Information on EC 2.7.13.1 - protein-histidine pros-kinase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY
2.7.13.1
-
RECOMMENDED NAME
GeneOntology No.
protein-histidine pros-kinase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + protein L-histidine = ADP + protein Npi-phospho-L-histidine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein-L-histidine Npi-phosphotransferase
A number of histones can act as acceptor.
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
histidine kinase
-
-
-
-
histidine protein kinase
-
-
-
-
kinase, protein (phosphorylating histidine)
-
-
-
-
protein histidine kinase
-
-
-
-
protein kinase (histidine)
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
99283-67-7
not distinguishable from EC 2.7.3.12 in Chemical Abstracts
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + chemotaxis protein CheA
ADP + phosphorylated chemotaxis protein CheA
show the reaction diagram
-
sensory transduction in chemotaxis
-
-
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
-
-
-
-
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
-
-
-
-
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
-
-
phosphorylation of His 75
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
-
-
phosphorylation of His 75
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
-
-
formation of 1-phosphohistidine isomer
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
-
-
formation of 1-phosphohistidine isomer
-
ATP + protein L-histidine
ADP + phosphohistidine containing protein
show the reaction diagram
-
P36, i.e. 36 kDa protein of rat
-
-
-
ATP + protein L-histidine
ADP + phosphohistidine containing protein
show the reaction diagram
-
P36, i.e. 36 kDa protein of rat
-
-
ATP + protein L-histidine
ADP + phosphohistidine containing protein
show the reaction diagram
-
CheA, i.e. chemotaxis protein of E. coli
-
-
ATP + protein L-histidine
ADP + phosphohistidine containing protein
show the reaction diagram
-
proteins: OmpR, i.e. regulator protein of E. coli
-
-
ATP + protein L-histidine
ADP + phosphohistidine containing protein
show the reaction diagram
-
NRII, i.e. regulatory protein of E. coli
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + chemotaxis protein CheA
ADP + phosphorylated chemotaxis protein CheA
show the reaction diagram
-
sensory transduction in chemotaxis
-
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
-
2 mM, activation
Mg2+
-
15-20 mM, activation
Mn2+
-
1.5 mM, activation
additional information
-
not activated by Ca2+, Zn2+, Fe2+, Cu2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
GTP
-
activation
Recombinant RAS protein
-
activation
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00025
ATP
-
in presence of activators: GTP or recombinant RAS protein
0.00125
ATP
-
in absence of activators: GTP or recombinant RAS protein
0.014
histone H4
-
-
0.017
histone H4
-
-
0.06
MgATP2-
-
-
0.085
peptide corresponding to residues 70-102 of histone H4
-
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
PDB
SCOP
CATH
ORGANISM
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
32000
-
gel filtration
441644
36000
-
gel filtration
441639
70000
-
HPLC
441640
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
monomer
-
1 * 32000, SDS-PAGE
additional information
-
after solubilization the enzyme dissociates to proteins of 25000 and 10000 kDa, the 25000 kDa fragment being a dimer
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE