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Reference on EC 2.7.11.4 - [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Reed, L.J.; Damuni, Z.; Merryfield, M.L.
Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation
Curr. Top. Cell. Regul.
27
41-49
1985
Bos taurus, Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Lau, K.S.; Cooper, A.J.L.; Chuang, D.T.
Inhibition of the bovine branched-chain 2-oxo acid dehydrogenase complex and its kinase by arylidenepyruvates
Biochim. Biophys. Acta
1038
360-366
1990
Bos taurus
Manually annotated by BRENDA team
Harris, R.A.; Kuntz, M.J.; Simpson, R.
Inhibition of branched-chain alpha-keto acid dehydrogenase kinase by alpha-chloroisocaproate
Methods Enzymol.
166
114-123
1988
Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Paxton, R.
Branched-chain alpha-keto acid dehydrogenase and its kinase from rabbit liver and heart
Methods Enzymol.
166
313-320
1988
Bos taurus, Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Paxton, R.; Harris, R.A.
Isolation of rabbit liver branched chain alpha-ketoacid dehydrogenase and regulation by phosphorylation
J. Biol. Chem.
257
14433-14439
1982
Oryctolagus cuniculus
Manually annotated by BRENDA team
Hawes, J.W.; Schnepf, R.J.; Jenkins, A.E.; Shimomura, Y.; Popov, K.M.; Harris, R.A.
Roles of amino acid residues surrounding phosphorylation site 1 and branched-chain alpha-ketoacid dehydrogenase (BCKDH) in catalysis and phosphorylation site recognition by BCKDH kinase
J. Biol. Chem.
270
31071-31076
1995
Rattus norvegicus
Manually annotated by BRENDA team
Odessey, R.
Purification of rat kidney branched-chain oxo acid dehydrogenase complex with endogenous kinase activity
Biochem. J.
204
353-356
1982
Rattus norvegicus
Manually annotated by BRENDA team
Lau, K.S.; Fatania, H.R.; Randle, P.J.
Regulation of the branched chain 2-oxoacid dehydrogenase kinase reaction
FEBS Lett.
144
57-62
1982
Bos taurus
Manually annotated by BRENDA team
Lawson, R.; Cook, K.G.; Yeaman, S.J.
Rapid purification of bovine kidney branched-chain 2-oxoacid dehydrogenase complex containing endogenous kinase activity
FEBS Lett.
157
54-58
1982
Bos taurus
Manually annotated by BRENDA team
Cook, K.G.; Lawson, R.; Yeaman, S.J.
Multi-site phosphorylation of bovine kidney branched-chain 2-oxoacid dehydrogenase complex
FEBS Lett.
157
59-62
1982
Bos taurus
Manually annotated by BRENDA team
Paxton, R.; Harris, R.A.
Clofibric acid, phenylpyruvate, and dichloroacetate inhibition of branched-chain alpha-ketoacid dehydrogenase kinase in vitro and in perfused rat heart
Arch. Biochem. Biophys.
231
58-66
1984
Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Paxton, R.; Harris, R.A.
Regulation of branched-chain alpha-ketoacid dehydrogenase kinase
Arch. Biochem. Biophys.
231
48-57
1984
Oryctolagus cuniculus
Manually annotated by BRENDA team
Harris, R.A.; Paxton, R.; DePaoli-Roach, A.
Inhibition of branched chain alpha-ketoacid dehydrogenase kinase activity by alpha-chloroisocaproate
J. Biol. Chem.
257
13915-13918
1982
Oryctolagus cuniculus
Manually annotated by BRENDA team
Shimomura, Y.; Kuntz, M.J.; Suzuki, M.; Ozawa, T.; Harris, R.A.
Monovalent cations and inorganic phosphate alter branched-chain alpha-ketoacid dehydrogenase-kinase activity and inhibitor sensitivity
Arch. Biochem. Biophys.
266
210-218
1988
Rattus norvegicus
Manually annotated by BRENDA team
Espinal, J.; Beggs, M.; Randle, P.J.
Assay of branched-chain alpha-keto acid dehydrogenase kinase in mitochondrial extracts and purified branched-chain alpha-keto acid dehydrogenase complexes
Methods Enzymol.
166
166-175
1988
Bos taurus, Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Shimomura, Y.; Nanaumi, N.; Suzuki, M.; Popov, K.M.; Harris, R.A.
Purification and partial characterization of branched-chain alpha-ketoacid dehydrogenase kinase from rat liver and rat heart
Arch. Biochem. Biophys.
283
293-299
1990
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Popov, K.M.; Zhao, Y.; Shimomura, Y.; Kuntz, M.J.; Harris, R.A.
Branched-chain alpha-ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinases
J. Biol. Chem.
267
13127-13130
1992
Rattus norvegicus
Manually annotated by BRENDA team
Lee, H.Y.; Hall, T.B.; Kee, S.M.; Tung, H.Y.L.; Reed, L.J.
Purification and properties of branched-chain alpha-keto acid dehydrogenase kinase from bovine kidney
BioFactors
3
109-112
1991
Bos taurus
Manually annotated by BRENDA team
Davie, J.R.; Wynn, R.M.; Meng, M.; Huang, Y.S.; Aalund, G.; Chuang, D.T.; Lau, K.S.
Expression and characterization of branched-chain alpha-ketoacid dehydrogenase kinase from the rat. Is it a histidine-protein kinase?
J. Biol. Chem.
270
19861-19867
1995
Rattus norvegicus
Manually annotated by BRENDA team
Doering, C.B.; Coursey, C.; Spangler, W.; Danner, D.J.
Murine branched chain alpha-ketoacid dehydrogenase kinase; cDNA cloning, tissue distribution, and temporal expression during embryonic development
Gene
212
213-219
1998
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Doering, C.B.; Danner, D.J.
Expression of murine branched-chain alpha-keto acid dehydrogenase kinase
Methods Enzymol.
324
491-497
2000
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Fujii, H.; Shimomura, Y.; Murakami, T.; Nakai, N.; Sato, T.; Suzuki, M.; Harris, R.A.
Branched-chain alpha-keto acid dehydrogenase kinase content in rat skeletal muscle is decreased by endurance training
Biochem. Mol. Biol. Int.
44
1211-1216
1998
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Machius, M.; Chuang, J.L.; Wynn, R.M.; Tomchick, D.R.; Chuang, D.T.
Structure of rat BCKD kinase: nucleotide-induced domain communication in a mitochondrial protein kinase
Proc. Natl. Acad. Sci. USA
98
11218-11223
2001
Rattus norvegicus (Q00972)
Manually annotated by BRENDA team
Nakai, N.; Kobayashi, R.; Popov, K.M.; Harris, R.A.; Shimomura, Y.
Determination of branched-chain alpha-keto acid dehydrogenase activity state and branched-chain alpha-keto acid dehydrogenase kinase activity and protein in mammalian tissues
Methods Enzymol.
324
48-62
2000
Rattus norvegicus
Manually annotated by BRENDA team
Nellis, M.M.; Doering, C.B.; Kasinski, A.; Danner, D.J.
Insulin increases branched-chain alpha-ketoacid dehydrogenase kinase expression in Clone 9 rat cells
Am. J. Physiol.
283
E853-E860
2002
Rattus norvegicus
Manually annotated by BRENDA team
Obayashi, M.; Sato, Y.; Harris, R.A.; Shimomura, Y.
Regulation of the activity of branched-chain 2-oxo acid dehydrogenase (BCODH) complex by binding BCODH kinase
FEBS Lett.
491
50-54
2001
Rattus norvegicus
Manually annotated by BRENDA team
Popov, K.M.; Shimomura, Y.; Hawes, J.W.; Harris, R.A.
Branched-chain alpha-keto acid dehydrogenase kinase
Methods Enzymol.
324
162-178
2000
Rattus norvegicus
Manually annotated by BRENDA team
Popov, K.M.; Zhao, Y.; Shimomura, Y.; Jaskiewicz, J.; Kedishvili, N.Y.; Irwin, J.; Goodwin, G.W.; Harris, R.A.
Dietary control and tissue specific expression of branched-chain alpha-ketoacid dehydrogenase kinase
Arch. Biochem. Biophys.
316
148-154
1995
Rattus norvegicus
Manually annotated by BRENDA team
Li, J.; Wynn, R.M.; Machius, M.; Chuang, J.L.; Karthikeyan, S.; Tomchick, D.R.; Chuang, D.T.
Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase
J. Biol. Chem.
279
32968-32978
2004
Rattus norvegicus
Manually annotated by BRENDA team
Wang, X.; Price, S.R.
Differential regulation of branched-chain alpha-ketoacid dehydrogenase kinase expression by glucocorticoids and acidification in LLC-PK1-GR101 cells
Am. J. Physiol. Renal. Physiol.
286
F504-508
2004
Sus scrofa
Manually annotated by BRENDA team
Muller, E.A.; Danner, D.J.
Tissue-specific translation of murine branched-chain alpha-ketoacid dehydrogenase kinase mRNA is dependent upon an upstream open reading frame in the 5'-untranslated region
J. Biol. Chem.
279
44645-44655
2004
Mus musculus
Manually annotated by BRENDA team
Murakami, T.; Matsuo, M.; Shimizu, A.; Shimomura, Y.
Dissociation of branched-chain alpha-keto acid dehydrogenase kinase (BDK) from branched-chain alpha-keto acid dehydrogenase complex (BCKDC) by BDK inhibitors
J. Nutr. Sci. Vitaminol.
51
48-50
2005
Rattus norvegicus
Manually annotated by BRENDA team
Howarth, K.R.; Burgomaster, K.A.; Phillips, S.M.; Gibala, M.J.
Exercise training increases branched-chain oxoacid dehydrogenase kinase content in human skeletal muscle
Am. J. Physiol.
293
R1335-R1341
2007
Homo sapiens
Manually annotated by BRENDA team
Kuzuya, T.; Katano, Y.; Nakano, I.; Hirooka, Y.; Itoh, A.; Ishigami, M.; Hayashi, K.; Honda, T.; Goto, H.; Fujita, Y.; Shikano, R.; Muramatsu, Y.; Bajotto, G.; Tamura, T.; Tamura, N.; Shimomura, Y.
Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus
Biochem. Biophys. Res. Commun.
373
94-98
2008
Rattus norvegicus
Manually annotated by BRENDA team
Akita, K.; Fujimura, Y.; Bajotto, G.; Shimomura, Y.
Inhibition of branched-chain alpha-ketoacid dehydrogenase kinase by thiamine pyrophosphate at different potassium ionic levels
Biosci. Biotechnol. Biochem.
73
1189-1191
2009
Rattus norvegicus
Manually annotated by BRENDA team
Doisaki, M.; Katano, Y.; Nakano, I.; Hirooka, Y.; Itoh, A.; Ishigami, M.; Hayashi, K.; Goto, H.; Fujita, Y.; Kadota, Y.; Kitaura, Y.; Bajotto, G.; Kazama, S.; Tamura, T.; Tamura, N.; Feng, G.G.; Ishikawa, N.; Shimomura, Y.
Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease
Biochem. Biophys. Res. Commun.
393
303-307
2010
Rattus norvegicus
Manually annotated by BRENDA team
Novarino, G.; El-Fishawy, P.; Kayserili, H.; Meguid, N.; Scott, E.; Schroth, J.; Silhavy, J.; Kara, M.; Khalil, R.; Ben-Omran, T.; Ercan-Sencicek, A.; Hashish, A.; Sanders, S.; Gupta, A.; Hashem, H.; Matern, D.; Gabriel, S.; Sweetman, L.; Rahimi, Y.; Harr
Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy
Science
338
394-397
2012
Homo sapiens
Manually annotated by BRENDA team
Knapik-Czajka, M.
Stimulation of rat liver branched-chain alpha-keto acid dehydrogenase activity by low doses of bezafibrate
Toxicology
306
101-107
2013
Rattus norvegicus
Manually annotated by BRENDA team
Garcia-Cazorla, A.; Oyarzabal, A.; Fort, J.; Robles, C.; Castejon, E.; Ruiz-Sala, P.; Bodoy, S.; Merinero, B.; Lopez-Sala, A.; Dopazo, J.; Nunes, V.; Ugarte, M.; Artuch, R.; Palacin, M.; Rodriguez-Pombo, P.; Alcaide, P.; Navarrete, R.; Sanz, P.; Font-Llitjos, M.; Vilaseca, M.A.; Ormaizabal, A.; P, P.r.
Two novel mutations in the BCKDK (branched-chain keto-acid dehydrogenase kinase) gene are responsible for a neurobehavioral deficit in two pediatric unrelated patients
Hum. Mutat.
35
470-477
2014
Homo sapiens (Q14874), Homo sapiens
Manually annotated by BRENDA team
Tso, S.C.; Gui, W.J.; Wu, C.Y.; Chuang, J.L.; Qi, X.; Skvora, K.J.; Dork, K.; Wallace, A.L.; Morlock, L.K.; Lee, B.H.; Hutson, S.M.; Strom, S.C.; Williams, N.S.; Tambar, U.K.; Wynn, R.M.; Chuang, D.T.
Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain alpha-ketoacid dehydrogenase kinase
J. Biol. Chem.
289
20583-20593
2014
Mus musculus (O55028), Mus musculus, Homo sapiens (Q14874), Homo sapiens
Manually annotated by BRENDA team
Kadota, Y.; Toyoda, T.; Hayashi-Kato, M.; Kitaura, Y.; Shimomura, Y.
Octanoic acid promotes branched-chain amino acid catabolisms via the inhibition of hepatic branched-chain alpha-keto acid dehydrogenase kinase in rats
Metab. Clin. Exp.
64
1157-1164
2015
Rattus norvegicus (Q00972)
Manually annotated by BRENDA team
Zigler, J.S.; Hodgkinson, C.A.; Wright, M.; Klise, A.; Sundin, O.; Broman, K.W.; Hejtmancik, F.; Huang, H.; Patek, B.; Sergeev, Y.; Hose, S.; Brayton, C.; Xaiodong, J.; Vasquez, D.; Maragakis, N.; Mori, S.; Goldman, D.; Hoke, A.; Sinha, D.
A spontaneous missense mutation in branched chain keto acid dehydrogenase kinase in the rat affects both the central and peripheral nervous systems
PLoS ONE
11
e0160447
2016
Rattus norvegicus (Q00972)
Manually annotated by BRENDA team
Hatazawa, Y.; Tadaishi, M.; Nagaike, Y.; Morita, A.; Ogawa, Y.; Ezaki, O.; Takai-Igarashi, T.; Kitaura, Y.; Shimomura, Y.; Kamei, Y.; Miura, S.
PGC-1alpha-mediated branched-chain amino acid metabolism in the skeletal muscle
PLoS ONE
9
e91006
2014
Mus musculus (O55028), Mus musculus
Manually annotated by BRENDA team
Tso, S.C.; Qi, X.; Gui, W.J.; Chuang, J.L.; Morlock, L.K.; Wallace, A.L.; Ahmed, K.; Laxman, S.; Campeau, P.M.; Lee, B.H.; Hutson, S.M.; Tu, B.P.; Williams, N.S.; Tambar, U.K.; Wynn, R.M.; Chuang, D.T.
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
Proc. Natl. Acad. Sci. USA
110
9728-9733
2013
Mus musculus (O55028)
Manually annotated by BRENDA team
Noguchi, S.; Kondo, Y.; Ito, R.; Katayama, T.; Kazama, S.; Kadota, Y.; Kitaura, Y.; Harris, R.A.; Shimomura, Y.
Ca2+-dependent inhibition of branched-chain alpha-ketoacid dehydrogenase kinase by thiamine pyrophosphate
Biochem. Biophys. Res. Commun.
504
916-920
2018
Rattus norvegicus (Q00972)
Manually annotated by BRENDA team
Xue, P.; Zeng, F.; Duan, Q.; Xiao, J.; Liu, L.; Yuan, P.; Fan, L.; Sun, H.; Malyarenko, O.S.; Lu, H.; Xiu, R.; Liu, S.; Shao, C.; Zhang, J.; Yan, W.; Wang, Z.; Zheng, J.; Zhu, F.
BCKDK of BCAA catabolism cross-talking with the MAPK pathway promotes tumorigenesis of colorectal cancer
EBioMedicine
20
50-60
2017
Homo sapiens (O13874), Homo sapiens
Manually annotated by BRENDA team
Krishnan, B.; Massilamany, C.; Basavalingappa, R.H.; Gangaplara, A.; Kang, G.; Li, Q.; Uzal, F.A.; Strande, J.L.; Delhon, G.A.; Riethoven, J.J.; Steffen, D.; Reddy, J.
Branched chain alpha-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice
Immun. Inflamm. Dis.
5
421-434
2017
Mus musculus (O55028)
Manually annotated by BRENDA team
Samuel Zigler, J.; Hodgkinson, C.; Wright, M.; Klise, A.; Sundin, O.; Broman, K.; Hejtmancik, F.; Huang, H.; Patek, B.; Sergeev, Y.; Hose, S.; Brayton, C.; Xaiodong, J.; Vasquez, D.; Maragakis, N.; Mori, S.; Goldman, D.; Hoke, A.; Sinha, D.
A spontaneous missense mutation in branched chain keto acid dehydrogenase kinase in the rat affects both the central and peripheral nervous systems
PLoS ONE
11
e0160447
2016
Rattus norvegicus (Q00972)
Manually annotated by BRENDA team
Xu, M.; Kitaura, Y.; Ishikawa, T.; Kadota, Y.; Terai, C.; Shindo, D.; Morioka, T.; Ota, M.; Morishita, Y.; Ishihara, K.; Shimomura, Y.
Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism
PLoS ONE
12
e0180989
2017
Mus musculus (O55028)
Manually annotated by BRENDA team