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3'-phosphoadenylyl sulfate + heparosan
adenosine 3',5'-bisphosphate + heparosan sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
3'-phosphoadenylylsulfate + N-desulfated heparin
?
-
-
-
?
3'-phosphoadenylyl sulfate + heparosan
adenosine 3',5'-bisphosphate + heparosan sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + N-deacetylase K5-polysaccharide
?
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-D-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfo-D-glucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
3'-phosphoadenylylsulfate + chondroitin 4-sulfate
?
-
weak activity
-
-
?
3'-phosphoadenylylsulfate + dermatan sulfate
?
-
weak activity
-
-
?
3'-phosphoadenylylsulfate + heparan sulfate
adenosine 3',5'-bisphosphate + N-sulfoheparan sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + heparin
adenosine 3',5'-bisphosphate + N-sulfoheparin
-
-
-
-
?
3'-phosphoadenylylsulfate + N-acetylated heparan sulfate
?
-
-
-
-
?
3'-phosphoadenylylsulfate + N-deacetylated K5 polysaccharide
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
3'-phosphoadenylylsulfate + N-deacetylated K5-polysaccharide
?
-
from E. coli K5-derived capsular polysaccharide
-
-
?
3'-phosphoadenylylsulfate + N-desulfated heparin
?
3'-phosphoadenylylsulfate + N-desulfoheparin
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
additional information
?
-
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
-
-
product structure analysis, overview
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
-
in livers of wild-type and NDST mutant mice, overview
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
substrate needs to be deacetylated
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
substrate needs to be deacetylated
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
recombinant bifunctional enzyme overexpressed in human kidney cells shows 2.5fold increase in N-sulfation and 8fold increase of N-deacetylation of glucosaminyl residues of human heparan sulfate in vivo
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
structural analysis of substrate and product
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
may be involved in biosynthesis of heparin and not of heparan sulfate
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
isozyme regulation, developmental importance in different tissues
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
cerebral hypoplasia and craniofacial defects are detected in mice lacking heparan sulfate Ndst1 gene function. Ndst1 is a crucial regulator of mammalian forebrain and facial development. Properly modified heparan sulfate is necessary for neuronal, glia and neural crest development
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
expression of heparan sulfate sulfotransferase genes is spatiotemporally regulated in the developing brain, suggesting that the structure of heparan sulfate changes dynamically for the regulation of various biological processes. Posttranscriptional regulation also plays a critical role
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
the sulfation of heparin is initiated by the NDST enzymes, which catalyze the N-deacetylation and subsequent N-sulfation of selected GlcNAc residues of the [GlcUA-GlcNAc] polymer
-
-
?
3'-phosphoadenylylsulfate + N-desulfated heparin
?
-
-
-
-
?
3'-phosphoadenylylsulfate + N-desulfated heparin
?
-
-
-
?
additional information
?
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
-
p-nitrophenol is no acceptor
-
-
?
additional information
?
-
-
heparin is no acceptor
-
-
?
additional information
?
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
-
deacetylase/sulfotransferase ratio of the bifunctional isozyme, sulfotranferase in decreasing order: NDST4, NDST1, NDST2, NDST3
-
-
?
additional information
?
-
-
heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development, disruption of heparan sulfate synthesis in vertebrate development causes malformations that are composites of those caused by mutations of multiple heparan sulfate binding growth factors and morphogens, overview, molecular mechanisms leading to frontonasal dysplasia, impaired spinal and cranial neural tube fusion, and skeletal abnormalities in Ndst1 mutant embryos, impaired fibroblast growth factor, Hedgehog, and Wnt function may contribute to some of these phenotypes, overview
-
-
?
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3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
3'-phosphoadenylyl sulfate + [heparan sulfate]-D-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfo-D-glucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
3'-phosphoadenylylsulfate + N-desulfoheparin
adenosine 3',5'-bisphosphate + ?
-
-
-
-
?
additional information
?
-
-
heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development, disruption of heparan sulfate synthesis in vertebrate development causes malformations that are composites of those caused by mutations of multiple heparan sulfate binding growth factors and morphogens, overview, molecular mechanisms leading to frontonasal dysplasia, impaired spinal and cranial neural tube fusion, and skeletal abnormalities in Ndst1 mutant embryos, impaired fibroblast growth factor, Hedgehog, and Wnt function may contribute to some of these phenotypes, overview
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
-
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-D-sulfoglucosamine
-
in livers of wild-type and NDST mutant mice, overview
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
bifunctional enzyme initiates heparin and heparan sulfate biosynthesis
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
may be involved in biosynthesis of heparin and not of heparan sulfate
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
isozyme regulation, developmental importance in different tissues
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
cerebral hypoplasia and craniofacial defects are detected in mice lacking heparan sulfate Ndst1 gene function. Ndst1 is a crucial regulator of mammalian forebrain and facial development. Properly modified heparan sulfate is necessary for neuronal, glia and neural crest development
-
-
?
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
the sulfation of heparin is initiated by the NDST enzymes, which catalyze the N-deacetylation and subsequent N-sulfation of selected GlcNAc residues of the [GlcUA-GlcNAc] polymer
-
-
?
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additional information
construction of conditional deficiency of the glycocalyx-modifying enzyme N-deacetylase-N-sulfotransferase-1 (Ndst1f/f TekCre+) which reduces aortic allograft inflammation. Conditional donor allograft Ndst1 deficiency (Ndst1-/-, C57Bl/6 background) is compared to systemic treatment with M-T7, a broad-spectrum chemokine glycosaminoglycan (GAG) inhibitor. Early rejection is significantly reduced in Ndst1-/- kidneys engrafted into wild-type BALB/c mice (Ndst1+/+) and comparable to M-T7 treatment in C57Bl/6 allografts. M-T7 is a 37 kDa Myxomavirus-derived secreted glycoprotein that possesses both broad spectrum, species-independent, C, CC and CXC chemokine inhibitory activity and a rabbit species-specific interferon gamma (IFNgamma) inhibitory activity. M-T7 activity is blunted in Ndst1-deficient mouse donor aortic transplants, a model for chronic TAV and vascular injury, but not in CC chemokine receptor deficient aortic allograft transplants, supporting M-T7 interference with chemokine-GAG interactions. M-T7 loses activity in Ndst1-/- allografts, while M-T7 point mutants with modified GAG chemokine binding display a range of anti-rejection activity. CD3+ T cells, HS and CXC chemokine staining, gene expression in NFkappaB and JAK/STAT pathways, and HS and CS disaccharide content are significantly altered with reduced rejection
additional information
-
knockout mice construction: mice lacking NDST2 show a phenotype restricted to connective tissue-type mast cells, while NDST1 deficiency is lethal, double-knockouts show early embryonic lethality, in utero effect of NDST3 deficiency
additional information
knockout mice construction: mice lacking NDST2 show a phenotype restricted to connective tissue-type mast cells, while NDST1 deficiency is lethal, double-knockouts show early embryonic lethality, in utero effect of NDST3 deficiency
additional information
-
construction of mutant mice bearing a targeted disruption of the heparan sulfate-generating enzyme Ndst1, the mutant mice show severe developmental defects of the forebrain and the skull, overview, determination of molecular mechanisms leading to frontonasal dysplasia, impaired spinal and cranial neural tube fusion, and skeletal abnormalities in Ndst1 mutant embryos, impaired fibroblast growth factor, Hedgehog, and Wnt function may contribute to some of these phenotypes, organ defect phenotypes, overview
additional information
-
construction of NDST1+/- and NDST2-/- mice obtained by crossing NDST2-/- and NDST1 heterozygous mice, genotyping, neither NDST-1-/- nor NDST-2-/- mice display any obvious liver phenotype, deletion of one NDST gene does not influence expression of the other one, overview
additional information
-
early lens defects occur in Ndst1-knockout embryos, molecular defects underlying lens induction in Ndst1 mutants and phenotype, overview, Ndst1 knockout does not affect canonical bone morphogenic protein and Wnt signaling in the lens
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Cheung, W.F.; Eriksson, I.; Kusche-Gulberg, M.; Lindahl, U.; Kjellen, L.
Expression of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase in human kidney 293 cells results in increased N-sulfation of heparan sulfate
Biochemistry
35
5250-5256
1996
Mus musculus
brenda
Orellana, A.; Hirschberg, C.B.; Wei, Z.; Swiedler, S.J.; Ishihara, M.
Molecular cloning and expression of a glycosaminoglycan N-acetylglucosaminyl N-deacetylase/N-sulfotransferase from a heparin-producing cell line
J. Biol. Chem.
269
2270-2276
1994
Mus musculus
brenda
Eisenman, R.A.; Balasubramanian, A.S.; Marx, W.
3-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction
Arch. Biochem. Biophys.
119
387-397
1967
Mus musculus
brenda
Jansson, L.; Hk, M.; Wasteson, A.; Lindahl, U.
Biosynthesis of heparin. Solubilization and partial characterization of N- and O-sulphotransferases
Biochem. J.
149
49-55
1975
Mus musculus
brenda
Kusche-Gullberg, M.; Eriksson, I.; Pikas, D.S.; Kjellen, L.
Identification and expression in mouse of two heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase genes
J. Biol. Chem.
273
11902-11907
1998
Rattus norvegicus, Mus musculus (Q3UHN9), Mus musculus
brenda
Aikawa, J.; Grobe, K.; Tsujimoto, M.; Esko, J.D.
Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4
J. Biol. Chem.
276
5876-5882
2001
Homo sapiens (O95803), Homo sapiens (Q9H3R1), Homo sapiens, Mus musculus (P52850), Mus musculus (Q3UHN9), Mus musculus (Q9EQH7), Mus musculus (Q9EQW8), Mus musculus
brenda
Grobe, K.; Ledin, J.; Ringvall, M.; Holmborn, K.; Forsberg, E.; Esko, J.D.; Kjellen, L.
Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes
Biochim. Biophys. Acta
1573
209-215
2002
Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Homo sapiens (O95803), Homo sapiens (Q9H3R1), Mus musculus, Mus musculus (Q9EQW8), vertebrata
brenda
Grobe, K.; Inatani, M.; Pallerla, S.R.; Castagnola, J.; Yamaguchi, Y.; Esko, J.D.
Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene function
Development
132
3777-3786
2005
Mus musculus
brenda
Yabe, T.; Hata, T.; He, J.; Maeda, N.
Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain
Glycobiology
15
982-993
2005
Mus musculus
brenda
Pallerla, S.R.; Pan, Y.; Zhang, X.; Esko, J.D.; Grobe, K.
Heparan sulfate Ndst1 gene function variably regulates multiple signaling pathways during mouse development
Dev. Dyn.
236
556-563
2007
Mus musculus
brenda
Pan, Y.; Woodbury, A.; Esko, J.D.; Grobe, K.; Zhang, X.
Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development
Development
133
4933-4944
2006
Mus musculus
brenda
Ledin, J.; Ringvall, M.; Thuveson, M.; Eriksson, I.; Wilen, M.; Kusche-Gullberg, M.; Forsberg, E.; Kjellen, L.
Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation
J. Biol. Chem.
281
35727-35734
2006
Mus musculus
brenda
Duelli, A.; Roennberg, E.; Waern, I.; Ringvall, M.; Kolset, S.O.; Pejler, G.
Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases
J. Immunol.
183
7073-7083
2009
Mus musculus
brenda
Holley, R.J.; Deligny, A.; Wei, W.; Watson, H.A.; Ninonuevo, M.R.; Dagaelv, A.; Leary, J.A.; Bigger, B.W.; Kjellen, L.; Merry, C.L.
Mucopolysaccharidosis type I, unique structure of accumulated heparan sulfate and increased N-sulfotransferase activity in mice lacking alpha-L-iduronidase
J. Biol. Chem.
286
37515-37524
2011
Mus musculus
brenda
Gesteira, T.F.; Coulson-Thomas, V.J.; Taunay-Rodrigues, A.; Oliveira, V.; Thacker, B.E.; Juliano, M.A.; Pasqualini, R.; Arap, W.; Tersariol, I.L.; Nader, H.B.; Esko, J.D.; Pinhal, M.A.
Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1
J. Biol. Chem.
286
5338-5346
2011
Mus musculus
brenda
Bush, K.T.; Crawford, B.E.; Garner, O.B.; Nigam, K.B.; Esko, J.D.; Nigam, S.K.
N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland
J. Biol. Chem.
287
42064-42070
2012
Mus musculus
brenda
Deligny, A.; Dierker, T.; Dagaelv, A.; Lundequist, A.; Eriksson, I.; Nairn, A.V.; Moremen, K.W.; Merry, C.L.; Kjellen, L.
NDST2 (N-deacetylase/N-sulfotransferase-2) enzyme regulates heparan sulfate chain length
J. Biol. Chem.
291
18600-18607
2016
Mus musculus (P52850), Mus musculus
brenda
Chen, H.; Ambadapadi, S.; Wakefield, D.; Bartee, M.; Yaron, J.R.; Zhang, L.; Archer-Hartmann, S.A.; Azadi, P.; Burgin, M.; Borges, C.; Zheng, D.; Ergle, K.; Muppala, V.; Morshed, S.; Rand, K.; Clapp, W.; Proudfoot, A.; Lucas, A.
Selective deletion of heparan sulfotransferase enzyme, Ndst1, in donor endothelial and myeloid precursor cells significantly decreases acute allograft rejection
Sci. Rep.
8
13433
2018
Mus musculus (Q3UHN9), Mus musculus C57BL/6 (Q3UHN9)
brenda