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Information on EC 2.7.11.9 - Goodpasture-antigen-binding protein kinase

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EC Tree
IUBMB Comments
This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.
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This record set is specific for:
UNIPROT: Q9GKI7
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
gpbp-1, stard11, gpbpdelta26, gpbpdelta26/cert, gpbp kinase, goodpasture antigen-binding protein-1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Collagen type IV alpha 3 binding protein
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goodpasture-antigen-binding protein kinase
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GPBP
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StAR-related lipid transfer protein 11
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StARD11
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START domain-containing protein 11
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[Goodpasture antigen-binding protein] phosphotransferase
This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.
CAS REGISTRY NUMBER
COMMENTARY hide
230316-19-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
enzyme is preferentially expressed in small vessels and histological structures targeted by natural autoimmune responses including alveolar and glomerular basement membranes
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CERT_BOVIN
624
0
70847
Swiss-Prot
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Raya, A.; Revert-Ros, F.; Martinez-Martinez, P.; Navarro, S.; Rosello, E.; et al.
Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis
J. Biol. Chem.
275
40392-40399
2000
Mus musculus (Q9EQG9), Bos taurus (Q9GKI7), Homo sapiens (Q9Y5P4), Homo sapiens
Manually annotated by BRENDA team