Information on EC 2.7.11.6 - [tyrosine 3-monooxygenase] kinase

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The expected taxonomic range for this enzyme is: Rattus norvegicus

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EC NUMBER
COMMENTARY
2.7.11.6
-
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RECOMMENDED NAME
GeneOntology No.
[tyrosine 3-monooxygenase] kinase
GO:0050369
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]
show the reaction diagram
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[tyrosine-3-monoxygenase] phosphotransferase
The enzyme has no activating compound but is specific for its substrate, with which it co-purifies. Requires Mg2+. Activates EC 1.14.16.2, tyrosine 3-monooxygenase, by phosphorylation.
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SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
kinase, tyrosine 3-monooxygenase (phosphorylating)
-
-
-
-
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CAS REGISTRY NUMBER
COMMENTARY
103537-12-8
-
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Rattus norvegicus
-
640693, 640694
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + [tyrosine 3-monooxygenase]
ADP + [tyrosine 3-monooxygenase] phosphate
show the reaction diagram
Rattus norvegicus
-
-
640693, 640694
-
-
?
ATP + [tyrosine 3-monooxygenase]
ADP + [tyrosine 3-monooxygenase] phosphate
show the reaction diagram
Rattus norvegicus
-
specific, incorporates 1 mol phosphate per mol enzyme tetramer, phosphorylation site: Ser-40
640694
-
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + [tyrosine 3-monooxygenase]
ADP + [tyrosine 3-monooxygenase] phosphate
show the reaction diagram
Rattus norvegicus
-
-
640693, 640694
-
-
?
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METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Mg2+
Rattus norvegicus
-
requirement
640693
additional information
Rattus norvegicus
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no requirement for Ca2+
640693, 640694
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INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
additional information
Rattus norvegicus
-
no inhibition by EGTA
640693
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
additional information
Rattus norvegicus
-
no requirement for cAMP
640693, 640694
-
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pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7.2
-
Rattus norvegicus
-
assay at
640693, 640694
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TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
30
-
Rattus norvegicus
-
assay at
640693, 640694
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SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
pheochromocytoma cell
Rattus norvegicus
-
from adrenal gland
640693, 640694
Manually annotated by BRENDA team
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Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
partial, during purification the kinase remains associated with its substrate
Rattus norvegicus
-
640693
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LINKS TO OTHER DATABASES (specific for EC-Number 2.7.11.6)
ExplorEnz
ExPASy
KEGG
MetaCyc
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
SYSTERS
Protein Mutant Database
InterPro (database of protein families, domains and functional sites)