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Information on EC 2.7.7.41 - phosphatidate cytidylyltransferase and Organism(s) Mus musculus and UniProt Accession Q99L43
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2.7.7.41 phosphatidate cytidylyltransferaseSpecify your search results
Word Map
- 2.7.7.41
- phospholipid
- phosphatidylinositol
- phosphatidylglycerol
- cardiolipin
- cds1
- liponucleotide
-
raetz
-
phosphatidyltransferase
-
diphosphate-diacylglycerol
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
cdp-diacylglycerol synthase, cdp-dg, phosphatidate cytidylyltransferase, tam41, cdp-dag synthase, tamm41, ctp:phosphatidate cytidylyltransferase, cdp-diglyceride synthetase, cdp-dg synthase, tbcds, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CDP-DAG synthase
CDP-DG
-
-
-
-
CDP-DG synthetase
-
-
-
-
CDP-diacylglyceride synthetase
-
-
-
-
CDP-diacylglycerol synthase
CDP-diglyceride pyrophosphorylase
-
-
-
-
CDP-diglyceride synthetase
-
-
-
-
CDPdiglyceride pyrophosphorylase
-
-
-
-
CDS
-
-
-
-
CTP-diacylglycerol synthetase
-
-
-
-
CTP:1,2-diacylglycerophosphate-cytidyl transferase
-
-
-
-
CTP:phosphatidate cytidylyltransferase
-
-
-
-
cytidine diphosphoglyceride pyrophosphorylase
-
-
-
-
cytidylyltransferase, phosphatidate
-
-
-
-
DAG synthetase
-
-
-
-
phosphatidate cytidyltransferase
-
-
-
-
phosphatidic acid cytidylyltransferase
-
-
-
-
additional information
CDP-DAG synthase
-
-
-
-
CDP-diacylglycerol synthase
-
-
-
-
additional information
two different enzymes termed Cds1 and Cds2 with different genetical localization and different expression pattern
additional information
two different enzymes termed Cds1 and Cds2 with different genetical localization and different expression pattern
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -
SYSTEMATIC NAME
IUBMB Comments
CTP:phosphatidate cytidylyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY
9067-83-8
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
involved in the synthesis of phospholipids and of phosphatidylinositol 4,5-diphosphate, which plays an important role in phosphoinositide-mediated signallng pathways
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
involved in the de novo biosynthesis of cardiolipin
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
involved in the synthesis of phospholipids and of phosphatidylinositol 4,5-diphosphate, which plays an important role in phosphoinositide-mediated signallng pathways
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
involved in the synthesis of phospholipids and of phosphatidylinositol 4,5-diphosphate, which plays an important role in phosphoinositide-mediated signallng pathways
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
-
involved in the de novo biosynthesis of cardiolipin
-
-
?
CTP + phosphatidate
diphosphate + CDP-diacylglycerol
involved in the synthesis of phospholipids and of phosphatidylinositol 4,5-diphosphate, which plays an important role in phosphoinositide-mediated signallng pathways
-
-
?
pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
ganglion cell layer and inner nuclear layer, not expressed in photoreceptors
expressed in photoreceptors but not in other layers of the retina
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS2 in 3T3-L1 preadipocytes has a moderate inhibitory effect on adipocyte differentiation. Only a small number of phosphatidate species are increased upon depleting CDS2, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS2, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells
physiological function
malfunction
knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS1 almost completely blocked the differentiation of 3T3-L1 preadipocytes. The levels of many phosphatidate species are significantly increased upon knocking down CDS1, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS1, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells
physiological function
physiological function
knocking down either isoform CDS1 or isoform CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS2 has a moderate inhibitory effect on adipocyte differentiation. Only a small number of phosphatidic acid species are increased upon depleting CDS2. The amount of phosphatidic acid in the endoplasmic reticulum is dramatically increased upon knocking down CDS1 or CDS2
physiological function
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage
physiological function
knocking down either isoform CDS1 or isoform CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS1 almost completely blocks the differentiation of 3T3-L1 preadipocytes. The levels of many phosphatidic acid species are significantly increased upon knocking down CDS1. The amount of phosphatidic acid in the endoplasmic reticulum is dramatically increased upon knocking down CDS1 or CDS2
physiological function
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). CDS2_MOUSE
444
8
51314
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
different potential modification sites predicted from the deduced amino acid sequence
additional information
different potential modification sites predicted from the deduced amino acid sequence
additional information
-
different potential modification sites predicted from the deduced amino acid sequence
additional information
different potential modification sites predicted from the deduced amino acid sequence
additional information
different potential modification sites predicted from the deduced amino acid sequence
additional information
-
different potential modification sites predicted from the deduced amino acid sequence
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS2 by 90%. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells
additional information
transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS2 by 90%. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells
additional information
transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS1 by 48%. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells
additional information
transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS1 by 48%. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Inglis-Broadgate, S.L.; Ocaka, L.; Banerjee, R.; Gaasenbeek, M.; Chapple, J.P.; Cheetham, M.E.; Clark, B.J.; Hunt, D.M.; Halford, S.
Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2
Gene
356
19-31
2005
Mus musculus (P98191), Mus musculus (Q99L43), Mus musculus
Jiang, Y.J.; Lu, B.; Xu, F.Y.; Gartshore, J.; Taylor, W.A.; Halayko, A.J.; Gonzalez, F.J.; Takasaki, J.; Choy, P.C.; Hatch, G.M.
Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation
J. Lipid Res.
45
244-252
2004
Mus musculus, Rattus norvegicus
Qi, Y.; Kapterian, T.S.; Du, X.; Ma, Q.; Fei, W.; Zhang, Y.; Huang, X.; Dawes, I.W.; Yang, H.
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development
J. Lipid Res.
57
767-780
2016
Homo sapiens (O95674), Homo sapiens (Q92903), Mus musculus (P98191), Mus musculus (Q99L43)
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