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4-aminobutyrate degradation V
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acetyl-CoA fermentation to butyrate II
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gallate degradation III (anaerobic)
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glutamate degradation V (via hydroxyglutarate)
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succinate fermentation to butyrate
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Aminobenzoate degradation
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Microbial metabolism in diverse environments
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acetate coenzyme A-transferase
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acetate:succinate CoA-transferase
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butyryl CoA:acetate CoA transferase
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butyryl coenzyme A transferase
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butyryl-CoA:acetate CoA-transferase
B0MC58
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butyryl-CoA:acetate CoA-transferase
Anaerostipes caccae L1-92
B0MC58
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butyryl-CoA:acetate CoA-transferase
D2WEY7
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butyryl-CoA:acetate CoA-transferase
D2WEY7
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butyryl-CoA:acetate CoA-transferase
D2WEY8
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butyryl-CoA:acetate CoA-transferase
Eubacterium hallii M72/1
D2WEY8
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butyryl-CoA:acetate CoA-transferase
Eubacterium rectale
D2WEY1
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butyryl-CoA:acetate CoA-transferase
Eubacterium rectale A1-86
D2WEY1
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butyryl-CoA:acetate CoA-transferase
A8SFP6, C7H5K4, D2WEZ2
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butyryl-CoA:acetate CoA-transferase
C7H5K4
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butyryl-CoA:acetate CoA-transferase
D2WEZ2
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butyryl-CoA:acetate CoA-transferase
A8SFP6
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butyryl-CoA:acetate CoA-transferase
C7GB37
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butyryl-CoA:acetate CoA-transferase
C7GB37
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butyryl-CoA:acetate CoA-transferase
D2WEY6
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butyryl-CoA:acetate CoA-transferase
Roseburia inulinivorans A2-194
D2WEY6
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butyryl-coenzyme A CoA transferase
Q2QB27
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butyryl-coenzyme A CoA transferase
Q2QIH1
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butyryl-coenzyme A CoA transferase
Q2QIH0
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butyryl-coenzyme A CoA transferase
Q2TME9
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coenzyme A-transferase, acetate
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succinyl-CoA:acetate CoA transferase
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succinyl-CoA:acetate CoA-transferase
B3EY95
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succinyl-CoA:acetate CoA-transferase
B3EY95
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succinyl-coenzyme A:acetate CoA-transferase
B3EY95
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succinyl-coenzyme A:acetate CoA-transferase
B3EY95
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Anaerostipes caccae L1-92
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UniProt
Coprococcus sp.
strain L2-50, exponential and stationary phase
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Coprococcus sp. L2-50
strain L2-50, exponential and stationary phase
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K12, constitutive mutant strain V10 and strain D5H3G7
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Eubacterium hallii M72/1
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UniProt
Eubacterium rectale
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UniProt
Eubacterium rectale A1-86
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UniProt
formerly Fusobacterium, strain A2-165, exponential and stationary phase
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strain L1-82, L1-952, L1-8151, exponential and stationary phase
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strain L1-82, L1-952, L1-8151, exponential and stationary phase
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Roseburia inulinivorans A2-194
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UniProt
Roseburia sp.
strain A2-181, A2-183, exponential and stationary phase
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Roseburia sp. A2-181
strain A2-181, A2-183, exponential and stationary phase
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malfunction
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the acetate:succinate CoA-transferase null mutant is about 1000times more sensitive to oligomycin, a specific inhibitor of the mitochondrial F0/F1-ATP synthase, than wild type cells
metabolism
B3EY95
succinyl-CoA:acetate CoA-transferase is an acetic acid resistance factor (AarC) with a role in a variant citric acid cycle
metabolism
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the enzyme is involved in ATP production in the mitochondrion
metabolism
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succinyl-CoA:acetate CoA-transferase is an acetic acid resistance factor (AarC) with a role in a variant citric acid cycle
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physiological function
B3EY95
the enzyme is an acetic acid resistance factor that is required for acetate resistance
physiological function
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the enzyme is an acetic acid resistance factor that is required for acetate resistance
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acetate + succinyl-CoA
succinate + acetyl-CoA
B3EY95
5.1% activity compared to succinate
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r
acetate + succinyl-CoA
succinate + acetyl-CoA
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5.1% activity compared to succinate
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r
butanoyl-CoA + acetate
butanoate + acetyl-CoA
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?
butanoyl-CoA + acetate
butanoate + acetyl-CoA
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best substrate
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r
butanoyl-CoA + acetate
butanoate + acetyl-CoA
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?
pentanoyl-CoA + acetate
pentanoate + acetyl-CoA
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r
succinate + acetyl-CoA
acetate + succinyl-CoA
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?
succinate + acetyl-CoA
acetate + succinyl-CoA
B3EY95
100% activity
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r
succinate + acetyl-CoA
acetate + succinyl-CoA
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100% activity
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r
valeryl-CoA + acetate
valerate + acetyl-CoA
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r
butanoyl-CoA + acetate
?
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provides ability to grow on various fatty acids
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r
additional information
?
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B3EY95
less than 1% activity with acetoacetate, propionate, D-malate, fumarate, L-malate, formate, oxaloacetate, DL-methylsuccinate, and glutarate. No activity is detected with dethiaacetyl-CoA, glycolate, glyoxylate, oxalate, trifluoroacetate, DL-lactate, L-lactate, malonate, pyruvate, maleate, butyrate, D-tartrate, L-tartrate, alpha-ketoglutarate, citrate, or DL-isocitrate
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additional information
?
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less than 1% activity with acetoacetate, propionate, D-malate, fumarate, L-malate, formate, oxaloacetate, DL-methylsuccinate, and glutarate. No activity is detected with dethiaacetyl-CoA, glycolate, glyoxylate, oxalate, trifluoroacetate, DL-lactate, L-lactate, malonate, pyruvate, maleate, butyrate, D-tartrate, L-tartrate, alpha-ketoglutarate, citrate, or DL-isocitrate
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0.029
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acetate
B3EY95
mutant enzyme S71A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
47
0.16
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acetate
B3EY95
mutant enzyme N347A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
47
0.6
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acetate
B3EY95
mutant enzyme R228E, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
47
3
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acetate
B3EY95
mutant enzyme E435D, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
47
2600
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acetate
B3EY95
wild type enzyme, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
47
0.7
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acetyl-CoA
B3EY95
mutant enzyme N347A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C; mutant enzyme S71A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
29
2.3
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acetyl-CoA
B3EY95
mutant enzyme R228E, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
29
3.4
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acetyl-CoA
B3EY95
wild type enzyme, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
29
52
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acetyl-CoA
B3EY95
mutant enzyme E435D, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
29
0.03
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succinate
B3EY95
mutant enzyme S71A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
58
0.3
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succinate
B3EY95
mutant enzyme R228E, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
58
2.7
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succinate
B3EY95
mutant enzyme N347A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
58
73
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succinate
B3EY95
mutant enzyme E435D, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
58
79
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succinate
B3EY95
wild type enzyme, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
58
0.074
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succinyl-CoA
B3EY95
mutant enzyme S71A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
224
0.13
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succinyl-CoA
B3EY95
mutant enzyme R228E, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
224
0.39
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succinyl-CoA
B3EY95
mutant enzyme N347A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
224
9
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succinyl-CoA
B3EY95
mutant enzyme E435D, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C; wild type enzyme, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
224
0.1
1
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in crude cell extract
1.32
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in crude cell extract, stationary growth phase, strain L1-952
2.05
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in crude cell extract, stationary growth phase, strain L1-8151
2.79
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Roseburia sp.
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in crude cell extract, stationary growth phase, strain A2-181
8.9
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in crude cell extract, stationary growth phase, strain L1-82
9.1
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Roseburia sp.
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in crude cell extract, stationary growth phase, strain A2-183
9.24
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in crude cell extract, exponential growth phase, strain L1-8151
10.8
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Coprococcus sp.
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in crude cell extract, stationary growth phase, strain L2-50
15.58
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Roseburia sp.
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in crude cell extract, exponential growth phase, strain A2-181
17.45
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in crude cell extract, exponential growth phase, strain L1-952
18.64
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in crude cell extract, exponential growth phase, strain A2-165
19
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in crude cell extract, stationary growth phase, strain A2-165
25.5
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in crude cell extract, exponential growth phase, strain L1-82
38.95
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Roseburia sp.
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in crude cell extract, exponential growth phase, strain A2-183
118.4
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Coprococcus sp.
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in crude cell extract, exponential growth phase, strain L2-50
E294A
B3EY95
the mutant shows severely reduced catalytic efficiency compared to the wild type enzyme
E435A
B3EY95
insoluble mutant
E435D
B3EY95
the mutant shows almost wild type activity
E435Q
B3EY95
insoluble mutant
R228E
B3EY95
the mutant has a specific defect in its ability to bind both carboxylate substrates succinyl-CoA and acetyl-CoA and does not use 4-aminobutyrate as substrate
S71A
B3EY95
the mutant shows severely reduced catalytic efficiency compared to the wild type enzyme
E294A
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the mutant shows severely reduced catalytic efficiency compared to the wild type enzyme
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E435A
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insoluble mutant
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E435Q
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insoluble mutant
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R228E
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the mutant has a specific defect in its ability to bind both carboxylate substrates succinyl-CoA and acetyl-CoA and does not use 4-aminobutyrate as substrate
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S71A
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the mutant shows severely reduced catalytic efficiency compared to the wild type enzyme
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molecular biology
Q2QB27
a new degenerated real-time PCR approach to simultaneously quantify phylogenetically different butyrate-producing bacteria based on the detection of butyryl-coenzyme A (CoA) CoA transferase genes is described
molecular biology
Q2QIH1
a new degenerated real-time PCR approach to simultaneously quantify phylogenetically different butyrate-producing bacteria based on the detection of butyryl-coenzyme A (CoA) CoA transferase genes is described
molecular biology
Q2QIH0
a new degenerated real-time PCR approach to simultaneously quantify phylogenetically different butyrate-producing bacteria based on the detection of butyryl-coenzyme A (CoA) CoA transferase genes is described
molecular biology
Q2TME9
a new degenerated real-time PCR approach to simultaneously quantify phylogenetically different butyrate-producing bacteria based on the detection of butyryl-coenzyme A (CoA) CoA transferase genes is described
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Enzyme Nomenclature
----SYSTEMATIC NAMEIUBMB Commentsacyl-CoA:acetate CoA-transferaseActs on butanoyl-CoA and pentanoyl-CoA.SYNONYMSORGANISMUNIPROT ACCESSION NO.COMMENTARYLITERATUREacetate coenzyme A-transferase----butyryl CoA:acetate CoA transferase----butyryl coenzyme A transferase----butyryl-CoA:acetate CoA-transferaseAnaerostipes caccae L1-92B0MC58--butyryl-CoA:acetate CoA-transferaseEubacterium hallii M72/1D2WEY8--butyryl-CoA:acetate CoA-transferaseEubacterium rectale A1-86D2WEY1--butyryl-CoA:acetate CoA-transferaseRoseburia inulinivorans A2-194D2WEY6--coenzyme A-transferase, acetate----succinyl-CoA:acetate CoA transferase----ORGANISMCOMMENTARYLITERATURESEQUENCE CODESEQUENCE DBSOURCEformerly Fusobacterium, strain A2-165, exponential and stationary phase--
strain L1-82, L1-952, L1-8151, exponential and stationary phase--
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