Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CTP + 3,5-dideoxy-5-fluoro-beta-D-manno-2-octulopyranosonic acid
diphosphate + CMP-3,5-dideoxy-5-fluoro-beta-D-manno-2-octulopyranosonic acid
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
CMP-3-deoxy-D-manno-octulosonate + diphosphate
-
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
CTP + 5-deoxy-Kdo
diphosphate + CMP-5-deoxy-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 5-epi-Kdo
diphosphate + CMP-5-epi-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 5-fluoro-2-keto-3,5-dideoxyoctulosonate
diphosphate + CMP-5-fluoro-2-keto-3,5-dideoxy octulosonate
-
-
-
-
r
CTP + 8-azido-3,8-dideoxy-D-manno-oct-2-ulosonate
diphosphate + CMP-azido-3,8-dideoxy-D-manno-oct-2-ulosonate
the enzyme does not efficiently recognize azido-3,8-dideoxy-D-manno-oct-2-ulosonate as a substrate
-
-
?
dCTP + 3-deoxy-D-manno-octulosonate
diphosphate + dCMP-3-deoxy-D-manno-octulosonate
UTP + 3-deoxy-D-manno-octulosonate
diphosphate + UMP-3-deoxy-D-manno-octulosonate
additional information
?
-
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
involved in the expression of the capsular K5 polysaccharide K-CKS
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
biosynthesis of cell wall lipopolysaccharide
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
biosynthesis of cell wall lipopolysaccharide
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
dCTP + 3-deoxy-D-manno-octulosonate
diphosphate + dCMP-3-deoxy-D-manno-octulosonate
about 10% of the activity with CTP
-
-
?
dCTP + 3-deoxy-D-manno-octulosonate
diphosphate + dCMP-3-deoxy-D-manno-octulosonate
-
-
-
r
dCTP + 3-deoxy-D-manno-octulosonate
diphosphate + dCMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
dCTP + 3-deoxy-D-manno-octulosonate
diphosphate + dCMP-3-deoxy-D-manno-octulosonate
-
-
-
r
dCTP + 3-deoxy-D-manno-octulosonate
diphosphate + dCMP-3-deoxy-D-manno-octulosonate
-
reaction at pH 8.0
-
-
r
dCTP + 3-deoxy-D-manno-octulosonate
diphosphate + dCMP-3-deoxy-D-manno-octulosonate
-
reaction at pH 8.0 and 9.5
-
-
r
dCTP + 3-deoxy-D-manno-octulosonate
diphosphate + dCMP-3-deoxy-D-manno-octulosonate
-
reaction at pH 8.0 and 9.5
-
-
r
dCTP + 3-deoxy-D-manno-octulosonate
diphosphate + dCMP-3-deoxy-D-manno-octulosonate
-
reaction at pH 8.0
-
-
r
UTP + 3-deoxy-D-manno-octulosonate
diphosphate + UMP-3-deoxy-D-manno-octulosonate
about 45% of the activity with CTP
-
-
?
UTP + 3-deoxy-D-manno-octulosonate
diphosphate + UMP-3-deoxy-D-manno-octulosonate
about 60% of the activity with CTP
-
-
?
UTP + 3-deoxy-D-manno-octulosonate
diphosphate + UMP-3-deoxy-D-manno-octulosonate
-
-
-
r
UTP + 3-deoxy-D-manno-octulosonate
diphosphate + UMP-3-deoxy-D-manno-octulosonate
-
12% of the activity with CTP as substrate
-
-
r
UTP + 3-deoxy-D-manno-octulosonate
diphosphate + UMP-3-deoxy-D-manno-octulosonate
-
reaction at pH 9.5, approximately 50% the rate with CTP
-
-
r
UTP + 3-deoxy-D-manno-octulosonate
diphosphate + UMP-3-deoxy-D-manno-octulosonate
reaction at pH 9.5, approximately 50% the rate with CTP
-
-
r
UTP + 3-deoxy-D-manno-octulosonate
diphosphate + UMP-3-deoxy-D-manno-octulosonate
-
reaction at pH 9.5, to a lesser extent at pH 8.0
-
-
r
UTP + 3-deoxy-D-manno-octulosonate
diphosphate + UMP-3-deoxy-D-manno-octulosonate
-
reaction at pH 9.5, to a lesser extent at pH 8.0
-
-
r
UTP + 3-deoxy-D-manno-octulosonate
diphosphate + UMP-3-deoxy-D-manno-octulosonate
-
reaction at pH 9.5, approximately 50% the rate with CTP
-
-
r
UTP + 3-deoxy-D-manno-octulosonate
diphosphate + UMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
UTP + 3-deoxy-D-manno-octulosonate
diphosphate + UMP-3-deoxy-D-manno-octulosonate
nearly the same activity with CTP as pH 9.5, more active with CTP at pH 7.0
-
-
r
additional information
?
-
no substrates: ATP, GTP
-
-
?
additional information
?
-
-
no substrates: ATP, GTP
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
ATP and GTP are no substrates
-
-
?
additional information
?
-
ATP and GTP are no substrates
-
-
?
additional information
?
-
-
dUTP is no nucleotide acceptor for 3-deoxy-D-manno-octulosonate, 3-deoxy-D-manno-octulosonate-8-phosphate will not serve as substrate in place of 3-deoxy-D-manno-octulosonate
-
-
?
additional information
?
-
-
L-KDN is no substrate
-
-
?
additional information
?
-
-
no other sugar can replace 3-deoxy-D-manno-octulosonate, 3-deoxy-D-manno-octulosonate-8-phosphate and N-acetylneuraminic acid will not serve as substrates, neither dUTP nor any other nucleotide triphosphates, diphosphates or monophosphates like ATP, dATP, GTP, dGTP, ITP, dITP, TTP, CDP, UDP or CMP can substitute for CTP
-
-
?
additional information
?
-
-
3-deoxy-D-manno-octulosonate-8-phosphate is no substrate, neither NeuAc nor 3-deoxy-arabinoheptulosonate or 3-deoxy-erythro-hexulosonate are substrates
-
-
?
additional information
?
-
3-deoxy-D-manno-octulosonate-8-phosphate is no substrate, neither NeuAc nor 3-deoxy-arabinoheptulosonate or 3-deoxy-erythro-hexulosonate are substrates
-
-
?
additional information
?
-
-
no other sugar can replace 3-deoxy-D-manno-octulosonate, 3-deoxy-D-manno-octulosonate-8-phosphate and N-acetylneuraminic acid will not serve as substrates, neither dUTP nor any other nucleotide triphosphates, diphosphates or monophosphates like ATP, dATP, GTP, dGTP, ITP, dITP, TTP, CDP, UDP or CMP can substitute for CTP
-
-
?
additional information
?
-
-
dUTP is no nucleotide acceptor for 3-deoxy-D-manno-octulosonate, 3-deoxy-D-manno-octulosonate-8-phosphate will not serve as substrate in place of 3-deoxy-D-manno-octulosonate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
involved in the expression of the capsular K5 polysaccharide K-CKS
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
biosynthesis of cell wall lipopolysaccharide
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
biosynthesis of cell wall lipopolysaccharide
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
?
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
-
r
CTP + 3-deoxy-D-manno-octulosonate
diphosphate + CMP-3-deoxy-D-manno-octulosonate
-
-
-
r
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((2-(1-((5-fluoropyridin-2-yl)methyl)-1,6-dihydropyridin-2-yl)-6-methyl-1,4-dihydropyrimidin-4-yl)amino)(2-methyl-2,3-dihydro-1H-pyrazol-4-yl)methanol
-
(1R,4S,5R)-3-[2-[(S)-1-((S)-1-carboxy-ethylcarbamoyl)-ethylamino]-ethyl]-4,5-dihydroxy-cyclohexanecarboxylic acid
-
-
(Z)-4-((2'-methoxy-[1,1'-biphenyl]-3(2H)-ylidene)methyl)-N-(pyridin-1(4H)-ylmethyl)-4H-pyran-4-carboxamide
-
1-(4-(3-((4,5-dimethylthiazol-2-yl)amino)pyrazin-2-yl)pyridin-1(2H)-yl)-3-(2-methyl-2,5-dihydrothiazol-4-yl)propan-1-ol
-
2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate
2-(4-chloro-3-methylphenoxy)-1-(3-(5-(2-hydroxypropan-2-yl)-2-methyl-2,3-dihydrofuran-2-yl)-2-oxa-8-azaspiro[4.5]deca-6,9-dien-8-yl)-2-methylpropan-1-ol
-
4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein
-
4-(3-fluorophenoxy)-1-(4-((5-methylisoxazol-3-yl)methoxy)benzyl)pyrrolidin-3-ol
-
diphosphate
-
weak inhibition
2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate
-
2-deoxy KDO analog
2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate
-
2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate
-
2-deoxy KDO analog
2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate
-
-
4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein
Rose Bengal, competitive with 2-keto-3-deoxy-D-manno-octulosonate but non-competitive against CTP
-
4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein
-
Rose Bengal, competitive with 2-keto-3-deoxy-D-manno-octulosonate but non-competitive against CTP
-
4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein
Rose Bengal, competitive with 2-keto-3-deoxy-D-manno-octulosonate but non-competitive against CTP
-
additional information
not inhibited by 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein
-
additional information
-
not inhibited by 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein
-
additional information
-
no inhibition by CDP, CMP, 3-deoxy-manno-octulosonate 8-phosphate, N-acetylneuraminate
-
additional information
-
no inhibition with 3-deoxy-D-manno-octulosonate analog 2,6-anhydro-3-deoxy-D-glycero-D-galacto-octanoate
-
additional information
-
no inhibition with 3-deoxy-D-manno-octulosonate analog 2,6-anhydro-3-deoxy-D-glycero-D-galacto-octanoate
-
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Wylie, J.L.; Iliffe, E.R.; Wang, L.L.; McClarty, G.
Identification, characterization, and developmental regulation of Chlamydia trachomatis 3-deoxy-D-manno-octulosonate (KDO)-8-phosphate synthetase and CMP-KDO synthetase
Infect. Immun.
65
1527-1530
1997
Chlamydia trachomatis, Chlamydia trachomatis (P0CD75)
brenda
Ghalambor, M.A.; Heath, E.H.
The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. IV. Purification and properties of cytidine monophosphate 3-deoxy-D-manno-octulosonate synthetase
J. Biol. Chem.
241
3216-3221
1966
Escherichia coli, Escherichia coli 0111-B4
brenda
Ray, P.H.; Benedict, C.D.; Grasmuk, H.
Purification and characterization of cytidine 5-triphosphate:cytidine 5-monophosphate-3-deoxy-D-manno-octulosonate cytidylyltransferase
J. Bacteriol.
145
1273-1280
1981
Escherichia coli, Escherichia coli B / ATCC 11303
brenda
Ray, P.H.; Benedict, C.D.
CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase)
Methods Enzymol.
83
535-540
1982
Escherichia coli, Escherichia coli B / ATCC 11303
brenda
Claesson, A.; Luthman, K.; Gustafsson, K.; Bondesson, G.
A 2-deoxy analogue of KDO as the first inhibitor of the enzyme CMP-KDO synthetase
Biochem. Biophys. Res. Commun.
143
1063-1068
1987
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli D21, Salmonella enterica subsp. enterica serovar Typhimurium SL 1102
brenda
Rosenow, C.; Roberts, I.S.; Jann, K.
Isolation from recombinant Escherichia coli and characterization of CMP-Kdo synthetase, involved in the expression of the capsular K5 polysaccharide (K-CKS)
FEMS Microbiol. Lett.
125
159-164
1995
Escherichia coli
brenda
Sugai, T.; Lin, C.H.; Shen, G.J.; Wong, C.H.
CMP-KDO synthetase: overproduction and application to the synthesis of CMP-KDO and analogs
Bioorg. Med. Chem.
3
313-320
1995
Escherichia coli
brenda
Jelakovic, S.; Jann, K.; Schulz, G.E.
The three-dimensional structure of capsule-specific CMP: 2-keto-3-deoxy-manno-octonic acid synthetase from Escherichia coli
FEBS Lett.
391
157-161
1996
Escherichia coli
brenda
Royo, J.; Gomez, E.; Hueros, G.
A maize homologue of the bacterial CMP-3-deoxy-D-manno-2-octulosonate (KDO) synthetases. Similar pathways operate in plants and bacteria for the activation of KDO prior to its incorporation into outer cellular envelopes
J. Biol. Chem.
275
24993-24999
2000
Zea mays
brenda
Royo, J.; Gomez, E.; Hueros, G.
CMP-KDO synthetase. A plant gene borrowed from Gram-negative eubacteria
Trends Genet.
16
432-433
2000
Aggregatibacter actinomycetemcomitans, Aquifex pyrophilus, Arabidopsis thaliana, Chlamydia pneumoniae, Chlamydia trachomatis, Chlorobaculum tepidum, Escherichia coli, Haemophilus influenzae, Helicobacter pylori, Homo sapiens, Solanum lycopersicum, Neisseria meningitidis, no activity in Caenorhabditis elegans, no activity in Saccharomyces cerevisiae, no activity in Drosophila melanogaster, Yersinia pestis, Rickettsia prowazekii, Zea mays, Vibrio cholerae serotype O1
brenda
Jelakovic, S.; Schulz, G.E.
The structure of CMP:2-keto-3-deoxy-manno-octonic acid synthetase and of its complexes with substrates and substrate analogs
J. Mol. Biol.
312
143-155
2001
Escherichia coli, Escherichia coli (P42216)
brenda
Tzeng, Y.L.; Datta, A.; Strole, C.; Kolli, V.S.; Birck, M.R.; Taylor, W.P.; Carlson, R.W.; Woodard, R.W.; Stephens, D.S.
KpsF is the arabinose-5-phosphate isomerase required for 3-deoxy-D-manno-octulosonic acid biosynthesis and for both lipooligosaccharide assembly and capsular polysaccharide expression in Neisseria meningitidis
J. Biol. Chem.
277
24103-24113
2002
Neisseria meningitidis
brenda
Bravo, I.G.; Reglero, A.
The cytidyltransferases family: Properties, kinetics, genomic and phylogeny
Recent Res. Devel. Biochem.
4
224-254
2003
Aquifex aeolicus, Chlamydia muridarum, Chlamydia pneumoniae, Chlamydia trachomatis, Escherichia coli, Escherichia coli (P42216), Haemophilus influenzae, Helicobacter pylori, Neisseria meningitidis, Neisseria meningitidis (Q9K0D6), Pasteurella multocida, Pseudomonas aeruginosa, Rickettsia prowazekii, Salmonella enterica subsp. enterica serovar Typhimurium, Zea mays, Zea mays (Q9M4D3), Zea mays (Q9M4G3), Rickettsia conorii (Q92I96), Sinorhizobium meliloti (Q92SX6), Mesorhizobium loti (Q98BN3), Caulobacter vibrioides (Q9A4A3), Arabidopsis thaliana (Q9C920), Vibrio cholerae (Q9KQX2), Xylella fastidiosa (Q9PB46), Neisseria meningitidis MC58 (Q9K0D6)
-
brenda
Ku, M.J.; Yoon, H.J.; Ahn, H.J.; Kim, H.W.; Baek, S.H.; Suh, S.W.
Crystallization and preliminary X-ray crystallographic studies of 3-deoxy-manno-octulosonate cytidylyltransferase from Haemophilus influenzae
Acta Crystallogr. Sect. D
59
180-182
2003
Haemophilus influenzae
brenda
Kondo, K.; Doi, H.; Adachi, H.; Nishimura, Y.
Synergistic effect of CMP/KDO synthase inhibitors with antimicrobial agents on inhibition of production and release of vero toxin by enterohaemorrhagic Escherichia coli O157:H7
Bioorg. Med. Chem. Lett.
14
467-470
2004
Escherichia coli
brenda
Yoon, H.J.; Ku, M.J.; Mikami, B.; Suh, S.W.
Structure of 3-deoxy-manno-octulosonate cytidylyltransferase from Haemophilus influenzae complexed with the substrate 3-deoxy-manno-octulosonate in the beta-configuration
Acta Crystallogr. Sect. D
64
1292-1294
2008
Haemophilus influenzae (P44490), Haemophilus influenzae
brenda
Yi, L.; Velasquez, M.S.; Holler, T.P.; Woodard, R.W.
A simple assay for 3-deoxy-D-manno-octulosonate cytidylyltransferase and its use as a pathway screen
Anal. Biochem.
416
152-158
2011
Escherichia coli
brenda
Kobayashi, M.; Kouzu, N.; Inami, A.; Toyooka, K.; Konishi, Y.; Matsuoka, K.; Matoh, T.
Characterization of Arabidopsis CTP:3-deoxy-D-manno-2-octulosonate cytidylyltransferase (CMP-KDO synthetase), the enzyme that activates KDO during rhamnogalacturonan II biosynthesis
Plant Cell Physiol.
52
1832-1843
2011
Arabidopsis thaliana (Q9C920)
brenda
Schmidt, H.; Mesters, J.; Wu, J.; Woodard, R.; Hilgenfeld, R.; Mamat, U.
Evidence for a two-metal-ion mechanism in the cytidyltransferase KdsB, an enzyme involved in lipopolysaccharide biosynthesis
PLoS ONE
6
e23231
2011
Aquifex aeolicus (O66914), Aquifex aeolicus
brenda
Wen, L.; Zheng, Y.; Li, T.; Wang, P.G.
Enzymatic synthesis of 3-deoxy-D-manno-octulosonic acid (KDO) and its application for LPS assembly
Bioorg. Med. Chem. Lett.
26
2825-2828
2016
Escherichia coli (P04951)
brenda
Nilsson, I.; Grove, K.; Dovala, D.; Uehara, T.; Lapointe, G.; Six, D.A.
Molecular characterization and verification of azido-3,8-dideoxy-D-manno-oct-2-ulosonic acid incorporation into bacterial lipopolysaccharide
J. Biol. Chem.
292
19840-19848
2017
Escherichia coli (P04951)
brenda
Ahmad, S.; Raza, S.; Abro, A.; Liedl, K.R.; Azam, S.S.
Toward novel inhibitors against KdsB a highly specific and selective broad-spectrum bacterial enzyme
J. Biomol. Struct. Dyn.
37
1326-1345
2019
Acinetobacter baumannii (A3M4Z0), Acinetobacter baumannii ATCC 17978 (A3M4Z0)
brenda
Kim, S.; Jo, S.; Kim, M.S.; Shin, D.H.
A study of Rose Bengal against a 2-keto-3-deoxy-D-manno-octulosonate cytidylyltransferase as an antibiotic candidate
J. Enzyme Inhib. Med. Chem.
35
1414-1421
2020
Burkholderia thailandensis, Pseudomonas aeruginosa (A0A0C7D0B2), Pseudomonas aeruginosa, Chlamydia psittaci (A0A2D2D9V4), Chlamydia psittaci, Burkholderia pseudomallei (Q63WL5), Burkholderia pseudomallei, Burkholderia pseudomallei K96243 (Q63WL5)
brenda