GMP catalyzes the synthesis of GDP-mannose, an important step in the formation of all guanosine-containing sugar nucleotides in plants. The GDP-mannose produced by the enzymatic action of GMP plays vital roles in both prokaryotes and eukaryotes, overview. The enzyme activity is correlated to the amount of ascorbic acid, overview
GDP-mannose, the mannose donor, required for the main cryptococcal virulence factor, a polysaccharide capsule that surrounds the cell, is produced in the cytosol by the sequential actions of phosphomannose isomerase, phosphomannomutase, and GDP-mannose pyrophosphorylase. Cryptococcus neoformans is a fungal pathogen that is responsible for life-threatening disease, particularly in the context of compromised immunity
GMP catalyzes the synthesis of GDP-mannose, an important step in the formation of all guanosine-containing sugar nucleotides in plants. The GDP-mannose produced by the enzymatic action of GMP plays vital roles in both prokaryotes and eukaryotes, overview. The enzyme activity is correlated to the amount of ascorbic acid, overview
GDP-mannose, the mannose donor, required for the main cryptococcal virulence factor, a polysaccharide capsule that surrounds the cell, is produced in the cytosol by the sequential actions of phosphomannose isomerase, phosphomannomutase, and GDP-mannose pyrophosphorylase. Cryptococcus neoformans is a fungal pathogen that is responsible for life-threatening disease, particularly in the context of compromised immunity
over-expression of isoform GMP3 increases total L-ascorbic acid contents and enhances the tolerance to oxidative stress in tomato. On the contrary, knock-down of GMP3 significantly decreases L-ascorbic acid contents below the threshold level and alters the phenotype of tomato plants with lesions and further senescence. More reactive oxygen species accumulate in the leaves and then trigger expressions of defence-related genes and mimic symptom occur on the leaves similar to hypersensitive responses against pathogens. Consequently, the photosynthesis of leaves falls dramatically
transgenic tobacco expressing GMPase exhibits enhanced salinity and drought resistance, a higher seed germination rate, better growth performance, a higher ascorbic acid content, a more stable redox state, higher superoxide dismutase activity, and lower levels of malonaldehyde and H2O2 under drought and salinity stress
increase in ascorbate content of transgenic Nicotiana tabacum expressing the gene from Malpighia glabra, transient expression of the uidA reporter gene in the protoplasts of Nicotiana tabacum BY2 suspension cultures using the MgGMP gene promoter, which shows higher activity than the cauliflower mosaic virus 35S and Arabidopsis GMP promoters
Empadinhas, N.; Marugg, J.D.; Borges, N.; Santos, H.; Da Costa, M.S.
Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes
The pathogenic fungus Cryptococcus neoformans expresses two functional GDP-mannose transporters with distinct expression patterns and roles in capsule synthesis
Analysis of GDP-D-mannose pyrophosphorylase gene promoter from acerola (Malpighia glabra) and increase in ascorbate content of transgenic tobacco expressing the acerola gene
Zhang, C.; Ouyang, B.; Yang, C.; Zhang, X.; Liu, H.; Zhang, Y.; Zhang, J.; Li, H.; Ye, Z.
Reducing AsA leads to leaf lesion and defence response in knock-down of the AsA biosynthetic enzyme GDP-D-mannose pyrophosphorylase gene in tomato plant