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Information on EC 2.7.4.9 - dTMP kinase and Organism(s) Vaccinia virus and UniProt Accession P68693

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This record set is specific for:
Vaccinia virus
UNIPROT: P68693 not found.
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Word Map
The taxonomic range for the selected organisms is: Vaccinia virus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
tmpk, dtmp kinase, tmpkmt, thymidine monophosphate kinase, tmp kinase, pftmk, dtmpk, thymidylate monophosphate kinase, s. aureus thymidylate kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
thymidylate kinase
-
deoxythymidine 5'-monophosphate kinase
-
-
-
-
dTMP kinase
-
-
-
-
dTMPK
-
-
-
-
kinase, thymidine monophosphate (phosphorylating)
-
-
-
-
kinase, thymidylate (phosphorylating)
-
-
-
-
thymidine 5'-monophosphate kinase
-
-
-
-
thymidine monophosphate kinase
-
-
-
-
thymidylate kinase
-
-
-
-
thymidylate monophosphate kinase
-
-
-
-
thymidylic acid kinase
-
-
-
-
thymidylic kinase
-
-
-
-
TMK
-
-
-
-
TMP kinase
-
-
-
-
TMPK
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
ATP:dTMP phosphotransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9014-43-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + (E)-5-(2-bromovinyl)-deoxyuridine monophosphate
?
show the reaction diagram
5% of the TMP efficiency
-
-
?
ATP + brivudin
?
show the reaction diagram
-
-
-
?
ATP + dGMP
?
show the reaction diagram
5% of the TMP efficiency
-
-
?
ATP + dUMP
?
show the reaction diagram
-
-
-
?
ATP + TMP
?
show the reaction diagram
-
-
-
?
N-methanocarbathymidine
?
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
contains Mg2+ at the active site
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(E)-5-(2-bromovinyl)-deoxyuridine
-
5-bromo-deoxyuridine
-
5-chloro-deoxyuridine
-
5-fluoro-deoxyuridine
-
5-iodo-deoxyuridine
-
deoxythymidine
-
deoxyuridine
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.19
(E)-5-(2-bromovinyl)-deoxyuridine monophosphate
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.86
(E)-5-(2-bromovinyl)-deoxyuridine monophosphate
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.5
(E)-5-(2-bromovinyl)-deoxyuridine
-
0.007
5-bromo-deoxyuridine
-
0.015
5-chloro-deoxyuridine
-
0.7
5-fluoro-deoxyuridine
-
0.023
5-iodo-deoxyuridine
-
0.025
deoxythymidine
-
1
deoxyuridine
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
x-ray crystallography
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
TMPK bound to TDP and to brivudin monophosphate, hanging drop vapor diffusion method
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
42.5
the midtemperature of thermal denaturation is 42.5°C
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Caillat, C.; Topalis, D.; Agrofoglio, L.A.; Pochet, S.; Balzarini, J.; Deville-Bonne, D.; Meyer, P.
Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy
Proc. Natl. Acad. Sci. USA
105
16900-16905
2008
Vaccinia virus (P68693), Vaccinia virus
Manually annotated by BRENDA team