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Information on EC 2.7.8.27 - sphingomyelin synthase and Organism(s) Mus musculus and UniProt Accession Q8VCQ6
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2.7.8.27 sphingomyelin synthaseIUBMB Comments
The reaction can occur in both directions . This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism . Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types . Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin .
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Word Map
- 2.7.8.27
- sphingolipids
- sphingomyelinase
- diacylglycerol
- glucosylceramide
-
microdomains
- ceramidase
-
phosphatidylcholine-specific
- phosphoethanolamine
- pc-plc
- dihydroceramide
-
2-hydroxyoleic
- cert
- medicine
- tricyclodecan-9-yl-xanthogenate
- analysis
- drug development
- pharmacology
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
sphingomyelin synthase, sm synthase, sgms1, sphingomyelin synthase 1, sphingomyelin synthase 2, sgms2, sphingomyelin-synthase, sm synthase 1, sphingomyelin synthases 1, sphingomyelin synthase-related protein, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SM synthase
SMS
SMS1
SMS2
sphingomyelin synthase 2
SYSTEMATIC NAME
IUBMB Comments
ceramide:phosphatidylcholine cholinephosphotransferase
The reaction can occur in both directions [3]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [4]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [4]. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [2].
CAS REGISTRY NUMBER
COMMENTARY
58703-97-2
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)sphingosine + phosphatidylcholine
N-hexanoyl-4-nitrobenz-2-oxa-1,3-diazole-sphingomyelin + 1,2-diacylglycerol
-
-
-
?
6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)-sphingosine + 1,2-dimyristoyl-sn-glycero-3-phosphocholine
N-(N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-epsilon-aminohexanoyl)sphingosylphosphorylcholine + ?
-
-
-
-
?
6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)sphingosine + phosphatidylcholine
N-hexanoyl-4-nitrobenz-2-oxa-1,3-diazole-sphingomyelin + 1,2-diacylglycerol
-
-
-
?
a ceramide + a phosphatidylcholine
a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
-
-
?
N-(6-((7-nitrobenz-2-oxa-1.3-diazol-4-yl)amino)hexanoyl)-sphingosine + a phosphatidylcholine
N-(6-((7-nitro-2-1,3-benzoxadiazol-4-yl)amino)hexanoyl)-sphingosine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
i.e. C6-NBD-ceramide
i.e. C6-NBD-sphingomyelin or C6-NBDCerPCho
-
?
N-lauroyl-D-erythro-sphingosylphosphorylcholine + N-(6-[(7-nitro-benz-2-oxa-1,3-diazo-4-yl)amino]caproyl)-ceramide
?
-
i.e. lauroyl sphingomyelin and C6-NBD-ceramide
-
-
?
phosphatidylcholine + C6-ceramide
C6-sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
-
?
phosphatidylcholine + ceramide
sphingomyelin + 1,2-diacyl-sn-glycerol
-
-
-
?
additional information
?
-
SMS1 not only suppresses the effects of Bax overexpression, but it also blocks the deleterious effects of a number of other stresses, including hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sphingomyelin synthase 1 likely prevents cell death by counteracting stress-mediated accumulation of endogenous sphingolipids
-
-
?
additional information
?
-
-
SMS1 not only suppresses the effects of Bax overexpression, but it also blocks the deleterious effects of a number of other stresses, including hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sphingomyelin synthase 1 likely prevents cell death by counteracting stress-mediated accumulation of endogenous sphingolipids
-
-
?
additional information
?
-
-
SMS1 is located in the Golgi apparatus, where its two enzymatic products, sphingomyelin and diacylglycerol, play an important role in new lipid raft formation and secretory vesicle formation at the trans-Golgi network for transport to the plasma membrane, sphingomyelin synthesis through SMS1 depends on cholesterol homeostasis. S49AR cells are unable to synthesize sphingomyelin due to downregulated SMS1 expression
-
-
?
additional information
?
-
-
SMS2 regulates sphingomyelin levels in plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation, via multiple mechanisms, overview
-
-
?
additional information
?
-
development of a HPLC-FLD method for real-time monitoring of relative SMS activity based on the measurement of 6-((N-(7-nitrobenz-2-oxa-1.3-diazol-4-yl)amino)hexanoyl)-sphingosine (C6-NBD-Cer) and 6-((N-(7-nitro-2-1,3-benzoxadiazol-4-yl)amino)hexanoyl)-sphingosine-1-phosphocholine (C6-NBDCerPCho) in plasma, which is then used to assess the SMS inhibitory activity of D2 in vivo, kinetics, overview
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)-sphingosine + 1,2-dimyristoyl-sn-glycero-3-phosphocholine
N-(N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-epsilon-aminohexanoyl)sphingosylphosphorylcholine + ?
-
-
-
-
?
a ceramide + a phosphatidylcholine
a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
-
-
?
additional information
?
-
SMS1 not only suppresses the effects of Bax overexpression, but it also blocks the deleterious effects of a number of other stresses, including hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sphingomyelin synthase 1 likely prevents cell death by counteracting stress-mediated accumulation of endogenous sphingolipids
-
-
?
additional information
?
-
-
SMS1 not only suppresses the effects of Bax overexpression, but it also blocks the deleterious effects of a number of other stresses, including hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sphingomyelin synthase 1 likely prevents cell death by counteracting stress-mediated accumulation of endogenous sphingolipids
-
-
?
additional information
?
-
-
SMS1 is located in the Golgi apparatus, where its two enzymatic products, sphingomyelin and diacylglycerol, play an important role in new lipid raft formation and secretory vesicle formation at the trans-Golgi network for transport to the plasma membrane, sphingomyelin synthesis through SMS1 depends on cholesterol homeostasis. S49AR cells are unable to synthesize sphingomyelin due to downregulated SMS1 expression
-
-
?
additional information
?
-
-
SMS2 regulates sphingomyelin levels in plasma membrane and lipid rafts and has a potential to regulate NFkappaB activation, via multiple mechanisms, overview
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
-
1-methylcyclopropyl 4-(3-((3-((3-methoxy-5-(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
-
2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile
i.e. D2, development of a HPLC-FLD method for real-time monitoring of relative SMS activity based on the measurement of C6-NBD-Cer and C6-NBDCerPCho in plasma, which is then used to assess the SMS inhibitory activity of D2 in vivo, overview
4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
-
4-(3-(benzyloxy)pyrrolidin-1-yl)-N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
-
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-(4,4,4-trifluorobutoxy)-1,2-dihydroquinoline-3-carboxamide
-
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
-
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
-
additional information
-
disturbance of cholesterol homoeostasis by 3-beta-[2-(diethylamino)-ethoxy]androst-5-en-17-one, i.e. U18666A, indirectly inhibits sphingomyelin biosynthesis, overview
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00749
6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl)-sphingosine
-
at pH 7.4 and 37°C
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000003
1-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
Mus musculus
pH 7.5, 23°C
0.0000022
1-methylcyclopropyl 4-(3-((3-((3-methoxy-5-(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
Mus musculus
pH 7.5, 23°C
0.0000077
4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
Mus musculus
pH 7.5, 23°C
0.00066
4-(3-(benzyloxy)pyrrolidin-1-yl)-N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
Mus musculus
pH 7.5, 23°C
0.00024
N-(3,5-bis(trifluoromethyl)benzyl)-N,1-dimethyl-2-oxo-4-(4,4,4-trifluorobutoxy)-1,2-dihydroquinoline-3-carboxamide
Mus musculus
pH 7.5, 23°C
0.000032
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate
Mus musculus
pH 7.5, 23°C
0.000019
tert-butyl 4-(3-((3-((3,5-dimethoxybenzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate
Mus musculus
pH 7.5, 23°C
0.4027
tricyclodecan-9-yl-xanthogenate
Mus musculus
pH and temperature not specified in the publication
-
0.0135
2-(2-(benzyloxy)phenyl)-2-(phenylamino) acetonitrile
Mus musculus
SMS2, pH and temperature not specified in the publication
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
in cerebellum, isoform SMS1 is barely detectable both in granule and Purkinje cells while SMS2 is markedly expressed in Purkinje cells and inner granule cells
-
in hippocampus, both isoforms SMS1 and SMS2 are expressed in granule cells while SMS2 expression is stronger in dentate gyrus
additional information
-
no expression of SMS1 and SMS2 in alkyl-lysophospholipid-resistant S49AR mouse lymphoma cells
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
malfunction
metabolism
sphingomyelin synthase (SMS) is the last key enzyme in the sphingosine-1-phosphocholine synthesis process
physiological function
physiological function
Sms1-/- mice show a spermatogenesis defect, characterized by sloughing of spermatocytes and spermatids, causing progressive infertility of male homozygotes. A reduction in several long chain unsaturated phosphatidylcholins, lysophosphatidylcholins and sphingolipids is observed in the testes of mutants, together with blood-testis barrier dysfunction. A supplementary diet of the essential omega-3 docosahexaenoic acid and eicosapentaenoic acid diminishes germ cell sloughing from the seminiferous epithelium and restores spermatogenesis and fertility in 50% of previously infertile mutants
physiological function
treatment with bacterial lipopolysaccharide up-regulates the expression and activity of sphingomyelin synthases while exposure to inhibitor tricyclodecane-9-yl xanthogenate or silencing of isoforms SGMS1 and SGMS2 counteract this action. SGMS1 silencing leads to a depletion of sphingomyelin in cells. Concomitantly, the MyD88- and TRIF-dependent signaling pathways of TLR4 are inhibited with the latter being especially sensitive to the reduction of the SGMS1 and/or SGMS2 activity. The tricyclodecane-9-yl xanthogenate treatment and SMS1 and/or SMS2 depletion all reduce the level of CD14 protein in cells
malfunction
-
SMS2 deficiency causes significant induction of cholesterol efflux in vitro and in vivo, SMS2 deficiency in the macrophages reduces atherosclerosis in mice
malfunction
-
sphingomyelin synthase (SMS) deficiency promotes cell migration through a CXCL12/CXCR4-dependent signaling pathway involving extracellular signal-regulated kinase activation. In addition, SMS1/SMS2 double-knockout cells have heightened sensitivity to CXCL12. SMS deficiency facilitates relocalization of CXCR4 to lipid rafts, which form platforms for the regulation and transduction of receptor-mediated signaling. Furthermore, SMS deficiency potentiates CXCR4 dimerization, which is required for signal transduction
malfunction
glucose kinetics study using the radiolabeled glucose analog 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG), in wild-type (WT) and SMS2 knockout (KO) mice: insulin signaling is enhanced in the liver, white adipose tissue and skeletal muscle of SMS2 KO mice compared with those of wild-type mice. In addition, compared with in wild-type mice, blood clearance of 18F-FDG is accelerated in SMS2 KO mice when they are fed either a normal or a high fat diet. 18F-FDG uptake is also increased in insulin-targeted tissues such as skeletal muscle in the SMS2 KO mice, whereas skeletal muscle sphingolipid content is not clearly affected. Plasma levels of very long-chain fatty acid (VLCFA)-containing ceramides are markedly increased in SMS2 KO mice compared with in wild-type mice. Genetic inhibition of SMS2 elevates glucose clearance through activation of glucose uptake into insulin-targeted tissues such as skeletal muscle by a mechanism independent of hepatic SMS2. This occurs, at least in part, via indirect mechanisms such as elevation of VLCFA-containing ceramides
physiological function
-
isoform SMS2, rather than isoform SMS1, is the major enzyme that is important for sphingomyelin synthesis in the long neurites and the growth cone
physiological function
-
sphingomyelin synthase-generated sphingomyelin is involed in the regulation of cell migration
physiological function
role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice
physiological function
sphingomyelin synthase (SMS) is a key enzyme in the synthesis of sphingomyelin. Effect of SMS on the inflammatory pathway involving nuclear factor (NF)kappaB induced by lipopolysaccharide is analyzed in an ALI mouse model, overview. Compared with the control group, the mRNA and protein levels of CD14 are significantly increased, and the activity of SMS and expression of SMS2 are significantly upregulated in the model group. The expression of SMS2 may affect the induction of the NFkappaB pathway by LPS through CD14
physiological function
in SMS2 knockout mice, SMS2 deficiency significantly decreases very long chain sphingomyelin (d18:1/22:0 and d18:1/24:0 or d18:0/24:1) and increases very long chain ceramie (d18:1/24:0 or d18:0/24:1 and d18:1/24:1), but not long chain sphingomyelin (d18:1/16:0, d18:1/18:0 or d18:0/18:1 and d18:1/18:1) in plasma. Presence of sphingomyelin d18:1/24:0 strongly upregulated several macrophage activation markers, sphingomyelin d18:1/6:0 and ceramide d18:1/24:0 however, does not
physiological function
treatment with bacterial lipopolysaccharide up-regulates the expression and activity of sphingomyelin synthases while exposure to inhibitor tricyclodecane-9-yl xanthogenate or silencing of isoforms SGMS1 and SGMS2 counteract this action. SGMS1 silencing leads to a depletion of sphingomyelin in cells. Concomitantly, the MyD88- and TRIF-dependent signaling pathways of TLR4 are inhibited with the latter being especially sensitive to the reduction of the SGMS1 and/or SGMS2 activity. The tricyclodecane-9-yl xanthogenate treatment and SMS1 and/or SMS2 depletion all reduce the level of CD14 protein in cells
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). SMS1_MOUSE
419
6
49317
Swiss-Prot
other Location (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
S49AR cells show a defect in the synthesis of sphingomyelin and downregulated SMS1, phenotype, overview. Resistance to ALP can be mimicked by small interfering RNA-induced SMS1 suppression, resulting in sphingomyelin deficiency and blockage of raft-dependent internalization of ALP and induction of apoptosis, overview
additional information
-
sphingomyelin synthase 2 knockout deficiency attenuates NFkappaB activation, it impairs TNF receptor 1 recruitment tolipid rafts and TLR4-MD2 complex recruitment to plasma membrane
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
adenovirus approach to overexpress SMS1 in mice to investigate the relationship between sphingomyelin synthase and sphingomyelin metabolism
adenovirus approach to overexpress SMS2 in mice to investigate the relationship between sphingomyelin synthase and sphingomyelin metabolism
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
lipopolysaccharide induction analyzed in an ALI mouse model, compared with the control group, the mRNA and protein levels of CD14 are significantly increased, and the activity of SMS and expression of SMS2 are significantly upregulated in the model group
treatment with bacterial lipopolysaccharide up-regulates the expression and activity of sphingomyelin synthases
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
adenovirus-mediated SMS1 overexpression increases lipoprotein atherogenic potential. Such an effect may contribute to the increased plasma sphingomyelin levels observed in animal models of atherosclerosis and in human patients with coronary artery disease
medicine
pharmacology
sphingomyelin synthase 2 (SMS2) is a potential therapeutic target for obesity and insulin resistance
medicine
adenovirus-mediated SMS2 overexpression increases lipoprotein atherogenic potential. Such an effect may contribute to the increased plasma sphingomyelin levels observed in animal models of atherosclerosis and in human patients with coronary artery disease
medicine
-
regulation of liver SMS2 may be used as treatment for atherosclerosis
medicine
-
SMS2 is a potential therapeutic target for treatment of atherosclerosis
medicine
SMS inhibitors might be useful for the treatment of atherosclerosis or coronary artery disease
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Albi, E.; La Porta, C.A.; Cataldi, S.; Magni, M.V.
Nuclear sphingomyelin-synthase and protein kinase C delta in melanoma cells
Arch. Biochem. Biophys.
438
156-161
2005
Homo sapiens, Mus musculus
Huitema, K.; van den Dikkenberg, J.; Brouwers, J.F.H.M.; Holthuis, J.C.M.
Identification of a family of animal sphingomyelin synthases
EMBO J.
23
33-44
2004
Caenorhabditis elegans (Q20735), Caenorhabditis elegans (Q9U3D4), Caenorhabditis elegans, Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3), Homo sapiens, Mus musculus (Q8VCQ6), Mus musculus
Yang, Z.; Khoury, C.; Jean-Baptiste, G.; Greenwood, M.T.
Identification of mouse sphingomyelin synthase 1 as a suppressor of Bax-mediated cell death in yeast
FEMS Yeast Res.
6
751-762
2006
Mus musculus (Q8VCQ6), Mus musculus
Tafesse, F.G.; Ternes, P.; Holthuis, J.C.
The multigenic sphingomyelin synthase family
J. Biol. Chem.
281
29421-29425
2006
Mus musculus, Pseudomonas aeruginosa, Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3)
Dong, J.; Liu, J.; Lou, B.; Li, Z.; Ye, X.; Wu, M.; Jiang, X.C.
Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice
J. Lipid Res.
47
1307-1314
2006
Mus musculus (Q8VCQ6), Mus musculus (Q9D4B1), Mus musculus
Hailemariam, T.K.; Huan, C.; Liu, J.; Li, Z.; Roman, C.; Kalbfeisch, M.; Bui, H.H.; Peake, D.A.; Kuo, M.; Cao, G.; Wadgaonkar, R.; Jiang, X.
Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation
Arterioscler. Thromb. Vasc. Biol.
28
1519-1526
2008
Homo sapiens, Mus musculus
Van der luit, A.H.; Budde, M.; Zerp, S.; Caan, W.; Klarenbeek, J.B.; Verheij, M.; van Blitterswijk, W.J.
Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts
Biochem. J.
401
541-549
2007
Mus musculus
Tafesse, F.G.; Huitema, K.; Hermansson, M.; van der Poel, S.; van den Dikkenberg, J.; Uphoff, A.; Somerharju, P.; Holthuis, J.C.
Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells
J. Biol. Chem.
282
17537-17547
2007
Homo sapiens, Mus musculus
Liu, J.; Zhang, H.; Li, Z.; Hailemariam, T.K.; Chakraborty, M.; Jiang, K.; Qiu, D.; Bui, H.H.; Peake, D.A.; Kuo, M.S.; Wadgaonkar, R.; Cao, G.; Jiang, X.C.
Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice
Arterioscler. Thromb. Vasc. Biol.
29
850-856
2009
Mus musculus
Liu, J.; Huan, C.; Chakraborty, M.; Zhang, H.; Lu, D.; Kuo, M.S.; Cao, G.; Jiang, X.C.
Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice
Circ. Res.
105
295-303
2009
Mus musculus
Kidani, Y.; Ohshima, K.; Sakai, H.; Kohno, T.; Baba, A.; Hattori, M.
Differential localization of sphingomyelin synthase isoforms in neurons regulates sphingomyelin cluster formation
Biochem. Biophys. Res. Commun.
417
1014-1017
2012
Mus musculus
Asano, S.; Kitatani, K.; Taniguchi, M.; Hashimoto, M.; Zama, K.; Mitsutake, S.; Igarashi, Y.; Takeya, H.; Kigawa, J.; Hayashi, A.; Umehara, H.; Okazaki, T.
Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway
Mol. Cell. Biol.
32
3242-3252
2012
Mus musculus
Yeang, C.; Ding, T.; Chirico, W.J.; Jiang, X.C.
Subcellular targeting domains of sphingomyelin synthase 1 and 2
Nutr. Metab.
8
89
2011
Homo sapiens (Q86VZ5), Mus musculus (Q9D4B1)
Sugimoto, M.; Shimizu, Y.; Zhao, S.; Ukon, N.; Nishijima, K.; Wakabayashi, M.; Yoshioka, T.; Higashino, K.; Numata, Y.; Okuda, T.; Tamaki, N.; Hanamatsu, H.; Igarashi, Y.; Kuge, Y.
Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice
Biochim. Biophys. Acta
1861
688-702
2016
Mus musculus (Q9D4B1), Mus musculus C57BL/6N (Q9D4B1)
Huang, T.; Li, X.; Hu, S.; Zhao, B.; Chen, P.; Liu, X.; Ye, D.; Cheng, N.
Analysis of fluorescent ceramide and sphingomyelin analogs: a novel approach for in vivo monitoring of sphingomyelin synthase activity
Lipids
49
1071-1079
2014
Mus musculus (Q9D4B1)
Hu, S.; Ding, Y.; Gong, J.; Yan, N.
Sphingomyelin synthase 2 affects CD14-associated induction of NF kappaB by lipopolysaccharides in acute lung injury in mice
Mol. Med. Rep.
14
3301-3306
2016
Mus musculus (Q9D4B1), Mus musculus
Deng, X.; Sun, H.; Gao, X.; Gong, H.; Lu, W.; Chu, Y.; Zhou, L.; Ye., D.
Development, validation, and application of a novel method for mammalian sphingomyelin synthase activity measurement
Anal. Lett.
45
1581-1589
2012
Mus musculus
-
Sakamoto, H.; Yoshida, T.; Sanaki, T.; Shigaki, S.; Morita, H.; Oyama, M.; Mitsui, M.; Tanaka, Y.; Nakano, T.; Mitsutake, S.; Igarashi, Y.; Takemoto, H.
Possible roles of long-chain sphingomyelines and sphingomyelin synthase 2 in mouse macrophage inflammatory response
Biochem. Biophys. Res. Commun.
482
202-207
2017
Mus musculus (Q9D4B1), Mus musculus
Prymas, K.; Swiatkowska, A.; Traczyk, G.; Ziemlinska, E.; Dziewulska, A.; Ciesielska, A.; Kwiatkowska, K.
Sphingomyelin synthase activity affects TRIF-dependent signaling of Toll-like receptor 4 in cells stimulated with lipopolysaccharide
Biochim. Biophys. Acta
1865
158549
2020
Mus musculus (Q8VCQ6), Mus musculus (Q9D4B1)
Yukawa, T.; Nakahata, T.; Okamoto, R.; Ishichi, Y.; Miyamoto, Y.; Nishimura, S.; Oikawa, T.; Kubo, K.; Adachi, R.; Satomi, Y.; Nakakariya, M.; Amano, N.; Kamaura, M.; Matsunaga, N.
Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor
Bioorg. Med. Chem.
28
115376
2020
Homo sapiens (Q86VZ5), Homo sapiens (Q8NHU3), Mus musculus (Q9D4B1)
Wittmann, A.; Grimm, M.O.; Scherthan, H.; Horsch, M.; Beckers, J.; Fuchs, H.; Gailus-Durner, V.; Hrabe de Angelis, M.; Ford, S.J.; Burton, N.C.; Razansky, D.; Truembach, D.; Aichler, M.; Walch, A.K.; Calzada-Wack, J.; Neff, F.; Wurst, W.; Hartmann, T.; Floss, T.
Sphingomyelin synthase 1 is essential for male fertility in mice
PLoS ONE
11
e0164298
2016
Mus musculus (Q8VCQ6), Mus musculus
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