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ATP + AAYKTKKKK
?
-
-
-
?
ATP + AKRVSMMR
ADP + AKRVS(-phosphate)MMR
peptide derived from myosin I heavy chain kinase amino acid residues 4-11, exchange at position 4: Ser to Ala
phophorylation site is Ser8
?
ATP + caldesmon
ADP + caldesmon phosphate
catalytic domain
-
-
?
ATP + casein
ADP + casein phosphate
ATP + chicken gizzard myosin light chain
ADP + chicken gizzard myosin light chain phosphate
ATP + GRGRSSVYS
ADP + GRGRSS(-phosphate)VYS
ATP + GRSARVSTYA
ADP + GRSARVS(-phosphate)TYA
peptide derived from Dictyostelium myosin ID
-
?
ATP + histone 2A
ADP + histone 2A phosphate
ATP + MH1 peptide
ADP + MH1 peeptide phosphate
-
-
-
?
ATP + myelin basic protein
?
-
-
-
?
ATP + myelin basic protein
ADP + myelin basic protein phosphate
catalytic domain
-
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
ATP + myosin heavy-chain
ADP + myosin heavy chain phosphate
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
ATP + myosin IA
ADP + myosin IA phosphate
-
-
-
-
?
ATP + myosin IB
ADP + myosin IB phosphate
-
-
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
ATP + myosin regulatory light chain
ADP + myosin regulatory light chain phosphate
catalytic domain
-
-
?
ATP + peptide LMM58 of heavy chain
?
-
4 mol phosphate per mol, Thr-residues are phosphorylated
-
-
?
ATP + phosvitin
ADP + phosvitin phosphate
ATP + RKKFGESEKTKTKEFL-amide
?
ATP + smooth muscle myosin light chain
ADP + smooth muscle myosin light chain phosphate
-
-
-
-
?
ATP + synthetic peptides
?
ATP + troponin T
ADP + troponin T phosphate
-
-
-
-
?
ATP + [myosin heavy-chain]
ADP + [myosin heavy-chain] phosphate
ATP + [myosin II heavy-chain]
ADP + [myosin II heavy-chain] phosphate
-
-
-
?
ATP + [myosin-heavy-chain]
ADP + [myosin-heavy-chain]phosphate
ATP + [protein LMM58 heavy chain]
ADP + [protein LMM58 heavy chain] phosphate
-
-
-
-
?
additional information
?
-
ATP + casein
ADP + casein phosphate
-
poor substrate
-
-
?
ATP + casein
ADP + casein phosphate
-
-
-
-
?
ATP + casein
ADP + casein phosphate
-
no activity
-
-
?
ATP + casein
ADP + casein phosphate
catalytic domain, low activity
-
-
?
ATP + chicken gizzard myosin light chain
ADP + chicken gizzard myosin light chain phosphate
-
poor substrate
-
-
?
ATP + chicken gizzard myosin light chain
ADP + chicken gizzard myosin light chain phosphate
-
no activity
-
-
?
ATP + GRGRSSVYS
ADP + GRGRSS(-phosphate)VYS
-
-
-
-
?
ATP + GRGRSSVYS
ADP + GRGRSS(-phosphate)VYS
-
synthetic peptide with a sequence corresponding to the phosphorylation site of myosin IC
-
?
ATP + GRGRSSVYS
ADP + GRGRSS(-phosphate)VYS
-
synthetic peptide with a sequence corresponding to the phosphorylation site of myosin IC
-
?
ATP + GRGRSSVYS
ADP + GRGRSS(-phosphate)VYS
-
synthetic peptide with a sequence corresponding to the phosphorylation site of myosin IC
-
-
?
ATP + GRGRSSVYS
ADP + GRGRSS(-phosphate)VYS
synthetic peptide with a sequence corresponding to the phosphorylation site of myosin IC
-
-
?
ATP + histone 2A
ADP + histone 2A phosphate
-
-
-
-
?
ATP + histone 2A
ADP + histone 2A phosphate
-
no activity
-
-
?
ATP + histone 2A
ADP + histone 2A phosphate
-
low activity
-
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
-
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
protamine is no substrate
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
no activity with myosins from gizzard, cardiac or skeletal muscle, but active with the isolated 20 kDa gizzard myosin light chain
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
substrate: bovine brain myosin
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
specific for myosin heavy chains, no phosphorylation of light chains
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
-
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
-
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
substrate specificity
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
phosphorylates threonine residues
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
phosphorylates threonine residues
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
rabbit skeletal myosin heavy chains are phosphorylated
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
0.7 mol phosphate per mol of heavy chain
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
best substrate: chicken intestine brush border myosin
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
best substrate: chicken intestine brush border myosin
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
specific for myosin heavy chains, no phosphorylation of light chains
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
specific for myosin heavy chains, no phosphorylation of light chains
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
35 kDa trypsin fragment of the C-terminus of the maximally activated, phosphorylated enzyme is fully catalytically active and contains 2 thirds of the autophosphorylation sites of the native enzyme
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
intermolecular autophosphorylation with vesicle-bound enzyme in absence of substrates
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
intramolecular autophosphorylation
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
intramolecular autophosphorylation
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
leads to activation of the phosphorylation activity towards myosin I
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
leads to activation of the phosphorylation activity towards myosin I
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
enzyme incorporates 6-8 mol phosphate per mol of enzyme
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
intramolecular autophosphorylation
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
intramolecular autophosphorylation
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
intramolecular autophosphorylation
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
intramolecular autophosphorylation
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
intramolecular autophosphorylation
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
intramolecular autophosphorylation
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
enzyme incorporates 1 mol of phosphate per mol of enzyme
-
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
4 phosphorylation sites on each heavy chain
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
enzyme incorporates 20 mol phosphate per mol of kinase
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
enzyme incorporates 2-3 mol phosphate per mol of 130 kDa subunit
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
leads to activation of the phosphorylation activity towards myosin I
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
leads to activation of the phosphorylation activity towards myosin I
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
leads to activation of the phosphorylation activity towards myosin I
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
-
leads to activation of the phosphorylation activity towards myosin I
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
the enzyme contains a cluster of 23 serine and threonine residues at the carboxyterminal end that might be the autophosphorylation domain
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
increased activity during chemotaxis
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
intramolecular autophosphorylation
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
enzyme incorporates 20 mol phosphate per mol of kinase
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
the enzyme contains a cluster of 23 serine and threonine residues at the carboxyterminal end that might be the autophosphorylation domain
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
increased activity during chemotaxis
-
?
ATP + myosin heavy-chain
ADP + myosin heavy chain phosphate
-
-
-
?
ATP + myosin heavy-chain
ADP + myosin heavy chain phosphate
role of RasGEF Q in regulating myosin II function through MHCK A, overview
-
-
?
ATP + myosin heavy-chain
ADP + myosin heavy chain phosphate
phosphorylation of myosin takes place at three threonine residues in the tail region by myosin II heavy chain kinases
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
substrate: myosin IB, phosphorylation site is Ser315
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
substrate: myosin IB, phosphorylation site is Ser315
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
higher activity with membrane-bound substrate myosin I
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
myosin light chains are no substrates
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
substrate myosin IA: phosphorylation of a single threonine
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
phosphorylates serine-residues
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
substrate is heavy chain of myosin IC
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
substrate is heavy chain of myosin IC
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
substrate is heavy chain of myosin IC
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
incorporation of 0.9-1.0 mol phosphate per mol of heavy chain myosin
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
phosphorylates threonine residues
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
myosin I from intestinal brush border
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
35 kDa trypsin fragment of the C-terminus of the maximally activated, phosphorylated enzyme is fully catalytically active and contains 2 thirds of the autophosphorylation sites of the native enzyme
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
contains two myosin heavy chain kinases: one for myosin I and one for myosin II
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
substrate: myosin IC, phosphorylation site is Ser311
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
a basic amino acid is essential on amino-terminal side of phosphorylation site, two are preferable, and a Tyr-residue is essential two residues away on the COOH-terminal side
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
substrates are heavy chains of myosin IA and IB
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
substrates are heavy chains of myosin IA and IB
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
substrates are heavy chains of myosin IA and IB
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
myosin light chains are no substrates
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
myosin light chains are no substrates
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
4 mol phosphate per mol of myosin
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
phosphorylation of residues Thr1833 and Thr2029
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
phosphorylation of residues Thr1833 and Thr2029
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
phosphorylates threonine residues
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
phosphorylates threonine residues
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
phosphorylates threonine residues
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
phosphorylates threonine residues
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
1.9 mol phosphate per mol myosin
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
10 mol phosphate per mol of kinase subunit
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
20 mol phosphate per mol of kinase subunit, kinetics
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
major site of phosphorylation is Ser8
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
bovine muscle myosin is no substrate
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
no substrates are human platelet myosin, ovalbumin and smooth muscle myosin from turkey
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
6-8 mol phosphate per mol of enzyme
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
substrate: myosin ID
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
substrate: myosin ID
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
reaction in regulatory contractile activity in Dictyostelium discoideum
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
involved in regulation of myosin II filament assembly
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
involved in regulation of myosin II filament assembly
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
increased activity during chemotaxis
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
phosphorylation of residues Thr1833 and Thr2029
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
phosphorylates threonine residues
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
10 mol phosphate per mol of kinase subunit
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
6-8 mol phosphate per mol of enzyme
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
myosin light chains are no substrates
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
contains two myosin heavy chain kinases: one for myosin I and one for myosin II
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
incorporation of 3 mol phosphate per mol of myosin II heavy chain, phosphorylation sites are mainly identical in vitro and in vivo
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
phosphorylates serine residues
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
phosphorylates serine residues
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
specific isozyme A for the heavy chain of myosin II
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
specific isozyme A for the heavy chain of myosin II
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
isozyme MHCK B
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
drives filament disassembly in vitro
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
drives filament disassembly in vitro
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
catalytic domain
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
phosphorylates primarly threonine residues
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
phosphorylates primarly threonine residues
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
involved in regulation of myosin II filament assembly
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
involved in regulation of myosin II filament assembly
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
key role in regulating myosin localization
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
key role in regulating myosin localization
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
the enzymes anterior localization is dynamically regulated during chemotaxis, phagocytosis, and other polarized cell motility events via direct binding to F-actin
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
specific isozyme A for the heavy chain of myosin II
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
drives filament disassembly in vitro
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
phosphorylates primarly threonine residues
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
key role in regulating myosin localization
-
?
ATP + phosvitin
ADP + phosvitin phosphate
-
no activity
-
-
?
ATP + phosvitin
ADP + phosvitin phosphate
-
-
-
-
?
ATP + phosvitin
ADP + phosvitin phosphate
-
low activity
-
-
?
ATP + RKKFGESEKTKTKEFL
?
-
-
-
?
ATP + RKKFGESEKTKTKEFL
?
isozyme MHCK B
-
-
?
ATP + RKKFGESEKTKTKEFL
?
synthetic peptide MH1
-
-
?
ATP + RKKFGESEKTKTKEFL-amide
?
low activity
-
-
?
ATP + RKKFGESEKTKTKEFL-amide
?
catalytic domain
-
-
?
ATP + RKKFGESEKTKTKEFL-amide
?
-
isozyme myosin II heavy chain kinase A
-
-
?
ATP + RKKFGESEKTKTKEFL-amide
?
-
synthetic peptide MH-3
-
-
?
ATP + RKKFGESEKTKTKEFL-amide
?
synthetic peptide MH-3
-
-
?
ATP + synthetic peptides
?
-
variations in length, and number, location and kind of basic residues of the basic sequence of peptide GRGRSSVYS, overview
-
-
?
ATP + synthetic peptides
?
-
-
-
-
?
ATP + synthetic peptides
?
-
peptide MH-3, corresponding to myosin II heavy chain from residues 2020 to 2035 except that Ser-2026 and Thr-2031 have been replaced by alanine
-
-
?
ATP + YAYDTRYRR
?
consensus sequence
-
-
?
ATP + YAYDTRYRR
?
catalytic domain of the enzyme
-
-
?
ATP + [myosin heavy-chain]
ADP + [myosin heavy-chain] phosphate
-
-
-
-
?
ATP + [myosin heavy-chain]
ADP + [myosin heavy-chain] phosphate
-
-
-
?
ATP + [myosin heavy-chain]
ADP + [myosin heavy-chain] phosphate
-
-
-
-
?
ATP + [myosin heavy-chain]
ADP + [myosin heavy-chain] phosphate
-
-
-
?
ATP + [myosin heavy-chain]
ADP + [myosin heavy-chain] phosphate
-
-
-
?
ATP + [myosin heavy-chain]
ADP + [myosin heavy-chain] phosphate
phosphorylation of sites within the MHC alpha-helical, coiled-coil tail by MHCK A
-
-
?
ATP + [myosin-heavy-chain]
ADP + [myosin-heavy-chain]phosphate
-
-
-
?
ATP + [myosin-heavy-chain]
ADP + [myosin-heavy-chain]phosphate
-
-
-
-
?
additional information
?
-
-
substrate specificity study
-
-
?
additional information
?
-
enzyme contains several SH3-binding domains
-
-
?
additional information
?
-
-
the Mg2+-ATPase activity of the substrate myosin I is increased by its phosphorylation and the binding of F-actin
-
-
?
additional information
?
-
-
the Mg2+-ATPase activity of the substrate myosin I is increased by its phosphorylation and the binding of F-actin
-
-
?
additional information
?
-
-
the Mg2+-ATPase activity of the substrate myosin I is increased by its phosphorylation and the binding of F-actin
-
-
?
additional information
?
-
enzyme possesses binding domains for the Ras-related GTP-binding proteins Cdc42 and Rac
-
-
?
additional information
?
-
-
the Mg2+-ATPase activity of the substrate myosin II is inhibited in vitro by its phosphorylation
-
-
?
additional information
?
-
-
localization of autophosphorylation sites
-
-
?
additional information
?
-
enzyme possesses binding domains for the Ras-related GTP-binding proteins Cdc42 and Rac
-
-
?
additional information
?
-
the Mg2+-ATPase activity of the substrate myosin II is inhibited in vitro by its phosphorylation
-
-
?
additional information
?
-
-
the Mg2+-ATPase activity of the substrate myosin II is inhibited in vitro by its phosphorylation
-
-
?
additional information
?
-
O76739
localization of autophosphorylation sites
-
-
?
additional information
?
-
localization of autophosphorylation sites
-
-
?
additional information
?
-
localization of autophosphorylation sites
-
-
?
additional information
?
-
biochemical mechanism for the spatial regulation of myosin II filament disassembly acts via MHCK A activation by actin
-
-
?
additional information
?
-
-
biochemical mechanism for the spatial regulation of myosin II filament disassembly acts via MHCK A activation by actin
-
-
?
additional information
?
-
C-terminal phosphorylation of myosin heavy chain is required for regulation of myosin II filament assembly, regulation mechanism
-
-
?
additional information
?
-
-
C-terminal phosphorylation of myosin heavy chain is required for regulation of myosin II filament assembly, the 3 isozymes MHCK A, MHCK B, and MHCK C show differential localization patterns in living cells
-
-
?
additional information
?
-
MHCK A performs autophosphorylation
-
-
?
additional information
?
-
-
MHCK A performs autophosphorylation
-
-
?
additional information
?
-
MHCK A contains active RasB, and is the predominant exchange factor for RasB. RasGEF Q can bind to F-actin and has the potential to form complexes with MHCK A, overview
-
-
?
additional information
?
-
-
MHCK A contains active RasB, and is the predominant exchange factor for RasB. RasGEF Q can bind to F-actin and has the potential to form complexes with MHCK A, overview
-
-
?
additional information
?
-
substrate specificity of the MHCK A catalytic domain: a lysine or arginine in the P+1 position on the C-terminal side of the phosphoacceptor threonine, P site, is critical for peptide substrate recognition by MHCK A. Phosphorylation by MHCK A is enhanced 2 to 4fold by basic residues in the P+2, P+3 and P+4 positions, with a strong preference for threonine as the phosphoacceptor amino acid, overview
-
-
?
additional information
?
-
substrate specificity of the MHCK A catalytic domain: a lysine or arginine in the P+1 position on the C-terminal side of the phosphoacceptor threonine, P site, is critical for peptide substrate recognition by MHCK A. Phosphorylation by MHCK A is enhanced 2 to 4fold by basic residues in the P+2, P+3 and P+4 positions, with a strong preference for threonine as the phosphoacceptor amino acid, overview
-
-
?
additional information
?
-
-
substrate specificity of the MHCK A catalytic domain: a lysine or arginine in the P+1 position on the C-terminal side of the phosphoacceptor threonine, P site, is critical for peptide substrate recognition by MHCK A. Phosphorylation by MHCK A is enhanced 2 to 4fold by basic residues in the P+2, P+3 and P+4 positions, with a strong preference for threonine as the phosphoacceptor amino acid, overview
-
-
?
additional information
?
-
substrate specificity of the MHCK B catalytic domain: a lysine or arginine in the P+1 position on the C-terminal side of the phosphoacceptor threonine, P site, is critical for peptide substrate recognition by MHCK B. Phosphorylation by MHCK B is further enhanced 8fold by a basic residue in the P+2 position, strong preference for threonine as the phosphoacceptor amino acid, overview
-
-
?
additional information
?
-
substrate specificity of the MHCK B catalytic domain: a lysine or arginine in the P+1 position on the C-terminal side of the phosphoacceptor threonine, P site, is critical for peptide substrate recognition by MHCK B. Phosphorylation by MHCK B is further enhanced 8fold by a basic residue in the P+2 position, strong preference for threonine as the phosphoacceptor amino acid, overview
-
-
?
additional information
?
-
-
substrate specificity of the MHCK B catalytic domain: a lysine or arginine in the P+1 position on the C-terminal side of the phosphoacceptor threonine, P site, is critical for peptide substrate recognition by MHCK B. Phosphorylation by MHCK B is further enhanced 8fold by a basic residue in the P+2 position, strong preference for threonine as the phosphoacceptor amino acid, overview
-
-
?
additional information
?
-
the enzyme also exhibits ATPase and unspecific Ser/Thr protein kinase activities
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-
?
additional information
?
-
-
the enzyme also exhibits ATPase and unspecific Ser/Thr protein kinase activities
-
-
?
additional information
?
-
the enzyme performs autophosphorylation at Thr825
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-
?
additional information
?
-
-
the enzyme performs autophosphorylation at Thr825
-
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?
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ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
ATP + myosin heavy-chain
ADP + myosin heavy chain phosphate
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
ATP + [myosin heavy-chain]
ADP + [myosin heavy-chain] phosphate
ATP + [myosin II heavy-chain]
ADP + [myosin II heavy-chain] phosphate
-
-
-
?
ATP + [myosin-heavy-chain]
ADP + [myosin-heavy-chain]phosphate
additional information
?
-
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
-
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
-
-
?
ATP + myosin heavy chain
ADP + myosin heavy chain phosphate
-
-
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
intramolecular autophosphorylation
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
increased activity during chemotaxis
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
intramolecular autophosphorylation
-
?
ATP + myosin heavy chain kinase
ADP + myosin heavy chain kinase phosphate
increased activity during chemotaxis
-
?
ATP + myosin heavy-chain
ADP + myosin heavy chain phosphate
-
-
-
?
ATP + myosin heavy-chain
ADP + myosin heavy chain phosphate
role of RasGEF Q in regulating myosin II function through MHCK A, overview
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
reaction in regulatory contractile activity in Dictyostelium discoideum
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
involved in regulation of myosin II filament assembly
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
involved in regulation of myosin II filament assembly
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
increased activity during chemotaxis
-
?
ATP + myosin I heavy chain
ADP + myosin I heavy chain phosphate
-
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
involved in regulation of myosin II filament assembly
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
involved in regulation of myosin II filament assembly
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
key role in regulating myosin localization
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
key role in regulating myosin localization
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
the enzymes anterior localization is dynamically regulated during chemotaxis, phagocytosis, and other polarized cell motility events via direct binding to F-actin
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
-
?
ATP + myosin II heavy chain
ADP + myosin II heavy chain phosphate
-
key role in regulating myosin localization
-
?
ATP + [myosin heavy-chain]
ADP + [myosin heavy-chain] phosphate
-
-
-
?
ATP + [myosin heavy-chain]
ADP + [myosin heavy-chain] phosphate
-
-
-
-
?
ATP + [myosin heavy-chain]
ADP + [myosin heavy-chain] phosphate
-
-
-
?
ATP + [myosin heavy-chain]
ADP + [myosin heavy-chain] phosphate
-
-
-
?
ATP + [myosin-heavy-chain]
ADP + [myosin-heavy-chain]phosphate
-
-
-
?
ATP + [myosin-heavy-chain]
ADP + [myosin-heavy-chain]phosphate
-
-
-
-
?
additional information
?
-
biochemical mechanism for the spatial regulation of myosin II filament disassembly acts via MHCK A activation by actin
-
-
?
additional information
?
-
-
biochemical mechanism for the spatial regulation of myosin II filament disassembly acts via MHCK A activation by actin
-
-
?
additional information
?
-
C-terminal phosphorylation of myosin heavy chain is required for regulation of myosin II filament assembly, regulation mechanism
-
-
?
additional information
?
-
-
C-terminal phosphorylation of myosin heavy chain is required for regulation of myosin II filament assembly, the 3 isozymes MHCK A, MHCK B, and MHCK C show differential localization patterns in living cells
-
-
?
additional information
?
-
MHCK A contains active RasB, and is the predominant exchange factor for RasB. RasGEF Q can bind to F-actin and has the potential to form complexes with MHCK A, overview
-
-
?
additional information
?
-
-
MHCK A contains active RasB, and is the predominant exchange factor for RasB. RasGEF Q can bind to F-actin and has the potential to form complexes with MHCK A, overview
-
-
?
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Dictyostelium discoideum (P34125), Dictyostelium discoideum (P42527), Dictyostelium discoideum (P90648)
brenda
Ct, G.P.; Bukiejko, U.
Purification and characterization of a myosin heavy chain kinase from Dictyostelium discoideum
J. Biol. Chem.
262
1065-1072
1987
Dictyostelium discoideum
brenda
Medley, Q.W.; Bagshaw, W.L.; Truong, T.; Cote, G.P.
Dictyostelium myosin II heavy-chain kinase A is activated by heparin, DNA and acidic phospholipids and inhibited by polylysine, polyarginine and histones
Biochim. Biophys. Acta
1175
7-12
1992
Dictyostelium discoideum
brenda
Ravid, S.; Spudich, J.A.
Myosin heavy chain kinase from developed Dictyostelium cells. Purification and characterization
J. Biol. Chem.
264
15144-15150
1989
Dictyostelium discoideum
brenda
Lynch, T.J.; Brzeska, H.; Baines, I.C.; Korn, E.D.
Purification of myosin I and myosin I heavy chain kinase from Acanthamoeba castellanii
Methods Enzymol.
196
12-23
1991
Acanthamoeba castellanii
brenda
Medley, Q.W.; Lee, S.F.; Cote, G.P.
Purification and characterization of myosin II heavy chain kinase A from Dictyostelium
Methods Enzymol.
196
23-34
1991
Dictyostelium discoideum, Dictyostelium discoideum Ax-3
brenda
Hammer, J.A.; Albanesi, J.P.; Korn, E.D.
Purification and characterization of a myosin I heavy chain kinase from Acanthamoeba castellanii
J. Biol. Chem.
258
10168-10175
1983
Acanthamoeba castellanii
brenda
Brzeska, H.; Lynch, T.J.; Martin, B.; Corigliano-Murphy, A.; Korn, E.D.
Substrate specificity of Acanthamoeba myosin I heavy chain kinase as determined with synthetic peptides
J. Biol. Chem.
265
16138-16144
1990
Acanthamoeba castellanii
brenda
Ct, G.P.; Collins, J.H.; Korn, E.D.
Identification of three phosphorylation sites on each heavy chain of Acanthamoeba myosin II
J. Biol. Chem.
256
12811-12816
1981
Acanthamoeba castellanii
brenda
Maruta, H.; Korn, E.D.
Acanthamoeba cofactor protein is a heavy chain kinase required for actin activation of the Mg2+-ATPase activity of Acanthamoeba myosin I
J. Biol. Chem.
252
8329-8332
1977
Acanthamoeba castellanii
brenda
Rieker, J.P.; Swanljung-Collins, H.; Montibeller, J.; Collins, J.H.
Isolation and characterization of calmodulin-dependent myosin heavy chain kinase from intestinal brush border
Methods Enzymol.
139
105-114
1987
Gallus gallus
brenda
Rieker, J.P.; Swanljung-Collins, H.; Montibeller, J.; Collins, J.H.
Purification and characterization of a calmodulin-dependent myosin heavy chain kinase from intestinal brush border
J. Biol. Chem.
262
15262-15268
1987
Gallus gallus
brenda
Murakami, N.; Matsumura, S.; Kumon, A.
Purification and identification of myosin heavy chain kinase from bovine brain
J. Biochem.
95
651-660
1984
Bos taurus
brenda
Nagasaki, A.; Itoh, G.; Yumura, S.; Uyeda, T.Q.
Novel myosin heavy chain kinase involved in disassembly of myosin II filaments and efficient cleavage in mitotic dictyostelium cells
Mol. Biol. Cell
13
4333-4342
2002
Dictyostelium discoideum, Dictyostelium discoideum (Q8MY12), Dictyostelium discoideum AX2 (Q8MY12)
brenda
Rico, M.; Egelhoff, T.T.
Myosin heavy chain kinase B participates in the regulation of myosin assembly into the cytoskeleton
J. Cell. Biochem.
88
521-532
2003
Dictyostelium discoideum (P90648), Dictyostelium discoideum
brenda
Ravid, S.; Spudich, J.A.
Membrane-bound Dictyostelium myosin heavy chain kinase: a developmentally regulated substrate-specific member of the protein kinase C family
Proc. Natl. Acad. Sci. USA
89
5877-5881
1992
Dictyostelium discoideum (P34125), Dictyostelium discoideum AX3 (P34125)
brenda
Wang, Z.Y.; Brzeska, H.; Baines, I.C.; Korn, E.D.
Properties of Acanthamoeba myosin I heavy chain kinase bound to phospholipid vesicles
J. Biol. Chem.
270
27969-27976
1995
Acanthamoeba castellanii
brenda
Kolman, M.F.; Futey, L.M.; Egelhoff, T.T.
Dictyostelium myosin heavy chain kinase A regulates myosin localization during growth and development
J. Cell. Biol.
132
101-109
1996
Dictyostelium discoideum, Dictyostelium discoideum JH10
brenda
Lee, S.F.; Egelhoff, T.T.; Mahasneh, A.; Cote, G.P.
Cloning and characterization of a Dictyostelium myosin I heavy chain kinase activated by Cdc42 and Rac
J. Biol. Chem.
271
27044-27048
1996
Dictyostelium discoideum (Q869N2)
brenda
Brzeska, H.; Martin, B.M.; Korn, E.D.
The catalytic domain of Acanthamoeba myosin I heavy chain kinase. I. Identification and characterization following tryptic cleavage of the native enzyme
J. Biol. Chem.
271
27049-27055
1996
Acanthamoeba castellanii
brenda
Szczepanowska, J.; Ramachandran, U.; Herring, C.J.; Gruschus, J.M.; Qin, J.; Korn, E.D.; Brzeska, H.
Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinase
Proc. Natl. Acad. Sci. USA
95
4146-4151
1998
Acanthamoeba castellanii
brenda
Lee, S.F.; Mahasneh, A.; de la Roche, M.; Cote, G.P.
Regulation of the p21-activated kinase-related Dictyostelium myosin I heavy chain kinase by autophosphorylation, acidic phospholipids, and Ca2+-calmodulin
J. Biol. Chem.
273
27911-27917
1998
Dictyostelium discoideum (Q869N2)
brenda
Brzeska, H.; Young, R.; Knaus, U.; Korn, E.D.
Myosin I heavy chain kinase: cloning of the full-length gene and acidic lipid-dependent activation by Rac and Cdc42
Proc. Natl. Acad. Sci. USA
96
394-399
1999
Acanthamoeba castellanii (Q93107)
brenda
Brzeska, H.; Young, R.; Tan, C.; Szczepanowska, J.; Korn, E.D.
Calmodulin-binding and autoinhibitory domains of Acanthamoeba myosin I heavy chain kinase, a p21-activated kinase (PAK)
J. Biol. Chem.
276
47468-47473
2001
Acanthamoeba castellanii (Q93107)
brenda
Luo, X.; Crawley, S.W.; Steimle, P.A.; Egelhoff, T.T.; Cote, G.P.
Specific phosphorylation of threonine by the Dictyostelium myosin II heavy chain kinase family
J. Biol. Chem.
276
17836-17843
2001
Dictyostelium discoideum (O76739), Dictyostelium discoideum (P42527), Dictyostelium discoideum (P90648)
brenda
Steimle, P.A.; Licate, L.; Cote, G.P.; Egelhoff, T.T.
Lamellipodial localization of Dictyostelium myosin heavy chain kinase A is mediated via F-actin binding by the coiled-coil domain
FEBS Lett.
516
58-62
2002
Dictyostelium discoideum (P42527), Dictyostelium discoideum
brenda
Russ, M.; Croft, D.; Ali, O.; Martinez, R.; Steimle, P.A.
Myosin heavy chain kinase A from Dictyostelium possesses a novel actin binding domain that cross-links actin filaments
Biochem. J.
395
373-383
2005
Dictyostelium discoideum (P42527)
brenda
Egelhoff, T.T.; Croft, D.; Steimle, P.A.
Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly
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280
2879-2887
2005
Dictyostelium discoideum (P42527), Dictyostelium discoideum
brenda
Yumura, S.; Yoshida, M.; Betapudi, V.; Licate, L.S.; Iwadate, Y.; Nagasaki, A.; Uyeda, T.Q.; Egelhoff, T.T.
Multiple myosin II heavy chain kinases: roles in filament assembly control and proper cytokinesis in Dictyostelium
Mol. Biol. Cell
16
4256-4266
2005
Dictyostelium discoideum
brenda
Crawley, S.W.; Cote, G.P.
Determinants for substrate phosphorylation by Dictyostelium myosin II heavy chain kinases A and B and eukaryotic elongation factor-2 kinase
Biochim. Biophys. Acta
1784
908-915
2008
Dictyostelium discoideum (P42527), Dictyostelium discoideum (P90648), Dictyostelium discoideum
brenda
Mondal, S.; Bakthavatsalam, D.; Steimle, P.; Gassen, B.; Rivero, F.; Noegel, A.A.
Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions
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181
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2008
Dictyostelium discoideum (P42527), Dictyostelium discoideum
brenda
Franklin, A.; Hyatt, L.; Chowdhury, A.; Steimle, P.A.
The WD-repeat domain of Dictyostelium myosin heavy chain kinase C functions in both substrate targeting and cellular localization
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9
344-349
2010
Dictyostelium discoideum (Q8MY12), Dictyostelium discoideum
brenda
Underwood, J.; Greene, J.; Steimle, P.A.
Identification of a new mechanism for targeting myosin II heavy chain phosphorylation by Dictyostelium myosin heavy chain kinase B
BMC Res. Notes
3
56
2010
Dictyostelium discoideum (P90648)
brenda
Crawley, S.W.; Gharaei, M.S.; Ye, Q.; Yang, Y.; Raveh, B.; London, N.; Schueler-Furman, O.; Jia, Z.; Cote, G.P.
Autophosphorylation activates Dictyostelium myosin II heavy chain kinase A by providing a ligand for an allosteric binding site in the alpha-kinase domain
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286
2607-2616
2011
Dictyostelium discoideum (P42527), Dictyostelium discoideum
brenda
Ye, Q.; Crawley, S.W.; Yang, Y.; Cote, G.P.; Jia, Z.
Crystal structure of the alpha-kinase domain of Dictyostelium myosin heavy chain kinase A
Sci. Signal.
3
ra17
2010
Dictyostelium discoideum (P42527), Dictyostelium discoideum
brenda
Yang, Y.; Ye, Q.; Jia, Z.; Cote, G.P.
Characterization of the catalytic and nucleotide binding properties of the alpha-kinase domain of Dictyostelium myosin-II heavy chain kinase A
J. Biol. Chem.
290
23935-23946
2015
Dictyostelium discoideum (P42527)
brenda
Ye, Q.; Yang, Y.; van Staalduinen, L.; Crawley, S.W.; Liu, L.; Brennan, S.; Cote, G.P.; Jia, Z.
Structure of the Dictyostelium myosin-II heavy chain kinase A (MHCK-A) alpha-kinase domain apoenzyme reveals a novel autoinhibited conformation
Sci. Rep.
6
26634
2016
Dictyostelium discoideum (P42527)
brenda