Information on EC 2.7.7.33 - glucose-1-phosphate cytidylyltransferase

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The expected taxonomic range for this enzyme is: Bacteria

EC NUMBER
COMMENTARY
2.7.7.33
-
RECOMMENDED NAME
GeneOntology No.
glucose-1-phosphate cytidylyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
CTP + alpha-D-glucose 1-phosphate = diphosphate + CDP-glucose
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
nucleotidyl group transfer
-
-
-
-
nucleotidyl group transfer
Q8KN04
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PATHWAY
KEGG Link
MetaCyc Link
Amino sugar and nucleotide sugar metabolism
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Biosynthesis of secondary metabolites
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CDP-3,6-dideoxyhexose biosynthesis
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Metabolic pathways
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Starch and sucrose metabolism
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streptomycin biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
CTP:alpha-D-glucose-1-phosphate cytidylyltransferase
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SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
alpha-D-glucose-1-phosphate cytidylyltransferase
-
-
-
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alpha-D-glucose-1-phosphate cytidylyltransferase
-
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alpha-D-glucose-1-phosphate cytidylyltransferase
Q8KN04
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CDP-D-glucose synthase
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-
-
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CDP-D-glucose synthase
Q8KN04
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CDP-glucose pyrophosphorylase
-
-
-
-
CDPglucose pyrophosphorylase
-
-
-
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cytidine diphosphate glucose pyrophosphorylase
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-
-
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cytidine diphosphate-D-glucose pyrophosphorylase
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cytidine diphosphoglucose pyrophosphorylase
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-
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cytidylyltransferase, glucose 1-phosphate
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-
-
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CAS REGISTRY NUMBER
COMMENTARY
9027-10-5
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Azotobacter vinelandii O
strain O
-
-
Manually annotated by BRENDA team
no activity in Streptomyces griseus
streptomycin producing strain N2-3-11
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-
Manually annotated by BRENDA team
LT2, ecombinant, overproducing strain P9254
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-
Manually annotated by BRENDA team
strain GLA.0
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Manually annotated by BRENDA team
Streptomyces glaucescens GLA.0
strain GLA.0
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-
Manually annotated by BRENDA team
type V, rough mutant, strain 25VO
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-
Manually annotated by BRENDA team
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
additional information
-
no activation by dTDP-L-rhamnose, dTDP-4-amino-4,6-dideoxy-D-glucose and its N-acetyl-derivative, UDP-D-galactose, UDP-D-glucuronic acid, UDP-N-acetyl-D-glucosamine, GDP-D-mannose, D-glucose 6-phosphate, D-glucose 1,6-diphosphate, D-galactose 1-phosphate, D-glucosamine 1-phosphate, D-mannose 1-phosphate, N-acetyl-D-glucosamine 1-phosphate, D-fructose 6-phosphate, D-fructose 1,6-diphosphate, D-ribitol 5-phosphate, L-glycerol 3-phosphate, phosphoenolpyruvate, pyruvate, ADP, AMP, GMP, UMP, beta-NAD+ or beta-NADP+
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Ki VALUE [mM]
Ki VALUE [mM] Maximum
INHIBITOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.35
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CDPglucose
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pH 8.5, 37°C
0.3
-
diphosphate
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pH 8.5, 37°C
0.04
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dTTP
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pH 8.5, 37°C
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.2
9.5
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about half-maximal activity at pH 6.2 and about 70% of maximal activity at pH 9.5
PDB
SCOP
CATH
ORGANISM
Salmonella typhi
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Crystallization/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
hanging-drop vapour-diffusion method, crystallized in the presence of its product, CDP-glucose. Enzyme exists as a fully integrated hexamer with 32-point group symmetry
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hanging-drop vapour-diffusion method.The structure of the enzyme with bound MgCTP reveals that the binding pocket for the nucleotide is contained within one subunit rather than shared between two. Key side chains involved in nucleotide binding include Thr14, Arg15, Lys25, and Arg111
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Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
on a Ni-NTA His-Bind resin column
Q8KN04
APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
medicine
Q8KN04
ebosin is an exopolysaccharide with antagonist activity for interleukin-1 receptor in vitro and remarkable anti-rheumatic arthritis activity in vivo