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Information on EC 2.7.7.59 - [protein-PII] uridylyltransferase and Organism(s) Corynebacterium glutamicum and UniProt Accession Q9X706

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IUBMB Comments
The enzyme uridylylates and de-uridylylates the small trimeric protein PII. The enzymes from Escherichia coli and Salmonella typhimurium have been wrongly identified, in some databases, as EC 2.7.7.12 (UDP-glucose---hexose-1-phosphate uridylyltransferase), from which it differs greatly in both reaction catalysed and sequence.
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This record set is specific for:
Corynebacterium glutamicum
UNIPROT: Q9X706
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The taxonomic range for the selected organisms is: Corynebacterium glutamicum
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
uridylyltransferase, uridylyl transferase, utase/ur, uridylyltransferase/uridylyl-removing enzyme, utase, glnd protein, uridylyl-removing enzyme, uridylyl-removing activity, pii uridylyltransferase, uridylyltransferase enzyme, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PII uridylyl-transferase
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PII uridylyltransferase
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PII uridylyltransferase (Escherichia coli gene glnD)
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uridyl removing enzyme
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uridyltransferase, glutamine synthetase adenylyltransferase-regulating protein
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uridylyl removing enzyme
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uridylyltransferase, glutamine synthetase adenylyltransferase-regulating protein (Escherichia coli clone 21C8 gene glnD reduced)
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uridylyltransferase/uridylyl removing enzyme
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uridylyltransferase/uridylyl-removing enzyme
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UTase/UR
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UTP:PII protein uridylyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
UTP:[protein-PII] uridylyltransferase
The enzyme uridylylates and de-uridylylates the small trimeric protein PII. The enzymes from Escherichia coli and Salmonella typhimurium have been wrongly identified, in some databases, as EC 2.7.7.12 (UDP-glucose---hexose-1-phosphate uridylyltransferase), from which it differs greatly in both reaction catalysed and sequence.
CAS REGISTRY NUMBER
COMMENTARY hide
151596-34-8
Escherichia coli clone 21C8 gene glnD reduced
57657-57-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UTP + [protein-GlnK]
diphosphate + uridylyl-[protein-GlnK]
show the reaction diagram
UTP + [protein-PII]
diphosphate + uridylyl-[protein-PII]
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UTP + [protein-GlnK]
diphosphate + uridylyl-[protein-GlnK]
show the reaction diagram
uridylylation of GlnK protein is essential for the cell to respond to nitrogen limitation
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?
UTP + [protein-PII]
diphosphate + uridylyl-[protein-PII]
show the reaction diagram
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of glnD in a deficient mutant strain restores the constitutive enzyme, complementation
gene glnD, construction of chromosomal deletion mutant
gene glnD, DNA sequence determination and analysis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jakoby, M.; Kramer, R.; Burkovski, A.
Nitrogen regulation in Corynebacterium glutamicum: isolation of genes involved and biochemical characterization of corresponding proteins
FEMS Microbiol. Lett.
173
303-310
1999
Corynebacterium glutamicum (Q9X706), Corynebacterium glutamicum
Manually annotated by BRENDA team
Nolden, L.; Ngouoto-Nkili, C.E.; Bendt, A.K.; Kramer, R.; Burkovski, A.
Sensing nitrogen limitation in Corynebacterium glutamicum: the role of glnK and glnD
Mol. Microbiol.
42
1281-1295
2001
Corynebacterium glutamicum (Q9X706), Corynebacterium glutamicum
Manually annotated by BRENDA team