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Information on EC 2.7.2.1 - acetate kinase and Organism(s) Entamoeba histolytica and UniProt Accession C4M1C3

for references in articles please use BRENDA:EC2.7.2.1
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EC Tree
IUBMB Comments
Requires Mg2+ for activity. While purified enzyme from Escherichia coli is specific for acetate , others have found that the enzyme can also use propanoate as a substrate, but more slowly . Acetate can be converted into the key metabolic intermediate acetyl-CoA by coupling acetate kinase with EC 2.3.1.8, phosphate acetyltransferase. Both this enzyme and EC 2.7.2.15, propionate kinase, play important roles in the production of propanoate .
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Entamoeba histolytica
UNIPROT: C4M1C3
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The taxonomic range for the selected organisms is: Entamoeba histolytica
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
acetate kinase, ack, acetokinase, acka2, acka1, ackase, urkinase, atp-ecoak, acetic kinase, stacka, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acetate kinase (phosphorylating)
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acetic kinase
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acetokinase
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AK
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:acetate phosphotransferase
Requires Mg2+ for activity. While purified enzyme from Escherichia coli is specific for acetate [4], others have found that the enzyme can also use propanoate as a substrate, but more slowly [7]. Acetate can be converted into the key metabolic intermediate acetyl-CoA by coupling acetate kinase with EC 2.3.1.8, phosphate acetyltransferase. Both this enzyme and EC 2.7.2.15, propionate kinase, play important roles in the production of propanoate [9].
CAS REGISTRY NUMBER
COMMENTARY hide
9027-42-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + acetate
ADP + acetyl phosphate
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
C4M1C3_ENTHI
392
0
43247
TrEMBL
other Location (Reliability: 4)
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystallized at 2.4 A using the hanging drop vapor diffusion method. Each active site is located at an interdomain interface, and the acetate and phosphate binding pockets display sequence and structural conservation with their prokaryotic counterparts
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ingram-Smith, C.; Martin, S.R.; Smith, K.S.
Acetate kinase: not just a bacterial enzyme
Trends Microbiol.
14
249-253
2006
Mesoplasma florum, Histoplasma capsulatum, Cupriavidus necator, Aspergillus fumigatus, Aspergillus nidulans, Bacillus subtilis, Borreliella burgdorferi, Chaetomium globosum, Chlamydomonas reinhardtii, Phanerodontia chrysosporium, Coccidioides immitis, Coprinopsis cinerea, Cryptococcus neoformans, Streptococcus pneumoniae, Entamoeba histolytica, Enterococcus faecalis, Salmonella enterica, Fusarium graminearum, Helicobacter pylori, Lactobacillus acidophilus, Lactococcus lactis, Listeria monocytogenes, Pyricularia grisea, Methanosarcina mazei, Methanosarcina thermophila, Staphylococcus aureus, Mycoplasma pneumoniae, Neurospora crassa, Oceanobacillus iheyensis, Phytophthora sojae, Sclerotinia sclerotiorum, Trichoderma reesei, Ustilago maydis, Methanosarcina acetivorans, Parastagonospora nodorum, Uncinocarpus reesii, Phytophthora ramorum
Manually annotated by BRENDA team
Thaker, T.M.; Tanabe, M.; Fowler, M.L.; Preininger, A.M.; Ingram-Smith, C.; Smith, K.S.; Iverson, T.M.
Crystal structures of acetate kinases from the eukaryotic pathogens Entamoeba histolytica and Cryptococcus neoformans
J. Struct. Biol.
181
185-189
2013
Entamoeba histolytica (C4M1C3), Entamoeba histolytica, Cryptococcus neoformans (J9W3A6), Cryptococcus neoformans
Manually annotated by BRENDA team