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Information on EC 2.7.11.9 - Goodpasture-antigen-binding protein kinase

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EC Tree
IUBMB Comments
This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.
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This record set is specific for:
UNIPROT: Q9EQG9
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
stard11, gpbp-1, gpbpdelta26, gpbpdelta26/cert, gpbp kinase, goodpasture antigen-binding protein-1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Goodpasture antigen-binding protein-1
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Collagen type IV alpha 3 binding protein
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goodpasture-antigen-binding protein kinase
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GPBP
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StAR-related lipid transfer protein 11
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StARD11
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START domain-containing protein 11
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[Goodpasture antigen-binding protein] phosphotransferase
This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.
CAS REGISTRY NUMBER
COMMENTARY hide
230316-19-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
show the reaction diagram
the Goodpasture antigen-binding protein performs autophosphorylation
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additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + [Goodpasture antigen-binding protein]
ADP + [Goodpasture antigen-binding phosphoprotein]
show the reaction diagram
the Goodpasture antigen-binding protein performs autophosphorylation
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-
?
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GPBP-1 accumulates in the cytoplasm of differentiating mouse myoblasts prior to myosin synthesis
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
GPBP-1 is a non-conventional kinase that regulates glomerular basement membrane collagen organization. It targets GIP130, a new myosin-binding protein, and regulates myofibrillogenesis in cultured myoblasts. GPBP-1 is a kinase for structural protein organization at both intracellular and extracellular compartments
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CERT_MOUSE
624
0
71111
Swiss-Prot
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; et al.
Functional annotation of a full-length mouse cDNA collection
Nature
409
685-690
2001
Mus musculus (Q9EQG9)
Manually annotated by BRENDA team
Raya, A.; Revert-Ros, F.; Martinez-Martinez, P.; Navarro, S.; Rosello, E.; et al.
Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis
J. Biol. Chem.
275
40392-40399
2000
Mus musculus (Q9EQG9), Bos taurus (Q9GKI7), Homo sapiens (Q9Y5P4), Homo sapiens
Manually annotated by BRENDA team
Revert-Ros, F.; Lopez-Pascual, E.; Granero-Molto, F.; Macias, J.; Breyer, R.; Zent, R.; Hudson, B.G.; Saadeddin, A.; Revert, F.; Blasco, R.; Navarro, C.; Burks, D.; Saus, J.
Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130)
J. Biol. Chem.
286
35030-35043
2011
Mus musculus (Q9EQG9), Mus musculus
Manually annotated by BRENDA team