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Information on EC 2.7.4.3 - adenylate kinase and Organism(s) Methanothermococcus thermolithotrophicus and UniProt Accession P43410

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IUBMB Comments
Inorganic triphosphate can also act as donor.
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This record set is specific for:
Methanothermococcus thermolithotrophicus
UNIPROT: P43410
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Word Map
The taxonomic range for the selected organisms is: Methanothermococcus thermolithotrophicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphotransferase, adenylate kinase, myokinase, adenylate kinase 1, adenylate kinase 2, nonstructural protein 4b, cinap, adenylokinase, spadk, adenylate kinase isoenzyme 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5'-AMP-kinase
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adenylic kinase
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adenylokinase
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kinase, adenylate (phosphorylating)
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kinase, myo- (phosphorylating)
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myokinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:AMP phosphotransferase
Inorganic triphosphate can also act as donor.
CAS REGISTRY NUMBER
COMMENTARY hide
9013-02-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K+
maximum stimulation at 400 mM
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
P1,P5-di(adenosine-5')pentaphosphate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
81
substrate: ATP, pH and temperature not specified in the publication
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25000
x * 25000 (approximately), SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 25000 (approximately), SDS-PAGE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
86
-
Tm-value, wild-type enzyme
additional information
the application of 50 MPa pressure does not increase the thermostability
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
the application of 50 MPa pressure does not increase the thermostability
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
overexpression in Escherichia coli
overexpression in Escherichia coli
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rusnak, P.; Haney, P.; Konisky, J.
The adenylate kinases from a mesophilic and three thermophilic methanogenic members of the archaea
J. Bacteriol.
177
2977-2981
1995
Methanotorris igneus (P43408), Methanotorris igneus, Methanocaldococcus jannaschii (P43409), Methanocaldococcus jannaschii, Methanothermococcus thermolithotrophicus (P43410), Methanothermococcus thermolithotrophicus, Methanococcus voltae (P43411), Methanococcus voltae, Methanocaldococcus jannaschii DSM 2661 (P43409)
Manually annotated by BRENDA team
Criswell, A.R., Bae, E.; Stec, B.; Konisky, J.; Phillips, G.N. Jr.
Structures of thermophilic and mesophilic adenylate kinases from the genus Methanococcus
J. Mol. Biol.
330
1087-1099
2003
Methanothermococcus thermolithotrophicus (P43410), Methanothermococcus thermolithotrophicus, Methanococcus voltae (P43411), Methanococcus voltae
Manually annotated by BRENDA team
Konisky, J.; Michels, P.C.; Clark, D.S.
Pressure stabilization is not a general property of thermophilic enzymes: the adenylate kinases of Methanococcus voltae, Methanococcus maripaludis, Methanococcus thermolithotrophicus, and Methanococcus jannaschii
Appl. Environ. Microbiol.
61
2762-2764
1995
Methanococcus maripaludis, Methanocaldococcus jannaschii (P43409), Methanothermococcus thermolithotrophicus (P43410), Methanococcus voltae (P43411)
Manually annotated by BRENDA team
Haney, P.J.; Stees, M.; Konisky, J.
Analysis of thermal stabilizing interactions in mesophilic and thermophilic adenylate kinases from the genus Methanococcus
J. Biol. Chem.
274
28453-28458
1999
Methanothermococcus thermolithotrophicus, Methanotorris igneus, Methanocaldococcus jannaschii (P43409), Methanococcus voltae (P43411), Methanocaldococcus jannaschii DSM 2661 (P43409)
Manually annotated by BRENDA team