Information on EC 2.8.2.26 - quercetin-3-sulfate 3'-sulfotransferase

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The expected taxonomic range for this enzyme is: Flaveria chlorifolia

EC NUMBER
COMMENTARY
2.8.2.26
-
RECOMMENDED NAME
GeneOntology No.
quercetin-3-sulfate 3'-sulfotransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
sulfate group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Flavone and flavonol biosynthesis
-
-
quercetin sulfate biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase
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SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
3'-sulfotransferase
-
-
-
-
flavonol 3'-sulfotransferase
-
-
-
-
PAPS:flavonol 3-sulfate 3'-sulfotransferase
-
-
-
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sulfotransferase, flavonol 3'-
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
121855-11-6
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylylsulfate + patuletin 3-sulfate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
33% of activity compared to quercetin 3-sulfate
-
-
-
3'-phosphoadenylylsulfate + quercetin 3-sulfate
adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
-
3'-phosphoadenylylsulfate + quercetin 3-sulfate
adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
-
3'-phosphoadenylylsulfate + quercetin 3-sulfate
adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + quercetin 3-sulfate
adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + tamarixetin 3-sulfate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
-
3'-phosphoadenylylsulfate + tamarixetin 3-sulfate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
33% of activity compared to quercetin 3-sulfate
-
-
-
additional information
?
-
-
kaempferol 3-sulfate, isorhamnetin 3-sulfate or other flavonol aglycones are no substrates
-
-
-
additional information
?
-
-
sulfation at 3'-positions is second step in formation of polysulfated flavonoids
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-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylylsulfate + quercetin 3-sulfate
adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
-
3'-phosphoadenylylsulfate + quercetin 3-sulfate
adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
-
additional information
?
-
-
sulfation at 3'-positions is second step in formation of polysulfated flavonoids
-
-
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
EDTA up to 10 mM, or SH-group reagents, e.g. p-chloromercuribenzoate, iodoacetate, iodoacetamide at 1 and 10 mM, are not inhibitory
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00035
3'-phosphoadenylylsulfate
-
-
0.00029
quercetin 3-sulfate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
35000
-
gel filtration
644307, 644310
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, 1 mg/ml bovine serum albumin, half-life of 3 days
-
4°C, half-life of 24 h
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE