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acetate coenzyme A-transferase
-
-
-
-
acetate:succinate CoA-transferase
-
-
acetoacetate:acetate CoA-transferase
butyryl CoA:acetate CoA transferase
-
-
-
-
butyryl coenzyme A transferase
-
-
-
-
butyryl coenzyme A:acetate transferase
butyryl-CoA: acetate CoA-transferase
butyryl-CoA:acetate CoA-transferase
butyryl-coenzyme A CoA transferase
coenzyme A-transferase, acetate
-
-
-
-
succinyl-CoA:acetate CoA transferase
-
-
-
-
succinyl-CoA:acetate CoA-transferase
succinyl-coenzyme A:acetate CoA-transferase
AarC

-
acetoacetate:acetate CoA-transferase

-
-
acetoacetate:acetate CoA-transferase
-
-
-
ActA

-
-
But

-
-
butyryl coenzyme A:acetate transferase

-
-
butyryl coenzyme A:acetate transferase
-
-
butyryl coenzyme A:acetate transferase
-
-
-
butyryl coenzyme A:acetate transferase
-
-
butyryl coenzyme A:acetate transferase
-
-
-
butyryl-CoA: acetate CoA-transferase

-
-
butyryl-CoA: acetate CoA-transferase
-
-
-
butyryl-CoA:acetate CoA-transferase

-
butyryl-CoA:acetate CoA-transferase
-
-
butyryl-CoA:acetate CoA-transferase
-
butyryl-CoA:acetate CoA-transferase
-
-
butyryl-CoA:acetate CoA-transferase
-
butyryl-CoA:acetate CoA-transferase
-
-
butyryl-CoA:acetate CoA-transferase
-
butyryl-CoA:acetate CoA-transferase
-
-
butyryl-CoA:acetate CoA-transferase
-
butyryl-CoA:acetate CoA-transferase
-
-
butyryl-CoA:acetate CoA-transferase
-
-
butyryl-CoA:acetate CoA-transferase
-
-
butyryl-CoA:acetate CoA-transferase
-
butyryl-CoA:acetate CoA-transferase
-
-
butyryl-CoA:acetate CoA-transferase
-
butyryl-CoA:acetate CoA-transferase
-
-
butyryl-coenzyme A CoA transferase

-
butyryl-coenzyme A CoA transferase
-
butyryl-coenzyme A CoA transferase
-
butyryl-coenzyme A CoA transferase
-
butyryl-coenzyme A CoA transferase
-
-
SCACT

-
succinyl-CoA:acetate CoA-transferase

-
succinyl-CoA:acetate CoA-transferase
-
-
succinyl-coenzyme A:acetate CoA-transferase

-
succinyl-coenzyme A:acetate CoA-transferase
-
-
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acetate + succinyl-CoA
succinate + acetyl-CoA
acetoacetyl-CoA + acetate
acetoacetate + acetyl-CoA
butanoyl-CoA + acetate
?
-
provides ability to grow on various fatty acids
-
-
r
butanoyl-CoA + acetate
butanoate + acetyl-CoA
butyryl-CoA + acetate
butanoate + acetyl-CoA
pentanoyl-CoA + acetate
pentanoate + acetyl-CoA
-
-
-
-
r
succinate + acetyl-CoA
acetate + succinyl-CoA
valeryl-CoA + acetate
valerate + acetyl-CoA
-
-
-
-
r
additional information
?
-
acetate + succinyl-CoA

succinate + acetyl-CoA
5.1% activity compared to succinate
-
-
r
acetate + succinyl-CoA
succinate + acetyl-CoA
-
5.1% activity compared to succinate
-
-
r
acetoacetyl-CoA + acetate

acetoacetate + acetyl-CoA
-
-
-
-
?
acetoacetyl-CoA + acetate
acetoacetate + acetyl-CoA
-
-
-
-
?
butanoyl-CoA + acetate

butanoate + acetyl-CoA
Coprococcus sp.
-
-
-
-
?
butanoyl-CoA + acetate
butanoate + acetyl-CoA
-
-
-
-
?
butanoyl-CoA + acetate
butanoate + acetyl-CoA
-
best substrate
-
r
butanoyl-CoA + acetate
butanoate + acetyl-CoA
-
-
-
-
?
butanoyl-CoA + acetate
butanoate + acetyl-CoA
-
-
-
-
?
butanoyl-CoA + acetate
butanoate + acetyl-CoA
-
-
-
-
?
butanoyl-CoA + acetate
butanoate + acetyl-CoA
Roseburia sp.
-
-
-
-
?
butanoyl-CoA + acetate
butanoate + acetyl-CoA
-
-
-
-
?
butyryl-CoA + acetate

butanoate + acetyl-CoA
-
-
-
-
?
butyryl-CoA + acetate
butanoate + acetyl-CoA
-
-
-
-
?
butyryl-CoA + acetate
butanoate + acetyl-CoA
-
-
-
-
?
butyryl-CoA + acetate
butanoate + acetyl-CoA
-
-
-
-
?
butyryl-CoA + acetate
butanoate + acetyl-CoA
-
-
-
-
?
butyryl-CoA + acetate
butanoate + acetyl-CoA
-
-
-
-
?
butyryl-CoA + acetate
butanoate + acetyl-CoA
-
-
-
-
?
succinate + acetyl-CoA

acetate + succinyl-CoA
100% activity
-
-
r
succinate + acetyl-CoA
acetate + succinyl-CoA
-
100% activity
-
-
r
succinate + acetyl-CoA
acetate + succinyl-CoA
-
-
-
-
?
additional information

?
-
less than 1% activity with acetoacetate, propionate, D-malate, fumarate, L-malate, formate, oxaloacetate, DL-methylsuccinate, and glutarate. No activity is detected with dethiaacetyl-CoA, glycolate, glyoxylate, oxalate, trifluoroacetate, DL-lactate, L-lactate, malonate, pyruvate, maleate, butyrate, D-tartrate, L-tartrate, alpha-ketoglutarate, citrate, or DL-isocitrate
-
-
-
additional information
?
-
-
less than 1% activity with acetoacetate, propionate, D-malate, fumarate, L-malate, formate, oxaloacetate, DL-methylsuccinate, and glutarate. No activity is detected with dethiaacetyl-CoA, glycolate, glyoxylate, oxalate, trifluoroacetate, DL-lactate, L-lactate, malonate, pyruvate, maleate, butyrate, D-tartrate, L-tartrate, alpha-ketoglutarate, citrate, or DL-isocitrate
-
-
-
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0.029
acetate

mutant enzyme S71A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
0.16
acetate
mutant enzyme N347A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
0.6
acetate
mutant enzyme R228E, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
3
acetate
mutant enzyme E435D, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
2600
acetate
wild type enzyme, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
0.7
acetyl-CoA

mutant enzyme N347A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C; mutant enzyme S71A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
2.3
acetyl-CoA
mutant enzyme R228E, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
3.4
acetyl-CoA
wild type enzyme, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
52
acetyl-CoA
mutant enzyme E435D, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
0.03
succinate

mutant enzyme S71A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
0.3
succinate
mutant enzyme R228E, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
2.7
succinate
mutant enzyme N347A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
73
succinate
mutant enzyme E435D, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
79
succinate
wild type enzyme, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
0.074
succinyl-CoA

mutant enzyme S71A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
0.13
succinyl-CoA
mutant enzyme R228E, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
0.39
succinyl-CoA
mutant enzyme N347A, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
9
succinyl-CoA
mutant enzyme E435D, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C; wild type enzyme, in 50 mM potassium phosphate (pH 8.0), 100 mM potassium chloride, at 30°C
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0.1 - 1
-
in crude cell extract
1.32
-
in crude cell extract, stationary growth phase, strain L1-952
2.05
-
in crude cell extract, stationary growth phase, strain L1-8151
2.79
Roseburia sp.
-
in crude cell extract, stationary growth phase, strain A2-181
8.9
-
in crude cell extract, stationary growth phase, strain L1-82
9.1
Roseburia sp.
-
in crude cell extract, stationary growth phase, strain A2-183
9.24
-
in crude cell extract, exponential growth phase, strain L1-8151
10.8
Coprococcus sp.
-
in crude cell extract, stationary growth phase, strain L2-50
15.58
Roseburia sp.
-
in crude cell extract, exponential growth phase, strain A2-181
17.45
-
in crude cell extract, exponential growth phase, strain L1-952
18.64
-
in crude cell extract, exponential growth phase, strain A2-165
19
-
in crude cell extract, stationary growth phase, strain A2-165
25.5
-
in crude cell extract, exponential growth phase, strain L1-82
38.95
Roseburia sp.
-
in crude cell extract, exponential growth phase, strain A2-183
118.4
Coprococcus sp.
-
in crude cell extract, exponential growth phase, strain L2-50
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Vanderwinkel, E.; Furmanski, P.; Reeves, H.C.; Ajl, S.J.
Growth of Escherichia coli on fatty acids: requirement for coenzyme A transferase activity
Biochem. Biophys. Res. Commun.
33
902-908
1968
Escherichia coli
brenda
Duncan, S.H.; Barcenilla, A.; Stewart, C.S.; Pryde, S.E.; Flint, H.J.
Acetate utilization and butyryl coenzyme A (CoA):acetate-CoA transferase in butyrate-producing bacteria from the human large intestine
Appl. Environ. Microbiol.
68
5186-5190
2002
Coprococcus sp., Coprococcus sp. L2-50, Faecalibacterium prausnitzii, Roseburia intestinalis, Roseburia intestinalis L1-82, Roseburia sp., Roseburia sp. A2-181
brenda
Korolev, S.; Koroleva, O.; Petterson, K.; Gu, M.; Collart, F.; Dementieva, I.; Joachimiak, A.
Autotracing of Escherichia coli acetate CoA-transferase alpha-subunit structure using 3.4 A MAD and 1.9 A native data
Acta Crystallogr. Sect. D
58
2116-2121
2002
Escherichia coli, Escherichia coli (P76458)
brenda
Louis, P.; Flint, H.J.
Development of a semiquantitative degenerate real-time PCR-based assay for estimation of numbers of butyryl-coenzyme A (CoA) CoA transferase genes in complex bacterial samples
Appl. Environ. Microbiol.
73
2009-2012
2007
Anaerostipes caccae (Q2QB27), Eubacterium hallii (Q2QIH1), Faecalibacterium prausnitzii (Q2QIH0), Roseburia hominis (Q2TME9), Roseburia hominis A2-183 (Q2TME9)
brenda
Mullins, E.A.; Kappock, T.J.
Crystal structures of Acetobacter aceti succinyl-coenzyme A (CoA):acetate CoA-transferase reveal specificity determinants and illustrate the mechanism used by class I CoA-transferases
Biochemistry
51
8422-8434
2012
Acetobacter aceti (B3EY95)
brenda
Louis, P.; Young, P.; Holtrop, G.; Flint, H.
Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene
Environ. Microbiol.
12
304-314
2010
Anaerostipes caccae (B0MC58), Anaerostipes caccae DSM 14662 (B0MC58), Butyrivibrio fibrisolvens 16/4 (D2WEY7), Butyrivibrio fibrisolvens (D2WEY7), Eubacterium hallii (D2WEY8), Eubacterium hallii, Eubacterium hallii M72/1 (D2WEY8), Eubacterium rectale (D2WEY1), Eubacterium rectale, Eubacterium rectale DSM 17629 (D2WEY1), Faecalibacterium prausnitzii (A8SFP6), Faecalibacterium prausnitzii (C7H5K4), Faecalibacterium prausnitzii (D2WEZ2), Faecalibacterium prausnitzii, Faecalibacterium prausnitzii A2-165 (C7H5K4), Faecalibacterium prausnitzii L2-6 (D2WEZ2), Faecalibacterium prausnitzii M21/2 (A8SFP6), Roseburia intestinalis (C7GB37), Roseburia intestinalis L1-82 (C7GB37), Roseburia inulinivorans (D2WEY6), Roseburia inulinivorans A2-194 (D2WEY6)
brenda
Millerioux, Y.; Morand, P.; Biran, M.; Mazet, M.; Moreau, P.; Wargnies, M.; Ebikeme, C.; Deramchia, K.; Gales, L.; Portais, J.C.; Boshart, M.; Franconi, J.M.; Bringaud, F.
ATP synthesis-coupled and -uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma
J. Biol. Chem.
287
17186-17197
2012
Trypanosoma brucei
brenda
Trachsel, J.; Bayles, D.O.; Looft, T.; Levine, U.Y.; Allen, H.K.
Function and phylogeny of bacterial butyryl coenzyme A:acetate transferases and their diversity in the proximal colon of swine
Appl. Environ. Microbiol.
82
6788-6798
2016
Butyricicoccus sp. BB10, Eubacterium nodatum, Eubacterium nodatum 68-3-10, Megasphaera elsdenii 14-14, Megasphaera elsdenii
brenda
Shaw, A.; Miller, B.; Rogers, S.; Kenealy, W.; Meola, A.; Bhandiwad, A.; Sillers, W.; Shikhare, I.; Hogsett, D.; Herring, C.
Anaerobic detoxification of acetic acid in a thermophilic ethanologen
Biotechnol. Biofuels
8
75
2015
Thermoanaerobacterium saccharolyticum, Thermoanaerobacterium saccharolyticum M2212
brenda
Deng, Y.; Mao, Y.; Zhang, X.
Driving carbon flux through exogenous butyryl-CoA: Acetate CoA-transferase to produce butyric acid at high titer in Thermobifida fusca
J. Biotechnol.
216
151-157
2015
Thermoanaerobacterium thermosaccharolyticum, Thermoanaerobacterium thermosaccharolyticum DSM 571
brenda