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Information on EC 2.8.3.28 - phenylsuccinyl-CoA transferase

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.3 CoA-transferases
                2.8.3.28 phenylsuccinyl-CoA transferase
IUBMB Comments
The enzyme, characterized from the bacterium Aromatoleum aromaticum, is involved in degradation of (indol-3-yl)acetate, where it is believed to function on (2-aminophenyl)succinate. It has a broad substrate specificity towards other C4-dicarboxylic acids, phenylacetate, and the non-physiological compound 2-naphthylacetate. The enzyme produces 2- and 3-phenylsuccinyl-CoA in equimolar amounts. It can also perform an intramolecular transfer of the CoA moiety to convert 2-phenylsuccinyl-CoA to 3-phenylsuccinyl-CoA.
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The expected taxonomic range for this enzyme is: Aromatoleum aromaticum
Synonyms
IaaL, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
phenylsuccinate + succinyl-CoA = 2-phenylsuccinyl-CoA + succinate
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(1)
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phenylsuccinate + succinyl-CoA = 3-phenylsuccinyl-CoA + succinate
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(2)
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