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Information on EC 2.7.7.38 - 3-deoxy-manno-octulosonate cytidylyltransferase and Organism(s) Haemophilus influenzae and UniProt Accession P44490

for references in articles please use BRENDA:EC2.7.7.38
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Haemophilus influenzae
UNIPROT: P44490 not found.
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Word Map
The taxonomic range for the selected organisms is: Haemophilus influenzae
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
cmp-kdo synthetase, 3-deoxy-manno-octulosonate cytidylyltransferase, 3-deoxy-d-manno-octulosonate cytidylyltransferase, ctp:cmp-3-deoxy-d-manno-octulosonate cytidylyltransferase, l-cks, cmp/kdo synthase, cmp:kdo synthase, 2-keto-3-deoxy-d-manno-octulosonate cytidylyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3-deoxy-manno-octulosonate cytidylyltransferase
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CMP-KDO synthetase
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2-keto-3-deoxyoctonate cytidylyltransferase
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-
-
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3-deoxy-D-manno-octulosonate cytidylyltransferase
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-
-
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CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase
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-
-
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CMP-3-deoxy-D-manno-octulosonate synthetase
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-
-
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CMP-KDO synthetase
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-
-
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CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase
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-
-
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cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase
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-
-
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cytidine monophospho-3-deoxy-D-manno-octulosonate synthetase
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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nucleotidyl group transfer
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-
-
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PATHWAY SOURCE
PATHWAYS
-
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SYSTEMATIC NAME
IUBMB Comments
CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
37278-28-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
show the reaction diagram
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
show the reaction diagram
-
-
-
-
r
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
show the reaction diagram
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
show the reaction diagram
-
-
-
-
r
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
the structure of 3-deoxy-manno-octulosonate cytidylyltransferase from Haemophilus influenzae complexed with the substrate 3-deoxy-manno-octulosonate is determined at 2.30 A resolution
native crystals are orthorhombic, belonging to space group P2(1)2(1)2(1) with unit-cell parameters a = 48.6, b = 83.1, c = 117.3 A
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
overexpressed with a C-terminal hexahistidine tag in Escherichia coli
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
the structure of 3-deoxy-manno-octulosonate cytidylyltransferase from Haemophilus influenzae in complex with 3-deoxy-manno-octulosonate will be useful in structure-based inhibitor design
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Royo, J.; Gomez, E.; Hueros, G.
CMP-KDO synthetase. A plant gene borrowed from Gram-negative eubacteria
Trends Genet.
16
432-433
2000
Aggregatibacter actinomycetemcomitans, Aquifex pyrophilus, Arabidopsis thaliana, Chlamydia pneumoniae, Chlamydia trachomatis, Chlorobaculum tepidum, Escherichia coli, Haemophilus influenzae, Helicobacter pylori, Homo sapiens, Neisseria meningitidis, no activity in Caenorhabditis elegans, no activity in Drosophila melanogaster, no activity in Saccharomyces cerevisiae, Rickettsia prowazekii, Solanum lycopersicum, Vibrio cholerae serotype O1, Yersinia pestis, Zea mays
Manually annotated by BRENDA team
Bravo, I.G.; Reglero, A.
The cytidyltransferases family: Properties, kinetics, genomic and phylogeny
Recent Res. Devel. Biochem.
4
224-254
2003
Aquifex aeolicus, Arabidopsis thaliana (Q9C920), Caulobacter vibrioides (Q9A4A3), Chlamydia muridarum, Chlamydia pneumoniae, Chlamydia trachomatis, Escherichia coli, Escherichia coli (P42216), Haemophilus influenzae, Helicobacter pylori, Mesorhizobium loti (Q98BN3), Neisseria meningitidis, Neisseria meningitidis (Q9K0D6), Neisseria meningitidis MC58 (Q9K0D6), Pasteurella multocida, Pseudomonas aeruginosa, Rickettsia conorii (Q92I96), Rickettsia prowazekii, Salmonella enterica subsp. enterica serovar Typhimurium, Sinorhizobium meliloti (Q92SX6), Vibrio cholerae (Q9KQX2), Xylella fastidiosa (Q9PB46), Zea mays, Zea mays (Q9M4D3), Zea mays (Q9M4G3)
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Manually annotated by BRENDA team
Ku, M.J.; Yoon, H.J.; Ahn, H.J.; Kim, H.W.; Baek, S.H.; Suh, S.W.
Crystallization and preliminary X-ray crystallographic studies of 3-deoxy-manno-octulosonate cytidylyltransferase from Haemophilus influenzae
Acta Crystallogr. Sect. D
59
180-182
2003
Haemophilus influenzae
Manually annotated by BRENDA team
Yoon, H.J.; Ku, M.J.; Mikami, B.; Suh, S.W.
Structure of 3-deoxy-manno-octulosonate cytidylyltransferase from Haemophilus influenzae complexed with the substrate 3-deoxy-manno-octulosonate in the beta-configuration
Acta Crystallogr. Sect. D
64
1292-1294
2008
Haemophilus influenzae (P44490), Haemophilus influenzae
Manually annotated by BRENDA team