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Information on EC 2.7.6.2 - thiamine diphosphokinase and Organism(s) Schizosaccharomyces pombe and UniProt Accession P41888

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.6 Diphosphotransferases
                2.7.6.2 thiamine diphosphokinase
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This record set is specific for:
Schizosaccharomyces pombe
UNIPROT: P41888 not found.
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Word Map
The taxonomic range for the selected organisms is: Schizosaccharomyces pombe
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
thiamine pyrophosphokinase, pyrophosphokinase, htpk1, thiamin pyrophosphotransferase, thiamine diphosphokinase, thiaminokinase, thiamin:atp pyrophosphotransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ATP:thiamin pyrophosphotransferase
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-
-
-
hTPK1
-
-
-
-
pyrophosphokinase
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-
pyrophosphokinase, thiamin
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-
-
-
thiamin kinase
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-
-
-
thiamin pyrophosphokinase
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-
-
-
thiamin pyrophosphotransferase
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-
-
-
thiamin:ATP pyrophosphotransferase
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-
-
-
thiamine kinase
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-
-
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thiamine pyrophosphokinase
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thiaminokinase
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-
-
-
TPK
-
-
-
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TPTase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diphosphate transfer
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-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -
SYSTEMATIC NAME
IUBMB Comments
ATP:thiamine diphosphotransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9026-24-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + thiamine
AMP + thiamine diphosphate
show the reaction diagram
thiamine + ATP
thiamine diphosphate + AMP
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + thiamine
AMP + thiamine diphosphate
show the reaction diagram
the enzyme is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth
-
-
?
thiamine + ATP
thiamine diphosphate + AMP
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.9
ATP
pH 8.6, 37°C
0.006
thiamine
pH 8.6, 37°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Frankhauser, H.; Zurlinden, A.; Schweingruber, A.M.; Edenharter, E.; Schweingruber, M.E.
Schizosaccharomyces pombe thiamin pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamin metabolism, phosphate metabolism, mating, and growth
J. Biol. Chem.
270
28457-28462
1995
Schizosaccharomyces pombe (P41888), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Eschbach, M.L.; Mueller, I.B.; Gilberger, T.W.; Walter, R.D.; Wrenger, C.
The human malaria parasite Plasmodium falciparum expresses an atypical N-terminally extended pyrophosphokinase with specificity for thiamine
Biol. Chem.
387
1583-1591
2006
Plasmodium falciparum, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Manually annotated by BRENDA team