Any feedback?
Information on EC 2.7.4.3 - adenylate kinase and Organism(s) Arabidopsis thaliana and UniProt Accession O82514
for references in articles please use BRENDA:EC2.7.4.3Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
2.7.4.3 adenylate kinaseIUBMB Comments
Inorganic triphosphate can also act as donor.
Specify your search results
Word Map
- 2.7.4.3
- phosphoenolpyruvate
- adp
- creatine
- hpr
- fructose
- nucleoside
-
permease
- streptococcus
-
phosphoenolpyruvate-dependent
- mannose
- 6-phosphate
-
catabolite
- deaminase
- lactose
- mannitol
- hexokinase
- mutans
- glucose-6-phosphate
-
camp-dependent
- aminoglycoside
- autophosphorylation
- phosphoglucomutase
-
phosphofructokinase
- kanamycin
- neomycin
- 6-phosphogluconate
-
phosphorelay
- 5'-nucleotidase
-
antiterminator
- mgatp
- 2-deoxyglucose
-
intermembrane
-
transphosphorylation
-
gamma-phosphate
- melibiose
- salivarius
- ganciclovir
- phosphocreatine
- nptii
-
diadenosine
-
diphosphohydrolase
-
gamma-32patp
-
p-loop
-
2.7.3.2
- dikinase
-
coarse-grained
- analysis
- phosvitin
- medicine
-
2,6-bisphosphate
- mucolipidosis
- phosphoenzyme
- diagnostics
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphotransferase, adenylate kinase, myokinase, adenylate kinase 1, adenylate kinase 2, nonstructural protein 4b, cinap, adenylokinase, spadk, adenylate kinase isoenzyme 1, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
5'-AMP-kinase
-
-
-
-
adenylic kinase
-
-
-
-
adenylokinase
-
-
-
-
kinase, adenylate (phosphorylating)
-
-
-
-
kinase, myo- (phosphorylating)
-
-
-
-
myokinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
BRENDA
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:AMP phosphotransferase
Inorganic triphosphate can also act as donor.
CAS REGISTRY NUMBER
COMMENTARY
9013-02-9
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + AMP
ADP + ADP
-
ATP is the preferred phosphate donor and AMP is the best phosphate acceptor
-
-
?
additional information
?
-
interaction between mitochondrial adenylate kinase and nucleoside diphosphate kinase. Adenylate kinase stimulates nucleoside diphosphate kinase activity, whereas nucleoside diphosphate kinase inhibits adenylate kinase activity. the net effect may be unchanged ADP production albeit with different rates of substrate consumption
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
interaction between mitochondrial adenylate kinase and nucleoside diphosphate kinase. Adenylate kinase stimulates nucleoside diphosphate kinase activity, whereas nucleoside diphosphate kinase inhibits adenylate kinase activity. the net effect may be unchanged ADP production albeit with different rates of substrate consumption
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
additional information
additional information
-
isoforms AMK1 to AMK5 are much higher expressed than AMK6, while AMK7 is at the detection limit
-
additional information
isoforms AMK1 to AMK5 are much higher expressed than AMK6, while AMK7 is at the detection limit
-
additional information
isoforms AMK1 to AMK5 are much higher expressed than AMK6, while AMK7 is at the detection limit
-
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
the absence of denylate kinase 6 reduces stem elongation but does not delay development
physiological function
-
adenylate kinase 6 is an essential stem growth factor in Arabidopsis
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). KAD4_ARATH
246
0
26932
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
interaction between mitochondrial adenylate kinase and nucleoside diphosphate kinase. Adenylate kinase stimulates nucleoside diphosphate kinase activity, whereas nucleoside diphosphate kinase inhibits adenylate kinase activity. The net effect may be unchanged ADP production albeit with different rates of substrate consumption
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
-
T-DNA insertion mutant. Developing siliques of heterozygous parents contain approximately 25% pale and approximately 75% green seeds. Embryos dissected out of these seeds have a pale green to white color, whitish embryos are homozygous amk2 mutants. Homozygous amk2 seedlings are bleached and strongly retarded in growth. Amk2 heterozygous plants show significantly reduced expression of genes involved in purine de novo synthesis such as PurA, PurB, PurC, PurL, and PurM. Total adenylate kinase activity is reduced by 21% in for ATP formation and 37% for ADP formation
additional information
T-DNA insertion mutant. Developing siliques of heterozygous parents contain approximately 25% pale and approximately 75% green seeds. Embryos dissected out of these seeds have a pale green to white color, whitish embryos are homozygous amk2 mutants. Homozygous amk2 seedlings are bleached and strongly retarded in growth. Amk2 heterozygous plants show significantly reduced expression of genes involved in purine de novo synthesis such as PurA, PurB, PurC, PurL, and PurM. Total adenylate kinase activity is reduced by 21% in for ATP formation and 37% for ADP formation
additional information
T-DNA insertion mutant. Developing siliques of heterozygous parents contain approximately 25% pale and approximately 75% green seeds. Embryos dissected out of these seeds have a pale green to white color, whitish embryos are homozygous amk2 mutants. Homozygous amk2 seedlings are bleached and strongly retarded in growth. Amk2 heterozygous plants show significantly reduced expression of genes involved in purine de novo synthesis such as PurA, PurB, PurC, PurL, and PurM. Total adenylate kinase activity is reduced by 21% in for ATP formation and 37% for ADP formation
additional information
-
T-DNA insertion mutants show no phenotype, but significantly increased expression of genes involved in adenine salvage such as Apt1 to Apt5, and Adk1 and Adk2. Also, the PRS genes, responsible for supplying phosphoribosyl diphosphate are significantly induced. 2.5fold increase in expression of isoform Amk2
additional information
T-DNA insertion mutants show no phenotype, but significantly increased expression of genes involved in adenine salvage such as Apt1 to Apt5, and Adk1 and Adk2. Also, the PRS genes, responsible for supplying phosphoribosyl diphosphate are significantly induced. 2.5fold increase in expression of isoform Amk2
additional information
T-DNA insertion mutants show no phenotype, but significantly increased expression of genes involved in adenine salvage such as Apt1 to Apt5, and Adk1 and Adk2. Also, the PRS genes, responsible for supplying phosphoribosyl diphosphate are significantly induced. 2.5fold increase in expression of isoform Amk2
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lange, P.R.; Geserick, C.; Tischendorf, G.; Zrenner, R.
Functions of chloroplastic adenylate kinases in Arabidopsis
Plant Physiol.
146
492-504
2008
Arabidopsis thaliana, Arabidopsis thaliana (Q8VYL1), Arabidopsis thaliana (Q9FIJ7)
Johansson, M.; Hammargren, J.; Uppsaell, E.; MacKenzie, A.; Knorpp, C.
The activities of nucleoside diphosphate kinase and adenylate kinase are influenced by their interaction
Plant Sci.
174
192-199
2008
Arabidopsis thaliana (O82514)
EXTERNAL LINKS (specific for EC-Number 2.7.4.3)
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
