Information on EC 2.7.7.22 - mannose-1-phosphate guanylyltransferase (GDP)

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The expected taxonomic range for this enzyme is: Eukaryota, Archaea

EC NUMBER
COMMENTARY
2.7.7.22
-
RECOMMENDED NAME
GeneOntology No.
mannose-1-phosphate guanylyltransferase (GDP)
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
nucleotidyl group transfer
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-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Amino sugar and nucleotide sugar metabolism
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Biosynthesis of secondary metabolites
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Fructose and mannose metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
GDP:alpha-D-mannose-1-phosphate guanylyltransferase
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SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
GDP mannose phosphorylase
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GDP-D-mannose pyrophosphorylase
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GDP-D-mannose pyrophosphorylase
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GDP-D-mannose pyrophosphorylase
A0EJL9
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GDP-mannose 1-phosphate guanylyltransferase
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-
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GDP:D-mannose-1-phosphate guanylyltransferase
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GDPmannose phosphorylase
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-
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guanosine diphosphate-mannose 1-phosphate guanylyltransferase
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guanosine diphosphomannose phosphorylase
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-
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guanylyltransferase, mannose 1-phosphate (guanosine diphosphate)
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mannose 1-phosphate guanylyltransferase
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-
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additional information
O58649
bifunctional enzyme, phosphomannose isomerase activity as well as mannose 1-phosphate guanylyltransferase activity
CAS REGISTRY NUMBER
COMMENTARY
9026-31-7
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
serotype D strains JEC21
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-
Manually annotated by BRENDA team
gene GMP
UniProt
Manually annotated by BRENDA team
hyperthermophilic archeon
GenBank
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GDP + alpha-D-mannose 1-phosphate
phosphate + GDP-mannose
show the reaction diagram
-
-
-
-
?
GDP + alpha-D-mannose 1-phosphate
phosphate + GDP-mannose
show the reaction diagram
-
-, GMP catalyzes the synthesis of GDP-mannose, an important step in the formation of all guanosine-containing sugar nucleotides in plants. The GDP-mannose produced by the enzymatic action of GMP plays vital roles in both prokaryotes and eukaryotes, overview. The enzyme activity is correlated to the amount of ascorbic acid, overview
-
-
?
GDPmannose + phosphate
GDP + mannose 1-phosphate
show the reaction diagram
-
-
-
?
GDPmannose + phosphate
GDP + mannose 1-phosphate
show the reaction diagram
O58649
-, reverse reaction involved in synthesis of the compatible solute alpha-mannosylglycerate
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r
additional information
?
-
-
diphosphate cannot substitute for phosphate
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-
-
additional information
?
-
-
GDP-mannose, the mannose donor, required for the main cryptococcal virulence factor, a polysaccharide capsule that surrounds the cell, is produced in the cytosol by the sequential actions of phosphomannose isomerase, phosphomannomutase, and GDP-mannose pyrophosphorylase. Cryptococcus neoformans is a fungal pathogen that is responsible for life-threatening disease, particularly in the context of compromised immunity
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-
-
additional information
?
-
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GMP is an important enzyme in the Smirnoff-Wheeler’s pathway for the biosynthesis of ascorbic acid in plants
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-
-
additional information
?
-
A0EJL9
the essential enzyme plays a major role in the Smirnoff-Wheeler’s L-ascorbic acid biosynthetic pathway in plants
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GDP + alpha-D-mannose 1-phosphate
phosphate + GDP-mannose
show the reaction diagram
-
-
-
-
?
GDP + alpha-D-mannose 1-phosphate
phosphate + GDP-mannose
show the reaction diagram
-
GMP catalyzes the synthesis of GDP-mannose, an important step in the formation of all guanosine-containing sugar nucleotides in plants. The GDP-mannose produced by the enzymatic action of GMP plays vital roles in both prokaryotes and eukaryotes, overview. The enzyme activity is correlated to the amount of ascorbic acid, overview
-
-
?
GDPmannose + phosphate
GDP + mannose 1-phosphate
show the reaction diagram
-
-
-
?
GDPmannose + phosphate
GDP + mannose 1-phosphate
show the reaction diagram
O58649
reverse reaction involved in synthesis of the compatible solute alpha-mannosylglycerate
-
r
additional information
?
-
-
GDP-mannose, the mannose donor, required for the main cryptococcal virulence factor, a polysaccharide capsule that surrounds the cell, is produced in the cytosol by the sequential actions of phosphomannose isomerase, phosphomannomutase, and GDP-mannose pyrophosphorylase. Cryptococcus neoformans is a fungal pathogen that is responsible for life-threatening disease, particularly in the context of compromised immunity
-
-
-
additional information
?
-
-
GMP is an important enzyme in the Smirnoff-Wheeler’s pathway for the biosynthesis of ascorbic acid in plants
-
-
-
additional information
?
-
A0EJL9
the essential enzyme plays a major role in the Smirnoff-Wheeler’s L-ascorbic acid biosynthetic pathway in plants
-
-
-
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
A0EJL9
enzyme expression at different ripening stages, overview
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
expression analysis, and promoter determination and analysis, functional expression in Nicotiana tabacum plants
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gene GMP, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, quantitative expression analysis
A0EJL9
ENGINEERING
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
increase in ascorbate content of transgenic Nicotiana tabacum expressing the gene from Malpighia glabra, transient expression of the uidA reporter gene in the protoplasts of Nicotiana tabacum BY2 suspension cultures using the MgGMP gene promoter, which shows higher activity than the cauliflower mosaic virus 35S and Arabidopsis GMP promoters