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Information on EC 2.7.12.1 - dual-specificity kinase and Organism(s) Dictyostelium discoideum and UniProt Accession P18160

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EC Tree
IUBMB Comments
This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
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This record set is specific for:
Dictyostelium discoideum
UNIPROT: P18160
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Word Map
The taxonomic range for the selected organisms is: Dictyostelium discoideum
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
dyrk1a, dyrk2, dyrk1b, dyrk3, dual-specificity kinase, dyrk1, dual specificity kinase, dual-specificity tyrosine phosphorylation-regulated kinase 1a, dual-specificity protein kinase, dyrk1a kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
non-receptor tyrosine kinase spore lysis A
-
Clik1
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating)
This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
CAS REGISTRY NUMBER
COMMENTARY hide
134549-83-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + protein tyrosine
ADP + protein tyrosine phosphate
show the reaction diagram
autophosphorylated on Ser and Thr residues
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SPLA_DICDI
2410
0
264919
Swiss-Prot
-
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
autophosphorylated on serine and threonine residues
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nuckolls, G.H.; Osherov, N.; Loomis, W.F.; Spudich, J.A.
The Dictyostelium dual-specificity kinase splA is essential for spore differentiation
Development
122
3295-3305
1996
Dictyostelium discoideum (P18160)
Manually annotated by BRENDA team
Tan, J.L.; Spudich, J.A.
Developmentally regulated protein-tyrosine kinase genes in Dictyostelium discoideum
Mol. Cell. Biol.
10
3578-3583
1990
Dictyostelium discoideum (P18160)
Manually annotated by BRENDA team