Information on EC 2.8.2.26 - quercetin-3-sulfate 3'-sulfotransferase

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The expected taxonomic range for this enzyme is: Flaveria chlorifolia

EC NUMBER
COMMENTARY
2.8.2.26
-
RECOMMENDED NAME
GeneOntology No.
quercetin-3-sulfate 3'-sulfotransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
3'-phosphoadenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
sulfate group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Flavone and flavonol biosynthesis
-
quercetin sulfate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase
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SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
3'-sulfotransferase
-
-
-
-
flavonol 3'-sulfotransferase
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-
-
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PAPS:flavonol 3-sulfate 3'-sulfotransferase
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-
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sulfotransferase, flavonol 3'-
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-
-
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CAS REGISTRY NUMBER
COMMENTARY
121855-11-6
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylylsulfate + patuletin 3-sulfate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
33% of activity compared to quercetin 3-sulfate
-
-
-
3'-phosphoadenylylsulfate + quercetin 3-sulfate
adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
-
3'-phosphoadenylylsulfate + quercetin 3-sulfate
adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
-
3'-phosphoadenylylsulfate + quercetin 3-sulfate
adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + quercetin 3-sulfate
adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylylsulfate + tamarixetin 3-sulfate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
-
-
-
-
3'-phosphoadenylylsulfate + tamarixetin 3-sulfate
adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
33% of activity compared to quercetin 3-sulfate
-
-
-
additional information
?
-
-
kaempferol 3-sulfate, isorhamnetin 3-sulfate or other flavonol aglycones are no substrates
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-
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additional information
?
-
-
sulfation at 3'-positions is second step in formation of polysulfated flavonoids
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylylsulfate + quercetin 3-sulfate
adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
-
3'-phosphoadenylylsulfate + quercetin 3-sulfate
adenosine 3',5'-bisphosphate + quercetin 3,3'-bissulfate
show the reaction diagram
-
-
-
-
additional information
?
-
-
sulfation at 3'-positions is second step in formation of polysulfated flavonoids
-
-
-
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
additional information
-
EDTA up to 10 mM, or SH-group reagents, e.g. p-chloromercuribenzoate, iodoacetate, iodoacetamide at 1 and 10 mM, are not inhibitory
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KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.00035
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3'-phosphoadenylylsulfate
-
-
0.00029
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quercetin 3-sulfate
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-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
35000
-
-
gel filtration
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-20°C, 1 mg/ml bovine serum albumin, half-life of 3 days
-
4°C, half-life of 24 h
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Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE