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Information on EC 2.8.2.35 - dermatan 4-sulfotransferase and Organism(s) Mus musculus and UniProt Accession Q80V53

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.2 Sulfotransferases
                2.8.2.35 dermatan 4-sulfotransferase
IUBMB Comments
The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAalpha(1,3)GalNAcbeta(1,4) that is flanked by GlcUAbeta(1,3)GalNAcbeta(1,4) as compared with IdoUAalpha(1,3)GalNAcbeta(1,4) flanked by IdoUAalpha(1,3)GalNAcbeta(1,4) .
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This record set is specific for:
Mus musculus
UNIPROT: Q80V53
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
chst14, d4st-1, dermatan 4-o-sulfotransferase-1, d4st1, dermatan 4-o-sulfotransferase 1, chst14/d4st1, dermatan 4-o-sulfotransferase, carbohydrate sulfotransferase 14, n-acetylgalactosamine 4-o-sulfotransferase 1, dermatan-4-sulfotransferase-1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carbohydrate sulfotransferase 14
-
-
CHST14
-
-
Chst14/D4st1
-
-
dermatan 4-O-sulfotransferase-1
-
-
dermatan-4O-sulfotransferase1
-
-
SYSTEMATIC NAME
IUBMB Comments
3'-phospho-5'-adenylyl sulfate:[dermatan]-N-acetyl-D-galactosamine 4-sulfotransferase
The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAalpha(1,3)GalNAcbeta(1,4) that is flanked by GlcUAbeta(1,3)GalNAcbeta(1,4) as compared with IdoUAalpha(1,3)GalNAcbeta(1,4) flanked by IdoUAalpha(1,3)GalNAcbeta(1,4) [1].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine
adenosine 3',5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine
adenosine 3',5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine
show the reaction diagram
-
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
the expression of D4ST-1 is restricted in the developing cerebellum and culminates at postnatal day 14
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CHSTE_MOUSE
376
0
43145
Swiss-Prot
Mitochondrion (Reliability: 3)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mitsunaga, C.; Mikami, T.; Mizumoto, S.; Fukuda, J.; Sugahara, K.
Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases
J. Biol. Chem.
281
18942-18952
2006
Mus musculus (Q80V53), Mus musculus
Manually annotated by BRENDA team
Bian, S.; Akyuez, N.; Bernreuther, C.; Loers, G.; Laczynska, E.; Jakovcevski, I.; Schachner, M.
Dermatan sulfotransferase Chst14/D4st1, but not chondroitin sulfotransferase Chst11/C4st1, regulates proliferation and neurogenesis of neural progenitor cells
J. Cell Sci.
124
4051-4063
2011
Mus musculus
Manually annotated by BRENDA team
Rost, S.; Akyuez, N.; Martinovic, T.; Huckhagel, T.; Jakovcevski, I.; Schachner, M.
Germline ablation of dermatan-4O-sulfotransferase1 reduces regeneration after mouse spinal cord injury
Neuroscience
312
74-85
2016
Mus musculus
Manually annotated by BRENDA team