Information on EC 2.7.7.22 - mannose-1-phosphate guanylyltransferase (GDP)

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The expected taxonomic range for this enzyme is: Eukaryota, Archaea

EC NUMBER
COMMENTARY hide
2.7.7.22
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RECOMMENDED NAME
GeneOntology No.
mannose-1-phosphate guanylyltransferase (GDP)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Amino sugar and nucleotide sugar metabolism
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d-mannose degradation
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Fructose and mannose metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
GDP:alpha-D-mannose-1-phosphate guanylyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-31-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
serotype D strains JEC21
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Manually annotated by BRENDA team
hyperthermophilic archeon
GenBank
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GDP + alpha-D-mannose 1-phosphate
phosphate + GDP-mannose
show the reaction diagram
GDPmannose + phosphate
GDP + mannose 1-phosphate
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GDP + alpha-D-mannose 1-phosphate
phosphate + GDP-mannose
show the reaction diagram
GDPmannose + phosphate
GDP + mannose 1-phosphate
show the reaction diagram
additional information
?
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
enzyme expression at different ripening stages, overview
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression analysis, and promoter determination and analysis, functional expression in Nicotiana tabacum plants
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gene GMP, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis, quantitative expression analysis
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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increase in ascorbate content of transgenic Nicotiana tabacum expressing the gene from Malpighia glabra, transient expression of the uidA reporter gene in the protoplasts of Nicotiana tabacum BY2 suspension cultures using the MgGMP gene promoter, which shows higher activity than the cauliflower mosaic virus 35S and Arabidopsis GMP promoters
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