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Information on EC 2.8.3.5 - 3-oxoacid CoA-transferase and Organism(s) Mus musculus and UniProt Accession Q9JJN4

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.3 CoA-transferases
                2.8.3.5 3-oxoacid CoA-transferase
IUBMB Comments
Acetoacetate and, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptors; malonyl-CoA can act instead of succinyl-CoA.
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This record set is specific for:
Mus musculus
UNIPROT: Q9JJN4
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
coa transferase, oxct1, 3-oxoacid coa-transferase, succinyl-coa:3-ketoacid coa transferase, 3-ketoacid coa-transferase, scot-t, succinyl-coa transferase, succinyl-coa:3-oxoacid coa transferase, succinyl-coa:3-ketoacid coenzyme a transferase, succinyl-coa:3-oxoacid coa-transferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-ketoacid CoA-transferase
-
-
-
-
3-ketoacid coenzyme A transferase
-
-
-
-
3-ketoacid coenzyme A-transferase
-
-
-
-
3-oxo-CoA transferase
-
-
-
-
3-oxoacid CoA dehydrogenase
-
-
-
-
3-oxoacid coenzyme A-transferase
-
-
-
-
acetoacetate succinyl-CoA transferase
-
-
-
-
acetoacetyl coenzyme A-succinic thiophorase
-
-
-
-
coenzyme A-transferase, 3-oxoacid
-
-
-
-
SCOT-t
-
-
-
-
succinyl coenzyme A-acetoacetyl coenzyme A-transferase
-
-
-
-
succinyl-CoA transferase
-
-
-
-
succinyl-CoA:3-ketoacid coenzyme A transferase-1
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succinyl-CoA:acetoacetate CoA transferase
-
-
-
-
testis-specific succinyl-CoA:3-oxo-acid CoA-transferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
coenzyme A transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
succinyl-CoA:3-oxo-acid CoA-transferase
Acetoacetate and, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptors; malonyl-CoA can act instead of succinyl-CoA.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-43-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
succinyl-CoA + acetoacetate
?
show the reaction diagram
-
liver enzyme: produces a substrate circle between acetoacetyl-CoA and acetoacetate
-
-
?
succinyl-CoA + acetoacetate
succinate + acetoacetyl-CoA
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
succinyl-CoA + acetoacetate
?
show the reaction diagram
-
liver enzyme: produces a substrate circle between acetoacetyl-CoA and acetoacetate
-
-
?
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
assay at
37
-
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9.24
calculated from nucleotide sequence
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
neuroblastoma N2a cell line
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SCO2A_MOUSE
520
0
56473
Swiss-Prot
Mitochondrion (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50000
SDS-PAGE
56530
calculated from nucleotide sequence
58000
x * 58000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 58000, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nitrosylation
diabetes is associated with a higher nitrosylation degree of tyrosine 76 and tyrosine374
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
degradation of 3-oxo acid CoA-transferase in glioma and neuroblastoma cells
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the enzyme catalytic activity is significantly reduced in the hearts of diabetic wild type diabetic mice at weeks 4-12 postinduction, with the lowest level observed at week 4 postinduction
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zammit, V.A.; Beis, A.; Newsholme, E.A.
The role of 3-oxo acid-CoA transferase in the regulation of ketogenesis in the liver
FEBS Lett.
103
212-215
1979
Gallus gallus, Clupea harengus, Columba livia, Oryctolagus cuniculus, Dicentrarchus labrax, Lacerta viridis, Mus musculus, Oncorhynchus mykiss, Pleuronectes platessa, Raja clavata, Rattus norvegicus, Scomber scombrus, Scyliorhinus canicula
Manually annotated by BRENDA team
Haney, P.M.; Bolinger, L.; Raefsky, C.; Patel, M.S.
Turnover of succinyl-CoA:3-oxoacid CoA-transferase in glioma and neuroblastoma cells. Specific influence of acetoacetate in neuroblastoma cells
Biochem. J.
224
67-74
1984
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Koga, M.; Tanaka, H.; Yomogida, K.; Nozaki, M.; Tsuchida, J.; Ohta, H.; Nakamura, Y.; Masai, K.; Yoshimura, Y.; Yamanaka, M.; Iguchi, N.; Nojima, H.; Matsumiya, K.; Okuyama, A.; Nishimune, Y.
Isolation and characterization of a haploid germ cell-specific novel complementary deoxyribonucleic acid; testis-specific homologue of succinyl CoA:3-Oxo acid CoA transferase
Biol. Reprod.
63
1601-1609
2000
Mus musculus, Mus musculus (Q9JJN4)
Manually annotated by BRENDA team
Cong, W.; Ma, W.; Zhao, T.; Zhu, Z.; Wang, Y.; Tan, Y.; Li, X.; Jin, L.; Cai, L.
Metallothionein prevents diabetes-induced cardiac pathological changes, likely via the inhibition of succinyl-CoA:3-ketoacid coenzyme A transferase-1 nitration at Trp(374)
Am. J. Physiol. Endocrinol. Metab.
304
E826-E835
2013
Mus musculus (Q9D0K2)
Manually annotated by BRENDA team