Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.7.12.2 - mitogen-activated protein kinase kinase and Organism(s) Schizosaccharomyces pombe and UniProt Accession P10506

for references in articles please use BRENDA:EC2.7.12.2
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues . Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Schizosaccharomyces pombe
UNIPROT: P10506
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Schizosaccharomyces pombe
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
mek/erk, mitogen-activated protein kinase kinase, map kinase kinase, mapkk, mek-1, extracellular-signal-regulated kinase, mapk/erk kinase, map2k4, erk 1, mitogen-activated protein kinase kinase 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cdc7 protein kinase
-
cell division control protein 7
-
MAP kinase kinase skh1/pek1
-
p120cdc7 protein kinase
-
wis1 protein kinase
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKKK-activated)
This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues [5]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
CAS REGISTRY NUMBER
COMMENTARY hide
142805-58-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + protein
ADP + phosphoprotein
show the reaction diagram
byr1 is an important gene in the sexual differentiation pathway and at least part of ras1 function is to act directly or indirectly through byr1 to modulate protein phosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + protein
ADP + phosphoprotein
show the reaction diagram
byr1 is an important gene in the sexual differentiation pathway and at least part of ras1 function is to act directly or indirectly through byr1 to modulate protein phosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
66000
x * 66000, calculation from nucleotide sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 66000, calculation from nucleotide sequence
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
Pek1 has a dual stimulatory and inhibitory function which depends on its phosphorylation state
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al.
The genome sequence of Schizosaccharomyces pombe
Nature
415
871-880
2002
Schizosaccharomyces pombe (P10506), Schizosaccharomyces pombe (P33886), Schizosaccharomyces pombe (Q9Y884)
Manually annotated by BRENDA team
Nadin-Davis, S.A.; Nasim, A.
A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast
EMBO J.
7
985-993
1988
Schizosaccharomyces pombe (P10506)
Manually annotated by BRENDA team
Warbrick, E.; Fantes, P.A.
The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe
EMBO J.
10
4291-4299
1991
Schizosaccharomyces pombe (P33886), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Fankhauser, C.; Simanis, V.
The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast
EMBO J.
13
3011-3019
1994
Schizosaccharomyces pombe (P41892), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Schmidt, S.; Sohrmann, M.; Hofmann, K.; Woollard, A.; Simanis, V.
The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe
Genes Dev.
11
1519-1534
1997
Schizosaccharomyces pombe (P41892), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Loewith, R.; Hubberstey, A.; Young, D.
Skh1, the MEK component of the mkh1 signaling pathway in Schizosaccharomyces pombe
J. Cell Sci.
113
153-160
2000
Schizosaccharomyces pombe (Q9Y884)
Manually annotated by BRENDA team
Sugiura, R.; Toda, T.; Dhut, S.; Shuntoh, H.; Kuno, T.
The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch
Nature
399
479-483
1999
Schizosaccharomyces pombe (Q9Y884), Schizosaccharomyces pombe
Manually annotated by BRENDA team