NDPK is involved in multiple signaling pathways in mammalian systems, including G-protein signaling. Physical interaction between NDPK2 and small G proteins, as well as the heterotrimeric G protein GPA1. NDPK2 can stimulate their GTPase activities, but the dimeric form of NDPK2 is also unable to enhance the GTPase activities of both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
NDPK is involved in multiple signaling pathways in mammalian systems, including G-protein signaling. Physical interaction between NDPK2 and small G proteins, as well as the heterotrimeric G protein GPA1. NDPK2 can stimulate their GTPase activities, but the dimeric form of NDPK2 is also unable to enhance the GTPase activities of both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
nucleoside diphosphate kinase is a housekeeping enzyme that maintains the intracellular levels of all (d)NTPs used in biosynthesis except ATP, but it also plays a significant role in signal transduction pathways involved in oxidative stress. The enzyme protects the plants against reactive ocygen species, heat, and salt stress, overview
NDPK2 interacts with plant small G proteins in vitro, both Pra2 and Pra3both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
NDPK2 interacts with plant small G proteins in vitro, both Pra2 and Pra3both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
NDPK is involved in multiple signaling pathways in mammalian systems, including G-protein signaling. Physical interaction between NDPK2 and small G proteins, as well as the heterotrimeric G protein GPA1. NDPK2 can stimulate their GTPase activities, but the dimeric form of NDPK2 is also unable to enhance the GTPase activities of both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
NDPK is involved in multiple signaling pathways in mammalian systems, including G-protein signaling. Physical interaction between NDPK2 and small G proteins, as well as the heterotrimeric G protein GPA1. NDPK2 can stimulate their GTPase activities, but the dimeric form of NDPK2 is also unable to enhance the GTPase activities of both Pra2 and Pra3, the role oligomeric states may play in the interaction of NDPK2 with small G proteins
nucleoside diphosphate kinase is a housekeeping enzyme that maintains the intracellular levels of all (d)NTPs used in biosynthesis except ATP, but it also plays a significant role in signal transduction pathways involved in oxidative stress. The enzyme protects the plants against reactive ocygen species, heat, and salt stress, overview
decreases the reaction speed of NDPK1 proportionally to the ligand concentration. Addition of 0.1 mM, 0.2 mM, and 0.5 mM cAMP reduces the specific activity of NDPK1 to 96%, 91%, and 84%, respectively, of the control
decreases the reaction speed of NDPK1 proportionally to the ligand concentration. Addition of 0.1 mM, 0.2 mM, and 0.5 mM cGMP reduces the reaction speed to 84%, 69%, and 51% of the control
NDPK1 is the most highly expressed isozyme, followed by isozymes NDPK3a and NDPK3b, the latter is generally expressed at very low extent but increased in inflorescences and dividing cells
Arabidopsis thaliana nucleoside diphosphate kinase, NDPK-3, is involved in stress signaling in response to polycyclic aromatic hydrocarbon exposure. Isozyme NDPK3 is a positive regulator in the Arabidopsis response to phenanthrene stress
the enzyme plays a key role in the transfer of energy between the cytosolic adenine and uridine nucleotide pools and in the distribution of carbon between starch and cellulose
transgenic Solanum tubersoum plants overexpressing the Arabidopsis thaliana NDPK2 isozyme show reduced sensitivity to stress caused by methyl viologen, i.e. reactive oxigen species, or salt or heat, compared to the wild-type plants, overview
a ndpk2 knockout mutant shows increased salt stress sensitivity compared to the wild-type enzyme. The sos2-2/ndpk2 double mutant is more salt sensitive than a sos2-2 single mutant, and does not hyperaccumulate H2O2 in response to salt stress
NDPK3a induction by sugars is reduced in AtWrky4 and AtWrky34 knockout mutants, Wrky4 and Wrky34 are transcription factor proteins involved in sugar induction and response, overview
construction of NDPK3 knockout and overexpression lines: in the NDPK-3 overexpressor, the enzyme activities of ascorbate peroxidase, peroxiredoxin, catalase, as well as superoxide dismutase are all increased compared to wild-type, in the NDPK-3 knockout line, these enzymes have reduced activity compared to wild-type. Proteomic analysis of mutants, overview
expression of isozyme NDPK2 in Solanum tuberosum cv. Atlantic plant leaf cytosol under the control of an oxidative stress-inducible SWPA2 promoter or enhanced CaMV 35S promoter, resulting in transgenic lines SN1, SN19 and EN1, EN2
gene ndpk2, expression of GST-tagged wild-type enzyme in Escherichia coli, expression of SOS2 and NDPK2 in Saccharomyces cerevisiae in the two-hybrid system
NDPK isozymes, sequence comparisons and phylogenetic analysis, expression of GFP-tagged isozyme NDPK3 in Arabidopsis thaliana protoplasts, targeting to the mitochondria
Verslues, P.E.; Batelli, G.; Grillo, S.; Agius, F.; Kim, Y.S.; Zhu, J.; Agarwal, M.; Katiyar-Agarwal, S.; Zhu, J.K.
Interaction of SOS2 with nucleoside diphosphate kinase 2 and catalases reveals a point of connection between salt stress and H2O2 signaling in Arabidopsis thaliana
Hammargren, J.; Rosenquist, S.; Jansson, C.; Knorpp, C.
A novel connection between nucleotide and carbohydrate metabolism in mitochondria: sugar regulation of the Arabidopsis nucleoside diphosphate kinase 3a gene