Reference on EC 2.7.7.24 - glucose-1-phosphate thymidylyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yoshida, Y.; Nakano, Y.; Nezu, T.; Yamashita, Y.; Koga, T.
A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the synthesis of thymidine diphosphate-D-fucose
J. Biol. Chem.
274
16933-16939
1999
Bacteria, Aggregatibacter actinomycetemcomitans
Pazur, J.H.; Shuey, E.W.
The enzymatic synthesis of thymidine diphosphate glucose and its conversion to thymidine diphosphate rhamnose
J. Biol. Chem.
236
1780-1785
1961
Bacillus subtilis, Leuconostoc mesenteroides, Escherichia coli, Enterococcus faecalis, Glycine max, Lactiplantibacillus plantarum, Medicago sativa, Micrococcus luteus, Streptococcus zymogenes, Leuconostoc mesenteroides P-60
Kornfeld, S.; Glaser, L.
The enzymatic synthesis of thymidine-linked sugars I. Thymidine diphosphate glucose
J. Biol. Chem.
236
1791-1794
1961
Pseudomonas aeruginosa
Eun, S.H.; Kim, D.J.; Kim, Y.S.
Acinetobacter calcoaceticus glucose-1-phosphate thymidylyltransferase: cloning, sequencing, and expression in E.coli
J. Biochem. Mol. Biol.
34
230-236
2001
Acinetobacter calcoaceticus
-
Zuccotti, S.; Zanardi, D.; Rosano, C.; Sturla, L.; Tonetti, M.; Bolognesi, M.
Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase
J. Mol. Biol.
313
831-843
2001
Escherichia coli
Ma, Y.; Mills, J.A.; Belisle, J.T.; Vissa, V.; Howell, M.; Bowlin, K.; Scherman, M.S.; McNeil, M.
Determination of the pathway for rhamnose biosynthesis in mycobacteria: cloning, sequencing and expression of the Mycobacterium tuberculosis gene encoding alpha-D-glucose-1-phosphate thymidylyltransferase
Microbiology
143
937-945
1997
Mycobacterium tuberculosis, Mycolicibacterium smegmatis
Blankenfeldt, W.; Giraud, M.F.; Leonard, G.; Rahim, R.; Creuzenet, C.; Lam, J.S.; Naismith, J.H.
The purification, crystallization and preliminary structural characterization of glucose-1-phosphate thymidylyltransferase (RmlA), the first enzyme of the dTDP-L-rhamnose synthesis pathway from Pseudomonas aeruginosa
Acta Crystallogr. Sect. D
56
1501-1504
2000
BRENDA: Pseudomonas aeruginosa
Textmining: Bacteria
Blankenfeldt, W.; Asuncion, M.; Lam, J.S.; Naismith, J.H.
The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA)
EMBO J.
19
6652-6663
2000
BRENDA: Pseudomonas aeruginosa
Textmining: Bacteria
Yoo, J.C.; Lee, E.H.; Han, J.M.; Bang, H.J.; Sohng, J.K.
Expression of orf8 (chlD) as glucose-1-phosphate thymidylyltransferase gene involved in olivose biosynthesis from Streptomyces antibioticus Tu99 and biochemical properties of the expressed protein
J. Biochem. Mol. Biol.
32
363-369
1999
Streptomyces antibioticus, Streptomyces antibioticus Tu99
-
Silva, E.; Marques, A.R.; Fialho, A.M.; Granja, A.T.; Sa-Correia, I.
Proteins encoded by Sphingomonas elodea ATCC 31461 rmlA and ugpG genes, involved in gellan gum biosynthesis, exhibit both dTDP- and UDP-glucose pyrophosphorylase activities
Appl. Environ. Microbiol.
71
4703-4712
2005
BRENDA: Sphingomonas elodea
Textmining: Sphingomonas elodea ATCC 31461, Escherichia coli
Parajuli, N.; Lee, D.S.; Lee, H.C.; Liou, K.; Sohng, J.K.
Cloning, expression and characterization of glucose-1-phosphate thymidylyltransferase (strmlA) from Thermus caldophilus
Biotechnol. Lett.
26
437-442
2004
BRENDA: Thermus caldophilus (Q400H3), Thermus caldophilus
Textmining: Streptomyces argillaceus
Koropatkin, N.M.; Holden, H.M.
Molecular structure of alpha-D-glucose-1-phosphate cytidylyltransferase from Salmonella typhi
J. Biol. Chem.
279
44023-44029
2004
Ursidae
Zhang, Z.; Tsujimura, M.; Akutsu, J.; Sasaki, M.; Tajima, H.; Kawarabayasi, Y.
Identification of an extremely thermostable enzyme with dual sugar-1-phosphate nucleotidylyltransferase activities from an acidothermophilic archaeon, Sulfolobus tokodaii strain 7
J. Biol. Chem.
280
9698-9705
2005
BRENDA: Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii 7 (Q975F9)
Textmining: Sulfurisphaera tokodaii str. 7, archaeon
Murrell, J.M.; Liu, W.; Shen, B.
Biochemical characterization of the SgcA1 alpha-D-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic C-1027 biosynthetic pathway and overexpression of sgcA1 in Streptomyces globisporus to improve C-1027 production
J. Nat. Prod.
67
206-213
2004
BRENDA: Streptomyces globisporus
Textmining: Escherichia coli
Lee, H.C.; Sohng, J.K.; Kim, H.J.; Nam, D.H.; Han, J.M.; Cho, S.S.; Choi, J.H.; Yoo, J.C.
Cloning and expression of the glucose-1-phosphate thymidylyltransferase gene (gerD) from Streptomyces sp. GERI-155
Mol. Cells
17
274-280
2004
BRENDA: Streptomyces sp., Streptomyces sp. GERI-155
Textmining: Streptomyces, Escherichia coli, Firmicutes, Streptomyces sp. KCTC 0041BP
Aragao, D.; Fialho, A.M.; Marques, A.R.; Mitchell, E.P.; Sa-Correia, I.; Frazao, C.
The complex of Sphingomonas elodea ATCC 31461 glucose-1-phosphate uridylyltransferase with glucose-1-phosphate reveals a novel quaternary structure, unique among nucleoside diphosphate-sugar pyrophosphorylase members
J. Bacteriol.
189
4520-4528
2007
Sphingomonas elodea
Moretti, R.; Thorson, J.S.
Enhancing the latent nucleotide triphosphate flexibility of the glucose-1-phosphate thymidylyltransferase RmlA
J. Biol. Chem.
282
16942-16947
2007
Salmonella enterica typhimurium, Salmonella enterica typhimurium LT2
Han, J.; Kim, S.; Lee, H.; Yoo, J.
Cloning and expression of glucose-1-phosphate thymidylyltransferase gene (schS6) from Streptomyces sp. SCC-2136
J. Microbiol. Biotechnol.
17
685-690
2007
BRENDA: Streptomyces sp., Streptomyces sp. (Q2HR55), Streptomyces sp. SCC-2136, Streptomyces sp. SCC-2136 (Q2HR55)
Textmining: Streptomyces, Escherichia coli
Thoden, J.B.; Holden, H.M.
The molecular architecture of glucose-1-phosphate uridylyltransferase
Protein Sci.
16
432-440
2007
Escherichia coli (P0AEP3), Escherichia coli
Moretti, R.; Thorson, J.S.
A comparison of sugar indicators enables a universal high-throughput sugar-1-phosphate nucleotidyltransferase assay
Anal. Biochem.
377
251-258
2008
Salmonella enterica
Qu, H.; Xin, Y.; Dong, X.; Ma, Y.
An rmlA gene encoding D-glucose-1-phosphate thymidylyltransferase is essential for mycobacterial growth
FEMS Microbiol. Lett.
275
237-243
2007
BRENDA: Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
Textmining: Mycobacterium smegmatis mc(2)155
Kudo, F.; Kawabe, K.; Kuriki, H.; Eguchi, T.; Kakinuma, K.
A new family of glucose-1-phosphate/glucosamine-1-phosphate nucleotidylyltransferase in the biosynthetic pathways for antibiotics
J. Am. Chem. Soc.
127
1711-1718
2005
Niallia circulans
Alphey, M.S.; Pirrie, L.; Torrie, L.S.; Boulkeroua, W.A.; Gardiner, M.; Sarkar, A.; Maringer, M.; Oehlmann, W.; Brenk, R.; Scherman, M.S.; McNeil, M.; Rejzek, M.; Field, R.A.; Singh, M.; Gray, D.; Westwood, N.J.; Naismith, J.H.
Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa
ACS Chem. Biol.
8
387-396
2013
BRENDA: Pseudomonas aeruginosa (Q9HU22), Pseudomonas aeruginosa
Textmining: Mycobacterium tuberculosis
Sha, S.; Zhou, Y.; Xin, Y.; Ma, Y.
Development of a colorimetric assay and kinetic analysis for Mycobacterium tuberculosis D-glucose-1-phosphate thymidylyltransferase
J. Biomol. Screen.
17
252-257
2012
Mycobacterium tuberculosis
Singh, B.; Lee, C.; Park, J.; Sohng, J.
The amino acid sequences in the C-terminal region of glucose-1-phosphate thymidylyltransferases determine their soluble expression in Escherichia coli
Protein Eng. Des. Sel.
25
179-187
2012
Streptomyces peucetius (C6K8M0), Streptomyces peucetius ATCC 27952 (C6K8M0)
Zhang, Z.; Akutsu, J.; Kawarabayasi, Y.
Identification of novel acetyltransferase activity on the thermostable protein ST0452 from Sulfolobus tokodaii strain 7
J. Bacteriol.
192
3287-3293
2010
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii, archaeon
Zhang, Z.; Akutsu, J.; Tsujimura, M.; Kawarabayasi, Y.
Increasing in archaeal GlcNAc-1-P uridyltransferase activity by targeted mutagenesis while retaining its extreme thermostability
J. Biochem.
141
553-562
2007
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii 7 (Q975F9)
Raety, K.; Kunnari, T.; Hakala, J.; Maentsaelae, P.; Ylihonko, K.
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin
Mol. Gen. Genet.
264
164-172
2000
Streptomyces galilaeus, Streptomyces peucetius
Forget, S.M.; Smithen, D.A.; Jee, A.; Jakeman, D.L.
Mechanistic evaluation of a nucleoside tetraphosphate with a thymidylyltransferase
Biochemistry
54
1703-1707
2015
Streptococcus pneumoniae
Smithen, D.A.; Forget, S.M.; McCormick, N.E.; Syvitski, R.T.; Jakeman, D.L.
Polyphosphate-containing bisubstrate analogues as inhibitors of a bacterial cell wall thymidylyltransferase
Org. Biomol. Chem.
13
3347-3350
2015
BRENDA: Streptococcus pneumoniae
Textmining: Streptococcus
Forget, S.M.; Jee, A.; Smithen, D.A.; Jagdhane, R.; Anjum, S.; Beaton, S.A.; Palmer, D.R.; Syvitski, R.T.; Jakeman, D.L.
Kinetic evaluation of glucose 1-phosphate analogues with a thymidylyltransferase using a continuous coupled enzyme assay
Org. Biomol. Chem.
13
866-875
2015
Streptococcus pneumoniae
Kaminski, L.; Eichler, J.
Haloferax volcanii N-glycosylation: delineating the pathway of dTDP-rhamnose biosynthesis
PLoS ONE
9
e97441
2014
Haloferax volcanii (D4GU71), Haloferax volcanii, Bacteria, Archaea, eukaryota, Viruses, halophilic archaeon
Feng, L.; Shou, Q.; Butcher, R.A.
Identification of a dTDP-rhamnose biosynthetic pathway that oscillates with the molting cycle in Caenorhabditis elegans
Biochem. J.
473
1507-1521
2016
Caenorhabditis elegans (Q9XUS5), Caenorhabditis elegans
Li, Z.Z.; Riegert, A.S.; Goneau, M.F.; Cunningham, A.M.; Vinogradov, E.; Li, J.; Schoenhofen, I.C.; Thoden, J.B.; Holden, H.M.; Gilbert, M.
Characterization of the dTDP-Fuc3N and dTDP-Qui3N biosynthetic pathways in Campylobacter jejuni 81116
Glycobiology
27
358-369
2017
Campylobacter jejuni (Q5EPE6), Campylobacter jejuni
Zhang, Z.; Akutsu, J.; Tsujimura, M.; Kawarabayasi, Y.
Increasing in archaeal GlcNAc-1-P uridyltransferase activity by targeted mutagenesis while retaining its extreme thermostability
J. Biochem.
141
553-562
2007
Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii DSM 16993 (Q975F9)
Zhang, Z.; Tsujimura, M.; Akutsu, J.; Sasaki, M.; Tajima, H.; Kawarabayasi, Y.
Identification of an extremely thermostable enzyme with dual sugar-1-phosphate nucleotidylyltransferase activities from an acidothermophilic archaeon, Sulfolobus tokodaii strain 7
J. Biol. Chem.
280
9698-9705
2005
BRENDA: Sulfurisphaera tokodaii (Q975F9), Sulfurisphaera tokodaii DSM 16993 (Q975F9)
Textmining: Sulfurisphaera tokodaii str. 7, archaeon
Kaminski, L.; Eichler, J.
Haloferax volcanii N-glycosylation delineating the pathway of dTDP-rhamnose biosynthesis
PLoS ONE
9
e97441
2014
Haloferax volcanii, Haloferax volcanii (D4GU69), Bacteria, Archaea, eukaryota, Viruses, halophilic archaeon
Baumgartner, J.; Lee, J.; Halavaty, A.; Minasov, G.; Anderson, W.; Kuhn, M.
Structure of the Bacillus anthracis dTDP-l-rhamnose-biosynthetic enzyme glucose-1-phosphate thymidylyltransferase (RfbA)
Acta Crystallogr. Sect. F
73
621-628
2017
Bacillus anthracis (A0A4Y1W0P1), Bacillus anthracis, Bacillus anthracis Ames (A0A4Y1W0P1)
Li, S.; Wang, H.; Ma, J.; Gu, G.; Chen, Z.; Guo, Z.
One-pot four-enzyme synthesis of thymidine diphosphate-l-rhamnose
Chem. Commun. (Camb.)
52
13995-13998
2016
BRENDA: Streptococcus pneumoniae (O54574)
Textmining: Escherichia coli, Streptococcus
Bais, V.; Batra, S.; Prakash, B.
Identification of two highly promiscuous thermostable sugar nucleotidylyltransferases for glycorandomization
FEBS J.
285
2840-2855
2018
Pyrococcus horikoshii
Brown, H.A.; Thoden, J.B.; Tipton, P.A.; Holden, H.M.
The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes
Protein Sci.
27
441-450
2018
Mycobacterium tuberculosis (P9WH13), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WH13)
Li, S.; Wang, H.; Jin, G.; Chen, Z.; Gu, G.
Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F
RSC Adv.
10
30110-30114
2020
Streptococcus pneumoniae
-
Lew, HC; Mäkelä, PH; Kuhn, HM; Mayer, H; Nikaido, H
Biosynthesis of enterobacterial common antigen requires dTDPglucose pyrophosphorylase determined by a Salmonella typhimurium rfb gene and a Salmonella montevideo rfe gene.
J Bacteriol
168
715-21
1986
Isla Vista hantavirus, Salmonella enterica subsp. enterica serovar Montevideo, Salmonella enterica subsp. enterica serovar Typhimurium
Sivaraman, J; Sauvé, V; Matte, A; Cygler, M
Crystal structure of Escherichia coli glucose-1-phosphate thymidylyltransferase (RffH) complexed with dTTP and Mg2+.
J Biol Chem
277
44214-9
2002
Escherichia coli, Bacteria
KALINA, M; AVIGAD, G
OCCURRENCE OF THYMIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHORYLASE IN YEAST.
Biochim Biophys Acta
73
652-5
1963
Saccharomyces cerevisiae
Mansuri, R; Ansari, MY; Rana, S; Singh, J; Sinha, S; Dikhit, MR; Sahoo, GC; Das, P
Computational Elucidation of Structural Basis for Ligand Binding with Mycobacterium tuberculosis Glucose-1-Phosphate Thymidylyltransferase (RmlA).
Curr Pharm Biotechnol
2016
Mycobacterium tuberculosis
Hyun, C; Kim, SS; Sohng, JK; Hahn, J; Kim, J; Suh, J
An efficient approach for cloning the dNDP-glucose synthase gene from actinomycetes and its application in Streptomyces spectabilis, a spectinomycin producer.
FEMS Microbiol Lett
183
183-9
2000
Streptomyces spectabilis
Graninger, M; Kneidinger, B; Bruno, K; Scheberl, A; Messner, P
Homologs of the Rml enzymes from Salmonella enterica are responsible for dTDP-beta-L-rhamnose biosynthesis in the gram-positive thermophile Aneurinibacillus thermoaerophilus DSM 10155.
Appl Environ Microbiol
68
3708-15
2002
Bacteria, Aneurinibacillus thermoaerophilus DSM 10155, Salmonella enterica, Escherichia coli, Aneurinibacillus, Aneurinibacillus thermoaerophilus, bacterium
Bechthold, A; Sohng, JK; Smith, TM; Chu, X; Floss, HG
Identification of Streptomyces violaceoruber Tü22 genes involved in the biosynthesis of granaticin.
Mol Gen Genet
248
610-20
1995
Streptomyces griseus
Goethals, K; Leyman, B; Van Den Eede, G; Van Montagu, M; Holsters, M
An Azorhizobium caulinodans ORS571 locus involved in lipopolysaccharide production and nodule formation on Sesbania rostrata stems and roots.
J Bacteriol
176
92-9
1994
insertion sequences
Gutacker, F; Schmidt-Bohli, YI; Strobel, T; Qiu, D; Jessen, H; Paululat, T; Bechthold, A
Identification and Characterization of a Novel N- and O-Glycosyltransferase from Saccharopolyspora erythraea.
Molecules
25
2020
Streptomyces albus J1074
James, DB; Yother, J
Genetic and biochemical characterizations of enzymes involved in Streptococcus pneumoniae serotype 2 capsule synthesis demonstrate that Cps2T (WchF) catalyzes the committed step by addition of ?1-4 rhamnose, the second sugar residue in the repeat unit.
J Bacteriol
194
6479-89
2012
Streptococcus pneumoniae
Marolda, CL; Valvano, MA
Genetic analysis of the dTDP-rhamnose biosynthesis region of the Escherichia coli VW187 (O7:K1) rfb gene cluster: identification of functional homologs of rfbB and rfbA in the rff cluster and correct location of the rffE gene.
J Bacteriol
177
5539-46
1995
Escherichia coli VW187 (O7:K1), Bacteria, Escherichia coli
Morona, JK; Miller, DC; Coffey, TJ; Vindurampulle, CJ; Spratt, BG; Morona, R; Paton, JC
Molecular and genetic characterization of the capsule biosynthesis locus of Streptococcus pneumoniae type 23F.
Microbiology
145 ( Pt 4)
781-9
1999
Streptococcus pneumoniae
Zheng, YD; Pan, Y; He, K; Li, N; Yang, D; Du, GF; Ge, R; He, QY; Sun, X
SPD_1495 Contributes to Capsular Polysaccharide Synthesis and Virulence in Streptococcus pneumoniae.
mSystems
5
2020
Electron
Vermeersch, P; Buys, E; Sips, P; Pokreisz, P; Marsboom, G; Gillijns, H; Pellens, M; Dewerchin, M; Bloch, KD; Brouckaert, P; Janssens, S
Gender-Specific Modulation of the Response to Arterial Injury by Soluble Guanylate Cyclase alpha1.
Open Cardiovasc Med J
3
98-104
2009
Mus sp.
Olano, C; Lomovskaya, N; Fonstein, L; Roll, JT; Hutchinson, CR
A two-plasmid system for the glycosylation of polyketide antibiotics: bioconversion of epsilon-rhodomycinone to rhodomycin D.
Chem Biol
6
845-55
1999
Streptomyces
Oh, J; Lee, SG; Kim, BG; Sohng, JK; Liou, K; Lee, HC
One-pot enzymatic production of dTDP-4-keto-6-deoxy-D-glucose from dTMP and glucose-1-phosphate.
Biotechnol Bioeng
84
452-8
2003
Escherichia coli BL21
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