Information on EC 2.7.7.22 - mannose-1-phosphate guanylyltransferase (GDP)

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The expected taxonomic range for this enzyme is: Eukaryota, Archaea

SplaateEC_Number,Commentary
EC NUMBER
COMMENTARY
2.7.7.22
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SplaateRecommended_Name,GO_Number
RECOMMENDED NAME
GeneOntology No.
mannose-1-phosphate guanylyltransferase (GDP)
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SplaateReaction,Reaction_id,Commentary,IF(Commentary != '',Organism,'') ,IF(Commentary != '',Literature,'')
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose
show the reaction diagram
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SplaateReaction_Type,Organism,Commentary,Literature
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
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-
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SplaatePathway,BRENDA_Link,KEGG_Link,MetaCyc_Link,Source_Database
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
d-mannose degradation
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Fructose and mannose metabolism
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Amino sugar and nucleotide sugar metabolism
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Metabolic pathways
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SplaateSystematic_Name,Commentary_IUBMB
SYSTEMATIC NAME
IUBMB Comments
GDP:alpha-D-mannose-1-phosphate guanylyltransferase
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SplaateSynonyms,Organism,Commentary,Literature
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
GDP mannose phosphorylase
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GDP-D-mannose pyrophosphorylase
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GDP-D-mannose pyrophosphorylase
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GDP-D-mannose pyrophosphorylase
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GDP-mannose 1-phosphate guanylyltransferase
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GDP:D-mannose-1-phosphate guanylyltransferase
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GDPmannose phosphorylase
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guanosine diphosphate-mannose 1-phosphate guanylyltransferase
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guanosine diphosphomannose phosphorylase
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guanylyltransferase, mannose 1-phosphate (guanosine diphosphate)
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mannose 1-phosphate guanylyltransferase
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additional information
bifunctional enzyme, phosphomannose isomerase activity as well as mannose 1-phosphate guanylyltransferase activity
SplaateCAS_Registry_Number,Commentary
CAS REGISTRY NUMBER
COMMENTARY
9026-31-7
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SplaateOrganism, Commentary,Literature, Sequence_Code,Sequence_db,Textmining
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
serotype D strains JEC21
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Manually annotated by BRENDA team
gene GMP
UniProt
Manually annotated by BRENDA team
hyperthermophilic archeon
GenBank
Manually annotated by BRENDA team
SplaateGeneral_Information, Organism, Commentary, Literature
SplaateSubstrates,Products,id,Organism_Substrates,Commentary_Substrates, Literature_Substrates, Commentary_Products, Literature_Products,Reversibility
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GDP + alpha-D-mannose 1-phosphate
phosphate + GDP-mannose
show the reaction diagram
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?
GDP + alpha-D-mannose 1-phosphate
phosphate + GDP-mannose
show the reaction diagram
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GMP catalyzes the synthesis of GDP-mannose, an important step in the formation of all guanosine-containing sugar nucleotides in plants. The GDP-mannose produced by the enzymatic action of GMP plays vital roles in both prokaryotes and eukaryotes, overview. The enzyme activity is correlated to the amount of ascorbic acid, overview
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?
GDPmannose + phosphate
GDP + mannose 1-phosphate
show the reaction diagram
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-
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?
GDPmannose + phosphate
GDP + mannose 1-phosphate
show the reaction diagram
reverse reaction involved in synthesis of the compatible solute alpha-mannosylglycerate
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r
additional information
?
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diphosphate cannot substitute for phosphate
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additional information
?
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GDP-mannose, the mannose donor, required for the main cryptococcal virulence factor, a polysaccharide capsule that surrounds the cell, is produced in the cytosol by the sequential actions of phosphomannose isomerase, phosphomannomutase, and GDP-mannose pyrophosphorylase. Cryptococcus neoformans is a fungal pathogen that is responsible for life-threatening disease, particularly in the context of compromised immunity
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additional information
?
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GMP is an important enzyme in the Smirnoff-Wheeler’s pathway for the biosynthesis of ascorbic acid in plants
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additional information
?
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the essential enzyme plays a major role in the Smirnoff-Wheeler’s L-ascorbic acid biosynthetic pathway in plants
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SplaateNatural_Substrates,Natural_Products,id,Organism_Substrates,Commentary_Substrates,Literature_Substrates,Commentary_Products,Literature_Products,Reversibility
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GDP + alpha-D-mannose 1-phosphate
phosphate + GDP-mannose
show the reaction diagram
-
-
-
?
GDP + alpha-D-mannose 1-phosphate
phosphate + GDP-mannose
show the reaction diagram
-
GMP catalyzes the synthesis of GDP-mannose, an important step in the formation of all guanosine-containing sugar nucleotides in plants. The GDP-mannose produced by the enzymatic action of GMP plays vital roles in both prokaryotes and eukaryotes, overview. The enzyme activity is correlated to the amount of ascorbic acid, overview
-
?
GDPmannose + phosphate
GDP + mannose 1-phosphate
show the reaction diagram
-
-
-
?
GDPmannose + phosphate
GDP + mannose 1-phosphate
show the reaction diagram
O58649
reverse reaction involved in synthesis of the compatible solute alpha-mannosylglycerate
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r
additional information
?
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GDP-mannose, the mannose donor, required for the main cryptococcal virulence factor, a polysaccharide capsule that surrounds the cell, is produced in the cytosol by the sequential actions of phosphomannose isomerase, phosphomannomutase, and GDP-mannose pyrophosphorylase. Cryptococcus neoformans is a fungal pathogen that is responsible for life-threatening disease, particularly in the context of compromised immunity
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additional information
?
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GMP is an important enzyme in the Smirnoff-Wheeler’s pathway for the biosynthesis of ascorbic acid in plants
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additional information
?
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A0EJL9
the essential enzyme plays a major role in the Smirnoff-Wheeler’s L-ascorbic acid biosynthetic pathway in plants
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SplaateCofactor,Organism,Commentary,Literature,Filename
SplaateMetals_Ions,Organism,Commentary, Literature
SplaateInhibitors, Organism, Commentary, Literature,Filename
SplaateActivating_Compound, Organism, Commentary, Literature,Filename
SplaateKM_Value,KM_Value_Maximum, Substrate,Organism, Commentary, Literature, Filename
SplaateTurnover_Number, Turnover_Number_Maximum, Substrate,Organism,Commentary, Literature, Filename
SplaateKCat_KM_Value,KCat_KM_Value_Maximum, Substrate,Organism, Commentary, Literature, Filename
SplaateKI_Value,KI_Value_Maximum, Inhibitor,Organism, Commentary, Literature, Filename
SplaateIC50_Value,IC50_Value_Maximum, Inhibitor,Organism, Commentary, Literature, Filename
SplaateSpecific_Activity, Specific_Activity_Maximum, Organism ,Commentary, Literature
SplaatepH_Optimum, pH_Optimum_Maximum, Organism, Commentary, Literature
SplaatepH_Range,pH_Range_Maximum, Organism,Commentary, Literature
SplaateTemperature_Optimum, Temperature_Optimum_Maximum, Organism, Commentary, Literature
SplaateTemperature_Range, Temperature_Range_Maximum, Organism, Commentary, Literature
SplaatepI_Value,pI_Value_Maximum, Organism,Commentary, Literature
SplaateSource_Tissue, Organism, Commentary, Literature, Textmining
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
enzyme expression at different ripening stages, overview
Manually annotated by BRENDA team
SplaateLocalization, Organism, Commentary, id_go, Literature, Textmining
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
SplaatePDB,PDB,PDB,Organism,Uniprot_ID
SplaateMolecular_Weight, Molecular_Weight_Maximum, Organism, Commentary, Literature
SplaateSubunits, Organism, Commentary, Literature
SplaatePosttranslational_Modification, Organism, Commentary, Literature
SplaateCommentary, Organism, Literature
SplaatepH_Stability,pH_Stability_Maximum, Organism, Commentary, Literature
SplaateTemperature_Stability,Temperature_Stability_Maximum, Organism, Commentary, Literature
SplaateGeneral_Stability, Organism, Literature
SplaateOrganic_Solvent, Organism, Commentary, Literature
SplaateOxidation_Stability,Organism,Literature
SplaateStorage_Stability, Organism, Literature
SplaateCommentary, Organism, Literature
SplaateCommentary, Organism, Literature
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression analysis, and promoter determination and analysis, functional expression in Nicotiana tabacum plants
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gene GMP, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, quantitative expression analysis
SplaateCommentary, Organism, Literature
SplaateEngineering, Organism, Commentary, Literature
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
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increase in ascorbate content of transgenic Nicotiana tabacum expressing the gene from Malpighia glabra, transient expression of the uidA reporter gene in the protoplasts of Nicotiana tabacum BY2 suspension cultures using the MgGMP gene promoter, which shows higher activity than the cauliflower mosaic virus 35S and Arabidopsis GMP promoters
SplaateCommentary, Organism, Literature
SplaateApplication,Organism,Commentary,Literature