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ATP + MoO42-
AMP + adenylylmolybdate
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ATP + sulfate
diphosphate + adenylyl sulfate
ATP + sulfate
diphosphate + adenylylsulfate
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diphosphate + adenylyl sulfate
ATP + sulfate
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ATP + sulfate
diphosphate + adenylyl sulfate
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ATP + sulfate
diphosphate + adenylylsulfate
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r
diphosphate + adenylyl sulfate
ATP + sulfate
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r
additional information
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ATP + sulfate
diphosphate + adenylyl sulfate
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ATP + sulfate
diphosphate + adenylyl sulfate
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additional information
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substrate binding structure analysis, overview
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additional information
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substrate binding structure analysis, overview
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additional information
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substrate binding structure analysis, overview
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additional information
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the bifunctional PAPS synthases 1 and 2 consist of an N-terminal adenosine-5'-phosphosulphate kinase domain and a C-terminal ATP sulphurylase domain connected by a short irregular linker
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additional information
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the bifunctional PAPS synthases 1 and 2 consist of an N-terminal adenosine-5'-phosphosulphate kinase domain and a C-terminal ATP sulphurylase domain connected by a short irregular linker
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?
additional information
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for human PAPS synthase 1, the steady-state concentration of APS is modelled to be 0.0016 mM, but this may increase up to 0.060 mM under conditions of sulfate excess. The APS concentration for maximal APS kinase activity is 0.015 mM
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additional information
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for human PAPS synthase 1, the steady-state concentration of APS is modelled to be 0.0016 mM, but this may increase up to 0.060 mM under conditions of sulfate excess. The APS concentration for maximal APS kinase activity is 0.015 mM
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-
?
additional information
?
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-
for human PAPS synthase 1, the steady-state concentration of APS is modelled to be 0.0016 mM, but this may increase up to 0.060 mM under conditions of sulfate excess. The APS concentration for maximal APS kinase activity is 0.015 mM
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?
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Alcohol-Related Disorders
Rate of alcoholism diagnoses in community mental health centers: the effect of the presence of an alcoholism treatment program.
Anovulation
Inactivating PAPSS2 mutations in a patient with premature pubarche.
Breast Neoplasms
Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis.
Breast Neoplasms
Zr-89 Immuno-PET Targeting Ectopic ATP Synthase Enables In-Vivo Imaging of Tumor Angiogenesis.
CADASIL
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy without Anterior Temporal Pole Involvement: A Case Report.
Carcinogenesis
Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.
Chondrosarcoma
Co-purification and characterization of ATP-sulfurylase and adenosine-5'-phosphosulfate kinase from rat chondrosarcoma.
Chondrosarcoma
Intermediate channeling between ATP sulfurylase and adenosine 5'-phosphosulfate kinase from rat chondrosarcoma.
Chondrosarcoma
Rat chondrosarcoma ATP sulfurylase and adenosine 5'-phosphosulfate kinase reside on a single bifunctional protein.
Chondrosarcoma
Sulfate activation and transport in mammals: system components and mechanisms.
Colitis
Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.
Colonic Neoplasms
Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.
Dengue
In situ removal of consensus dengue virus envelope protein domain III fused to hydrophobin in Pichia pastoris cultures.
Dry Eye Syndromes
A Decade of Effective Dry Eye Disease Management with Systane Ultra (Polyethylene Glycol/Propylene Glycol with Hydroxypropyl Guar) Lubricant Eye Drops.
Dry Eye Syndromes
The Effect of Artificial Tear Preparations with Three Different Ingredients on Contrast Sensitivity in Patients with Dry Eye Syndrome.
Dwarfism
Essential roles of 3'-phosphoadenosine 5'-phosphosulfate synthase in embryonic and larval development of the nematode Caenorhabditis elegans.
Epilepsy
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy without Anterior Temporal Pole Involvement: A Case Report.
Gallstones
Hypothyroidism Increases Cholesterol Gallstone Prevalence in Mice by Elevated Hydrophobicity of Primary Bile Acids.
Head and Neck Neoplasms
Planning comparison of five automated treatment planning solutions for locally advanced head and neck cancer.
Heart Diseases
Lipid metabolism in the heart--contribution of BMIPP to the diseased heart.
Hepatitis C
A continuous nonradioactive assay for RNA-dependent RNA polymerase activity.
Hyperandrogenism
Low DHEAS Concentration in a Girl Presenting with Short Stature and Premature Pubarche: A Novel PAPSS2 Gene Mutation.
Inflammatory Bowel Diseases
Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.
Intellectual Disability
Exclusion of the dymeclin and PAPSS2 genes in a novel form of spondyloepimetaphyseal dysplasia and mental retardation.
Joint Diseases
Degenerative knee joint disease in mice lacking 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis.
Leukoencephalopathies
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy without Anterior Temporal Pole Involvement: A Case Report.
Malaria
Single-step, paper-based concentration and detection of a malaria biomarker.
Mastocytoma
Activation of mouse mastocytoma ATP sulfurylase by p-hydroxymercuribenzoate.
Mastocytoma
Enzyme-substrate complexes of ATP-sulfurylase from mouse mastocytoma.
Mastocytoma
Purification and properties of ATP-sulfurylase from Furth mouse mastocytoma.
Mastocytoma
Two forms of ATP sulfurylase in Furth mouse mastocytoma.
Melanoma, Experimental
ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction.
Metabolic Diseases
Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1.
Migraine Disorders
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy without Anterior Temporal Pole Involvement: A Case Report.
Neoplasms
Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors.
Neoplasms
Extra-low-frequency magnetic fields alter cancer cells through metabolic restriction.
Neoplasms
Interfacial Tension Effect on Cell Partition in Aqueous Two-Phase Systems.
Neoplasms
Molecular determinants as therapeutic targets in cancer chemotherapy: An update.
Neoplasms
Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges".
Neoplasms
Zr-89 Immuno-PET Targeting Ectopic ATP Synthase Enables In-Vivo Imaging of Tumor Angiogenesis.
Onchocerciasis
The elimination of the vector Simulium neavei from the Itwara onchocerciasis focus in Uganda by ground larviciding.
Osteoarthritis
Degenerative knee joint disease in mice lacking 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis.
Osteoarthritis, Knee
Identification of sequence polymorphisms in two sulfation-related genes, PAPSS2 and SLC26A2, and an association analysis with knee osteoarthritis.
Osteochondrodysplasias
Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency.
Osteosarcoma
[In vivo 31P-NMR studies on energy metabolism and the effect of methotrexate in murine implanted osteosarcoma]
Polycystic Ovary Syndrome
PAPSS2 deficiency causes androgen excess via impaired DHEA sulfation - in vitro and in vivo studies in a family harboring two novel PAPSS2 mutations.
Prostatic Neoplasms
Aqueous two-phase system to isolate extracellular vesicles from urine for prostate cancer diagnosis.
Prostatic Neoplasms
Exploring Prostate Cancer Genome Reveals Simultaneous Losses of PTEN, FAS and PAPSS2 in Patients with PSA Recurrence after Radical Prostatectomy.
Prostatic Neoplasms
Zr-89 Immuno-PET Targeting Ectopic ATP Synthase Enables In-Vivo Imaging of Tumor Angiogenesis.
Starvation
Catalytic and regulatory properties of sulphur metabolizing enzymes in cyanobacterium Synechococcus elongatus PCC 7942.
Starvation
Coordinated expression of sulfate uptake and components of the sulfate assimilatory pathway in maize.
Starvation
Effect of ATP sulfurylase overexpression in bright yellow 2 tobacco cells. Regulation Of atp sulfurylase and SO4(2-) transport activities.
Starvation
Inter-organ signaling in plants: regulation of ATP sulfurylase and sulfate transporter genes expression in roots mediated by phloem-translocated compound.
Starvation
Regulation of adenosine triphosphate sulfurylase in cultured tobacco cells. Effects of sulfur and nitrogen sources on the formation and decay of the enzyme.
Starvation
Transcriptional and Proteomic Profiling of Aspergillus flavipes in Response to Sulfur Starvation.
Stomach Neoplasms
Radiolabeled Anti-Adenosine Triphosphate Synthase Monoclonal Antibody as a Theragnostic Agent Targeting Angiogenesis.
Stroke
Cysteine biosynthetic enzymes are the pieces of a metabolic energy pump.
Stroke
Mechanochemistry of a viral DNA packaging motor.
Stroke, Lacunar
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy without Anterior Temporal Pole Involvement: A Case Report.
sulfate adenylyltransferase deficiency
Inactivating PAPSS2 mutations in a patient with premature pubarche.
sulfate adenylyltransferase deficiency
Low DHEAS Concentration in a Girl Presenting with Short Stature and Premature Pubarche: A Novel PAPSS2 Gene Mutation.
sulfate adenylyltransferase deficiency
PAPSS2 deficiency causes androgen excess via impaired DHEA sulfation - in vitro and in vivo studies in a family harboring two novel PAPSS2 mutations.
Tuberculosis
Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis.
Tuberculosis
The Mycobacterium tuberculosis cysD and cysNC genes form a stress-induced operon that encodes a tri-functional sulfate-activating complex.
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malfunction
the suppression of PAPSS1 and 2 decreases the levels of obligate cofactor and sulfate donor PAPS and reduce cellular sulfotransferase activity. Endogenous SULT2A1 is not upregulated in PAPSS1/2 double knockdown HepG2 cells, whereas the amount of UGT2B4 mRNA is significantly increased. Mechanism(s) responsible for the PAPSS1/2 knockdown-mediated upregulation of human UGT2B4, overview
metabolism
all sulfation reactions rely on active sulfate in the form of 3'-phosphoadenosine-5'-phosphosulfate (PAPS). Sulfate is converted to the sulfonucleotide adenylyl sulfate, APS, by the ubiquitous ATP sulfurylase. APS represents a metabolic branchpoint in bacteria and plants, where it is reduced by APS reductase to sulfite, and finally incorporated into primary metabolites after further reduction. Alternatively, APS is phosphorylated by APS kinase to the universal sulfate donor PAPS. In metazoans and humans, ATP sulfurylase and APS kinase reside on one polypeptide, the bifunctional PAPS synthase. All eukaryotic sulfotransferases depend on the provision of active sulfate inthe form of 3?-phospho-adenosine-5'-phosphosulfate (PAPS) for their proper action. The importance of PAPS for sulfation can rival that of ATP for phosphorylation processes. Various regulatory roles of APS in the overall process of PAPS biosynthesis
metabolism
all sulfation reactions rely on active sulfate in the form of 3'-phosphoadenosine-5'-phosphosulfate (PAPS). Sulfate is converted to the sulfonucleotide adenylyl sulfate, APS, by the ubiquitous ATP sulfurylase. APS represents a metabolic branchpoint in bacteria and plants, where it is reduced by APS reductase to sulfite, and finally incorporated into primary metabolites after further reduction. Alternatively, APS is phosphorylated by APS kinase to the universal sulfate donor PAPS. In metazoans and humans, ATP sulfurylase and APS kinase reside on one polypeptide, the bifunctional PAPS synthase. All eukaryotic sulfotransferases depend on the provision of active sulfate inthe form of 3'-phospho-adenosine-5'-phosphosulfate (PAPS) for their proper action. The importance of PAPS for sulfation can rival that of ATP for phosphorylation processes. Various regulatory roles of APS in the overall process of PAPS biosynthesis
additional information
the bifunctional PAPS synthase comprises a C-terminal ATP sulfurylase domain and an N-terminal APS kinase domain connected by a short irregular linker, no intermediate channeling by the human enzyme. The human PAPS synthases, PAPS synthase 1 (PAPSS1) and PAPS synthase 2 (PAPSS2) are bifunctional enzymes that consist of ATP sulfurylase and APS kinase domains connected by a flexible linker. Adenylyl sulfate, APS, is a highly specific stabilizer of bifunctional PAPS synthases. APS most likely stabilizes the APS kinase part of these proteins by forming a dead-end enzyme-ADP-APS complex at APS concentrations between 0.0005 and 0.005 mM. At higher concentrations, APS may bind to the catalytic centers of ATP sulfurylase
additional information
the bifunctional PAPS synthase comprises a C-terminal ATP sulfurylase domain and an N-terminal APS kinase domain connected by a short irregular linker, no intermediate channeling by the human enzyme. The human PAPS synthases, PAPS synthase 1 (PAPSS1) and PAPS synthase 2 (PAPSS2) are bifunctional enzymes that consist of ATP sulfurylase and APS kinase domains connected by a flexible linker. Adenylyl sulfate, APS, is a highly specific stabilizer of bifunctional PAPS synthases. APS most likely stabilizes the APS kinase part of these proteins by forming a dead-end enzyme-ADP-APS complex at APS concentrations between 0.0005 and 0.005 mM. At higher concentrations, APS may bind to the catalytic centers of ATP sulfurylase
additional information
-
the bifunctional PAPS synthase comprises a C-terminal ATP sulfurylase domain and an N-terminal APS kinase domain connected by a short irregular linker, no intermediate channeling by the human enzyme. The human PAPS synthases, PAPS synthase 1 (PAPSS1) and PAPS synthase 2 (PAPSS2) are bifunctional enzymes that consist of ATP sulfurylase and APS kinase domains connected by a flexible linker. Adenylyl sulfate, APS, is a highly specific stabilizer of bifunctional PAPS synthases. APS most likely stabilizes the APS kinase part of these proteins by forming a dead-end enzyme-ADP-APS complex at APS concentrations between 0.0005 and 0.005 mM. At higher concentrations, APS may bind to the catalytic centers of ATP sulfurylase
additional information
the bifunctional PAPS synthase comprises a C-terminal ATP sulfurylase domain and an N-terminal APS kinase domain connected by a short irregular linker, no intermediate channeling by the human enzyme. The human PAPS synthases, PAPS synthase 1 (PAPSS1) and PAPS synthase 2 (PAPSS2) are bifunctional enzymes that consist of ATP sulfurylase and APS kinase domains connected by a flexible linker. Adenylyl sulfate, APS, is a highly specific stabilizer of bifunctional PAPS synthases. APS most likely stabilizes the APS kinase part of these proteins by forming a dead-end enzyme-ADP-APS complex at APS concentrations between 0.0005 and 0.005 mM. At higher concentrations, APS may bind to the catalytic centers of ATP sulfurylase
additional information
the bifunctional PAPS synthase comprises a C-terminal ATP sulfurylase domain and an N-terminal APS kinase domain connected by a short irregular linker, no intermediate channeling by the human enzyme. The human PAPS synthases, PAPS synthase 1 (PAPSS1) and PAPS synthase 2 (PAPSS2) are bifunctional enzymes that consist of ATP sulfurylase and APS kinase domains connected by a flexible linker. Adenylyl sulfate, APS, is a highly specific stabilizer of bifunctional PAPS synthases. APS most likely stabilizes the APS kinase part of these proteins by forming a dead-end enzyme-ADP-APS complex at APS concentrations between 0.0005 and 0.005 mM. At higher concentrations, APS may bind to the catalytic centers of ATP sulfurylase
additional information
-
the bifunctional PAPS synthase comprises a C-terminal ATP sulfurylase domain and an N-terminal APS kinase domain connected by a short irregular linker, no intermediate channeling by the human enzyme. The human PAPS synthases, PAPS synthase 1 (PAPSS1) and PAPS synthase 2 (PAPSS2) are bifunctional enzymes that consist of ATP sulfurylase and APS kinase domains connected by a flexible linker. Adenylyl sulfate, APS, is a highly specific stabilizer of bifunctional PAPS synthases. APS most likely stabilizes the APS kinase part of these proteins by forming a dead-end enzyme-ADP-APS complex at APS concentrations between 0.0005 and 0.005 mM. At higher concentrations, APS may bind to the catalytic centers of ATP sulfurylase
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Yanagisawa, K.; Sakakibara, Y.; Suiko, M.; Takami, Y.; Nakayama, T.; Nakajima, H.; Takayanagi, K.; Natori, Y.; Liu, M.C.
cDNA cloning, expression, and characterization of the human bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase enzyme
Biosci. Biotechnol. Biochem.
62
1037-1040
1998
Homo sapiens
brenda
Lansdon, E.B.; Fisher, A.J.; Segel, I.H.
Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains
Biochemistry
43
4356-4365
2004
Homo sapiens (O43252), Homo sapiens
brenda
Schroeder, E.; Gebel, L.; Eremeev, A.A.; Morgner, J.; Grum, D.; Knauer, S.K.; Bayer, P.; Mueller, J.W.
Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm
PLoS ONE
7
e29559
2012
Homo sapiens (O43252), Homo sapiens
brenda
Barrett, K.G.; Fang, H.; Cukovic, D.; Dombkowski, A.A.; Kocarek, T.A.; Runge-Morris, M.
Upregulation of UGT2B4 expression by 3-phosphoadenosine-5-phosphosulfate synthase knockdown: implications for coordinated control of bile acid conjugation
Drug Metab. Dispos.
43
1061-1070
2015
Homo sapiens (O43252), Homo sapiens
brenda
Mueller, J.W.; Shafqat, N.
Adenosine-5-phosphosulfate - a multifaceted modulator of bifunctional 3-phospho-adenosine-5-phosphosulfate synthases and related enzymes
FEBS J.
280
3050-3057
2013
Homo sapiens (O43252), Homo sapiens (O95340), Homo sapiens
brenda