 3.5.1.13 (aryl-acylamidase). Also hydrolyses vitamin A esters.
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UNIPROT: O73957
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
esterase, carboxylesterase, butyrate esterase, carboxyl esterase, carboxylesterase 1, egasyn, serine protease-like, hce-2, acyl coenzyme a:cholesterol acyltransferase, esterase a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ACAT
-
-
-
-
Acyl coenzyme A:cholesterol acyltransferase
-
-
-
-
ali-esterase
-
-
-
-
aliesterase
-
-
-
-
alpha-carboxylesterase
-
-
-
-
B-esterase
-
-
-
-
Brain carboxylesterase hBr1
-
-
-
-
butyrate esterase
-
-
-
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butyryl esterase
-
-
-
-
CaE
-
-
-
-
carboxyesterase
-
-
-
-
Carboxyesterase ES-10
-
-
-
-
carboxyl ester hydrolase
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-
-
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carboxylate esterase
-
-
-
-
Carboxylesterase-5C
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-
-
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carboxylic acid esterase
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-
-
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carboxylic ester hydrolase
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-
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carboxylic esterase
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-
-
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Carboxylic-ester hydrolase
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-
-
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CES
-
-
-
-
cocaine esterase
-
-
-
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Egasyn
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-
-
-
Es-22
-
-
-
-
ES-HTEL
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-
-
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ES-HVEL
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-
-
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ES-Male
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-
-
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ES-THET
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-
-
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EST-5A
-
-
-
-
EST-5B
-
-
-
-
EST-5C
-
-
-
-
esterase A
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-
-
-
esterase B
-
-
-
-
esterase D
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-
-
-
esterase, carboxyl
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-
-
-
Esterase-22
-
-
-
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Esterase-31
-
-
-
-
HMSE
-
-
-
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Kidney microsomal carboxylesterase
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-
-
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Liver microsomal carboxylesterase
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-
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methylbutyrase
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-
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methylbutyrate esterase
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-
-
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Microsomal palmitoyl-CoA hydrolase
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-
-
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monobutyrase
-
-
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Monocyte/macrophage serine esterase
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-
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Non-specific carboxylesterase
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nonspecific carboxylesterase
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-
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PI 5.5 esterase
-
-
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PI 6.1 esterase
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-
-
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procaine esterase
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-
-
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Proline-beta-naphthylamidase
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-
-
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propionyl esterase
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-
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triacetin esterase
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-
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vitamin A esterase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -
SYSTEMATIC NAME
IUBMB Comments
carboxylic-ester hydrolase
Wide specificity. The enzymes from microsomes also catalyse the reactions of EC 3.1.1.2 (arylesterase), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.6 (acetylesterase), EC 3.1.1.23 (acylglycerol lipase), EC 3.1.1.28 (acylcarnitine hydrolase), EC 3.1.2.2 (palmitoyl-CoA hydrolase), EC 3.5.1.4 (amidase) and EC 3.5.1.13 (aryl-acylamidase). Also hydrolyses vitamin A esters.
CAS REGISTRY NUMBER
COMMENTARY hide
9016-18-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,2-O-dilauryl-rac-glycero-3-glutaric acid-resorufin ester + H2O
?
show the reaction diagram
-
-
-
?
4-nitrophenyl butyrate + H2O
4-nitrophenol + butyrate
show the reaction diagram
-
-
-
?
tributyrin + H2O
?
show the reaction diagram
no activity with triolein, suggesting that this lipolytic enzyme is not a true lipase
-
-
?
additional information
?
-
no activity towards various granular polyhydroxyalkanoates
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
O73957_9CREN
314
0
34271
TrEMBL
-
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60
120 min, about 5% loss of activity
80
30 min, about 40% loss of activity. 60 min, 60% loss of activity. 120 min, about 80% loss of activity
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Arpigny, J.L.; Jendrossek, D.; Jaeger, K.E.
A novel heat-stable lipolytic enzyme from Sulfolobus acidocaldarius DSM 639 displaying similarity to polyhydroxyalkanoate depolymerases
FEMS Microbiol. Lett.
167
69-73
1998
Sulfolobus acidocaldarius (O73957), Sulfolobus acidocaldarius DSM 639 (O73957)
Manually annotated by BRENDA team