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ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol-1,3,4,5,6-pentakisphosphate
ADP + diphospho-1D-myo-inositol tetrakisphosphate
-
-
-
?
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
-
-
r
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 1-diphosphate pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
-
-
?
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
-
-
r
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate
-
-
-
r
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
additional information
?
-
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
apoptosis regulation
-
-
?
additional information
?
-
role of the enzyme as a mediator of growth inhibition and apoptosis in response to interferon-beta treatment. The cellular level of the enzyme is posttranscriptionally enhanced by interferon-beta, in ovarian carcinoma cells
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-
?
additional information
?
-
-
role of the enzyme as a mediator of growth inhibition and apoptosis in response to interferon-beta treatment. The cellular level of the enzyme is posttranscriptionally enhanced by interferon-beta, in ovarian carcinoma cells
-
-
?
additional information
?
-
-
IP6Ks change their kinase activity towards InsP6 at a decreasing ATP/ADP ratio to an ADP phosphotransferase activity and dephosphorylate InsP6. Enantioselective analysis reveals that Ins(2,3,4,5,6)P5 is the main InsP5 product of the IP6K reaction
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-
?
additional information
?
-
the bifunctional enzyme also catalyzes the reaction of EC 2.7.4.24. The enzyme exhibits an unusual, nonproductive, substrate-stimulated ATPase activity, that is stimulated by the natural substratesand by 5-O-alpha-phosphonoacetyl-myo-inositol 1,2,3,4,6-pentakisphosphate and 2-O-benzyl-5-O-alpha-phosphonoacetyl-myo-inositol 1,3,4,6-tetrakisphosphate. The enzyme has two adjacent ligand-binding sites
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-
?
additional information
?
-
enzyme additionally catalyzes the reaction of EC 2.7.4.24, i.e. conversion of 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate to 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate. The kinase activities toward 1D-myo-inositol hexakisphosphate are 4fold lower than the kinase activites toward 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
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-
-
additional information
?
-
enzyme additionally catalyzes the reaction of EC 2.7.4.24, i.e. conversion of 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate to 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate. The kinase activities toward 1D-myo-inositol hexakisphosphate are 4fold lower than the kinase activites toward 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
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-
-
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2,5-O-benzyl-myo-inositol 1,3,4,6-tetrakisphosphate
activates the ATP hydrolysis activity and inhibits the PPIP5K2 activity and InsP6 kinase activity, and the 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme. The compound can inhibit inositol phosphate kinase activity without occupying the catalytic site
2-O-benzyl-5-O-alpha-phosphonoacetyl-myo-inositol 1,3,4,6-tetrakisphosphate
stimulates ATP hydrolysis 9fold, but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme. The compound can inhibit inositol phosphate kinase activity without occupying the catalytic site
2-O-benzyl-5-O-diphosphate-myo-inositol 1,3,4,6-tetrakisphosphate
activates ATP hydrolysis activity but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme
2-O-benzyl-myo-inositol 1,2,3,4,6-pentakisphosphate
activates ATP hydrolysis activity but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme
5-O-alpha-diphosphate-myo-inositol 1,3,4,6-tetrakisphosphate
activates ATP hydrolysis activity but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme
5-O-alpha-phosphonoacetyl-myo-inositol 1,2,3,4,6-pentakisphosphate
stimulates ATP hydrolysis 5fold, but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme
C8-PtdIns(4,5)P2
0.05 mM, inhibits 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate dephosphorylation by approximately 60%
-
N(2)-(m-(trifluoromethyl)benzyl) N(6)-(p-nitrobenzyl)purine
-
selective inhibitor in vitro
N2-(3-trifluorobenzyl)-N6-(4-nitrobenzyl)purine
-
TNP, a selective IP6K inhibitor, abolishes the production of enantiomer Ins(2,3,4,5,6)P5 in different types of cells
N2-(m-trifluorobenzyl),N6-(p-nitrobenzyl)purine
ATP competitive inhibitor
-
phosphate
1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate phosphatase activities of PPIP5Ks are 40-90% inhibited by phosphate within the 0-1 mM range
additional information
isoform PPIP5K2 is insensitive to physiological changes in either [AMP] or [ATP]/[ADP] ratios
-
additional information
-
isoform PPIP5K2 is insensitive to physiological changes in either [AMP] or [ATP]/[ADP] ratios
-
additional information
synthesis and effects of inositol phosphates and analogues upon ATPase activity, overview. The compounds are also inhibitors of [PP]2-InsP4 dephosphorylation. Binding structures, overview
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Alzheimer Disease
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease.
Amyotrophic Lateral Sclerosis
Inositol Hexakisphosphate Kinase 2 is a Presymptomatic Biomarker for Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis
Inositol hexakisphosphate kinase 2 promotes cell death of anterior horn cells in the spinal cord of patients with amyotrophic lateral sclerosis.
Autoimmune Diseases
Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.
Breast Neoplasms
IP6K2 predicts favorable clinical outcome of primary breast cancer.
Breast Neoplasms
miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting.
Carcinogenesis
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.
Carcinogenesis
The Key Role of IP6K: A Novel Target for Anticancer Treatments?
Carcinoma
Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma.
Carcinoma
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.
Carcinoma
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.
Carcinoma
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.
Carcinoma
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells.
Carcinoma
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics.
Colorectal Neoplasms
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2.
Confusion
Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1.
Fatty Liver
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.
Hearing Loss
Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse.
Hyperinsulinism
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.
Hypersensitivity
A G-protein ? subunit, AGB1, negatively regulates the ABA response and drought tolerance by down-regulating AtMPK6-related pathway in Arabidopsis.
Infections
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.
Infertility
IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids.
Influenza, Human
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.
Insulin Resistance
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.
Insulin Resistance
Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes.
Insulin Resistance
Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain.
Insulin Resistance
High intensity exercise decreases IP6K1 muscle content & improves insulin sensitivity (SI2*) in glucose intolerant individuals.
Insulin Resistance
Ingestion of lean meat elevates muscle inositol hexakisphosphate kinase 1 protein content independent of a distinct post-prandial circulating proteome in young adults with obesity.
Insulin Resistance
Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis.
Insulin Resistance
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.
Insulin Resistance
IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.
Insulin Resistance
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.
Insulin Resistance
The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.
Insulin Resistance
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway.
Keratoconus
PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus.
Neoplasm Metastasis
Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1.
Neoplasm Metastasis
miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting.
Neoplasms
Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice.
Neoplasms
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.
Neoplasms
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.
Neoplasms
Identification of novel Sp1 targets involved in proliferation and cancer by functional genomics.
Neoplasms
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics.
Neoplasms
Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1.
Neoplasms
IP6K2 is a client for HSP90 and a target for cancer therapeutics development.
Neoplasms
IP6K2 predicts favorable clinical outcome of primary breast cancer.
Neoplasms
miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting.
Neoplasms
Serum miR-1181 and miR-4314 associated with ovarian cancer: MiRNA microarray data analysis for a pilot study.
Neoplasms
The Key Role of IP6K: A Novel Target for Anticancer Treatments?
Neurodegenerative Diseases
Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease.
Obesity
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.
Obesity
Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain.
Obesity
Ingestion of lean meat elevates muscle inositol hexakisphosphate kinase 1 protein content independent of a distinct post-prandial circulating proteome in young adults with obesity.
Obesity
Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis.
Obesity
Inositol pyrophosphates as mammalian cell signals.
Obesity
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.
Obesity
IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.
Obesity
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases.
Obesity
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway.
Pancreatitis
Platelet IP6K1 regulates neutrophil extracellular trap-microparticle complex formation in acute pancreatitis.
Pneumonia, Bacterial
Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia.
Sarcopenia
The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle.
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malfunction
deletion of inositol hexakisphosphate kinase 3 (IP6K3) causes defects in cell motility and neuronal dendritic growth, eventually leading to brain malformations
physiological function
inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2
evolution
the absence of diphosphorylation in the IC(1-70)fragment suggests that the Ser-Pro cluster (residues 71-111) is required to facilitate pyrophosphorylation on Ser51. The site of diphosphorylation in mouse IC-2C is well conserved in human and rat, suggesting that the effect of IP7 on dynein is likely to be conserved in these species
malfunction
-
gene disruption of isoform IP6K2 in colorectal cancer cells selectively impairs p53-mediated apoptosis, instead favoring cell-cycle arrest
malfunction
-
isoform InsP6K1 disruption augments phosphatidylinositol-(3,4,5)-trisphosphate signaling and enhances superoxide production in neutrophils
malfunction
mammalian cells lacking IP6K1 display defects in dynein-dependent trafficking pathways, including endosomal sorting, vesicle movement, and Golgi maintenance. Expression of catalytically active but not inactive IP6K1 reverses the defects. Intermediate chain recruitment to membranes is reduced in cells lacking IP6K1
malfunction
IP6K1/2-knockout cells have nondetectable levels of the IP6-derived 5-diphosphoinositol pentakisphosphate and bisdiphosphoinositol tetrakisphosphate and also exhibit reduced synthesis of the 5-diphosphoinositol pentakisphosphate-derived diphosphoinositol tetrakisphosphate. Knockout cells contain increased amounts of ATP, and elevated levels of free intracellular phosphate. Phosphate import and export of phosphate are decreased in the knockout cells
physiological function
-
inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. The enzyme does not regulate neutrophil trafficking and survival
physiological function
-
inositol hexakisphosphate kinase induces cell death in Huntington disease. The enzyme mediates apoptotic cell death via its translocation from the nucleus to the cytoplasm. Overexpression of the enzyme leads to the depletion of Akt phosphorylation and the induction of cell death
physiological function
-
isoform IP6K2 is required for p53-mediated apoptosis and modulates the outcome of the p53 response. IP6K2 acts by binding directly to p53 and decreasing expression of proarrest gene targets such as the cyclin-dependent kinase inhibitor p21
physiological function
generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein function by posttranslational serine diphosphorylation. Ser51 in the dynein intermediate chain is a target for diphosphorylation by IP7, and this modification promotes the interaction of the intermediate chain N-terminus with the p150Glued subunit of dynactin. Involvement of IP6Ks in dynein function, inositol pyrophosphate-mediated diphosphorylation may act as a regulatory signal to enhance dynein-driven transport. IP6K1 activity regulates Tfn trafficking, overview
physiological function
inositol hexakisphosphate kinase type 2 (InsP6K2), which converts inositol hexakisphosphate (InsP6) to InsP7, mediates cell death in mammalian cells. Cell death is augmented in the presence of cytoplasmic TDP-43 aggregations and activated InsP6K2, while cells with only cytoplasmic TDP-43 aggregation survive because Akt activity increases. Enzyme InsP6K2 causes neuronal cell death in patients suffering frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) or amyotrophic lateral sclerosis (ALS). InsP6K2 and cytoplasmic TDP-43 induce depletion of Akt phosphorylation and decrease casein kinase 2
physiological function
-
InsP6 (inositol hexakisphosphate), the most abundant inositol phosphate in metazoa, is pyrophosphorylated to InsP7 [5PP-InsP5 (diphosphoinositol pentakisphosphate)] by cytosolic and nuclear IP6Ks (InsP6 kinases) and to 1PP-InsP5 by another InsP6/InsP7 kinase family. IP6Ks are also nuclear and cytosolic InsP6- (and InsP5-)dephosphorylating enzymes whose activity is sensitively driven by a decrease in the cellular ATP/ADP ratio, thus suggesting a role for IP6Ks as cellular adenylate energy sensors
physiological function
1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate kinase activity is dominant when PPIP5K1 is expressed in intact cells. 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate phosphatase activity prevails when the enzyme is isolated from its cellular environment. Exogenous expression of PPIP5K1 in Drosophila melanogaster S3 cells elevates levels of 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate and 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
physiological function
inositol hexakisphosphate kinase (IP6K1) and IP6K2 together control inositol pyrophosphate metabolism and thereby physiologically regulate phosphate export and other aspects of mammalian cellular phosphate homeostasis
physiological function
islets from patients with T2D (a multifactorial, polygenetic disease) show impaired ATP generation in response to nutrients, in association with mitochondrial dysfunction. The regulation of IP6K1 activity is likely to be a vulnerable point in early disease development
physiological function
levels of both 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate and ATP decrease upon phosphate starvation and subsequently recover during phosphate replenishment
physiological function
the enzyme (IP6K1) integrates glucose metabolism and insulin exocytosis
physiological function
the enzyme is important in numerous areas of cell physiology such as DNA repair and glucose homeostasis. It is implicated in the pathology of diabetes and other human diseases
physiological function
the enzyme promotes cell death of anterior horn cells in the spinal cord of patients with amyotrophic lateral sclerosis
additional information
enzyme InsP6K2 is translocated from the nucleus to the cytosol during apoptosis
additional information
-
enzyme InsP6K2 is translocated from the nucleus to the cytosol during apoptosis
additional information
-
lentiviral RNAi-based depletion of MINPP1 at falling cellular ATP/ADP ratios has no significant impact on Ins(2,3,4,5,6)P5 production
additional information
a homogenous coupled bioluminescence assay is developed for measuring inositol hexakisphosphate kinase 1 activity in a 384-well format
additional information
-
a homogenous coupled bioluminescence assay is developed for measuring inositol hexakisphosphate kinase 1 activity in a 384-well format
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Saiardi, A.; Erdjument-Bromage, H.; Snowman, A.M.; Tempst, P.; Snyder, S.H.
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases
Curr. Biol.
9
1323-1326
1999
Homo sapiens (Q9UHH9), Mus musculus (Q6PD10)
brenda
Albert, C.; Safrany, S.T.; Bembenek, M.E.; Reddy, K.M.; Reddy, K.K.; Falck, J.R.; Brcker, M.; Shears, S.B.; Mayr, G.W.
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells
Biochem. J.
327
553-560
1997
Cricetulus griseus, Homo sapiens, Mus musculus
-
brenda
Morrison, B.H.; Bauer, J.A.; Kalvakolanu, D.V.; Lindner, D.J.
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells
J. Biol. Chem.
276
24965-24970
2001
Homo sapiens (Q9UHH9), Homo sapiens
brenda
Saiardi, A.; Nagata, E.; Luo, H.R.; Snowman, A.M.; Snyder, S.H.
Identification and characterization of a novel inositol hexakisphosphate kinase
J. Biol. Chem.
276
39179-39185
2001
Mus musculus, Homo sapiens (Q96PC2)
brenda
Morrison, B.H.; Tang, Z.; Jacobs, B.S.; Bauer, J.A.; Lindner, D.J.
Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma
Biochem. J.
385
595-603
2005
Homo sapiens
brenda
Nagata, E.; Luo, H.R.; Saiardi, A.; Bae, B.I.; Suzuki, N.; Snyder, S.H.
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death
J. Biol. Chem.
280
1634-1640
2005
Homo sapiens
brenda
Morrison, B.H.; Bauer, J.A.; Hu, J.; Grane, R.W.; Ozdemir, A.M.; Chawla-Sarkar, M.; Gong, B.; Almasan, A.; Kalvakolanu, D.V.; Lindner, D.J.
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics
Oncogene
21
1882-1889
2002
Homo sapiens
brenda
Morrison, B.H.; Bauer, J.A.; Lupica, J.A.; Tang, Z.; Schmidt, H.; DiDonato, J.A.; Lindner, D.J.
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation
J. Biol. Chem.
282
15349-15356
2007
Homo sapiens, Mus musculus
brenda
Weaver, J.D.; Wang, H.; Shears, S.B.
The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment
Biosci. Rep.
33
e00022
2013
Homo sapiens (O43314), Homo sapiens
brenda
Nagata, E.; Saiardi, A.; Tsukamoto, H.; Okada, Y.; Itoh, Y.; Satoh, T.; Itoh, J.; Margolis, R.L.; Takizawa, S.; Sawa, A.; Takagi, S.
Inositol hexakisphosphate kinases induce cell death in Huntington disease
J. Biol. Chem.
286
26680-26686
2011
Homo sapiens
brenda
Prasad, A.; Jia, Y.; Chakraborty, A.; Li, Y.; Jain, S.K.; Zhong, J.; Roy, S.G.; Loison, F.; Mondal, S.; Sakai, J.; Blanchard, C.; Snyder, S.H.; Luo, H.R.
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling
Nat. Immunol.
12
752-760
2011
Homo sapiens, Mus musculus
brenda
Koldobskiy, M.A.; Chakraborty, A.; Werner, J.K.; Snowman, A.M.; Juluri, K.R.; Vandiver, M.S.; Kim, S.; Heletz, S.; Snyder, S.H.
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2
Proc. Natl. Acad. Sci. USA
107
20947-20951
2010
Homo sapiens
brenda
Wundenberg, T.; Grabinski, N.; Lin, H.; Mayr, G.W.
Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio
Biochem. J.
462
173-184
2014
Homo sapiens, Rattus norvegicus
brenda
Chanduri, M.; Rai, A.; Malla, A.B.; Wu, M.; Fiedler, D.; Mallik, R.; Bhandari, R.
Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport
Biochem. J.
473
3031-3047
2016
Dictyostelium discoideum, Homo sapiens (Q92551), Mus musculus (Q6PD10), Mus musculus C57BL/6 (Q6PD10)
brenda
Wang, H.; Godage, H.Y.; Riley, A.M.; Weaver, J.D.; Shears, S.B.; Potter, B.V.
Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery
Chem. Biol.
21
689-699
2014
Homo sapiens (O43314)
brenda
Nagata, E.; Nonaka, T.; Moriya, Y.; Fujii, N.; Okada, Y.; Tsukamoto, H.; Itoh, J.; Okada, C.; Satoh, T.; Arai, T.; Hasegawa, M.; Takizawa, S.
Inositol hexakisphosphate kinase 2 promotes cell death in cells with cytoplasmic TDP-43 aggregation
Mol. Neurobiol.
53
5377-5383
2016
Homo sapiens (Q9UHH9), Homo sapiens
brenda
Nair, V.; Gu, C.; Janoshazi, A.; Jessen, H.; Wang, H.; Shears, S.
Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate
Biosci. Rep.
38
BSR20171549
2018
Homo sapiens (Q6PFW1)
brenda
Rajasekaran, S.S.; Kim, J.; Gaboardi, G.C.; Gromada, J.; Shears, S.B.; Dos Santos, K.T.; Nolasco, E.L.; Ferreira, S.S.; Illies, C.; Koehler, M.; Gu, C.; Ryu, S.H.; Martins, J.O.; Dare, E.; Barker, C.J.; Berggren, P.O.
Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic beta-cells
Cell. Signal.
46
120-128
2018
Mus musculus (Q6PD10), Homo sapiens (Q92551)
brenda
Gu, C.; Nguyen, H.N.; Hofer, A.; Jessen, H.J.; Dai, X.; Wang, H.; Shears, S.B.
The significance of the bifunctional kinase/phosphatase activities of diphosphoinositol pentakisphosphate kinases (PPIP5Ks) for coupling inositol pyrophosphate cell signaling to cellular phosphate homeostasis
J. Biol. Chem.
292
4544-4555
2017
Homo sapiens (O43314), Homo sapiens (Q6PFW1)
brenda
Wilson, M.S.; Jessen, H.J.; Saiardi, A.
The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export
J. Biol. Chem.
294
11597-11608
2019
Homo sapiens (Q92551), Homo sapiens (Q9UHH9), Homo sapiens
brenda
Nagata, E.; Fujii, N.; Kohara, S.; Okada, C.; Satoh, T.; Takekoshi, S.; Takao, M.; Mihara, B.; Takizawa, S.
Inositol hexakisphosphate kinase 2 promotes cell death of anterior horn cells in the spinal cord of patients with myotrophic lateral sclerosis
Mol. Biol. Rep.
47
6479-6485
2020
Homo sapiens (Q9UHH9), Homo sapiens
brenda
Yousaf, R.; Gu, C.; Ahmed, Z.M.; Khan, S.N.; Friedman, T.B.; Riazuddin, S.; Shears, S.B.; Riazuddin, S.
Mutations in diphosphoinositol-pentakisphosphate kinase PPIP5K2 are associated with hearing loss in human and mouse
PLoS Genet.
14
e1007297
2018
Homo sapiens (O43314), Homo sapiens
brenda
Wormald, M.; Liao, G.; Kimos, M.; Barrow, J.; Wei, H.
Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity
PLoS ONE
12
e0188852
2017
Homo sapiens (Q92551), Homo sapiens
brenda
Rojas, T.; Cheng, W.; Gao, Z.; Liu, X.; Wang, Y.; Malla, A.P.; Chin, A.C.; Romer, L.H.; Snyder, S.H.; Fu, C.
Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2
Proc. Natl. Acad. Sci. USA
116
3278-3287
2019
Mus musculus (Q8BWD2), Homo sapiens (Q96PC2)
brenda
Moritoh, Y.; Oka, M.; Yasuhara, Y.; Hozumi, H.; Iwachidow, K.; Fuse, H.; Tozawa, R.
Inositol hexakisphosphate kinase 3 regulates metabolism and lifespan in mice
Sci. Rep.
6
32072
2016
Homo sapiens (Q96PC2), Homo sapiens, Mus musculus (Q8BWD2), Mus musculus
brenda