Information on EC 2.7.13.1 - protein-histidine pros-kinase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY
2.7.13.1
-
RECOMMENDED NAME
GeneOntology No.
protein-histidine pros-kinase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
ATP + protein L-histidine = ADP + protein Npi-phospho-L-histidine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein-L-histidine Npi-phosphotransferase
A number of histones can act as acceptor.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
histidine kinase
-
-
-
-
histidine protein kinase
-
-
-
-
kinase, protein (phosphorylating histidine)
-
-
-
-
protein histidine kinase
-
-
-
-
protein kinase (histidine)
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
99283-67-7
not distinguishable from EC 2.7.3.12 in Chemical Abstracts
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + chemotaxis protein CheA
ADP + phosphorylated chemotaxis protein CheA
show the reaction diagram
-
sensory transduction in chemotaxis
-
-
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
-
-
-
-
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
-
-
-
-
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
-
-
phosphorylation of His 75
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
-
-
phosphorylation of His 75
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
-
-
formation of 1-phosphohistidine isomer
-
ATP + histone H4
ADP + phosphohistone H4
show the reaction diagram
-
-
formation of 1-phosphohistidine isomer
-
ATP + protein L-histidine
ADP + phosphohistidine containing protein
show the reaction diagram
-
P36, i.e. 36 kDa protein of rat
-
-
-
ATP + protein L-histidine
ADP + phosphohistidine containing protein
show the reaction diagram
-
P36, i.e. 36 kDa protein of rat
-
-
ATP + protein L-histidine
ADP + phosphohistidine containing protein
show the reaction diagram
-
CheA, i.e. chemotaxis protein of E. coli
-
-
ATP + protein L-histidine
ADP + phosphohistidine containing protein
show the reaction diagram
-
proteins: OmpR, i.e. regulator protein of E. coli
-
-
ATP + protein L-histidine
ADP + phosphohistidine containing protein
show the reaction diagram
-
NRII, i.e. regulatory protein of E. coli
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + chemotaxis protein CheA
ADP + phosphorylated chemotaxis protein CheA
show the reaction diagram
-
sensory transduction in chemotaxis
-
-
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Co2+
-
2 mM, activation
Mg2+
-
15-20 mM, activation
Mn2+
-
1.5 mM, activation
additional information
-
not activated by Ca2+, Zn2+, Fe2+, Cu2+
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
GTP
-
activation
Recombinant RAS protein
-
activation
-
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.00025
-
ATP
-
in presence of activators: GTP or recombinant RAS protein
0.00125
-
ATP
-
in absence of activators: GTP or recombinant RAS protein
0.014
-
histone H4
-
-
0.017
-
histone H4
-
-
0.085
-
peptide corresponding to residues 70-102 of histone H4
-
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
PDB
SCOP
CATH
ORGANISM
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
32000
-
-
gel filtration
36000
-
-
gel filtration
70000
-
-
HPLC
SUBUNITS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
monomer
-
1 * 32000, SDS-PAGE
additional information
-
after solubilization the enzyme dissociates to proteins of 25000 and 10000 kDa, the 25000 kDa fragment being a dimer
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE