Reference on EC 2.7.7.60 - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Anfuso, C.D.; Sipione S.; Lupo, G.; Alberghina, M.
Evolutionary comparison of enzyme activities of phosphatidylcholine metabolism in the nervous system of an invertebrate (Loligo pealei), lower vertebrate (Mustelus canis) and the rat
Comp. Biochem. Physiol. B
112
493-501
1995
Doryteuthis pealeii, animal, dogfish
Cane, D.E.; Chow, C.; Lillo, A.; Kang, I.
Molecular cloning, expression and characterization of the first three genes in the mevalonate-independent isoprenoid pathway in Streptomyces coelicolor
Bioorg. Med. Chem.
9
1467-1477
2001
Escherichia coli, Streptomyces coelicolor, Streptomyces coelicolor CH999
Richard, S.B.; Bowman, M.E.; Kwiatkowski, W.; Kang, L.; Chow, C.; Lillo, A.M.; Cane, D.E.; Noel, J.P.
Structure of 4-diphosphocytidyl-2-C-methylerythritol synthetase involved in mevalonate-independent isoprenoid biosynthesis
Nature Struct. Biol.
8
641-648
2001
BRENDA: Escherichia coli, Mycobacterium tuberculosis, Plasmodium falciparum
Textmining: vertebrata
Kemp, L.E.; Bond, C.S.; Hunter, W.N.
Crystallization and preliminary x-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase
Acta Crystallogr. Sect. D
57
1189-1191
2001
Escherichia coli
Rohdich, F.; Wungsintaweekul, J.; Eisenreich, W.; Richter, G.; Schuhr, C.A.; Hecht, S.; Zenk, M.H.; Bacher, A.
Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana
Proc. Natl. Acad. Sci. USA
97
6451-6456
2000
Arabidopsis thaliana, Escherichia coli (Q46893), Escherichia coli
Kuzuyama, T.; Takagi, M.; Kaneda, K.; Dairi, T.; Seto, H.
Formation of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway
Tetrahedron Lett.
41
703-706
2000
Escherichia coli
-
Rohdich, F.; Wungsintaweekul, J.; Fellermeier, M.; Sagner, S.; Herz, S.; Kis, K.; Eisenreich, W.; Bacher, A.; Zenk, M.H.
Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol
Proc. Natl. Acad. Sci. USA
96
11758-11763
1999
Arabidopsis thaliana, Escherichia coli, Escherichia coli DH5-alpha
Sundler, R.
Ethanolaminephosphate cytidylyltransferase. Purification and characterization of the enzyme from rat liver
J. Biol. Chem.
250
8585-8590
1975
Rattus
Vermeulen, P.S.; Tijburg, L.B.M.; Geelen, M.J.H.; van Golde, L.M.G.
Immunological characterization, lipid dependence, and subcellular localization of CTP:phosphoethanolamine cytidylyltransferase purified from rat liver. Comparison with CTP:phosphocholine cytidylyltransferase
J. Biol. Chem.
268
7458-7464
1993
Rattus
Cornell, R.
Chemical cross-linking reveals a dimeric structure for CTP:phosphocholine cytidylyltransferase
J. Biol. Chem.
264
9077-9082
1989
Rattus
Choy, P.C.; Lim, P.H.; Vance, D.E.
Purification and characterization of CTP: cholinephosphate cytidylytransferase from rat liver cytosol
J. Biol. Chem.
252
7673-7677
1977
Rattus
Wang, X.; Moore, T.S.
Partial purification and characterization of CTP:cholinephosphate cytidylyltransferase from castor bean endosperm
Arch. Biochem. Biophys.
274
338-347
1989
Ricinus communis
Wang, X.; Moore, T.S.
Phosphatidylylcholine biosynthesis in castor bean endosperm. Purification and properties of cytidine 5'-triphosphate:choline-phosphate cytidylyltransferase
Plant Physiol.
93
250-255
1990
Ricinus communis
Weinhold, P.A.; Rounsifer, M.E.; Charles, L.; Feldman, D.A.
Characterization of cytosolic forms of CTP:choline-phosphate cytidylyltransferase in lung, isolated alveolar type II cells, A549 cell and Hep G2 cells
Biochim. Biophys. Acta
1006
299-310
1989
Rattus
Weinhold, P.A.; Charles, L.G.; Feldman, D.A.
Microsomal CTP:choline phosphate cytidylyltransferase: kinetic mechanism of fatty acid stimulation
Biochim. Biophys. Acta
1086
57-62
1991
Rattus
Thorson, J.S.; Kelly, T.M.; Liu, H.W.
Cloning, sequencing, and overexpression in Escherichia coli of the alpha-D-glucose-1-phosphate cytidylyltransferase gene isolated from Yersinia pseudotuberculosis
J. Bacteriol.
176
1840-1849
1994
Yersinia pseudotuberculosis (Q57430), Yersinia pseudotuberculosis
Kelley, M.J.; Carman, G.M.
Purification and characterization of CDP-diacylglycerol synthase from Saccharomyces cerevisiae
J. Biol. Chem.
262
14563-14570
1987
Saccharomyces cerevisiae
Langley, K.E.; Kennedy, E.P.
Partial purification and properties of CTP:phosphatidic acid cytidylyltransferase from membranes of Escherichia coli
J. Bacteriol.
136
85-95
1978
Escherichia coli
Weber, C.H.; Park, Y.S.; Sanker, S.; Kent, C.; Ludwig, M.L.
A prototypical cytidylyltransferase: CTP:glycerol-3-phosphate cytidylyltransferase from Bacillus subtilis
Structure Fold. Des.
7
1113-1124
1999
Bacillus subtilis
Cao, S.G.; Cheng, P.; Angel, A.; Hatch, G.M.
Thyroxine stimulates phosphatidylglycerolphosphate synthase activity in rat heart mitochondria
Biochim. Biophys. Acta
1256
241-244
1995
Rattus
Fernandez-Tome, M. del C.; Speziale, E.H.; Sterin-Speziale, N.B.
Phospholipase C inhibitors and prostaglandins differentially regulate phosphatidylcholine synthesis in rat renal papilla. Evidence of compartmental regulation of CTP:phosphocholine cytidylyltransferase and CDP-choline:1,2-diacylglycerol cholinephosphotransferase
Biochim. Biophys. Acta
1583
185-194
2002
Rattus
Ray, P.H.; Benedict, C.D.; Grasmuk, H.
Purification and characterization of cytidine 5-triphosphate:cytidine 5-monophosphate-3-deoxy-D-manno-octulosonate cytidylyltransferase
J. Bacteriol.
145
1273-1280
1981
Escherichia coli B
Claesson, A.; Luthman, K.; Gustafsson, K.; Bondesson, G.
A 2-deoxy analogue of KDO as the first inhibitor of the enzyme CMP-KDO synthetase
Biochem. Biophys. Res. Commun.
143
1063-1068
1987
Bacteria
Sugai, T.; Lin, C.H.; Shen, G.J.; Wong, C.H.
CMP-KDO synthetase: overproduction and application to the synthesis of CMP-KDO and analogs
Bioorg. Med. Chem.
3
313-320
1995
Escherichia coli
Badurina, D.S.; Zolli-Juran, M.; Brown, E.D.
CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered bi-bi reaction mechanism with micromolar K(m) values
Biochim. Biophys. Acta
1646
196-206
2003
Bacillus subtilis
Zolli, M.; Kobric, D.J.; Brown, E.D.
Reduction precedes cytidylyl transfer without substrate channeling in distinct active sites of the bifunctional CDP-ribitol synthase from Haemophilus influenzae
Biochemistry
40
5041-5048
2001
Haemophilus influenzae (Q48230), Haemophilus influenzae, Transformation
Kolisis, F.N.
Studies on acylneuraminate cytidylytransferase from human placenta
Arch. Int. Physiol. Biochim.
92
179-184
1984
Homo sapiens
Rodriguez-Aparicio, L.B.; Luengo, J.M.; Gonzalez-Clemente, C.; Reglero, A.
Purification and characterization of the nuclear cytidine 5-monophosphate N-acetylneuraminic acid synthetase from rat liver
J. Biol. Chem.
267
9257-9263
1992
Rattus
Schauer, R.; Wember, M.
Studies on the substrate specificity of acylneuraminate cytidylyltransferase and sialytransferase of submandibular glands from cow, pig and horse
Hoppe-Seyler's Z. Physiol. Chem.
354
1405-1414
1973
Equus caballus, Sus scrofa, Bos taurus
Revilla-Nuin, B.; Reglero, A.; Feo, J.C.; Rodriguez-Aparicio, L.B.; Ferrero, M.A.
Identification, expression and tissue distribution of cytidine 5'-monophosphate N-acetylneuraminic acid synthetase activity in the rat
Glycoconj. J.
15
233-241
1998
Rattus
Bravo, I.G.; Barrallo, S.; Ferrero, M.A.; Rodriguez-Aparicio, L.B.; Martinez-Blanco, H.; Reglero, A.
Kinetic properties of the acylneuraminate cytidylyltransferase from Pasteurella haemolytica A2
Biochem. J.
358
585-598
2001
Mannheimia haemolytica
Tullius, M.V.; Munson, R.S., Jr.; Wang, J.; Gibson, B.W.
Purification, cloning, and expression of a cytidine 5'-monophosphate N-acetylneuraminic acid synthetase from Haemophilus ducreyi
J. Biol. Chem.
271
15373-15380
1996
[Haemophilus] ducreyi
Pereira, M.P.; Brown, E.D.
Bifunctional catalysis by CDP-ribitol synthase: convergent recruitment of the reductase and cytidylyltransferase activities in Haemophilus influenzae and Staphylococcus aureus
Biochemistry
43
11802-11812
2004
Haemophilus influenzae, Staphylococcus aureus
von Delft, F.; Lewendon, A.; Dhanaraj, V.; Blundell, T.L.; Abell, C.; Smith, A.G.
The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily
Structure
9
439-450
2001
Escherichia coli
Gabrielsen, M.; Bond, C.S.; Hallyburton, I.; Hecht, S.; Bacher, A.; Eisenreich, W.; Rohdich, F.; Hunter, W.N.
Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis
J. Biol. Chem.
279
52753-52761
2004
Agrobacterium tumefaciens, Campylobacter jejuni, Escherichia coli (Q46893), Escherichia coli
Kemp, L.E.; Bond, C.S.; Hunter, W.N.
Structure of a tetragonal crystal form of Escherichia coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Acta Crystallogr. Sect. D
59
607-610
2003
Escherichia coli
Bernal, C.; Palacin, C.; Boronat, A.; Imperial, S.
A colorimetric assay for the determination of 4-diphosphocytidyl-2-C-methyl-D-erythritol 4-phosphate synthase activity
Anal. Biochem.
337
55-61
2005
Escherichia coli
Richard, S.B.; Lillo, A.M.; Tetzlaff, C.N.; Bowman, M.E.; Noel, J.P.; Cane, D.E.
Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids
Biochemistry
43
12189-12197
2004
Escherichia coli (Q46893), Escherichia coli
Zhao, X.; Miller, J.R.; Jiang, Y.; Marletta, M.A.; Cronan, J.E.
Assembly of the covalent linkage between lipoic acid and its cognate enzymes
Chem. Biol.
10
1293-1302
2003
Escherichia coli
Lherbet, C.; Pojer, F.; Richard, S.B.; Noel, J.P.; Poulter, C.D.
Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway
Biochemistry
45
3548-3553
2006
Agrobacterium tumefaciens
Gabrielsen, M.; Kaiser, J.; Rohdich, F.; Eisenreich, W.; Laupitz, R.; Bacher, A.; Bond, C.S.; Hunter, W.N.
The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate
FEBS J.
273
1065-1073
2006
BRENDA: Arabidopsis thaliana (P69834), Arabidopsis thaliana
Textmining: plant
Illarionova, V.; Kaiser, J.; Ostrozhenkova, E.; Bacher, A.; Fischer, M.; Eisenreich, W.; Rohdich, F.
Nonmevalonate terpene biosynthesis enzymes as antiinfective drug targets: substrate synthesis and high-throughput screening methods
J. Org. Chem.
71
8824-8834
2006
Escherichia coli
Kim, S.M.; Kuzuyama, T.; Chang, Y.J.; Kwon, H.J.; Kim, S.U.
Cloning and functional characterization of 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (GbMECT) gene from Ginkgo biloba
Phytochemistry
67
1435-1441
2006
Ginkgo biloba (Q0R5D7), Ginkgo biloba
Mizoi, J.; Nakamura, M.; Nishida, I.
Defects in CTP:phosphorylethanolamine cytidylyltransferase affect embryonic and postembryonic development in Arabidopsis
Plant Cell
18
3370-3385
2006
Arabidopsis, Arabidopsis thaliana
Sando, T.; Takeno, S.; Watanabe, N.; Okumoto, H.; Kuzuyama, T.; Yamashita, A.; Hattori, M.; Ogasawara, N.; Fukusaki, E.; Kobayashi, A.
Cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes of a natural-rubber producing plant, Hevea brasiliensis
Biosci. Biotechnol. Biochem.
72
2903-2917
2008
BRENDA: Hevea brasiliensis (A9ZN09), Hevea brasiliensis (A9ZN10), Hevea brasiliensis
Textmining: Escherichia coli (P45568), Escherichia coli, Arabidopsis thaliana (Q9XFS9), Arabidopsis thaliana
Shi, W.; Feng, J.; Zhang, M.; Lai, X.; Xu, S.; Zhang, X.; Wang, H.
Biosynthesis of isoprenoids: characterization of a functionally active recombinant 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD) from Mycobacterium tuberculosis H37Rv
J. Biochem. Mol. Biol.
40
911-920
2007
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Valvano, M.A.; Marolda, C.L.; Bittner, M.; Glaskin-Clay, M.; Simon, T.L.; Klena, J.D.
The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose
J. Bacteriol.
182
488-497
2000
Ralstonia
Obiol-Pardo, C.; Cordero, A.; Rubio-Martinez, J.; Imperial, S.
Homology modeling of Mycobacterium tuberculosis 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase, the third enzyme in the MEP pathway for isoprenoid biosynthesis
J. Mol. Model.
16
1061-1073
2010
Mycobacterium tuberculosis (P9WKG9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKG9)
Rodrigues, M.V.; Borges, N.; Henriques, M.; Lamosa, P.; Ventura, R.; Fernandes, C.; Empadinhas, N.; Maycock, C.; da Costa, M.S.; Santos, H.
Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles
J. Bacteriol.
189
5405-5412
2007
Escherichia coli, Pyrococcus furiosus, Pyrococcus furiosus (Q8U1Z6), Thermotoga maritima, Rubrobacter, Hyperthermus butylicus, Aeropyrum pernix, Aquifex aeolicus, Aquifex aeolicus (O67379), Thermococcus kodakarensis, Thermococcus kodakarensis (Q5JDA9)
Neumann, M.; Mittelstdt, G.; Seduk, F.; Iobbi-Nivol, C.; Leimkuhler, S.
MocA is a specific cytidylyltransferase involved in molybdopterin cytosine dinucleotide biosynthesis in Escherichia coli
J. Biol. Chem.
284
21891-21898
2009
Escherichia coli
Chen, S.C.; Yang, C.S.; Lin, C.T.; Chan, N.L.; Chang, M.C.; Chen, Y.
Expression, purification, crystallization and preliminary X-ray analysis of ribitol-5-phosphate cytidylyltransferase from Bacillus subtilis
Acta Crystallogr. Sect. F
68
1195-1197
2012
Bacillus subtilis (Q8RKI9), Bacillus subtilis
Maheshwari, S.; Lavigne, M.; Contet, A.; Alberge, B.; Pihan, E.; Kocken, C.; Wengelnik, K.; Douguet, D.; Vial, H.; Cerdan, R.
Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active
Biochem. J.
450
159-167
2013
Plasmodium falciparum (Q8IDM2), Plasmodium falciparum
Shastri, S.; Zeeman, A.M.; Berry, L.; Verburgh, R.J.; Braun-Breton, C.; Thomas, A.W.; Gannoun-Zaki, L.; Kocken, C.H.; Vial, H.J.
Plasmodium CDP-DAG synthase: an atypical gene with an essential N-terminal extension
Int. J. Parasitol.
40
1257-1268
2010
Plasmodium, Plasmodium falciparum (Q8ILZ6), Plasmodium falciparum
Kobayashi, M.; Kouzu, N.; Inami, A.; Toyooka, K.; Konishi, Y.; Matsuoka, K.; Matoh, T.
Characterization of Arabidopsis CTP:3-deoxy-D-manno-2-octulosonate cytidylyltransferase (CMP-KDO synthetase), the enzyme that activates KDO during rhamnogalacturonan II biosynthesis
Plant Cell Physiol.
52
1832-1843
2011
Arabidopsis
Tsang, A.; Seidle, H.; Jawaid, S.; Zhou, W.; Smith, C.; Couch, R.
Francisella tularensis 2-C-Methyl-D-Erythritol 4-phosphate Cytidylyltransferase: Kinetic characterization and phosphoregulation
PLoS ONE
6
e20884
2011
Francisella tularensis, Francisella tularensis FSC155
Brault, J.P.; Friesen, J.A.
Characterization of cytidylyltransferase enzyme activity through high performance liquid chromatography
Anal. Biochem.
510
26-32
2016
Listeria monocytogenes
Tian, S.; Ohtsuka, J.; Wang, S.; Nagata, K.; Tanokura, M.; Ohta, A.; Horiuchi, H.; Fukuda, R.
Human CTP:phosphoethanolamine cytidylyltransferase: enzymatic properties and unequal catalytic roles of CTP-binding motifs in two cytidylyltransferase domains
Biochem. Biophys. Res. Commun.
449
26-31
2014
Homo sapiens (Q99447), Homo sapiens
Pavlovic, Z.; Singh, R.K.; Bakovic, M.
A novel murine CTP:phosphoethanolamine cytidylyltransferase splice variant is a post-translational repressor and an indicator that both cytidylyltransferase domains are required for activity
Gene
543
58-68
2014
Mus musculus (Q540F5), Mus musculus, Indicator
Nakamura, Y.
Arabidopsis DOK1 encodes a functional dolichol kinase involved in reproduction
Plant J.
81
292-303
2015
Arabidopsis, Saccharomyces cerevisiae
Imlay, L.; Armstrong, C.; Masters, M.; Li, T.; Price, K.; Edwards, R.; Mann, K.; Li, L.; Stallings, C.; Berry, N.; O'Neill, P.; Odom, A.
Plasmodium IspD (2-C-methyl-D-erythritol 4-phosphate cytidyltransferase), an essential and druggable antimalarial target
ACS Infect. Dis.
1
157-167
2016
Plasmodium vivax (A5K9U5), Mycobacterium tuberculosis (P9WKG9), Plasmodium falciparum (Q8I273), Plasmodium falciparum, Plasmodium vivax Salvador I (A5K9U5), Mycobacterium tuberculosis H37Rv (P9WKG9), Mycobacterium tuberculosis ATCC 25618 (P9WKG9)
Ghavami, M.; Merino, E.F.; Yao, Z.K.; Elahi, R.; Simpson, M.E.; Fernandez-Murga, M.L.; Butler, J.H.; Casasanta, M.A.; Krai, P.M.; Totrov, M.M.; Slade, D.J.; Carlier, P.R.; Cassera, M.B.
Biological studies and target engagement of the 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD)-targeting antimalarial agent (1 R,3 S)-MMV008138 and analogs
ACS Infect. Dis.
4
549-559
2018
Plasmodium falciparum (Q8I273)
Haymond, A.; Dowdy, T.; Johny, C.; Johnson, C.; Ball, H.; Dailey, A.; Schweibenz, B.; Villarroel, K.; Young, R.; Mantooth, C.J.; Patel, T.; Bases, J.; Dowd, C.S.; Couch, R.D.
A high-throughput screening campaign to identify inhibitors of DXP reductoisomerase (IspC) and MEP cytidylyltransferase (IspD)
Anal. Biochem.
542
63-75
2018
Francisella tularensis subsp. novicida (A0Q5K1), Escherichia coli (Q46893), Francisella tularensis subsp. novicida Utah 112 (A0Q5K1)
Susila, H.; Nasim, Z.; Gawarecka, K.; Jung, J.Y.; Jin, S.; Youn, G.; Ahn, J.H.
Phosphorylethanolamine cytidyltransferase 1 modulates flowering in a florigen-independent manner by regulating SVP
Development
148
dev193870
2020
Arabidopsis thaliana, Arabidopsis thaliana (Q9ZVI9)
Saggu, G.S.; Garg, S.; Pala, Z.R.; Kochar, S.K.; Saxena, V.
Deciphering the role of IspD (2-C-methyl-D-erythritol 4-phosphate cytidyltransferase) enzyme as a potential therapeutic drug target against Plasmodium vivax
Gene
675
240-253
2018
Plasmodium vivax (A5K9U5), Plasmodium vivax, Plasmodium vivax Salvador I (A5K9U5)
Kumar, P.; Kumar, M.; Kumar, H.; Rana, S.; Kumar, J.; Sahoo, G.
In silico targeting methylerythritol phosphate pathway IspD enzyme of Mycobacterium tuberculosis for novel anti-mycobacterial drug discovery
J. Appl. Pharm. Sci.
10
23-29
2020
Mycobacterium tuberculosis (P9WKG9), Mycobacterium tuberculosis H37Rv (P9WKG9), Mycobacterium tuberculosis ATCC 25618 (P9WKG9)
-
Chellapandi, P.; Prathiviraj, R.; Prisilla, A.
Deciphering structure, function and mechanism of Plasmodium IspD homologs from their evolutionary imprints
J. Comput. Aided Mol. Des.
33
419-436
2019
BRENDA: Plasmodium falciparum (A0A024WEN0), Plasmodium falciparum Tanzania (20000708) (A0A024WEN0)
Textmining: Plasmodium
Jin, Y.; Liu, Z.; Li, Y.; Liu, W.; Tao, Y.; Wang, G.
A structural and functional study on the 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase (IspD) from Bacillus subtilis
Sci. Rep.
6
36379
2016
Bacillus subtilis (Q06755), Bacillus subtilis, Escherichia coli (Q46893), Escherichia coli, Bacillus subtilis 168 (Q06755), Bacillus subtilis DSM 23778 (Q06755)
Zhang, M.; Xiang, L.; Wang, H.; Lan, X.; Chen, M.; Liao, Z.
Molecular cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase gene from Artemisia annua L
Yao Xue Xue Bao
51
1334-1339
2016
BRENDA: Artemisia annua (A0A1B2G2H8), Artemisia annua
Textmining: Arabidopsis thaliana
Heath, MF; Jacobson, W
Developmental changes in enzyme activities in fetal and neonatal rabbit lung. Cytidylyltransferase, cholinephosphotransferase, phospholipases A1 and A2, beta-galactosidase, and beta-glucuronidase.
Pediatr Res
18
395-401
1984
Oryctolagus cuniculus
Terada, T; Kitazume, S; Kitajima, K; Inoue, S; Ito, F; Troy, FA; Inoue, Y
Synthesis of CMP-deaminoneuraminic acid (CMP-KDN) using the CTP:CMP-3-deoxynonulosonate cytidylyltransferase from rainbow trout testis. Identification and characterization of a CMP-KDN synthetase.
J Biol Chem
268
2640-8
1993
Oncorhynchus mykiss
Gao, P; Yang, Y; Xiao, C; Liu, Y; Gan, M; Guan, Y; Hao, X; Meng, J; Zhou, S; Chen, X; Cui, J
Identification and validation of a novel lead compound targeting 4-diphosphocytidyl-2-C-methylerythritol synthetase (IspD) of mycobacteria.
Eur J Pharmacol
2012
Corynebacteriales, Mycolicibacterium smegmatis, Mycobacterium tuberculosis, Homo sapiens, Mammalia
Li, Z; Hwang, S; Ericson, J; Bowler, K; Bar-Peled, M
Pen and Pal are nucleotide-sugar dehydratases that convert UDP-GlcNAc to UDP-6-deoxy-D-GlcNAc-5,6-ene and then to UDP-4-keto-6-deoxy-L-AltNAc for CMP-pseudaminic acid synthesis in Bacillus thuringiensis.
J Biol Chem
290
691-704
2015
Bacillus thuringiensis
Watkins, JD; Kent, C
Regulation of CTP:phosphocholine cytidylyltransferase activity and subcellular location by phosphorylation in Chinese hamster ovary cells. The effect of phospholipase C treatment.
J Biol Chem
266
21113-7
1991
Cricetulus griseus
Sleight, R; Kent, C
Regulation of phosphatidylcholine biosynthesis in mammalian cells. I. Effects of phospholipase C treatment on phosphatidylcholine metabolism in Chinese hamster ovary cells and LM mouse fibroblasts.
J Biol Chem
258
824-30
1983
Mus musculus
Sleight, R; Kent, C
Regulation of phosphatidylcholine biosynthesis in mammalian cells. II. Effects of phospholipase C treatment on the activity and subcellular distribution of CTP:phosphocholine cytidylyltransferase in Chinese hamster ovary and LM cell lines.
J Biol Chem
258
831-5
1983
Cricetulus griseus, Clostridium perfringens
Tronchère, H; Planat, V; Record, M; Tercé, F; Ribbes, G; Chap, H
Phosphatidylcholine turnover in activated human neutrophils. Agonist-induced cytidylyltransferase translocation is subsequent to phospholipase D activation.
J Biol Chem
270
13138-46
1995
Homo sapiens
Gielen, W; Schaper, R
[Neuraminidase, acetylneuraminate cytidylyltransferase and neuraminyltransferase in human leukocytes]
Hoppe Seylers Z Physiol Chem
355
660-8
1974
Homo sapiens
Houweling, M; Tijburg, LB; Jamil, H; Vance, DE; Nyathi, CB; Vaartjes, WJ; van Golde, LM
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Homo sapiens, Rattus
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Comparison of the phospholipid requirements and molecular form of CTP : phosphocholine cytidylyltransferase from rat lung, kidney, brain and liver.
Biochim Biophys Acta
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Pelech, SL; Pritchard, PH; Brindley, DN; Vance, DE
Fatty acids promote translocation of CTP:phosphocholine cytidylyltransferase to the endoplasmic reticulum and stimulate rat hepatic phosphatidylcholine synthesis.
J Biol Chem
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Lim, PH; Pritchard, PH; Paddon, HB; Vance, DE
Stimulation of hepatic phosphatidylcholine biosynthesis in rats fed a high cholesterol and cholate diet correlates with translocation of CTP: phosphocholine cytidylyltransferase from cytosol to microsomes.
Biochim Biophys Acta
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Montanini, I; De Medio, GE; Porcellati, S
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Cricetulus griseus, Pseudomonas cerasi, Rattus
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Halminski, MA; Marsh, JB; Harrison, EH
Differential effects of fish oil, safflower oil and palm oil on fatty acid oxidation and glycerolipid synthesis in rat liver.
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One of the origins of plasma membrane phosphatidylserine in plant cells is a local synthesis by a serine exchange activity.
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Allium ampeloprasum
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Helicobacter pylori
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Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development.
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Mycobacterium tuberculosis
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Plant Cell Physiol
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Homo sapiens
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J Biol Chem
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Bacillus cereus
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Hormonal regulation of phosphatidylcholine synthesis in plants. The inhibition of cytidylyltransferase activity by indol-3-ylacetic acid.
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Pisum sativum
Dobrzyn, A; Dobrzyn, P; Miyazaki, M; Sampath, H; Chu, K; Ntambi, JM
Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver.
J Biol Chem
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Mus sp.
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15-deoxy-Delta12,14-prostaglandin J2 impairs phosphatidylcholine synthesis and induces nuclear accumulation of thiol-modified cytidylyltransferase.
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animal
Verkade, HJ; Havinga, R; Shields, DJ; Wolters, H; Bloks, VW; Kuipers, F; Vance, DE; Agellon, LB
The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion.
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Phosphorylation of CTP:phosphocholine cytidylyltransferase in vivo. Lack of effect of phorbol ester treatment in HeLa cells.
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Post, M
Maternal administration of dexamethasone stimulates choline-phosphate cytidylyltransferase in fetal type II cells.
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Rattus
Cornell, R; Vance, DE
Translocation of CTP: phosphocholine cytidylyltransferase from cytosol to membranes in HeLa cells: stimulation by fatty acid, fatty alcohol, mono- and diacylglycerol.
Biochim Biophys Acta
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Bos taurus
Wang, Y; Kent, C
Effects of altered phosphorylation sites on the properties of CTP:phosphocholine cytidylyltransferase.
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Cricetulus griseus, Pseudomonas cerasi
Hogan, M; Zimmermann, LJ; Wang, J; Kuliszewski, M; Liu, J; Post, M
Increased expression of CTP:phosphocholine cytidylyltransferase in maturing type II cells.
Am J Physiol
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Rattus
Zimmermann, LJ; Lee, WS; Smith, BT; Post, M
Cyclic AMP-dependent protein kinase does not regulate CTP:phosphocholine cytidylyltransferase activity in maturing type II cells.
Biochim Biophys Acta
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Rattus
Houweling, M; Jamil, H; Hatch, GM; Vance, DE
Dephosphorylation of CTP-phosphocholine cytidylyltransferase is not required for binding to membranes.
J Biol Chem
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Rattus
Viscardi, RM; McKenna, MC
Developmental changes in cholinephosphate cytidylyltransferase activity and microsomal phospholipid fatty acid composition in alveolar type II cells.
Life Sci
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Rattus
Mallampalli, RK; Walter, ME; Peterson, MW; Hunninghake, GW
Betamethasone activation of CTP:cholinephosphate cytidylyltransferase in vivo is lipid dependent.
Am J Respir Cell Mol Biol
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Rattus
Wieprecht, M; Wieder, T; Paul, C; Geilen, CC; Orfanos, CE
Evidence for phosphorylation of CTP:phosphocholine cytidylyltransferase by multiple proline-directed protein kinases.
J Biol Chem
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Homo sapiens
Veitch, DP; Cornell, RB
Substitution of serine for glycine-91 in the HXGH motif of CTP:phosphocholine cytidylyltransferase implicates this motif in CTP binding.
Biochemistry
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Sander
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Transient inactivation of phosphatidylethanolamine N-methyltransferase-2 and activation of cytidine triphosphate: phosphocholine cytidylyltransferase during non-neoplastic liver growth.
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Rattus
Viscardi, RM; Strauss, K; Hasday, JD
Oleic acid stimulates rapid translocation of cholinephosphate cytidylyltransferase in type II cells.
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Mus musculus
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Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization.
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Rodionov, DA; Kurnasov, OV; Stec, B; Wang, Y; Roberts, MF; Osterman, AL
Genomic identification and in vitro reconstitution of a complete biosynthetic pathway for the osmolyte di-myo-inositol-phosphate.
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Escherichia coli, Thermotoga maritima
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De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy.
Autophagy
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Mus musculus
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Structure and reactivity in the non-mevalonate pathway of isoprenoid biosynthesis.
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Escherichia coli
Infante, JP
Rate-limiting steps in the cytidine pathway for the synthesis of phosphatidylcholine and phosphatidylethanolamine.
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Kaplan, O; Cohen, JS
Lymphocyte activation and phospholipid pathways. 31P magnetic resonance studies.
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Homo sapiens
Mock, T; Slater, TL; Arthur, G; Chan, AC; Choy, PC
Effects of fatty acids on phosphatidylcholine biosynthesis in isolated hamster heart.
Biochem Cell Biol
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Rattus
Clough, JM; Dale, RP; Elsdon, B; Hawkes, TR; Hogg, BV; Howell, A; Kloer, DP; Lecoq, K; McLachlan, MM; Milnes, PJ; O'Riordan, TJ; Ranasinghe, S; Shanahan, SE; Sumner, KD; Tayab, S
Synthesis and evaluation of hydroxyazolopyrimidines as herbicides; the generation of amitrole in planta.
Pest Manag Sci
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Nicotiana tabacum
Jerant, A; Lichte, M; Kravitz, RL; Tancredi, DJ; Magnan, EM; Hudnut, A; Franks, P
Physician training in self-efficacy enhancing interviewing techniques (SEE IT): Effects on patient psychological health behavior change mediators.
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Homo sapiens
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