Information on EC 2.7.13.1 - protein-histidine pros-kinase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
2.7.13.1
-
RECOMMENDED NAME
GeneOntology No.
protein-histidine pros-kinase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + protein L-histidine = ADP + protein Npi-phospho-L-histidine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:protein-L-histidine Npi-phosphotransferase
A number of histones can act as acceptor.
CAS REGISTRY NUMBER
COMMENTARY hide
99283-67-7
not distinguishable from EC 2.7.3.12 in Chemical Abstracts
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + chemotaxis protein CheA
ADP + phosphorylated chemotaxis protein CheA
show the reaction diagram
-
sensory transduction in chemotaxis
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-
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
ATP + protein L-histidine
ADP + phosphohistidine containing protein
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + chemotaxis protein CheA
ADP + phosphorylated chemotaxis protein CheA
show the reaction diagram
-
sensory transduction in chemotaxis
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-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
-
2 mM, activation
Mg2+
-
15-20 mM, activation
Mn2+
-
1.5 mM, activation
additional information
-
not activated by Ca2+, Zn2+, Fe2+, Cu2+
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
GTP
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activation
Recombinant RAS protein
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activation
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00025 - 0.11
ATP
0.014 - 0.017
histone H4
0.06
MgATP2-
-
-
0.085
peptide corresponding to residues 70-102 of histone H4
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-
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
PDB
SCOP
CATH
ORGANISM
UNIPROT
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
32000
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gel filtration
36000
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gel filtration
70000
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HPLC
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
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1 * 32000, SDS-PAGE
additional information
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after solubilization the enzyme dissociates to proteins of 25000 and 10000 kDa, the 25000 kDa fragment being a dimer
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE