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Information on EC 2.8.2.1 - aryl sulfotransferase and Organism(s) Macaca fascicularis and UniProt Accession P52846

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EC Tree
     2 Transferases
         2.8 Transferring sulfur-containing groups
             2.8.2 Sulfotransferases
                2.8.2.1 aryl sulfotransferase
IUBMB Comments
A number of aromatic compounds can act as acceptors. Organic hydroxylamines are not substrates (cf. EC 2.8.2.9 tyrosine-ester sulfotransferase).
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This record set is specific for:
Macaca fascicularis
UNIPROT: P52846
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Word Map
The taxonomic range for the selected organisms is: Macaca fascicularis
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
sult1a1, sult2a1, sult1e1, sulphotransferase, sult1a3, phenol sulfotransferase, cytosolic sulfotransferase, sult4a1, sult1b1, sult1a2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cytosolic sulfotransferase
-
1-naphthol phenol sulfotransferase
-
-
-
-
2-naphtholsulfotransferase
-
-
-
-
4-nitrocatechol sulfokinase
-
-
-
-
arylsulfotransferase
-
-
-
-
ASTIV
-
-
-
-
catecholamine-sulfating phenol sulfotransferase
-
-
-
-
DOPA/tyrosine sulfotransferase
-
-
-
-
dopamine sulfotransferase
-
-
-
-
HAST1/HAST2
-
-
-
-
HAST3
-
-
-
-
hippocampal phenol sulfotransferase
-
-
-
-
M-PST
-
-
-
-
minoxidil sulfotransferase
-
-
-
-
monoamine sulfotransferase
-
-
-
-
p-nitrophenol sulfotransferase
-
-
-
-
P-PST
-
-
-
-
phenol sulfokinase
-
-
-
-
phenol sulfotransferase
-
-
-
-
phenol/aryl sulfotransferase
-
-
-
-
Pst
-
-
-
-
ritodrine sulfotransferase
-
-
-
-
ST1A2
-
-
-
-
ST1A3
-
-
-
-
ST1A4
-
-
-
-
sulfokinase
-
-
-
-
sulfotransferase, aryl
-
-
-
-
sulfotransferase, monoamine-preferring
-
-
-
-
thermolabile phenol sulfotransferase
-
-
-
-
thermostable phenol sulfotransferase
-
-
-
-
TL-PST
-
-
-
-
TS-PST
-
-
-
-
tyrosine-ester sulfotransferase
-
-
-
-
additional information
cf. EC 2.8.2.4
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
mechanism
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
sulfate group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -
SYSTEMATIC NAME
IUBMB Comments
3'-phosphoadenylyl-sulfate:phenol sulfotransferase
A number of aromatic compounds can act as acceptors. Organic hydroxylamines are not substrates (cf. EC 2.8.2.9 tyrosine-ester sulfotransferase).
CAS REGISTRY NUMBER
COMMENTARY hide
9026-09-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylyl sulfate + 1-naphthol
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
show the reaction diagram
3'-phosphoadenylyl sulfate + 4-nitrophenol
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + a phenol
adenosine 3',5'-bisphosphate + an aryl sulfate
show the reaction diagram
-
-
r
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + dopamine
adenosine 3',5'-bisphosphate + dopamine sulfate
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenylyl sulfate + 17beta-estradiol
adenosine 3',5'-bisphosphate + 17beta-estradiol sulfate
show the reaction diagram
-
-
-
?
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
show the reaction diagram
-
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
kinetics
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
predominantly
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
gene structure and genomic organization of each cynomolgus SULTs are similar to those of the human orthologues. Tissue distribution and sbstrate specificities of SULTS from humans and Cynomolgus macaques, overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ST1A1_MACFA
295
0
34239
Swiss-Prot
other Location (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene SULT1A1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, gene structure and genomic organization of each cynomolgus SULTs, cynomolgus SULT1A1 and SULT1A3 form a gene cluster with SULT1A1-like and SULT1A-like genes on chromosome 20, recombinant expression in Escherichia coli cytosol, quantitative real-time RT-PCR enzyme expression analysis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Duffel, M.W.; Marshall, A.D.; McPhie, P.; Sharma, V.; Jakoby, W.B.
Enzymatic aspects of the phenol (aryl) sulfotransferases
Drug Metab. Rev.
33
369-395
2001
Bos taurus, Homo sapiens, Homo sapiens (O00338), Homo sapiens (O43704), Homo sapiens (O75897), Mus musculus, Mus musculus (Q3UZZ6), Mus musculus (Q80VR3), Mus musculus (Q9QWG7), Rattus norvegicus, Rattus norvegicus (P50237), Rattus norvegicus (P52847), Rattus norvegicus (Q9WUW8), Rattus norvegicus (Q9WUW9), Oryctolagus cuniculus (O46503), Oryctolagus cuniculus (Q9XT99), Macaca fascicularis (P52846), Canis lupus familiaris (Q29476), Oryctolagus cuniculus ST1A8 (Q9XT99), Oryctolagus cuniculus ST1C5 (O46503), Mus musculus ST1c4 (Q80VR3), Macaca fascicularis ST1A9 (P52846), Mus musculus ST1a4
Manually annotated by BRENDA team
Uno, Y.; Murayama, N.; Yamazaki, H.
Molecular and functional characterization of cytosolic sulfotransferases in cynomolgus macaque
Biochem. Pharmacol.
166
153-162
2019
Macaca fascicularis (P52846), Macaca fascicularis
Manually annotated by BRENDA team