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3'-phosphoadenylyl sulfate + benzyl-Glu-Tyr
adenosine 3',5'-bisphosphate + benzyl-Glu-Tyr-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + C4P5Y5 peptide
adenosine 3',5'-bisphosphate + sulfated C4P5Y5 peptide
a C4 complement derived peptide substrate, sulfation of the Tyr741 residue
-
-
?
3'-phosphoadenylyl sulfate + CXC-chemokine receptor 4
adenosine 3',5'-bisphosphate + ?
3'-phosphoadenylyl sulfate + CXCR4 1-38
adenosine 3',5'-bisphosphate + ?
CC-chemokine receptor 4 peptide, amino acids 1-38
the enzyme has a strong site preference for sulfation of Tyr-21 over Tyr-7 and Tyr-12, sulfation of Tyr-21 is required for high-affinity interaction with stromal cell-derived factor-1 (SDF-1alpha)
-
?
3'-phosphoadenylyl sulfate + EDFEDYEFDG
adenosine 3',5'-bisphosphate + EDFEDY(sulfated)EFDG
GST-tagged CC4-tide, peptide 5-FAM-EDFEDYEFDG-CONH2, from human complement C4 protein
-
-
?
3'-phosphoadenylyl sulfate + EDYDTTTEFDsYGD
adenosine 3',5'-bisphosphate + EDsYDTTTEFDsYGD
G protein-coupled receptor, human chemokine receptor 1, amino acids 8-20
-
-
?
3'-phosphoadenylyl sulfate + EDYDTTTEFDYGD
adenosine 3',5'-bisphosphate + EDYDTTTEFDsYGD
G protein-coupled receptor human chemokine receptor 1, amino acids 8-20
-
-
?
3'-phosphoadenylyl sulfate + ENYSYDLDYYS
adenosine 3',5'-bisphosphate + ENsYSsYDLDsYsYS
G protein-coupled receptor human gpr1, amino acids 13-23, sulfation order: first Tyr21, second Tyr22, third Tyr15 or 17, fourth Tyr 15 or 17
-
-
?
3'-phosphoadenylyl sulfate + ERHTRSYDYMEGGD
adenosine 3',5'-bisphosphate + ERHTRSYDY(sulfated)MEGGD
FGF7-tide, peptide 5-FAM-ERHTRSYDYMEGGD-CONH2, from fibroblast growth factor 7
-
-
?
3'-phosphoadenylyl sulfate + gastrin peptide
adenosine 3',5'-bisphosphate + sulfated gastrin peptide
-
-
-
?
3'-phosphoadenylyl sulfate + P-selectin glycoprotein ligand-1
?
recombinantly expressed substrate PSGL-1, glycoprotein found on the plasma membrane of neutrophils or monocytes. TPST activity on GST-tagged PSGL-1 is not affected by the GST fusion tag
-
-
?
3'-phosphoadenylyl sulfate + peptide Y+1 tyrosine
adenosine 3',5'-bisphosphate + peptide Y+1 tyrosine-O-sulfate
i.e. peptide Glu-Leu-Asp-Tyr-Dap-Gly-Glu-Ala
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
3'-phosphoadenylyl sulfate + PSGL-1
adenosine 3',5'-bisphosphate + PSGL-1 sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + PSGL-1 1-15 peptide
adenosine 3',5'-bisphosphate + sulfated PSGL-1 1-15 peptide
QATEYEYLDYDFLPE-NH2
-
-
?
3'-phosphoadenylyl sulfate + QATEYEYLDYDFLPE
adenosine 3',5'-bisphosphate + QATEsYEsYLDsYDFLPE
human PSGL-1, amino acids 42-56, sulfation order: first Tyr51, second Tyr46 or 48, third Tyr46 or 48
-
-
?
3'-phosphoadenylyl sulfate + QATEYEYLDYDFLPE-NH2
adenosine 3',5'-bisphosphate + ?
P-selectin glycoprotein ligand-1, amino acids 1-15
-
-
?
3'-phosphoadenylyl sulfate + SYGDEYPDYLD
adenosine 3',5'-bisphosphate + SsYGDEsYPDsYLD
G protein-coupled receptor human dez, amino acids 13-23, sulfation order: first Tyr21, second Tyr18, third Tyr14
-
-
?
3'-phosphoadenylyl sulfate + TEYEYLDYDFLPETE
adenosine 3',5'-bisphosphate + TEYEYLDY(sulfated)DFLPETE
PSGL1-tide, peptide 5-FAM-TEYEYLDYDFLPETE-CONH2, from P-selectin glycoprotein ligand-1
-
-
?
3'-phosphoadenylyl sulfate + TTFFDsYDYGA
adenosine 3',5'-bisphosphate + TTFFDsYDsYGA
G protein-coupled receptor, human chemokine receptor 2, amino acids 21-30
-
-
?
3'-phosphoadenylyl sulfate + TTFFDYDsYGA
adenosine 3',5'-bisphosphate + TTFFDsYDsYGA
G protein-coupled receptor, human chemokine receptor 2, amino acids 21-30
-
-
?
3'-phosphoadenylyl sulfate + TTFFDYDYGA
adenosine 3',5'-bisphosphate + TTFFDsYDYGA
G protein-coupled receptor, human chemokine receptor 2, amino acids 21-30
-
-
?
3'-phosphoadenylyl sulfate + TTFFDYDYGA
adenosine 3',5'-bisphosphate + TTFFDYDsYGA
G protein-coupled receptor, human chemokine receptor 2, amino acids 21-30
-
-
?
3'-phosphoadenylyl sulfate + TTVTDYYYPDIFSS
adenosine 3',5'-bisphosphate + TTVTDY(sulfated)YYPDIFSS
CCR8-tide, peptide 5-FAM-TTVTDYYYPDIFSS-CONH2, from C-C motif chemokine receptor 8
-
-
?
3'-phosphoadenylyl sulfate + Tyr-Tyr-Tyr
adenosine 3',5'-bisphosphate + Tyr-Tyr-Tyr-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + vitronectin peptide
adenosine 3',5'-bisphosphate + vitronectin-O-sulfate
amino acids 75-91, Y(SO3H)TVY(SO3H)DDGEEKNDATVHE
-
-
?
3'-phosphoadenylyl sulfate + VTDsYsYYPDI
adenosine 3',5'-bisphosphate + VTDsYsYsYPDI
Tyr16-sulfated G protein-coupled receptor CCR8, amino acids 12-20
-
-
?
3'-phosphoadenylyl sulfate + VTDsYYsYPDI
adenosine 3',5'-bisphosphate + VTDsYsYsYPDI
CC-chemokine receptor 8 nonapeptide, sY15CCR8
-
-
?
3'-phosphoadenylyl sulfate + VTDsYYYPDG
adenosine 3',5'-bisphosphate + VTDsYYsYPDI
CC-chemokine receptor 8 nonapeptide, sY15sY17CCR8
-
-
?
3'-phosphoadenylyl sulfate + VTDsYYYPDI
adenosine 3',5'-bisphosphate + VTDsYYsYPDI
CC-chemokine receptor 8 nonapeptide, amino acids 12-20
-
-
?
3'-phosphoadenylyl sulfate + VTDYsYYPDI
adenosine 3',5'-bisphosphate + VTDsYsYYPDI
Tyr16-sulfated G protein-coupled receptor CCR8, amino acids 12-20
-
-
?
3'-phosphoadenylyl sulfate + VTDYYsYPDI
adenosine 3',5'-bisphosphate + VTDsYYsYPDI
both isoenzymes sequentially sulfate the CCR8 peptide such that Tyr15 is sulfated first followed by Tyr17 sulfation
-
-
?
3'-phosphoadenylyl sulfate + VTDYYYPDI
adenosine 3',5'-bisphosphate + VTDsYYYPDI
non CC-chemokine receptor 8
-
-
?
3'-phosphoadenylyl sulfate + VTDYYYPDI
adenosine 3',5'-bisphosphate + VTDYYsYPDI
a peptide modeled on the N-terminal extracellular domain of human CCR8, amino acids 12-20
-
-
?
3'-phosphoadenylyl sulfate + [PSGL-1 peptide]-L-tyrosine
adenosine 3',5'-bisphosphate + [PSGL-1 peptide]-L-tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + [Y+3 peptide]-L-tyrosine
adenosine 3',5'-bisphosphate + [Y+3 peptide]-L-tyrosine-O-sulfate
i.e. biotin-RDRRQATEYEYLDYDFLPETEPPP
-
-
?
3'-phosphoadenylylsulfate + QATEYEYLDYDFLPEC
adenosine 3',5'-bisphosphate + ?
derived from N-terminal residues of the mature leukocyte adhesion molecule P-selectin glycoprotein ligand 1
-
-
?
3'-phosphoadenylyl sulfate + Ac-YLFSVHWPPLNK(COOSu)A-OH
adenosine 3',5'-bisphosphate + Ac-Y(O-sulfate)LFSVHWPPLNK(COOSu)A-OH
-
an N-succinimidyl carbamate modified peptide substrate
-
-
?
3'-phosphoadenylyl sulfate + Ac-YLFSVHWPPLNKA-OH
adenosine 3',5'-bisphosphate + Ac-Y(O-sulfate)LFSVHWPPLNKA-OH
-
-
-
-
?
3'-phosphoadenylyl sulfate + benzyl-Glu-Tyr
adenosine 3',5'-bisphosphate + benzyl-Glu-Tyr-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + C3aR tyrosine
adenosine 3',5'-bisphosphate + C3aR tyrosine O-sulfate
-
C3a-anaphylatoxin chemotactic receptor,C3aR. Sulfation sequence motif is HNRCGY174KFGLSSSLDY184PDFY188 GDPLEQGFQDY317Y318NLGQF
-
-
?
3'-phosphoadenylyl sulfate + C5aR tyrosine
adenosine 3',5'-bisphosphate + C5aR tyrosine O-sulfate
-
C5a-anaphylatoxin chemotactic receptor. Sulfation sequence motif is TTPDY11GHY14DDKDTLD
-
-
?
3'-phosphoadenylyl sulfate + CC receptor tyrosine
adenosine 3',5'-bisphosphate + CC receptor tyrosine O-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + CCR5 1-18 peptide
adenosine 3',5'-bisphosphate + sulfated CCR5 1-18peptide
-
substrate is a synthetic human CCR5 peptide MDYQVSSPIYDINYYTSE-NH2. Sulfation pattern: Tyr3 is sulfated first, followed by Tyr14 or Tyr15, and finally Tyr10
-
-
?
3'-phosphoadenylyl sulfate + CCR5 2-18 peptide
adenosine 3',5'-bisphosphate + sulfated CCR5 2-18peptide
-
substrate is a synthetic human CCR5 peptide DYQVSSPIYDINYYTSE-NH2. Sulfation pattern: Tyr14 and Tyr15 are sulfated first, followed by Tyr10, with Tyr3 sulfated last
-
-
?
3'-phosphoadenylyl sulfate + CCR8 1-17 M1A peptide
adenosine 3',5'-bisphosphate + sulfated CCR8 1-17 M1A peptide
-
substrate is a synthetic modified mouse CCR8 peptide ADYTMEPNVTMTDYYPD-NH2. Sulfation pattern: Tyr3 is sulfated first, followed by Tyr14, with Tyr15 last
-
-
?
3'-phosphoadenylyl sulfate + CCR8 2-17 M1A peptide
adenosine 3',5'-bisphosphate + sulfated CCR8 2-17 M1A peptide
-
substrate is a synthetic modified mouse CCR8 peptide DYTMEPNVTMTDYYPD-NH2. Sulfation pattern: Tyr14 is sulfated first, followed by Tyr3 and Tyr15
-
-
?
3'-phosphoadenylyl sulfate + CX3CR1 tyrosine
adenosine 3',5'-bisphosphate + CX3CR1 tyrosine O-sulfate
3'-phosphoadenylyl sulfate + CXC-chemokine receptor 4
adenosine 3',5'-bisphosphate + ?
3'-phosphoadenylyl sulfate + CXCR4 1-38
adenosine 3',5'-bisphosphate + ?
CC-chemokine receptor 4 peptide, amino acids 1-38
the enzyme has a strong site preference for sulfation of Tyr-21 over Tyr-7 and Tyr-12, sulfation of Tyr-21 is required for high-affinity interaction with stromal cell-derived factor-1 (SDF-1alpha)
-
?
3'-phosphoadenylyl sulfate + CXCR4 peptide tyrosine
adenosine 3',5'-bisphosphate + CXCR4 peptide tyrosine O-sulfate
-
a cytokine receptor peptide fragment
-
-
?
3'-phosphoadenylyl sulfate + EDFEDYEFDG
adenosine 3',5'-bisphosphate + EDFEDY(sulfated)EFDG
GST-tagged CC4-tide, peptide 5-FAM-EDFEDYEFDG-CONH2, from human complement C4 protein
-
-
?
3'-phosphoadenylyl sulfate + EDYDTTTEFDsYGD
adenosine 3',5'-bisphosphate + EDsYDTTTEFDsYGD
G protein-coupled receptor, human chemokine receptor 1, amino acids 8-20
-
-
?
3'-phosphoadenylyl sulfate + EDYDTTTEFDYGD
adenosine 3',5'-bisphosphate + EDYDTTTEFDsYGD
G protein-coupled receptor human chemokine receptor 1, amino acids 8-20
-
-
?
3'-phosphoadenylyl sulfate + EEPEYGE
adenosine 3',5'-bisphosphate + EEPEY(O-sulfate)GE
-
-
-
-
?
3'-phosphoadenylyl sulfate + ENYSYDLDYYS
adenosine 3',5'-bisphosphate + ENsYSsYDLDsYsYS
G protein-coupled receptor human gpr1, amino acids 13-23, sulfation order: first Tyr21, second Tyr22, third Tyr15 or 17, fourth Tyr 15 or 17
-
-
?
3'-phosphoadenylyl sulfate + ERHTRSYDYMEGGD
adenosine 3',5'-bisphosphate + ERHTRSYDY(sulfated)MEGGD
FGF7-tide, peptide 5-FAM-ERHTRSYDYMEGGD-CONH2, from fibroblast growth factor 7
-
-
?
3'-phosphoadenylyl sulfate + FSHR tyrosine
adenosine 3',5'-bisphosphate + FSHR tyrosine O-sulfate
-
follicle-stimulating hormone receptor, FSHR. Sulfation sequence motif is F-D/E-Y335
-
-
?
3'-phosphoadenylyl sulfate + human anionic trypsinogen tyrosine
adenosine 3',5'-bisphosphate + trypsinogen tyrosine O-sulfate
i.e. serine protease 2, sulfation of Tyr154 facilitated by a unique sequence context which is characteristically found in primate trypsinogens
-
-
?
3'-phosphoadenylyl sulfate + LHR/CGR tyrosine
adenosine 3',5'-bisphosphate + LHR/CGR tyrosine O-sulfate
-
luteinising hormone receptor, LHR/chorionic gonadotropin receptor, CGR. Sulfation sequence motif is Y385-D/E-Y
-
-
?
3'-phosphoadenylyl sulfate + P-selectin glycoprotein ligand-1
?
recombinantly expressed substrate PSGL-1, glycoprotein found on the plasma membrane of neutrophils or monocytes. TPST activity on GST-tagged PSGL-1 is not affected by the GST fusion tag
-
-
?
3'-phosphoadenylyl sulfate + P-selectin glycoprotein ligand-1 tyrosine
adenosine 3',5'-bisphosphate + P-selectin glycoprotein ligand-1 tyrosine O-sulfate
3'-phosphoadenylyl sulfate + peptide C4P5Y3
?
-
-
-
?
3'-phosphoadenylyl sulfate + peptide EAY
adenosine 3',5'-bisphosphate + peptide EAY(O-sulfate)
-
-
-
-
?
3'-phosphoadenylyl sulfate + peptide Y+1 tyrosine
adenosine 3',5'-bisphosphate + peptide Y+1 tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + poly-Glu6Ala3Tyr1 peptide
adenosine 3',5'-bisphosphate + poly-Glu6Ala3Tyrsulfate peptide
-
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
3'-phosphoadenylyl sulfate + PSGL-1
adenosine 3',5'-bisphosphate + PSGL-1 sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + PSGL-1 1-15 peptide
adenosine 3',5'-bisphosphate + sulfated PSGL-1 1-15 peptide
QATEYEYLDYDFLPE-NH2
-
-
?
3'-phosphoadenylyl sulfate + PSGL-1 protein
adenosine 3',5'-bisphosphate + PSGL-1 protein tyrosine-O-sulfate
-
i.e. ATEYEYLDYDFL
-
-
?
3'-phosphoadenylyl sulfate + QATEYEYLDYDFLPE
adenosine 3',5'-bisphosphate + QATEsYEsYLDsYDFLPE
human PSGL-1, amino acids 42-56, sulfation order: first Tyr51, second Tyr46 or 48, third Tyr46 or 48
-
-
?
3'-phosphoadenylyl sulfate + QATEYEYLDYDFLPE-NH2
adenosine 3',5'-bisphosphate + ?
P-selectin glycoprotein ligand-1, amino acids 1-15
-
-
?
3'-phosphoadenylyl sulfate + S1P1R tyrosine
adenosine 3',5'-bisphosphate + S1P1R tyrosine O-sulfate
-
type 1 Sphingosine 1-phosphate receptor, S1P1R. Sulfation sequence motif is D-Y19-V/G/-N-Y22-D
-
-
?
3'-phosphoadenylyl sulfate + statherin
adenosine 3',5'-bisphosphate + statherin O-sulfate
3'-phosphoadenylyl sulfate + statherin
adenosine 3',5'-bisphosphate + statherin-O-sulfate
-
a 43-residue polypeptide, which is tyrosine-rich and contains 7 tyrosine residues
-
-
?
3'-phosphoadenylyl sulfate + SYGDEYPDYLD
adenosine 3',5'-bisphosphate + SsYGDEsYPDsYLD
G protein-coupled receptor human dez, amino acids 13-23, sulfation order: first Tyr21, second Tyr18, third Tyr14
-
-
?
3'-phosphoadenylyl sulfate + TEYEYLDYDFLPETE
adenosine 3',5'-bisphosphate + TEYEYLDY(sulfated)DFLPETE
PSGL1-tide, peptide 5-FAM-TEYEYLDYDFLPETE-CONH2, from P-selectin glycoprotein ligand-1
-
-
?
3'-phosphoadenylyl sulfate + trypsinogen tyrosine
adenosine 3',5'-bisphosphate + trypsinogen tyrosine O-sulfate
sulfation of Tyr154 with Asp as important determinant. Mutation D153N, a naturally occuring polymorphisms in African population, results in a complete loss of trypsinogen sulfation, while mutation of Gly151 and Pro155 of the trypsinogen has no effect on enzyme activity. Genotyping of different populations for the substrate polymorphism, overview
-
-
?
3'-phosphoadenylyl sulfate + TSHR tyrosine
adenosine 3',5'-bisphosphate + TSHR tyrosine O-sulfate
-
thyroid-stimulating hormone receptor, TSHR. Sulfation sequence motif is Y385-D/E-Y
-
-
?
3'-phosphoadenylyl sulfate + TTFFDsYDYGA
adenosine 3',5'-bisphosphate + TTFFDsYDsYGA
G protein-coupled receptor, human chemokine receptor 2, amino acids 21-30
-
-
?
3'-phosphoadenylyl sulfate + TTFFDYDsYGA
adenosine 3',5'-bisphosphate + TTFFDsYDsYGA
G protein-coupled receptor, human chemokine receptor 2, amino acids 21-30
-
-
?
3'-phosphoadenylyl sulfate + TTFFDYDYGA
adenosine 3',5'-bisphosphate + TTFFDsYDYGA
G protein-coupled receptor, human chemokine receptor 2, amino acids 21-30
-
-
?
3'-phosphoadenylyl sulfate + TTFFDYDYGA
adenosine 3',5'-bisphosphate + TTFFDYDsYGA
G protein-coupled receptor, human chemokine receptor 2, amino acids 21-30
-
-
?
3'-phosphoadenylyl sulfate + TTVTDYYYPDIFSS
adenosine 3',5'-bisphosphate + TTVTDY(sulfated)YYPDIFSS
CCR8-tide, peptide 5-FAM-TTVTDYYYPDIFSS-CONH2, from C-C motif chemokine receptor 8
-
-
?
3'-phosphoadenylyl sulfate + Tyr-Tyr-Tyr
adenosine 3',5'-bisphosphate + Tyr-Tyr-Tyr-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + vitronectin peptide
adenosine 3',5'-bisphosphate + vitronectin-O-sulfate
amino acids 75-91, Y(SO3H)TVY(SO3H)DDGEEKNDATVHE
-
-
?
3'-phosphoadenylyl sulfate + VTDsYsYYPDI
adenosine 3',5'-bisphosphate + VTDsYsYsYPDI
Tyr16-sulfated G protein-coupled receptor CCR8, amino acids 12-20
-
-
?
3'-phosphoadenylyl sulfate + VTDsYYsYPDI
adenosine 3',5'-bisphosphate + VTDsYsYsYPDI
CC-chemokine receptor 8 nonapeptide, sY15CCR8
-
-
?
3'-phosphoadenylyl sulfate + VTDsYYYPDG
adenosine 3',5'-bisphosphate + VTDsYYsYPDI
CC-chemokine receptor 8 nonapeptide, sY15sY17CCR8
-
-
?
3'-phosphoadenylyl sulfate + VTDsYYYPDI
adenosine 3',5'-bisphosphate + VTDsYYsYPDI
3'-phosphoadenylyl sulfate + VTDYsYYPDI
adenosine 3',5'-bisphosphate + VTDsYsYYPDI
Tyr16-sulfated G protein-coupled receptor CCR8, amino acids 12-20
-
-
?
3'-phosphoadenylyl sulfate + VTDYYsYPDI
adenosine 3',5'-bisphosphate + VTDsYYsYPDI
both isoenzymes sequentially sulfate the CCR8 peptide such that Tyr15 is sulfated first followed by Tyr17 sulfation
-
-
?
3'-phosphoadenylyl sulfate + VTDYYYPDI
adenosine 3',5'-bisphosphate + VTDsYYYPDI
3'-phosphoadenylyl sulfate + VTDYYYPDI
adenosine 3',5'-bisphosphate + VTDYYsYPDI
a peptide modeled on the N-terminal extracellular domain of human CCR8, amino acids 12-20
-
-
?
3'-phosphoadenylyl sulfate + [PSGL-1 peptide]-L-tyrosine
adenosine 3',5'-bisphosphate + [PSGL-1 peptide]-L-tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + [Y+3 peptide]-L-tyrosine
adenosine 3',5'-bisphosphate + [Y+3 peptide]-L-tyrosine-O-sulfate
i.e. biotin-RDRRQATEYEYLDYDFLPETEPPP
-
-
?
3'-phosphoadenylylsulfate + acidic amino acid polymer EAY
adenosine 3',5'-bisphosphate + ?
-
i.e. poly-EAY or Glu6,Ala3,Tyr1, model substrate
-
-
?
3'-phosphoadenylylsulfate + acidic polypeptide tyrosine
adenosine 3',5'-bisphosphate + acidic polypeptide tyrosine-O-sulfate
-
-
-
-
?
3'-phosphoadenylylsulfate + C4 alpha chain
adenosine 3',5'-bisphosphate + ?
-
more efficiently sulphated by TPST1 than TPST2
-
-
?
3'-phosphoadenylylsulfate + DYQVSSPIYDINYYTSE
adenosine 3',5'-bisphosphate + ?
-
amino acids 2-18 derived from peptide CC-chemokine receptor 5, final product has four sulfotyrosine residues, sulfation occurs in the following order: Tyr13, Tyr14, Tyr9, Tyr2
-
-
?
3'-phosphoadenylylsulfate + heparin cofactor II
adenosine 3',5'-bisphosphate + ?
-
more efficiently sulphated by TPST1 than TPST2
-
-
?
3'-phosphoadenylylsulfate + protein tyrosine
adenosine 3',5'-bisphosphate + acidic polypeptide tyrosine-O-sulfate
-
post-translational modification of biologically active peptides and proteins
-
-
?
3'-phosphoadenylylsulfate + QATEYEYLDYDFLPE
adenosine 3',5'-bisphosphate + ?
-
derived from N-terminal residues of the mature leukocyte adhesion molecule P-selectin glycoprotein ligand 1
-
-
?
additional information
?
-
3'-phosphoadenylyl sulfate + CXC-chemokine receptor 4
adenosine 3',5'-bisphosphate + ?
CXCR4 signaling is indispensable for embryonic development
-
-
?
3'-phosphoadenylyl sulfate + CXC-chemokine receptor 4
adenosine 3',5'-bisphosphate + ?
CXCR4
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
low activity, isozyme TPST-1
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
tyrosine O-sulfation is a key post-translational modification that regulates protein-protein interactions in extracellular space
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
CC-chemokine receptor 8 nonapeptide, sY15CCR8 I20G mutant
-
-
?
3'-phosphoadenylyl sulfate + CX3CR1 tyrosine
adenosine 3',5'-bisphosphate + CX3CR1 tyrosine O-sulfate
-
a cytokine receptor for CXCL10/IP-10 and CXCL11/I-TAC, contains two potential tyrosine sulfation sites within the sequence ENFSSSY27DY29GENESDS
-
-
?
3'-phosphoadenylyl sulfate + CX3CR1 tyrosine
adenosine 3',5'-bisphosphate + CX3CR1 tyrosine O-sulfate
-
a cytokine receptor for CXCL10/IP-10 and CXCL11/I-TAC, contains two potential tyrosine sulfation sites within the sequence ENFSSSY27DY29GENESDS. Determination of sulfation sites by mutational analyis, overview. CX3CR1 has one known chemokine ligand, fractalkine and two tyrosine residues in its N-terminal region, Tyr14 and Tyr22
-
-
?
3'-phosphoadenylyl sulfate + CXC-chemokine receptor 4
adenosine 3',5'-bisphosphate + ?
CXCR4 signaling is indispensable for embryonic development
-
-
?
3'-phosphoadenylyl sulfate + CXC-chemokine receptor 4
adenosine 3',5'-bisphosphate + ?
CXCR4
-
-
?
3'-phosphoadenylyl sulfate + P-selectin glycoprotein ligand-1 tyrosine
adenosine 3',5'-bisphosphate + P-selectin glycoprotein ligand-1 tyrosine O-sulfate
-
sulfoTyr plays a functional role is P-selectin glycoprotein ligand-1, which is involved in leukocyte-mediated inflammation
-
-
?
3'-phosphoadenylyl sulfate + P-selectin glycoprotein ligand-1 tyrosine
adenosine 3',5'-bisphosphate + P-selectin glycoprotein ligand-1 tyrosine O-sulfate
-
tyrosine sulfation of the amino-terminal region, structural basis of sulfotyrosine recognition, overview
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate
-
sulfation of protein in the retina, identification of protein substrates, sulfation pattern, overview
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
high activity, isozyme TPST-2
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
TPST is responsible for the sulfation of a variety of secretory and membrane proteins
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
tyrosine O-sulfation is a key post-translational modification that regulates protein-protein interactions in extracellular space
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
CC-chemokine receptor 8 nonapeptide, sY15CCR8 I20G mutant
-
-
?
3'-phosphoadenylyl sulfate + statherin
adenosine 3',5'-bisphosphate + statherin O-sulfate
-
TPST is responsible for the sulfation of a variety of secretory and membrane proteins, e.g. of the salivary secretory protein, statherin
-
-
?
3'-phosphoadenylyl sulfate + statherin
adenosine 3',5'-bisphosphate + statherin O-sulfate
-
determination of sulfation on a tyrosyl residue, probably in the sequence E-Q-P-L-Y, residues 26-30
-
-
?
3'-phosphoadenylyl sulfate + VTDsYYYPDI
adenosine 3',5'-bisphosphate + VTDsYYsYPDI
-
-
-
-
ir
3'-phosphoadenylyl sulfate + VTDsYYYPDI
adenosine 3',5'-bisphosphate + VTDsYYsYPDI
CC-chemokine receptor 8 nonapeptide, amino acids 12-20
-
-
?
3'-phosphoadenylyl sulfate + VTDYYYPDI
adenosine 3',5'-bisphosphate + VTDsYYYPDI
-
-
-
-
ir
3'-phosphoadenylyl sulfate + VTDYYYPDI
adenosine 3',5'-bisphosphate + VTDsYYYPDI
non CC-chemokine receptor 8
-
-
?
additional information
?
-
activity with peptides encompassing tyrosine sulfation sites of chemokine receptors, CCR2, CCR3, CCR5, CCR8, cholecystokinin CCK, and complement C4, overview
-
-
?
additional information
?
-
activity with peptides encompassing tyrosine sulfation sites of chemokine receptors, CCR2, CCR3, CCR5, CCR8, cholecystokinin CCK, and complement C4, overview
-
-
?
additional information
?
-
-
activity with peptides encompassing tyrosine sulfation sites of chemokine receptors, CCR2, CCR3, CCR5, CCR8, cholecystokinin CCK, and complement C4, overview
-
-
?
additional information
?
-
a microfluidic assay is used to quantify real-time peptide sulfation by TPST1. No activity with peptide lacking the single acceptor tyrosine residue, 5-FAM-EDFEDFEFDG-CONH2
-
-
-
additional information
?
-
a microfluidic assay is used to quantify real-time peptide sulfation by TPST1. No activity with peptide lacking the single acceptor tyrosine residue, 5-FAM-EDFEDFEFDG-CONH2
-
-
-
additional information
?
-
development of a fluorescent peptide assay, termed TPST2/Y+1 peptide assay, for TPST1 and 2 activity, substrate screening using the LOPAC library in a high-throughput screening, overview
-
-
-
additional information
?
-
development of a fluorescent peptide assay, termed TPST2/Y+1 peptide assay, for TPST1 and 2 activity, substrate screening using the LOPAC library in a high-throughput screening, overview
-
-
-
additional information
?
-
in vitro sulfation of peptide substrates, analytical and semipreparative-scale peptide sulfation reactions, product analysis by NMR
-
-
-
additional information
?
-
in vitro sulfation of peptide substrates, analytical and semipreparative-scale peptide sulfation reactions, product analysis by NMR
-
-
-
additional information
?
-
synthetic fluorescent substrates, fluorescein-tagged hexasaccharide glycans, or FAM-labelled peptides derived from physiological target proteins are used in microfluidics-based mobility shift assay (MSA) to carry out real-time analysis of the enzyme kinetics of TPST 1/2
-
-
-
additional information
?
-
the structures of TPST1 complexed with two substrate peptides (C4P5Y5 derived from complement C4 and a gastrin peptide), that are catalysed by human TPST1 with significantly different efficiencies, reveal details about the binding modes found in the two complexes and into the sulfation mechanism for these substrates. The structures also contain only lumenal portion of the enzyme, without the N-terminus and the TM domain. The active site of human TPST1 recognizes the residue at the -3 position in the substrate through electrostatic and hydrophobic interactions. The enzyme shows broad substrate specificity
-
-
-
additional information
?
-
-
the structures of TPST1 complexed with two substrate peptides (C4P5Y5 derived from complement C4 and a gastrin peptide), that are catalysed by human TPST1 with significantly different efficiencies, reveal details about the binding modes found in the two complexes and into the sulfation mechanism for these substrates. The structures also contain only lumenal portion of the enzyme, without the N-terminus and the TM domain. The active site of human TPST1 recognizes the residue at the -3 position in the substrate through electrostatic and hydrophobic interactions. The enzyme shows broad substrate specificity
-
-
-
additional information
?
-
activity with peptides encompassing tyrosine sulfation sites of chemokine receptors, CCR2, CCR3, CCR5, CCR8, cholecystokinin CCK, and complement C4, overview
-
-
?
additional information
?
-
activity with peptides encompassing tyrosine sulfation sites of chemokine receptors, CCR2, CCR3, CCR5, CCR8, cholecystokinin CCK, and complement C4, overview
-
-
?
additional information
?
-
-
activity with peptides encompassing tyrosine sulfation sites of chemokine receptors, CCR2, CCR3, CCR5, CCR8, cholecystokinin CCK, and complement C4, overview
-
-
?
additional information
?
-
-
sulfation patterns, overview
-
-
?
additional information
?
-
-
enzyme activity with CCR receptors, overview
-
-
?
additional information
?
-
a microfluidic assay is used to quantify real-time peptide sulfation by TPST2. No activity with peptide lacking the single acceptor tyrosine residue, 5-FAM-EDFEDFEFDG-CONH2
-
-
-
additional information
?
-
a microfluidic assay is used to quantify real-time peptide sulfation by TPST2. No activity with peptide lacking the single acceptor tyrosine residue, 5-FAM-EDFEDFEFDG-CONH2
-
-
-
additional information
?
-
development of a fluorescent peptide assay, termed TPST2/Y+1 peptide assay, for TPST1 and 2 activity, substrate screening using the LOPAC library in a high-throughput screening, overview
-
-
-
additional information
?
-
development of a fluorescent peptide assay, termed TPST2/Y+1 peptide assay, for TPST1 and 2 activity, substrate screening using the LOPAC library in a high-throughput screening, overview
-
-
-
additional information
?
-
in vitro sulfation of peptide substrates, analytical and semipreparative-scale peptide sulfation reactions
-
-
-
additional information
?
-
in vitro sulfation of peptide substrates, analytical and semipreparative-scale peptide sulfation reactions
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3'-phosphoadenylyl sulfate + CXC-chemokine receptor 4
adenosine 3',5'-bisphosphate + ?
CXCR4 signaling is indispensable for embryonic development
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
3'-phosphoadenylyl sulfate + C3aR tyrosine
adenosine 3',5'-bisphosphate + C3aR tyrosine O-sulfate
-
C3a-anaphylatoxin chemotactic receptor,C3aR. Sulfation sequence motif is HNRCGY174KFGLSSSLDY184PDFY188 GDPLEQGFQDY317Y318NLGQF
-
-
?
3'-phosphoadenylyl sulfate + C5aR tyrosine
adenosine 3',5'-bisphosphate + C5aR tyrosine O-sulfate
-
C5a-anaphylatoxin chemotactic receptor. Sulfation sequence motif is TTPDY11GHY14DDKDTLD
-
-
?
3'-phosphoadenylyl sulfate + CC receptor tyrosine
adenosine 3',5'-bisphosphate + CC receptor tyrosine O-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + CX3CR1 tyrosine
adenosine 3',5'-bisphosphate + CX3CR1 tyrosine O-sulfate
-
a cytokine receptor for CXCL10/IP-10 and CXCL11/I-TAC, contains two potential tyrosine sulfation sites within the sequence ENFSSSY27DY29GENESDS
-
-
?
3'-phosphoadenylyl sulfate + CXC-chemokine receptor 4
adenosine 3',5'-bisphosphate + ?
CXCR4 signaling is indispensable for embryonic development
-
-
?
3'-phosphoadenylyl sulfate + FSHR tyrosine
adenosine 3',5'-bisphosphate + FSHR tyrosine O-sulfate
-
follicle-stimulating hormone receptor, FSHR. Sulfation sequence motif is F-D/E-Y335
-
-
?
3'-phosphoadenylyl sulfate + LHR/CGR tyrosine
adenosine 3',5'-bisphosphate + LHR/CGR tyrosine O-sulfate
-
luteinising hormone receptor, LHR/chorionic gonadotropin receptor, CGR. Sulfation sequence motif is Y385-D/E-Y
-
-
?
3'-phosphoadenylyl sulfate + P-selectin glycoprotein ligand-1 tyrosine
adenosine 3',5'-bisphosphate + P-selectin glycoprotein ligand-1 tyrosine O-sulfate
-
sulfoTyr plays a functional role is P-selectin glycoprotein ligand-1, which is involved in leukocyte-mediated inflammation
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
3'-phosphoadenylyl sulfate + PSGL-1 protein
adenosine 3',5'-bisphosphate + PSGL-1 protein tyrosine-O-sulfate
-
i.e. ATEYEYLDYDFL
-
-
?
3'-phosphoadenylyl sulfate + S1P1R tyrosine
adenosine 3',5'-bisphosphate + S1P1R tyrosine O-sulfate
-
type 1 Sphingosine 1-phosphate receptor, S1P1R. Sulfation sequence motif is D-Y19-V/G/-N-Y22-D
-
-
?
3'-phosphoadenylyl sulfate + statherin
adenosine 3',5'-bisphosphate + statherin O-sulfate
-
TPST is responsible for the sulfation of a variety of secretory and membrane proteins, e.g. of the salivary secretory protein, statherin
-
-
?
3'-phosphoadenylyl sulfate + trypsinogen tyrosine
adenosine 3',5'-bisphosphate + trypsinogen tyrosine O-sulfate
sulfation of Tyr154 with Asp as important determinant. Mutation D153N, a naturally occuring polymorphisms in African population, results in a complete loss of trypsinogen sulfation, while mutation of Gly151 and Pro155 of the trypsinogen has no effect on enzyme activity. Genotyping of different populations for the substrate polymorphism, overview
-
-
?
3'-phosphoadenylyl sulfate + TSHR tyrosine
adenosine 3',5'-bisphosphate + TSHR tyrosine O-sulfate
-
thyroid-stimulating hormone receptor, TSHR. Sulfation sequence motif is Y385-D/E-Y
-
-
?
3'-phosphoadenylyl sulfate + VTDsYYYPDI
adenosine 3',5'-bisphosphate + VTDsYYsYPDI
-
-
-
-
ir
3'-phosphoadenylyl sulfate + VTDYYYPDI
adenosine 3',5'-bisphosphate + VTDsYYYPDI
-
-
-
-
ir
3'-phosphoadenylylsulfate + protein tyrosine
adenosine 3',5'-bisphosphate + acidic polypeptide tyrosine-O-sulfate
-
post-translational modification of biologically active peptides and proteins
-
-
?
additional information
?
-
-
sulfation patterns, overview
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
tyrosine O-sulfation is a key post-translational modification that regulates protein-protein interactions in extracellular space
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine O-sulfate
-
sulfation of protein in the retina, identification of protein substrates, sulfation pattern, overview
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
-
TPST is responsible for the sulfation of a variety of secretory and membrane proteins
-
-
?
3'-phosphoadenylyl sulfate + protein tyrosine
adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate
tyrosine O-sulfation is a key post-translational modification that regulates protein-protein interactions in extracellular space
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Rens-Domiano, S.; Roth, J.A.
Characterization of tyrosylprotein sulfotransferase from rat liver and other tissues
J. Biol. Chem.
264
899-905
1989
Homo sapiens, Mesocricetus auratus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
brenda
Lin, W.H.; Roth, J.A.
Characterization of a tyrosylprotein sulfotransferase in human liver
Biochem. Pharmacol.
40
629-635
1990
Homo sapiens
brenda
Goettsch, S.; Goettsch, W.; Morawietz, H.; Bayer, P.
Shear stress mediates tyrosylprotein sulfotransferase isoform shift in human endothelial cells
Biochem. Biophys. Res. Commun.
294
541-546
2002
Homo sapiens
brenda
Moore, K.L.
The biology and enzymology of protein tyrosine O-sulfation
J. Biol. Chem.
278
24243-24246
2003
Homo sapiens, Mammalia, no activity in yeast, no activity in prokaryotes, Drosophila melanogaster (Q9VYB7)
brenda
Ouyang, Y.; Lane, W.S.; Moore, K.L.
Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins
Proc. Natl. Acad. Sci. USA
95
2896-2901
1998
Homo sapiens (O60507), Homo sapiens, Mus musculus (O70281), Mus musculus, Rattus norvegicus
brenda
Seibert, C.; Cadene, M.; Sanfiz, A.; Chait, B.T.; Sakmar, T.P.
Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence
Proc. Natl. Acad. Sci. USA
99
11031-11036
2002
Homo sapiens
brenda
Kasinathan, C.; Ramaprasad, P.; Sundaram, P.
Identification and characterization of tyrosylprotein sulfotransferase from human saliva
Int. J. Biol. Sci.
1
141-145
2005
Homo sapiens
brenda
Mishiro, E.; Sakakibara, Y.; Liu, M.; Suiko, M.
Differential enzymatic characteristics and tissue-specific expression of human TPST-1 and TPST-2
J. Biochem.
140
731-737
2006
Homo sapiens (O60507), Homo sapiens (O60704), Homo sapiens
brenda
Goettsch, S.; Badea, R.A.; Mueller, J.W.; Wotzlaw, C.; Schoelermann, B.; Schulz, L.; Rabiller, M.; Bayer, P.; Hartmann-Fatu, C.
Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment
J. Mol. Biol.
361
436-449
2006
Homo sapiens
brenda
Kasinathan, C.; Jean, S.; Manowitz, P.
Tyrosine sulfation of arylsulfatase A and its peptide
Protein Pept. Lett.
13
357-361
2006
Homo sapiens
brenda
Seibert, C.; Veldkamp, C.T.; Peterson, F.C.; Chait, B.T.; Volkman, B.F.; Sakmar, T.P.
Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases
Biochemistry
47
11251-11262
2008
Homo sapiens (O60507), Homo sapiens (O60704), Homo sapiens
brenda
Nishimura, M.; Naito, S.
Tissue-specific mRNA expression profiles of human carbohydrate sulfotransferase and tyrosylprotein sulfotransferase
Biol. Pharm. Bull.
30
821-825
2007
Homo sapiens, Homo sapiens (O60507)
brenda
Kasinathan, C.; Gandhi, N.; Ramaprasad, P.; Sundaram, P.; Ramasubbu, N.
Tyrosine sulfation of statherin
Int. J. Biol. Sci.
3
237-241
2007
Homo sapiens
brenda
Danan, L.M.; Yu, Z.; Hoffhines, A.J.; Moore, K.L.; Leary, J.A.
Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2
J. Am. Soc. Mass Spectrom.
19
1459-1466
2008
Homo sapiens (O60507), Homo sapiens (O60704), Homo sapiens
brenda
Yu, Y.; Hoffhines, A.J.; Moore, K.L.; Leary, J.A.
Determination of the sites of tyrosine O-sulfation in peptides and proteins
Nat. Methods
4
583-588
2007
Homo sapiens (O60507), Homo sapiens (O60704)
brenda
Ronai, Z.; Witt, H.; Rickards, O.; Destro-Bisol, G.; Bradbury, A.R.; Sahin-Toth, M.
A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2)
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Homo sapiens (O60704), Homo sapiens
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Jen, C.H.; Moore, K.L.; Leary, J.A.
Pattern and temporal sequence of sulfation of CCR5 N-terminal peptides by tyrosylprotein sulfotransferase-2: an assessment of the effects of N-terminal residues
Biochemistry
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2009
Homo sapiens
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Mhidia, R.; Vallin, A.; Ollivier, N.; Blanpain, A.; Shi, G.; Christiano, R.; Johannes, L.; Melnyk, O.
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Homo sapiens
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Kanan, Y.; Hoffhines, A.; Rauhauser, A.; Murray, A.; Al-Ubaidi, M.R.
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Homo sapiens, Mus musculus
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Stone, M.J.; Chuang, S.; Hou, X.; Shoham, M.; Zhu, J.Z.
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Bos taurus, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
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Lu, L.; Chen, B.; Wu, J.; Wang, C.; Chen, D.; Yang, Y.
Implantation of post-translational tyrosylprotein sulfation into a prokaryotic expression system
ChemBioChem
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2011
Homo sapiens
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Danan, L.M.; Yu, Z.; Ludden, P.J.; Jia, W.; Moore, K.L.; Leary, J.A.
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Homo sapiens
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Teramoto, T.; Fujikawa, Y.; Kawaguchi, Y.; Kurogi, K.; Soejima, M.; Adachi, R.; Nakanishi, Y.; Mishiro-Sato, E.; Liu, M.C.; Sakakibara, Y.; Suiko, M.; Kimura, M.; Kakuta, Y.
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Nat. Commun.
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Homo sapiens (O60704), Homo sapiens
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Zhou, W.; Duckworth, B.P.; Geraghty, R.J.
Fluorescent peptide sensors for tyrosylprotein sulfotransferase activity
Anal. Biochem.
461
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Homo sapiens (O60507), Homo sapiens (O60704), Homo sapiens
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Marforio, T.D.; Giacinto, P.; Bottoni, A.; Calvaresi, M.
Computational evidence for the catalytic mechanism of tyrosylprotein sulfotransferases: a density functional theory investigation
Biochemistry
54
4404-4410
2015
Homo sapiens (O60704), Homo sapiens
brenda
Nedumpully-Govindan, P.; Li, L.; Alexov, E.G.; Blenner, M.A.; Ding, F.
Structural and energetic determinants of tyrosylprotein sulfotransferase sulfation specificity
Bioinformatics
30
2302-2309
2014
Homo sapiens (O60507), Homo sapiens (O60704)
brenda
Hartmann-Fatu, C.; Bayer, P.
Determinants of tyrosylprotein sulfation coding and substrate specificity of tyrosylprotein sulfotransferases in metazoans
Chem. Biol. Interact.
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2016
Homo sapiens (O60507), Homo sapiens (O60704)
brenda
Hartmann-Fatu, C.; Trusch, F.; Moll, C.N.; Michin, I.; Hassinen, A.; Kellokumpu, S.; Bayer, P.
Heterodimers of tyrosylprotein sulfotransferases suggest existence of a higher organization level of transferases in the membrane of the trans-Golgi apparatus
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Homo sapiens
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Jiang, Z.; Zhu, J.; Ma, Y.; Hong, C.; Xiao, S.; Jin, L.
Tyrosylprotein sulfotransferase 1 expression is negatively correlated with c-Met and lymph node metastasis in human lung cancer
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2015
Homo sapiens (O60507), Homo sapiens
brenda
Singh, W.; Karabencheva-Christova, T.; Black, G.; Sparagano, O.; Christov, C.
Conformational flexibility influences structure-function relationships in tyrosyl protein sulfotransferase-2
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2016
Homo sapiens (O60704)
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Singh, W.; Karabencheva-Christova, T.; Sparagano, O.; Black, G.; Petrov, P.; Christov, C.
Dimerization and ligand binding in tyrosylprotein sulfotransferase-2 are influenced by molecular motions
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Homo sapiens (O60704)
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Wang, C.C.; Chen, B.H.; Lu, L.Y.; Hung, K.S.; Yang, Y.S.
Preparation of tyrosylprotein sulfotransferases for in vitro one-pot enzymatic synthesis of sulfated proteins/peptides
ACS Omega
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11633-11642
2018
Drosophila melanogaster (Q9VYB7), Drosophila melanogaster, Homo sapiens (O60507), Homo sapiens (O60704), Homo sapiens
brenda
Zhou, W.; Wang, Y.; Xie, J.; Geraghty, R.J.
A fluorescence-based high-throughput assay to identify inhibitors of tyrosylprotein sulfotransferase activity
Biochem. Biophys. Res. Commun.
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Homo sapiens (O60507), Homo sapiens (O60704)
brenda
Byrne, D.P.; Li, Y.; Ngamlert, P.; Ramakrishnan, K.; Eyers, C.E.; Wells, C.; Drewry, D.H.; Zuercher, W.J.; Berry, N.G.; Fernig, D.G.; Eyers, P.A.
New tools for evaluating protein tyrosine sulfation tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors
Biochem. J.
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2018
Homo sapiens (O60507), Homo sapiens (O60704)
brenda
Yeoh, S.; Bayliss, R.
New tools for evaluating protein tyrosine sulfation and carbohydrate sulfation
Biochem. J.
475
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2018
Homo sapiens (O60507)
brenda
Seibert, C.; Sanfiz, A.; Sakmar, T.P.; Veldkamp, C.T.
Preparation and analysis of N-terminal chemokine receptor sulfopeptides using tyrosylprotein sulfotransferase enzymes
Methods Enzymol.
570
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2016
Homo sapiens (O60507), Homo sapiens (O60704)
brenda
Tanaka, S.; Nishiyori, T.; Kojo, H.; Otsubo, R.; Tsuruta, M.; Kurogi, K.; Liu, M.C.; Suiko, M.; Sakakibara, Y.; Kakuta, Y.
Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1
Sci. Rep.
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8776
2017
Homo sapiens (O60507), Homo sapiens
brenda