Reference on EC 2.7.6.5 - GTP diphosphokinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sy, J.; Akers, H.
Purification and properties of guanosine 5,3-polyphosphate synthetase from Bacillus brevis
Biochemistry
15
4399-4403
1976
BRENDA: Brevibacillus brevis
Textmining: Escherichia coli
Fehr, S.; Richter, D.
Stringent response of Bacillus stearothermophilus: evidence for the existence of two distinct guanosine 3,5-polyphosphate synthetases
J. Bacteriol.
145
68-73
1981
BRENDA: Geobacillus stearothermophilus
Textmining: Escherichia coli
Justesen, J.; Lund, T.; Skou Pedersen, F.; Kjeldgaard, N.O.
The physiology of stringent factor (ATP:GTP 3-diphosphotransferase) in Escherichia coli
Biochimie
68
715-722
1986
Escherichia coli
Jones, G.H.
Purification and properties of ATP:GTP 3-pyrophosphotransferase (guanosine pentaphosphate synthetase) from Streptomyces antibioticus
J. Bacteriol.
176
1475-1481
1994
Saccharopolyspora erythraea, Streptomyces fradiae, Streptomyces albus, Streptomyces ambofaciens, Streptomyces antibioticus, Streptomyces anulatus, Streptomyces coelicolor, Streptomyces glaucescens, Streptomyces lividans, Streptomyces parvulus, Streptomyces fradiae UC8306, Streptomyces glaucescens ETH 22794, Streptomyces lividans TK24
Jones, G.H.
Activation of ATP:GTP 3-pyrophosphotransferase (guanosine pentaphosphate synthetase) in Streptomyces antibioticus
J. Bacteriol.
176
1482-1487
1994
Streptomyces antibioticus
Metzger, S.; Dror, I.B.; Aizenman, E.; Schreiber, G.; Toone, M.; Friesen, J.D.; Cashel, M.; Glaser, G.
The nucleotide sequence and characterization of the relA gene of Escherichia coli
J. Biol. Chem.
263
15699-15704
1988
Escherichia coli
Jones, G.H.; Bibb, M.J.
Guanosine pentaphosphate synthetase from Streptomyces antibioticus is also a polynucleotide phosphorylase
J. Bacteriol.
178
4281-4288
1996
BRENDA: Streptomyces antibioticus (Q53597), Streptomyces antibioticus
Textmining: Escherichia coli
Avarbock, A.; Avarbock, D.; Teh, J.S.; Buckstein, M.; Wang, Z.m.; Rubin, H.
Functional Regulation of the Opposing (p)ppGpp Synthetase/Hydrolase Activities of RelMtb from Mycobacterium tuberculosis
Biochemistry
44
9913-9923
2005
Mycobacterium tuberculosis
Hogg, T.; Mechold, U.; Malke, H.; Cashel, M.; Hilgenfeld, R.
Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response [corrected]
Cell
117
57-68
2004
Streptococcus dysgalactiae
Knutsson Jenvert, R.M.; Holmberg Schiavone, L.
Characterization of the tRNA and ribosome-dependent pppGpp-synthesis by recombinant stringent factor from Escherichia coli
FEBS J.
272
685-695
2005
Escherichia coli, Escherichia coli MRE 600
Mercade, M.; Cocaign-Bousquet, M.; Loubiere, P.
Glyceraldehyde-3-phosphate dehydrogenase regulation in Lactococcus lactis ssp. cremoris MG1363 or relA mutant at low pH
J. Appl. Microbiol.
100
1364-1372
2006
Lactococcus lactis ssp. cremoris
Gruendling, A.; Missiakas, D.M.; Schneewind, O.
Staphylococcus aureus mutants with increased lysostaphin resistance
J. Bacteriol.
188
6286-6297
2006
BRENDA: Staphylococcus aureus
Textmining: Bursa
Payoe, R.; Fahlman, R.
Dependence of rela-mediated (p)ppGpp formation on tRNA identity
Biochemistry
50
3075-3083
2011
Escherichia coli
Murdeshwar, M.S.; Chatterji, D.
MS_RHII-RSD, a dual-function RNase HII-(p)ppGpp synthetase from Mycobacterium smegmatis
J. Bacteriol.
194
4003-4014
2012
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
Wilkinson, R.C.; Batten, L.E.; Wells, N.J.; Oyston, P.C.; Roach, P.L.
Biochemical studies on Francisella tularensis RelA in (p)ppGpp biosynthesis
Biosci. Rep.
35
e00268
2015
Francisella tularensis subsp. tularensis (Q5NEV0)
Weiss, L.A.; Stallings, C.L.
Essential roles for Mycobacterium tuberculosis Rel beyond the production of (p)ppGpp
J. Bacteriol.
195
5629-5638
2013
BRENDA: Mycobacterium tuberculosis (P9WHG9), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WHG9)
Textmining: Bacteria, Mus sp.
Kriel, A.; Brinsmade, S.R.; Tse, J.L.; Tehranchi, A.K.; Bittner, A.N.; Sonenshein, A.L.; Wang, J.D.
GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes
J. Bacteriol.
196
189-201
2014
Bacillus subtilis (O31611), Bacillus subtilis (O54408), Bacillus subtilis (P39583), Bacillus subtilis, Bacillus subtilis 168 (O31611), Bacillus subtilis 168 (O54408), Bacillus subtilis 168 (P39583)
Steinchen, W.; Schuhmacher, J.S.; Altegoer, F.; Fage, C.D.; Srinivasan, V.; Linne, U.; Marahiel, M.A.; Bange, G.
Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone
Proc. Natl. Acad. Sci. USA
112
13348-13353
2015
Bacillus subtilis (O31611), Bacillus subtilis, Bacillus subtilis 168 (O31611)
Fernandez-Coll, L.; Cashel, M.
Contributions of SpoT hydrolase, SpoT synthetase, and RelA synthetase to carbon source diauxic growth transitions in Escherichia coli
Front. Microbiol.
9
1802
2018
Escherichia coli (P0AG24)
Honoki, R.; Ono, S.; Oikawa, A.; Saito, K.; Masuda, S.
Significance of accumulation of the alarmone (p)ppGpp in chloroplasts for controlling photosynthesis and metabolite balance during nitrogen starvation in Arabidopsis
Photosynth. Res.
135
299-308
2018
Arabidopsis thaliana (Q9SYH1)
Gratani, F.; Horvatek, P.; Geiger, T.; Borisova, M.; Mayer, C.; Grin, I.; Wagner, S.; Steinchen, W.; Bange, G.; Velic, A.; Macek, B.; Wolz, C.
Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus
PLoS Genet.
14
e1007514
2018
BRENDA: Staphylococcus aureus (W8U368), Staphylococcus aureus
Textmining: Escherichia coli
Lee, J.W.; Park, Y.H.; Seok, Y.J.
Rsd balances (p)ppGpp level by stimulating the hydrolase activity of SpoT during carbon source downshift in Escherichia coli
Proc. Natl. Acad. Sci. USA
115
E6845-E6854
2018
Escherichia coli, Escherichia coli (P0AG24), Bacteria
Pausch, P.; Abdelshahid, M.; Steinchen, W.; Schaefer, H.; Gratani, F.; Freibert, S.; Wolz, C.; Turgay, K.; Wilson, D.; Bange, G.
Structural basis for regulation of the opposing (p)ppGpp synthetase and hydrolase within the stringent response orchestrator rel
Cell Rep.
32
108157
2020
Bacillus subtilis (O54408), Bacillus subtilis 168 (O54408)
Manav, M.; Beljantseva, J.; Bojer, M.; Tenson, T.; Ingmer, H.; Hauryliuk, V.; Brodersen, D.
Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus small alarmone synthetase RelP
J. Biol. Chem.
293
3254-3264
2018
Staphylococcus aureus (W8TMV6)
Arenz, S.; Abdelshahid, M.; Sohmen, D.; Payoe, R.; Starosta, A.L.; Berninghausen, O.; Hauryliuk, V.; Beckmann, R.; Wilson, D.N.
The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis
Nucleic Acids Res.
44
6471-6481
2016
Escherichia coli (P0AG20), Escherichia coli
Wood, A.; Irving, S.; Bennison, D.; Corrigan, R.
The (p)ppGpp-binding GTPase era promotes rRNA processing and cold adaptation in Staphylococcus aureus
PLoS Genet.
15
e1008346
2019
Staphylococcus aureus
Hata, M; Ogura, M; Tanaka, T
Involvement of stringent factor RelA in expression of the alkaline protease gene aprE in Bacillus subtilis.
J Bacteriol
183
4648-51
2001
Bacillus subtilis
Van der Henst, M; Carlier, E; De Bolle, X
Intracellular Growth and Cell Cycle Progression are Dependent on (p)ppGpp Synthetase/Hydrolase in Brucella abortus.
Pathogens
9
2020
Brucella abortus, Bacteria
Schmale, H; Farnung, K; Fehr, S; Richter, D
Transfer of pyrophosphate from ATP and its insertion into the 3'-position of guanosine nucleotides by a stringent factor associated with the particulate fraction from Escherichia coli.
Hoppe Seylers Z Physiol Chem
358
1613-22
1977
Escherichia coli, insertion sequences
Fehr, S; Godt, F; Isono, K; Richter, D
A ribosome-independent stringent factor from Bacillus stearothermophilus and a low molecular weight substance inhibitory to its activity.
FEBS Lett
97
91-5
1979
Geobacillus stearothermophilus
Martini, O; Richter, D
Eukaryotic ribosomal proteins stimulate Escherichia coli stringent factor to synthesize guanosine 5'-diphosphate, 3'-diphosphate (ppGpp) and guanosine 5'-triphosphate, 3'-diphosphate (ppGpp).
Mol Gen Genet
166
291-7
1978
Escherichia coli, Oryctolagus cuniculus
Schmale, H; Fehr, S; Richter, D
Stringent factor and ribosomes are present in equimolar amounts in cells from a stringent strain of Escherichia coli.
Hoppe Seylers Z Physiol Chem
359
125-7
1978
Escherichia coli
Richter, D
Discrimination between purine and pyrimidine base at the 3' terminus of the tRNA molecule by the stringent factor system from Escherichia coli.
Biochem Biophys Res Commun
81
359-65
1978
Escherichia coli
Richter, D
Stringent factor from Escherichia coli directs ribosomal binding and release of uncharged tRNA.
Proc Natl Acad Sci U S A
73
707-11
1976
Escherichia coli
Howard, GA; Gordon, J
Stringent factor binds to Escherichia coli ribosomes only in the presence of protein L10.
FEBS Lett
68
211-4
1976
Escherichia coli
Richter, D
The stringent control mechanism. Binding of uncharged tRNA and stringent factor to Escherichia coli ribosomes.
Arch Biol Med Exp (Santiago)
10
85-91
1976
Escherichia, Escherichia coli
Richter, D; Nowak, P; Kleinert, U
Escherichia coli stringent factor binds to ribosomes at a site different from that of elongation factor Tu or G.
Biochemistry
14
4414-20
1975
Escherichia coli
Sy, J
Reversibility of the pyrophosphoryl transfer from ATP to GTP by Escherichia coli stringent factor.
Proc Natl Acad Sci U S A
71
3470-3
1974
Escherichia coli
Block, R; Haseltine, WA
Thermolability of the stringent factor in rel mutants of Escherichia coli.
J Mol Biol
77
625-9
1973
Escherichia coli
Richter, D; Isono, K
A stringent factor activity associated with the 50 S ribosomal subunit of Bacillus stearothermophilus.
FEBS Lett
44
270-3
1974
Geobacillus stearothermophilus
Wagner, EG; Kurland, CG
Escherichia coli elongation factor G blocks stringent factor.
Biochemistry
19
1234-40
1980
Escherichia coli
Chakraburtty, R; White, J; Takano, E; Bibb, M
Cloning, characterization and disruption of a (p)ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2).
Mol Microbiol
19
357-368
1996
Streptomyces coelicolor A3(2)
Kasai, K; Usami, S; Yamada, T; Endo, Y; Ochi, K; Tozawa, Y
A RelA-SpoT homolog (Cr-RSH) identified in Chlamydomonas reinhardtii generates stringent factor in vivo and localizes to chloroplasts in vitro.
Nucleic Acids Res
30
4985-92
2002
Chlamydomonas reinhardtii
Brockmann-Gretza, O; Kalinowski, J
Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p)ppGpp synthase.
BMC Genomics
7
230
2006
Corynebacterium glutamicum
Jenvert, RM; Schiavone, LH
The flexible N-terminal domain of ribosomal protein L11 from Escherichia coli is necessary for the activation of stringent factor.
J Mol Biol
365
764-72
2007
Escherichia coli
Tozawa, Y; Nozawa, A; Kanno, T; Narisawa, T; Masuda, S; Kasai, K; Nanamiya, H
Calcium-activated (p)ppGpp synthetase in chloroplasts of land plants.
J Biol Chem
282
35536-45
2007
Embryophyta, Bacteria, Oryza sativa
Nanamiya, H; Kasai, K; Nozawa, A; Yun, CS; Narisawa, T; Murakami, K; Natori, Y; Kawamura, F; Tozawa, Y
Identification and functional analysis of novel (p)ppGpp synthetase genes in Bacillus subtilis.
Mol Microbiol
67
291-304
2008
Bacillus subtilis
Das, B; Pal, RR; Bag, S; Bhadra, RK
Stringent response in Vibrio cholerae: genetic analysis of spoT gene function and identification of a novel (p)ppGpp synthetase gene.
Mol Microbiol
72
380-98
2009
Vibrio cholerae
Natori, Y; Tagami, K; Murakami, K; Yoshida, S; Tanigawa, O; Moh, Y; Masuda, K; Wada, T; Suzuki, S; Nanamiya, H; Tozawa, Y; Kawamura, F
Transcription activity of individual rrn operons in Bacillus subtilis mutants deficient in (p)ppGpp synthetase genes, relA, yjbM, and ywaC.
J Bacteriol
191
4555-61
2009
Bacillus subtilis
Yan, X; Zhao, C; Budin-Verneuil, A; Hartke, A; Rincé, A; Gilmore, MS; Auffray, Y; Pichereau, V
The (p)ppGpp synthetase RelA contributes to stress adaptation and virulence in Enterococcus faecalis V583.
Microbiology
155
3226-37
2009
Enterococcus faecalis v583
Geiger, T; Goerke, C; Fritz, M; Schäfer, T; Ohlsen, K; Liebeke, M; Lalk, M; Wolz, C
Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus.
Infect Immun
78
1873-83
2010
Staphylococcus aureus
Tagami, K; Nanamiya, H; Kazo, Y; Maehashi, M; Suzuki, S; Namba, E; Hoshiya, M; Hanai, R; Tozawa, Y; Morimoto, T; Ogasawara, N; Kageyama, Y; Ara, K; Ozaki, K; Yoshida, M; Kuroiwa, H; Kuroiwa, T; Ohashi, Y; Kawamura, F
Expression of a small (p)ppGpp synthetase, YwaC, in the (p)ppGpp(0) mutant of Bacillus subtilis triggers YvyD-dependent dimerization of ribosome.
Microbiologyopen
1
115-34
2012
Bacillus subtilis
Bag, S; Das, B; Dasgupta, S; Bhadra, RK
Mutational analysis of the (p)ppGpp synthetase activity of the Rel enzyme of Mycobacterium tuberculosis.
Arch Microbiol
196
575-88
2014
Mycobacterium tuberculosis, Bacteria
Dasgupta, S; Basu, P; Pal, RR; Bag, S; Bhadra, RK
Genetic and mutational characterization of the small alarmone synthetase gene relV of Vibrio cholerae.
Microbiology
160
1855-66
2014
Vibrio cholerae
Gaca, AO; Kudrin, P; Colomer-Winter, C; Beljantseva, J; Liu, K; Anderson, B; Wang, JD; Rejman, D; Potrykus, K; Cashel, M; Hauryliuk, V; Lemos, JA
From (p)ppGpp to (pp)pGpp: Characterization of Regulatory Effects of pGpp Synthesized by the Small Alarmone Synthetase of Enterococcus faecalis.
J Bacteriol
197
2908-19
2015
Enterococcus faecalis
Krishnan, S; Petchiappan, A; Singh, A; Bhatt, A; Chatterji, D
R-loop induced stress response by second (p)ppGpp synthetase in Mycobacterium smegmatis: functional and domain interdependence.
Mol Microbiol
2016
Mycolicibacterium smegmatis
Wurm, P; Tutz, S; Mutsam, B; Vorkapic, D; Heyne, B; Grabner, C; Kleewein, K; Halscheidt, A; Schild, S; Reidl, J
Stringent factor and proteolysis control of sigma factor RpoS expression in Vibrio cholerae.
Int J Med Microbiol
307
154-165
2017
Vibrio cholerae, Escherichia coli, Homo sapiens
Beljantseva, J; Kudrin, P; Andresen, L; Shingler, V; Atkinson, GC; Tenson, T; Hauryliuk, V
Negative allosteric regulation of Enterococcus faecalis small alarmone synthetase RelQ by single-stranded RNA.
Proc Natl Acad Sci U S A
114
3726-3731
2017
Enterococcus faecalis
Pokhrel, A; Poudel, A; Purcell, EB
A Purification and In Vitro Activity Assay for a (p)ppGpp Synthetase from Clostridium difficile.
J Vis Exp
2018
Clostridioides difficile
Van Nerom, K; Tamman, H; Takada, H; Hauryliuk, V; Garcia-Pino, A
The Rel stringent factor from Thermus thermophilus: crystallization and X-ray analysis.
Acta Crystallogr F Struct Biol Commun
75
561-569
2019
Thermus thermophilus
Turnbull, KJ; Dzhygyr, I; Lindemose, S; Hauryliuk, V; Roghanian, M
Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA.
Front Microbiol
10
1966
2019
Escherichia coli
Germain, E; Guiraud, P; Byrne, D; Douzi, B; Djendli, M; Maisonneuve, E
YtfK activates the stringent response by triggering the alarmone synthetase SpoT in Escherichia coli.
Nat Commun
10
5763
2019
Escherichia coli
Pokhrel, A; Poudel, A; Castro, KB; Celestine, MJ; Oludiran, A; Rinehold, AJ; Resek, AM; Mhanna, MA; Purcell, EB
The (p)ppGpp Synthetase RSH Mediates Stationary-Phase Onset and Antibiotic Stress Survival in Clostridioides difficile.
J Bacteriol
202
2020
Clostridioides difficile
Fung, DK; Yang, J; Stevenson, DM; Amador-Noguez, D; Wang, JD
Small Alarmone Synthetase SasA Expression Leads to Concomitant Accumulation of pGpp, ppApp, and AppppA in Bacillus subtilis.
Front Microbiol
11
2083
2020
Bacillus subtilis
Muta, S; Osoegawa, K; Ezaki, S; Zubair, M; Kuhara, S; Mukai, J; Dixon, R
Streptomyces ATP nucleotide 3'-pyrophosphokinase and its gene.
Nucleic Acids Symp Ser
165-6
1992
Escherichia coli
Gaca, AO; Abranches, J; Kajfasz, JK; Lemos, JA
Global transcriptional analysis of the stringent response in Enterococcus faecalis.
Microbiology
158
1994-2004
2012
bacterium
Petchiappan, A; Naik, SY; Chatterji, D
RelZ-Mediated Stress Response in Mycobacterium smegmatis: pGpp Synthesis and Its Regulation.
J Bacteriol
202
2020
Mycolicibacterium smegmatis
Zhu, M; Dai, X
Growth suppression by altered (p)ppGpp levels results from non-optimal resource allocation in Escherichia coli.
Nucleic Acids Res
47
4684-4693
2019
Escherichia coli
Lger, L; Byrne, D; Guiraud, P; Germain, E; Maisonneuve, E
NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli.
Elife
10
2021
Escherichia coli
Juengert, JR; Borisova, M; Mayer, C; Wolz, C; Brigham, CJ; Sinskey, AJ; Jendrossek, D
Absence of ppGpp Leads to Increased Mobilization of Intermediately Accumulated Poly(3-Hydroxybutyrate) in Ralstonia eutropha H16.
Appl Environ Microbiol
83
2017
Cupriavidus necator H16
Pezzoni, M; Pizarro, RA; Costa, CS
Protective effect of low UVA irradiation against the action of lethal UVA on Pseudomonas aeruginosa: Role of the relA gene.
J Photochem Photobiol B
116C
95-104
2012
Pseudomonas aeruginosa
Wehmeier, L; Schäfer, A; Burkovski, A; Krämer, R; Mechold, U; Malke, H; Pühler, A; Kalinowski, J
The role of the Corynebacterium glutamicum rel gene in (p)ppGpp metabolism.
Microbiology
144 ( Pt 7)
1853-62
1998
Corynebacterium glutamicum
Fehr, S; Lin, A; Wool, IG; Richter, D
The stimulation of Escherichia coli stringent factor-dependent synthesis of guanosine 3',5'-polyphosphate [(p)ppGpp] by rat liver ribosomal proteins.
Mol Gen Genet
176
375-7
1979
Rattus, Escherichia coli
Smith, I; Paress, P; Cabane, K; Dubnau, E
Genetics and physiology of the rel system of Bacillus subtilis.
Mol Gen Genet
178
271-9
1980
Bacillus subtilis, Escherichia
Stark, MJ; Cundliffe, E; Dijk, J; Stöffler, G
Functional homology between E. coli ribosomal protein L11 and B. megaterium protein BM-L11.
Mol Gen Genet
180
11-5
1980
Escherichia coli, Priestia megaterium
Harris, BZ; Kaiser, D; Singer, M
The guanosine nucleotide (p)ppGpp initiates development and A-factor production in myxococcus xanthus.
Genes Dev
12
1022-35
1998
Escherichia coli
Martínez-Costa, OH; Fernández-Moreno, MA; Malpartida, F
The relA/spoT-homologous gene in Streptomyces coelicolor encodes both ribosome-dependent (p)ppGpp-synthesizing and -degrading activities.
J Bacteriol
180
4123-32
1998
Streptomyces coelicolor
Ojha, AK; Mukherjee, TK; Chatterji, D
High intracellular level of guanosine tetraphosphate in Mycobacterium smegmatis changes the morphology of the bacterium.
Infect Immun
68
4084-91
2000
Mycolicibacterium smegmatis
Mittenhuber, G
Occurrence of mazEF-like antitoxin/toxin systems in bacteria.
J Mol Microbiol Biotechnol
1
295-302
1999
Escherichia
Gropp, M; Strausz, Y; Gross, M; Glaser, G
Regulation of Escherichia coli RelA requires oligomerization of the C-terminal domain.
J Bacteriol
183
570-9
2001
Escherichia coli
Sun, J; Hesketh, A; Bibb, M
Functional analysis of relA and rshA, two relA/spoT homologues of Streptomyces coelicolor A3(2).
J Bacteriol
183
3488-98
2001
Streptomyces coelicolor A3(2)
Yang, X; Ishiguro, EE
Involvement of the N terminus of ribosomal protein L11 in regulation of the RelA protein of Escherichia coli.
J Bacteriol
183
6532-7
2001
Escherichia coli
Yang, X; Ishiguro, EE
Dimerization of the RelA protein of Escherichia coli.
Biochem Cell Biol
79
729-36
2001
Escherichia coli
Dahl, JL; Kraus, CN; Boshoff, HI; Doan, B; Foley, K; Avarbock, D; Kaplan, G; Mizrahi, V; Rubin, H; Barry, CE
The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice.
Proc Natl Acad Sci U S A
100
10026-31
2003
Mus sp.
Zhang, HB; Wang, C; Zhang, LH
The quormone degradation system of Agrobacterium tumefaciens is regulated by starvation signal and stress alarmone (p)ppGpp.
Mol Microbiol
52
1389-401
2004
transposons
Kasai, K; Kanno, T; Endo, Y; Wakasa, K; Tozawa, Y
Guanosine tetra- and pentaphosphate synthase activity in chloroplasts of a higher plant: association with 70S ribosomes and inhibition by tetracycline.
Nucleic Acids Res
32
5732-41
2004
plant, Bacteria, Pisum sativum
Simard, B; Turcotte, H; Marceau, P; Biron, S; Hould, FS; Lebel, S; Marceau, S; Boulet, LP
Asthma and sleep apnea in patients with morbid obesity: outcome after bariatric surgery.
Obes Surg
14
1381-8
0
Homo sapiens
Dozot, M; Boigegrain, RA; Delrue, RM; Hallez, R; Ouahrani-Bettache, S; Danese, I; Letesson, JJ; De Bolle, X; Köhler, S
The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virB.
Cell Microbiol
8
1791-802
2006
Brucella, Sinorhizobium meliloti
Mouery, K; Rader, BA; Gaynor, EC; Guillemin, K
The stringent response is required for Helicobacter pylori survival of stationary phase, exposure to acid, and aerobic shock.
J Bacteriol
188
5494-500
2006
Helicobacter pylori
Clarke, MJ; Cohen-Gadol, AA; Ebersold, MJ; Cabanela, ME
Long-term incidence of subaxial cervical spine instability following cervical arthrodesis surgery in patients with rheumatoid arthritis.
Surg Neurol
66
136-40; discussion 140
2006
Homo sapiens
Hesketh, A; Chen, WJ; Ryding, J; Chang, S; Bibb, M
The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2).
Genome Biol
8
R161
2007
Bacteria
Nascimento, MM; Lemos, JA; Abranches, J; Lin, VK; Burne, RA
Role of RelA of Streptococcus mutans in global control of gene expression.
J Bacteriol
190
28-36
2008
Streptococcus mutans
Ryu, YG; Kim, ES; Kim, DW; Kim, SK; Lee, KJ
Differential stringent responses of Streptomyces coelicolor M600 to starvation of specific nutrients.
J Microbiol Biotechnol
17
305-12
2007
Streptomyces coelicolor, Streptomyces coelicolor M600
Gomez-Escribano, JP; Martín, JF; Hesketh, A; Bibb, MJ; Liras, P
Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp.
Microbiology
154
744-55
2008
Streptomyces clavuligerus, Streptomyces
Knauber, T; Doss, SD; Gerth, K; Perlova, O; Müller, R; Treuner-Lange, A
Mutation in the rel gene of Sorangium cellulosum affects morphological and physiological differentiation.
Mol Microbiol
69
254-66
2008
Sorangium cellulosum So ce56
Zhou, YN; Coleman, WG; Yang, Z; Yang, Y; Hodgson, N; Chen, F; Jin, DJ
Regulation of cell growth during serum starvation and bacterial survival in macrophages by the bifunctional enzyme SpoT in Helicobacter pylori.
J Bacteriol
190
8025-32
2008
Helicobacter pylori, Escherichia coli
Pérez-Tornero, O; Tallón, CI; Porras, I; Navarro, JM
Physiological and growth changes in micropropagated Citrus macrophylla explants due to salinity.
J Plant Physiol
2009
plant
Mechold, U; Potrykus, K; Murphy, H; Murakami, KS; Cashel, M
Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Nucleic Acids Res
41
6175-89
2013
Escherichia coli, Streptococcus
Geiger, T; Kstle, B; Gratani, FL; Goerke, C; Wolz, C
Two small (p)ppGpp synthases in Staphylococcus aureus mediate tolerance against cell envelope stress conditions.
J Bacteriol
196
894-902
2014
Firmicutes, Staphylococcus aureus
Gonzalez, D; Collier, J
Effects of (p)ppGpp on the progression of the cell cycle of Caulobacter crescentus.
J Bacteriol
196
2514-25
2014
Escherichia coli
Yan, X; Budin-Verneuil, A; Auffray, Y; Pichereau, V
Proteome phenotyping of ?relA mutants in Enterococcus faecalis V583.
Can J Microbiol
60
525-31
2014
Enterococcus faecalis v583
Negahban, H; Mohtasebi, E; Goharpey, S
Reliability, validity, and responsiveness of the Persian version of Shoulder Activity Scale in a group of patients with shoulder disorders.
Disabil Rehabil
1-6
2014
Homo sapiens
Bugrysheva, JV; Pappas, CJ; Terekhova, DA; Iyer, R; Godfrey, HP; Schwartz, I; Cabello, FC
Characterization of the RelBbu Regulon in Borrelia burgdorferi Reveals Modulation of Glycerol Metabolism by (p)ppGpp.
PLoS One
10
e0118063
2015
Borreliella burgdorferi, Mus sp.
Chuang, YM; Dutta, NK; Hung, CF; Wu, TC; Rubin, H; Karakousis, PC
The stringent response factors PPX1 and PPK2 play an important role in Mycobacterium tuberculosis metabolism, biofilm formation, and sensitivity to isoniazid in vivo.
Antimicrob Agents Chemother
2016
Mus musculus
Brown, DR; Barton, G; Pan, Z; Buck, M; Wigneshweraraj, S
Combinatorial stress responses: direct coupling of two major stress responses in Escherichia coli.
Microb Cell
1
315-317
2014
Escherichia coli
Syal, K; Flentie, K; Bhardwaj, N; Maiti, K; Jayaraman, N; Stallings, CL; Chatterji, D
Synthetic (p)ppGpp Analogue Is an Inhibitor of Stringent Response in Mycobacteria.
Antimicrob Agents Chemother
61
2017
Corynebacteriales
Liu, H; Xiao, Y; Nie, H; Huang, Q; Chen, W
Influence of (p)ppGpp on biofilm regulation in Pseudomonas putida KT2440.
Microbiol Res
204
1-8
2017
Pseudomonas putida KT2440, Pisum sativum
Brown, DR
Nitrogen Starvation Induces Persister Cell Formation in Escherichia coli.
J Bacteriol
201
2019
Escherichia coli
Xu, Z; You, D; Tang, LY; Zhou, Y; Ye, BC
Metabolic Engineering Strategies Based on Secondary Messengers (p)ppGpp and C-di-GMP To Increase Erythromycin Yield in Saccharopolyspora erythraea.
ACS Synth Biol
8
332-345
2019
Streptomyces coelicolor
Dutta, NK; Klinkenberg, LG; Vazquez, MJ; Segura-Carro, D; Colmenarejo, G; Ramon, F; Rodriguez-Miquel, B; Mata-Cantero, L; Porras-De Francisco, E; Chuang, YM; Rubin, H; Lee, JJ; Eoh, H; Bader, JS; Perez-Herran, E; Mendoza-Losana, A; Karakousis, PC
Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence.
Sci Adv
5
eaav2104
2019
Mycobacterium tuberculosis, Bacteria, Mus sp.
Avilan, L; Puppo, C; Villain, A; Bouveret, E; Menand, B; Field, B; Gontero, B
RSH enzyme diversity for (p)ppGpp metabolism in Phaeodactylum tricornutum and other diatoms.
Sci Rep
9
17682
2019
Phaeodactylum tricornutum
Osaka, N; Kanesaki, Y; Watanabe, M; Watanabe, S; Chibazakura, T; Takada, H; Yoshikawa, H; Asai, K
Novel (p)ppGpp0 suppressor mutations reveal an unexpected link between methionine catabolism and GTP synthesis in Bacillus subtilis.
Mol Microbiol
2020
Bacillus subtilis
Block, R; Haseltine, AW
Purification and properties of stringent factor.
J Biol Chem
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Escherichia coli
Takada, H; Roghanian, M; Caballero-Montes, J; Van Nerom, K; Jimmy, S; Kudrin, P; Trebini, F; Murayama, R; Akanuma, G; Garcia-Pino, A; Hauryliuk, V
Ribosome association primes the stringent factor Rel for tRNA-dependent locking in the A-site and activation of (p)ppGpp synthesis.
Nucleic Acids Res
49
444-457
2021
Bacillus subtilis, Varanidae, bacterium
Kudrin, P; Varik, V; Oliveira, SR; Beljantseva, J; Del Peso Santos, T; Dzhygyr, I; Rejman, D; Cava, F; Tenson, T; Hauryliuk, V
Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA-Dependent and relA-Independent Tolerance to ?-Lactams.
Antimicrob Agents Chemother
61
2017
Escherichia coli
Roghanian, M; Van Nerom, K; Takada, H; Caballero-Montes, J; Tamman, H; Kudrin, P; Talavera, A; Dzhygyr, I; Ekstrm, S; Atkinson, GC; Garcia-Pino, A; Hauryliuk, V
(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains.
Mol Cell
81
3310-3322.e6
2021
Escherichia coli, Bacillus subtilis
Huang, Q; Gruner, SM; Kim, CU; Mao, Y; Wu, X; Szebenyi, DM
Reduction of lattice disorder in protein crystals by high-pressure cryocooling.
J Appl Crystallogr
49
149-157
2016
Homo sapiens
Libby, EA; Reuveni, S; Dworkin, J
Multisite phosphorylation drives phenotypic variation in (p)ppGpp synthetase-dependent antibiotic tolerance.
Nat Commun
10
5133
2019
Bacillus subtilis
Sanselicio, S; Viollier, PH
Convergence of alarmone and cell cycle signaling from trans-encoded sensory domains.
MBio
6
e01415-15
2015
Caulobacter vibrioides
Belitsina, NV; Klyachko, EV; Shakulov, RS
Template-independent synthesis of guanosine tetra- and pentaphosphates on ribosomes.
FEBS Lett
162
39-42
1983
Escherichia coli
Apirakaramwong, A; Kashiwagi, K; Raj, VS; Sakata, K; Kakinuma, Y; Ishihama, A; Igarashi, K
Involvement of ppGpp, ribosome modulation factor, and stationary phase-specific sigma factor sigma(S) in the decrease in cell viability caused by spermidine.
Biochem Biophys Res Commun
264
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1999
Escherichia coli, Transformation
Bennink, RJ; Peeters, M; Rutgeerts, P; Mortelmans, L
Evaluation of early treatment response and predicting the need for colectomy in active ulcerative colitis with 99mTc-HMPAO white blood cell scintigraphy.
J Nucl Med
45
1698-704
2004
Homo sapiens
Hwang, J; Inouye, M
RelA functionally suppresses the growth defect caused by a mutation in the G domain of the essential Der protein.
J Bacteriol
190
3236-43
2008
Escherichia coli
Hauryliuk, V; Atkinson, GC
Small Alarmone Synthetases as novel bacterial RNA-binding proteins.
RNA Biol
2017
Enterococcus faecalis
Kushwaha, GS; Oyeyemi, BF; Bhavesh, NS
Stringent response protein as a potential target to intervene persistent bacterial infection.
Biochimie
165
67-75
2019
Mycobacterium tuberculosis
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