Reference on EC 2.7.11.28 - tropomyosin kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
deBelle, I.; Mak, A.S.
Isolation and characterization of tropomyosin kinase from chicken embryo
Biochim. Biophys. Acta
925
17-26
1987
Gallus gallus, Oryctolagus cuniculus
Montgomery, K.; Mak, A.S.
In vitro phosphorylation of tropomyosin by a kinase from chicken embryo
J. Biol. Chem.
259
5555-5560
1984
Gallus gallus
Watson, M.H.; Taneja, A.K.; Hodges, R.S.; Mak, A.S.
Phosphorylation of alphaalpha- and betabeta-tropomyosin and synthetic peptide analogues
Biochemistry
27
4506-4512
1988
Gallus gallus
Krishnamurthy, K.; Huang, Y.Z.; Harward, S.C.; Sharma, K.K.; Tamayo, D.L.; McNamara, J.O.
Regression of epileptogenesis by inhibiting tropomyosin kinase B signaling following a seizure
Ann. Neurol.
86
939-950
2019
Mus musculus
Cranston, A.; Stocken, D.D.; Stamp, E.; Roblin, D.; Hamlin, J.; Langtry, J.; Plummer, R.; Ashworth, A.; Burn, J.; Rajan, N.
Tropomyosin receptor antagonism in cylindromatosis (TRAC), an early phase trial of a topical tropomyosin kinase inhibitor as a treatment for inherited CYLD defective skin tumours study protocol for a randomised controlled trial
Trials
18
111
2017
Homo sapiens
Xu, J; Kurup, P; Azkona, G; Baguley, TD; Saavedra, A; Nairn, AC; Ellman, JA; Pérez-Navarro, E; Lombroso, PJ
Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels.
J Neurochem
136
285-94
2016
Mus musculus
Kim, YR; Kim, HN; Hong, KW; Shin, HK; Choi, BT
Anti-depressant effects of phosphodiesterase 3 inhibitor cilostazol in chronic mild stress-treated mice after ischemic stroke.
Psychopharmacology (Berl)
233
1055-66
2016
Hippocampus, Mus sp.
Xu, R; Duan, SR; Zhao, JW; Wang, CY
Changes in expression of BDNF and its receptors TrkB and p75NTR in the hippocampus of a dog model of chronic alcoholism and abstinence.
Braz J Med Biol Res
48
703-10
2015
Canis lupus familiaris, Hippocampus
Naito, Y; Mishima, S; Akagi, K; Igarashi, A; Ikeda, M; Okano, S; Kato, S; Takano, T; Tsuchihara, K; Terashima, K; Nishihara, H; Nishiyama, H; Hiyama, E; Hirasawa, A; Hosoi, H; Maeda, O; Yatabe, Y; Okamoto, W; Ono, S; Kajiyama, H; Nagashima, F; Hatanaka, Y; Miyachi, M; Kodera, Y; Yoshino, T; Taniguchi, H
Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology.
Int J Clin Oncol
25
403-417
2020
Homo sapiens
Weiss, GJ; Hidalgo, M; Borad, MJ; Laheru, D; Tibes, R; Ramanathan, RK; Blaydorn, L; Jameson, G; Jimeno, A; Isaacs, JD; Scaburri, A; Pacciarini, MA; Fiorentini, F; Ciomei, M; Von Hoff, DD
Phase I study of the safety, tolerability and pharmacokinetics of PHA-848125AC, a dual tropomyosin receptor kinase A and cyclin-dependent kinase inhibitor, in patients with advanced solid malignancies.
Invest New Drugs
2011
Homo sapiens
Su, L; Zhao, J; Zhao, BX; Zhang, SL; Miao, JY
Safrole oxide induces human umbilical vein endothelial cell transdifferentiation to 5-hydroxytryptaminergic neuron-like cells through tropomyosin receptor kinase A/cyclooxygenase 2/nuclear factor-kappa B/interleukin 8 signaling.
Int J Biochem Cell Biol
43
1512-22
2011
Homo sapiens
Hung, YY; Huang, TL
Lower serum tropomyosin receptor kinase B levels in patients with schizophrenia.
Biomed J
36
132-6
0
Homo sapiens
Warnault, V; Darcq, E; Morisot, N; Phamluong, K; Wilbrecht, L; Massa, SM; Longo, FM; Ron, D
The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation.
Biol Psychiatry
79
463-73
2016
Mus sp.
Nwosu, LN; Mapp, PI; Chapman, V; Walsh, DA
Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis.
Ann Rheum Dis
75
1246-54
2016
Rattus
Mehta, P; Premkumar, B; Morris, R
Production of high quality brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) RNA from isolated populations of rat spinal cord motor neurons obtained by Laser Capture Microdissection (LCM).
Neurosci Lett
627
132-8
2016
Rattus
Zheng, M; Duan, J; He, Z; Wang, Z; Mu, S; Zeng, Z; Qu, J; Zhang, J; Wang, D
Overexpression of tropomyosin receptor kinase A improves the survival and Schwann-like cell differentiation of bone marrow stromal cells in nerve grafts for bridging rat sciatic nerve defects.
Cytotherapy
18
1256-69
2016
Rattus
Traub, S; Stahl, H; Rosenbrock, H; Simon, E; Florin, L; Hospach, L; Hörer, S; Heilker, R
Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell-Derived Neurons.
J Pharmacol Exp Ther
361
355-365
2017
Homo sapiens
Prince, CS; Maloyan, A; Myatt, L
Tropomyosin Receptor Kinase B Agonist, 7,8-Dihydroxyflavone, Improves Mitochondrial Respiration in Placentas From Obese Women.
Reprod Sci
1933719117716776
2017
Homo sapiens
Chartier, SR; Mitchell, SA; Majuta, LA; Mantyh, PW
Immunohistochemical localization of nerve growth factor, tropomyosin receptor kinase A, and p75 in the bone and articular cartilage of the mouse femur.
Mol Pain
13
1744806917745465
0
Mus musculus
Duarte, JG; Nascimento, RD; Martins, PR; d'Ávila Reis, D
Evaluation of the immunoreactivity of nerve growth factor and tropomyosin receptor kinase A in the esophagus of noninfected and infected individuals with Trypanosoma cruzi.
Parasitol Res
2018
Trypanosoma cruzi
Wang, Y; Xu, O; Liu, Y; Lu, H
Auditory deprivation modifies the expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B in the rat auditory cortex.
J Otol
12
34-40
2017
Rattus
Han, HM; Kim, TH; Bae, JY; Bae, YC
Primary sensory neurons expressing tropomyosin receptor kinase A in the rat trigeminal ganglion.
Neurosci Lett
690
56-60
2019
Rattus
Sparidans, RW; Wang, Y; Schinkel, AH; Schellens, JHM; Beijnen, JH
Quantitative bioanalytical assay for the tropomyosin receptor kinase inhibitor larotrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
1102-1103
167-172
2018
Mus musculus, Mus sp.
Hawley, WR; Mosura, DE
Sexual motivation in male rats is modulated by tropomyosin receptor kinase B (TrkB).
Behav Neurosci
133
32-38
2019
Rattus, Areas
Suto, T; Kato, D; Obata, H; Saito, S
Tropomyosin Receptor Kinase B Receptor Activation in the Locus Coeruleus Restores Impairment of Endogenous Analgesia at a Late Stage Following Nerve Injury in Rats.
J Pain
2018
Rattus
Westphalen, CB; Preinfalk, A; Kruger, S; Haas, M; Renz, BW; Riener, MO; Weber, A; Kirchner, T; Werner, J; Heinemann, V; von Bergwelt-Baildon, M; Baba, HA; Siveke, JT; Ormanns, S; Boeck, S
Neurotrophic tropomyosin receptor kinase (NTRK) and nerve growth factor (NGF) are not expressed in Caucasian patients with biliary tract cancers: pooled data from three independent cohorts.
Clin Transl Oncol
2019
Homo sapiens
Subramanian, G; Johnson, PD; Zachary, T; Roush, N; Zhu, Y; Bowen, SJ; Janssen, A; Duclos, BA; Williams, T; Javens, C; Shalaly, ND; Molina, DM; Wittwer, AJ; Hirsch, JL
Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors.
ACS Chem Biol
14
1205-1216
2019
Homo sapiens
Wong, D; Yip, S; Sorensen, PH
Methods for Identifying Patients with Tropomyosin Receptor Kinase (TRK) Fusion Cancer.
Pathol Oncol Res
2019
Homo sapiens
Subramanian, G; Bowen, SJ; Zhu, Y; Roush, N; Zachary, T; Javens, C; Williams, T; Janssen, A; Gonzales, A
Type 2 inhibitor leads of human tropomyosin receptor kinase (hTrkA).
Bioorg Med Chem Lett
29
126624
2019
Homo sapiens
Shi, H; Zhu, S; Qin, B; Wang, L; Yang, J; Lu, G; Dai, F
Nerve growth factor and Tropomyosin receptor kinase A are increased in the gastric mucosa of patients with functional dyspepsia.
BMC Gastroenterol
19
221
2019
Homo sapiens
Subramanian, G; Vairagoundar, R; Bowen, SJ; Roush, N; Zachary, T; Javens, C; Williams, T; Janssen, A; Gonzales, A
Synthetic inhibitor leads of human tropomyosin receptor kinase A (hTrkA).
RSC Med Chem
11
370-377
2020
Homo sapiens
Duan, S; Dong, L; Wang, B; Wei, S; Gong, X; Yu, P; Li, C; Gao, Y; Ye, L; Wang, H; Tian, J
Assessment of the toxicity and toxicokinetics of the novel potent tropomyosin receptor kinase (Trk) inhibitor LPM4870108 in rhesus monkeys.
Regul Toxicol Pharmacol
122
104886
2021
Macaca mulatta, Homo sapiens
Kummar, S; Berlin, J; Mascarenhas, L; van Tilburg, CM; Geoerger, B; Lassen, UN; Schilder, RJ; Turpin, B; Nanda, S; Keating, K; Childs, BH; Chirila, C; Laetsch, TW; Hyman, DM; Drilon, A; Hong, DS
Quality of Life in Adult and Pediatric Patients with Tropomyosin Receptor Kinase Fusion Cancer Receiving Larotrectinib.
Curr Probl Cancer
100734
2021
Homo sapiens
Sedmak, G; Jovanov-Miloševi?, N; Puskarjov, M; Ulamec, M; Krušlin, B; Kaila, K; Judaš, M
Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain.
Cereb Cortex
2015
Rodentia
Luo, L; Li, C; Deng, Y; Wang, Y; Meng, P; Wang, Q
High-Intensity Interval Training on Neuroplasticity, Balance between Brain-Derived Neurotrophic Factor and Precursor Brain-Derived Neurotrophic Factor in Poststroke Depression Rats.
J Stroke Cerebrovasc Dis
28
672-682
2019
Hippocampus
Wu, Y; Deng, F; Wang, J; Liu, Y; Zhou, W; Qu, L; Cheng, M
Intensity-dependent effects of consecutive treadmill exercise on spatial learning and memory through the p-CREB/BDNF/NMDAR signaling in hippocampus.
Behav Brain Res
386
112599
2020
Hippocampus, Rattus
Kim, Y; Kim, J; He, M; Lee, A; Cho, E
Apigenin Ameliorates Scopolamine-Induced Cognitive Dysfunction and Neuronal Damage in Mice.
Molecules
26
2021
Mus sp.
Perreault, ML; Jones-Tabah, J; O'Dowd, BF; George, SR
A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex.
Int J Neuropsychopharmacol
1-7
2012
Mus sp., Rattus
Ikeno, T; Weil, ZM; Nelson, RJ
Photoperiod affects the diurnal rhythm of hippocampal neuronal morphology of siberian hamsters.
Chronobiol Int
30
1089-100
2013
Cricetinae, Hippocampus
Oakes, HV; DeVee, CE; Farmer, B; Allen, SA; Hall, AN; Ensley, T; Medlock, K; Hanley, A; Pond, BB
Neurogenesis within the hippocampus after chronic methylphenidate exposure.
J Neural Transm (Vienna)
126
201-209
2019
Hippocampus
Kim, TE; Son, HJ; Lim, DW; Yoon, M; Lee, J; Kim, YT; Han, D; Lee, C; Um, MY
Memory-enhancing effects of Ishige foliacea extract: In vitro and in vivo study.
J Food Biochem
e13162
2020
Hippocampus
Zhang, D; Wang, X; Li, R; Wang, L; Zhou, Z; Fu, Q; Cao, Y; Fang, M
Extract of the Aerial Part of Polygala tenuifolia Attenuates d-Galactose/NaNO2-induced Learning and Memory Impairment in Mice.
Planta Med
2020
Polygala tenuifolia, Hippocampus
Qu, P; Wang, Y; Liu, L; Qi, M; Sun, Y; Zheng, S; Xu, Z; Liu, C; Bai, X; Zhang, Q; Yang, L
Habenula lesions improve glucose metabolism in rats with type 2 diabetes by increasing insulin sensitivity and inhibiting gluconeogenesis.
BMJ Open Diabetes Res Care
8
2020
Hippocampus
Brivio, P; Sbrini, G; Corsini, G; Paladini, MS; Racagni, G; Molteni, R; Calabrese, F
Chronic Restraint Stress Inhibits the Response to a Second Hit in Adult Male Rats: A Role for BDNF Signaling.
Int J Mol Sci
21
2020
Metazoa
Chou, W; Liu, YF; Lin, CH; Lin, MT; Chen, CC; Liu, WP; Chang, CP; Chio, CC
Exercise Rehabilitation Attenuates Cognitive Deficits in Rats with Traumatic Brain Injury by Stimulating the Cerebral HSP20/BDNF/TrkB Signalling Axis.
Mol Neurobiol
2018
Rattus
Yokoi, F; Oleas, J; Xing, H; Liu, Y; Dexter, KM; Misztal, C; Gerard, M; Efimenko, I; Lynch, P; Villanueva, M; Alsina, R; Krishnaswamy, S; Vaillancourt, DE; Li, Y
Decreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice.
Neurobiol Dis
134
104638
2020
Mus sp.
Rojas-Carvajal, M; Sequeira-Cordero, A; Brenes, JC
Neurobehavioral Effects of Restricted and Unpredictable Environmental Enrichment in Rats.
Front Pharmacol
11
674
2020
Hippocampus
Li, X; Inoue, T; Hayashi, M; Maejima, H
Exercise enhances the expression of brain-derived neurotrophic factor in the hippocampus accompanied by epigenetic alterations in senescence-accelerated mice prone 8.
Neurosci Lett
706
176-181
2019
Hippocampus
Jahangiri, Z; Gholamnezhad, Z; Hosseini, M
Neuroprotective effects of exercise in rodent models of memory deficit and Alzheimer's.
Metab Brain Dis
34
21-37
2019
Hippocampus
Honda, T; Yasuda, T; Tanaka, T; Hagiwara, K; Arai, T; Yoshino, T
Functional expression of full-length TrkA in the prokaryotic host Magnetospirillum magneticum AMB-1 by using a magnetosome-display system.
Appl Environ Microbiol
2014
Magnetospirillum magneticum AMB-1
Watson, JA; Bhattacharyya, BJ; Vaden, JH; Wilson, JA; Icyuz, M; Howard, AD; Phillips, E; DeSilva, TM; Siegal, GP; Bean, AJ; King, GD; Phillips, SE; Miller, RJ; Wilson, SM
Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.
PLoS Genet
11
e1005290
2015
Mus sp.
Haas, CB; Kalinine, E; Zimmer, ER; Hansel, G; Brochier, AW; Oses, JP; Portela, LV; Muller, AP
Brain Insulin Administration Triggers Distinct Cognitive and Neurotrophic Responses in Young and Aged Rats.
Mol Neurobiol
2015
Rattus, Hippocampus
Darcq, E; Morisot, N; Phamluong, K; Warnault, V; Jeanblanc, J; Longo, FM; Massa, SM; Ron, D
The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking.
J Neurosci
36
10116-27
2016
Rattus
Chawla, A; Cordner, ZA; Boersma, G; Moran, TH
Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder.
Physiol Behav
180
78-90
2017
Rattus, Hippocampus
Luo, L; Li, C; Du, X; Shi, Q; Huang, Q; Xu, X; Wang, Q
Effect of aerobic exercise on BDNF/proBDNF expression in the ischemic hippocampus and depression recovery of rats after stroke.
Behav Brain Res
362
323-331
2019
Hippocampus
Tepper, B; Bartkowska, K; Okrasa, M; Ngati, S; Braszak, M; Turlejski, K; Djavadian, R
Downregulation of TrkC Receptors Increases Dendritic Arborization of Purkinje Cells in the Developing Cerebellum of the Opossum, Monodelphis domestica.
Front Neuroanat
14
56
2020
Didelphidae
Zhang, F; Lin, X; Liu, A; Chen, J; Shan, Z; Teng, W; Yu, X
Maternal Subclinical Hypothyroidism in Rats Impairs Spatial Learning and Memory in Offspring by Disrupting Balance of the TrkA/p75NTR Signal Pathway.
Mol Neurobiol
2021
Hippocampus
Krautmann, M; Walters, R; Cole, P; Tena, J; Bergeron, LM; Messamore, J; Mwangi, D; Rai, S; Dominowski, P; Saad, K; Zhu, Y; Guillot, M; Chouinard, L
Laboratory safety evaluation of bedinvetmab, a canine anti-nerve growth factor monoclonal antibody, in dogs.
Vet J
276
105733
2021
Canis lupus familiaris
Gao, L; Tian, M; Zhao, HY; Xu, QQ; Huang, YM; Si, QC; Tian, Q; Wu, QM; Hu, XM; Sun, LB; McClintock, SM; Zeng, Y
TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease.
J Neurochem
136
620-36
2016
Mus sp.
de Almeida, AA; Gomes da Silva, S; Lopim, GM; Vannucci Campos, D; Fernandes, J; Cabral, FR; Arida, RM
Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy.
J Neurosci Res
96
911-920
2018
Rattus norvegicus
Yang, SJ; Song, ZJ; Wang, XC; Zhang, ZR; Wu, SB; Zhu, GQ
Curculigoside facilitates fear extinction and prevents depression-like behaviors in a mouse learned helplessness model through increasing hippocampal BDNF.
Acta Pharmacol Sin
2019
Hippocampus
Ru, Q; Xiong, Q; Zhou, M; Chen, L; Tian, X; Xiao, H; Li, C; Li, Y
Withdrawal from chronic treatment with methamphetamine induces anxiety and depression-like behavior in mice.
Psychiatry Res
271
476-483
2019
Mus sp., Hippocampus
Chen, HL; Lan, YW; Tu, MY; Tung, YT; Chan, MN; Wu, HS; Yen, CC; Chen, CM
Kefir peptides exhibit antidepressant-like activity in mice through the BDNF/TrkB pathway.
J Dairy Sci
104
6415-6430
2021
Hippocampus
Looti Bashiyan, M; Nasehi, M; Vaseghi, S; Khalifeh, S
Investigating the effect of crocin on memory deficits induced by total sleep deprivation (TSD) with respect to the BDNF, TrkB and ERK levels in the hippocampus of male Wistar rats.
J Psychopharmacol
35
744-754
2021
Hippocampus
Park, SH; Jang, S; Lee, SW; Park, SD; Sung, YY; Kim, HK
Akebia quinata Decaisne aqueous extract acts as a novel anti-fatigue agent in mice exposed to chronic restraint stress.
J Ethnopharmacol
222
270-279
2018
Hippocampus
Ren, L; Tao, W; Zhang, H; Xue, W; Tang, J; Wu, R; Xia, B; Wu, H; Chen, G
Two standardized fractions of Gardenia jasminoides Ellis with rapid antidepressant effects are differentially associated with BDNF up-regulation in the hippocampus.
J Ethnopharmacol
187
66-73
2016
Hippocampus
Martini, F; Régis Leite, M; Gonçalves Rosa, S; Pregardier Klann, I; Wayne Nogueira, C
Strength exercise suppresses STZ-induced spatial memory impairment and modulates BDNF/ERK-CAMKII/CREB signalling pathway in the hippocampus of mice.
Cell Biochem Funct
2020
Mus sp.
Barbany, G; Persson, H
Adrenalectomy attenuates kainic acid-elicited increases of messenger RNAs for neurotrophins and their receptors in the rat brain.
Neuroscience
54
909-22
1993
Metazoa
Joseph, EK; Levine, JD
Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat.
Neuroscience
171
344-50
2010
Rattus
Wu, YW; Kou, XX; Bi, RY; Xu, W; Wang, KW; Gan, YH; Ma, XC
Hippocampal nerve growth factor potentiated by 17?-estradiol and involved in allodynia of inflamed TMJ in rat.
J Pain
13
555-63
2012
Rattus
Qiu, XC; Jin, H; Zhang, RY; Ding, Y; Zeng, X; Lai, BQ; Ling, EA; Wu, JL; Zeng, YS
Donor mesenchymal stem cell-derived neural-like cells transdifferentiate into myelin-forming cells and promote axon regeneration in rat spinal cord transection.
Stem Cell Res Ther
6
105
2015
Rattus
Li, L; Yu, T; Yu, L; Li, H; Liu, Y; Wang, D
Exogenous brain-derived neurotrophic factor relieves pain symptoms of diabetic rats by reducing excitability of dorsal root ganglion neurons.
Int J Neurosci
1-10
2015
Rattus
Wang, J; Hu, L; Xu, J; Li, QH; Wu, ZJ; Cai, RL; Wang, CH; Liu, L; He, L
[Electroacupuncture Stimulation of Different Acupoint or Paired Acupoints on Expression of BDNF and TrkB Proteins and Genes in Hippocampus in Myocardial Ischemic Rats].
Zhen Ci Yan Jiu
41
40-4
2016
Hippocampus, Rattus, Areas
Tabbaa, M; Lei, K; Liu, Y; Wang, Z
Paternal deprivation affects social behaviors and neurochemical systems in the offspring of socially monogamous prairie voles.
Neuroscience
343
284-297
2017
Hippocampus
Sarabi, M; Perraud, A; Mazouffre, C; Nouaille, M; Jauberteau, MO; Mathonnet, M
Psychoactive drugs influence brain-derived neurotrophic factor and neurotrophin 4/5 levels in the serum of colorectal cancer patients.
Biomed Rep
6
89-94
2017
Homo sapiens
Egawa, J; Schilling, JM; Cui, W; Posadas, E; Sawada, A; Alas, B; Zemljic-Harpf, AE; Fannon-Pavlich, MJ; Mandyam, CD; Roth, DM; Patel, HH; Patel, PM; Head, BP
Neuron-specific caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma.
FASEB J
31
3403-3411
2017
Mus sp.
Botsakis, K; Mourtzi, T; Panagiotakopoulou, V; Vreka, M; Stathopoulos, GT; Pediaditakis, I; Charalampopoulos, I; Gravanis, A; Delis, F; Antoniou, K; Zisimopoulos, D; Georgiou, CD; Panagopoulos, NT; Matsokis, N; Angelatou, F
BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the "weaver" mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor.
Neuropharmacology
121
140-157
2017
Mus musculus
Lin, R; Li, X; Liu, W; Chen, W; Yu, K; Zhao, C; Huang, J; Yang, S; Peng, H; Tao, J; Chen, L
Electro-acupuncture ameliorates cognitive impairment via improvement of brain-derived neurotropic factor-mediated hippocampal synaptic plasticity in cerebral ischemia-reperfusion injured rats.
Exp Ther Med
14
2373-2379
2017
Rattus
JiaWen, W; Hong, S; ShengXiang, X; Jing, L
Depression- and anxiety-like behaviour is related to BDNF/TrkB signalling in a mouse model of psoriasis.
Clin Exp Dermatol
43
254-261
2018
Mus musculus, animal
Liu, H; Zhong, L; Zhang, Y; Liu, X; Li, J
Rutin attenuates cerebral ischemia/reperfusion injury in ovariectomized rats via estrogen receptor-mediated BDNF-TrkB and NGF-TrkA signaling.
Biochem Cell Biol
2018
Rattus, Hippocampus
Lim, DW; Um, MY; Han, T; Lee, J; Kim, YT; Cho, S; Kim, IH; Han, D; Lee, C
Standardized Citrus unshiu peel extract ameliorates dexamethasone-induced neurotoxicity and depressive-like behaviors in mice.
Metab Brain Dis
2018
Hippocampus
Shen, M; Lv, D; Liu, X; Li, S; Chen, Y; Zhang, Y; Wang, Z; Wang, C
Essential roles of neuropeptide VGF regulated TrkB/mTOR/BICC1 signaling and phosphorylation of AMPA receptor subunit GluA1 in the rapid antidepressant-like actions of ketamine in mice.
Brain Res Bull
143
58-65
2018
Mus musculus
Wang, XM; Pan, W; Xu, N; Zhou, ZQ; Zhang, GF; Shen, JC
Environmental enrichment improves long-term memory impairment and aberrant synaptic plasticity by BDNF/TrkB signaling in nerve-injured mice.
Neurosci Lett
694
93-98
2019
Mus sp.
Chen, YC; Chiu, YJ; Lin, CH; Hsu, WC; Wu, JL; Huang, CH; Lin, CW; Yao, CF; Huang, HJ; Lo, YS; Chen, CM; Wu, YR; Chang, KH; Lee-Chen, GJ; Mei Hsieh-Li, H
Indole Compound NC009-1 Augments APOE and TRKA in Alzheimer's Disease Cell and Mouse Models for Neuroprotection and Cognitive Improvement.
J Alzheimers Dis
67
737-756
2019
Homo sapiens
Subaraja, M; Kulandaisamy, A; Shanmugam, NRS; Vanisree, AJ
Homology modeling identified for purported drug targets to the neuroprotective effects of levodopa and asiaticoside-D in degenerated cerebral ganglions of Lumbricus terrestris.
Indian J Pharmacol
51
31-39
0
Homo sapiens, Lumbricus terrestris
Ishiguro, N; Oyama, S; Higashi, R; Yanagida, K
Efficacy, Safety, and Tolerability of ONO-4474, an Orally Available Pan-Tropomyosin Receptor Kinase Inhibitor, in Japanese Patients With Moderate to Severe Osteoarthritis of the Knee: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparative Study.
J Clin Pharmacol
2019
Homo sapiens
Ge, H; Guan, S; Shen, Y; Sun, M; Hao, Y; He, L; Liu, L; Yin, C; Huang, R; Xiong, W; Gao, Y
Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression.
Sci Rep
9
14619
2019
Rattus
Kulinich, AO; Reinhard, SM; Rais, M; Lovelace, JW; Scott, V; Binder, DK; Razak, KA; Ethell, IM
Beneficial effects of sound exposure on auditory cortex development in a mouse model of Fragile X Syndrome.
Neurobiol Dis
134
104622
2020
Mus sp.
Solomon, JP; Benayed, R; Hechtman, JF; Ladanyi, M
Identifying patients with NTRK fusion cancer.
Ann Oncol
30
viii16-viii22
2019
Homo sapiens
Wykes, AD; Ma, S; Bathgate, RAD; Gundlach, AL
Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter.
IBRO Rep
8
1-10
2020
Rattus
Guan, L; Yu, WS; Shrestha, S; Or, YZ; Lufkin, T; Chan, YS; Lin, VCL; Lim, LW
TTC9A deficiency induces estradiol-mediated changes in hippocampus and amygdala neuroplasticity-related gene expressions in female mice.
Brain Res Bull
157
162-168
2020
Mus sp., Hippocampus
Xu, L; Zheng, YL; Yin, X; Xu, SJ; Tian, D; Zhang, CY; Wang, S; Ma, JZ
Excessive Treadmill Training Enhances Brain-Specific MicroRNA-34a in the Mouse Hippocampus.
Front Mol Neurosci
13
7
2020
Mus musculus, Hippocampus
Fujimura, M; Usuki, F
Pregnant rats exposed to low-level methylmercury exhibit cerebellar synaptic and neuritic remodeling during the perinatal period.
Arch Toxicol
2020
Rattus
Solomon, JP; Benayed, R; Hechtman, JF; Ladanyi, M
Identifying patients with NTRK fusion cancer.
Ann Oncol
30 Suppl 8
viii16-viii22
2019
Homo sapiens
Robinson, JA; Guenthner, G; Warfield, R; Kublin, JR; Smith, MD; Shekarabi, M; Miller, AD; Burdo, TH
Atrophy and Death of Nonpeptidergic and Peptidergic Nociceptive Neurons in SIV Infection.
Am J Pathol
190
1530-1544
2020
Metazoa
Moradi-Kor, N; Ghanbari, A; Rashidipour, H; Bandegi, AR; Youse?, B; Barati, M; Kokhaei, P; Rashidy-Pour, A
Therapeutic Effects of Spirulina platensis Against Adolescent Stress-Induced Oxidative Stress, Brain-Derived Neurotrophic Factor Alterations and Morphological Remodeling in the Amygdala of Adult Female Rats.
J Exp Pharmacol
12
75-85
2020
Metazoa
Cardona, AF; Arrieta, O; Ruiz-Patiño, A; Sotelo, C; Zamudio-Molano, N; Zatarain-Barrón, ZL; Ricaurte, L; Raez, L; Álvarez, MPP; Barrón, F; Rojas, L; Rolfo, C; Karachaliou, N; Molina-Vila, MA; Rosell, R
Precision medicine and its implementation in patients with NTRK fusion genes: perspective from developing countries.
Ther Adv Respir Dis
14
1753466620938553
0
Homo sapiens
Sari, LM; Zampini, R; Argañaraz, ME; Ratto, MH; Apichela, SA
Effect of mating on mRNA and protein expression of beta nerve growth factor and its receptor, TrKA, in the oviduct of llama (Lama glama).
Mol Reprod Dev
87
1133-1140
2020
Lama glama
Kim, HR; Lee, YJ; Kim, TW; Lim, RN; Hwang, DY; Moffat, JJ; Kim, S; Seo, JW; Ka, M
Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress.
BMC Complement Med Ther
20
325
2020
Rattus
Beros, J; Rodger, J; Harvey, AR
Age Related Response of Neonatal Rat Retinal Ganglion Cells to Reduced TrkB Signaling in vitro and in vivo.
Front Cell Dev Biol
9
671087
2021
Rattus
Li, Y; Xiang, LL; Miao, JX; Miao, MS; Wang, C
Protective effects of andrographolide against cerebral ischemia?reperfusion injury in mice.
Int J Mol Med
48
2021
Mus sp.
Kim, YS; Jo, DH; Lee, H; Kim, JH; Kim, KW; Kim, JH
Nerve growth factor-mediated vascular endothelial growth factor expression of astrocyte in retinal vascular development.
Biochem Biophys Res Commun
431
740-5
2013
Mus sp.
Kimura, A; Namekata, K; Guo, X; Noro, T; Harada, C; Harada, T
Valproic Acid Prevents NMDA-Induced Retinal Ganglion Cell Death via Stimulation of Neuronal TrkB Receptor Signaling.
Am J Pathol
185
756-64
2015
Mus musculus
Gu, F; Parada, I; Yang, T; Longo, FM; Prince, DA
Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons.
Neurobiol Dis
113
45-58
2018
Rattus
Moriwaki, K; Ayani, Y; Kuwabara, H; Terada, T; Kawata, R; Asahi, M
TRKB tyrosine kinase receptor is a potential therapeutic target for poorly differentiated oral squamous cell carcinoma.
Oncotarget
9
25225-25243
2018
Homo sapiens
Albanese, C; Alzani, R; Amboldi, N; Avanzi, N; Ballinari, D; Brasca, MG; Festuccia, C; Fiorentini, F; Locatelli, G; Pastori, W; Patton, V; Roletto, F; Colotta, F; Galvani, A; Isacchi, A; Moll, J; Pesenti, E; Mercurio, C; Ciomei, M
Dual targeting of CDK and tropomyosin receptor kinase families by the oral inhibitor PHA-848125, an agent with broad-spectrum antitumor efficacy.
Mol Cancer Ther
9
2243-54
2010
Homo sapiens, Rodentia, Mus sp.
Braun, AA; Herring, NR; Schaefer, TL; Hemmerle, AM; Dickerson, JW; Seroogy, KB; Vorhees, CV; Williams, MT
Neurotoxic (+)-methamphetamine treatment increases brain-derived neurotrophic factor and tropomyosin receptor kinase B expression in multiple brain regions.
Neuroscience
2011
Rattus
Alam, MS; Choi, SU; Lee, DU
Synthesis, anticancer, and docking studies of salicyl-hydrazone analogues: A novel series of small potent tropomyosin receptor kinase A inhibitors.
Bioorg Med Chem
25
389-396
2017
Homo sapiens
Zheng, M; Duan, J; He, Z; Wang, Z; Mu, S; Zeng, Z; Qu, J; Wang, D; Zhang, J
Transplantation of bone marrow stromal stem cells overexpressing tropomyosin receptor kinase A for peripheral nerve repair.
Cytotherapy
19
916-926
2017
Rattus
Friedrich, C; Shalaby, T; Oehler, C; Pruschy, M; Seifert, B; Picard, D; Remke, M; Warmuth-Metz, M; Kortmann, RD; Rutkowski, S; Grotzer, MA; von Bueren, AO
Tropomyosin receptor kinase C (TrkC) expression in medulloblastoma: relation to the molecular subgroups and impact on treatment response.
Childs Nerv Syst
2017
Homo sapiens
Pietropaolo, A; Magrì, A; Greco, V; Losasso, V; La Mendola, D; Sciuto, S; Carloni, P; Rizzarelli, E
Binding of Zn(II) to Tropomyosin Receptor Kinase A in Complex with Its Cognate Nerve Growth Factor: Insights from Molecular Simulation and in Vitro Essays.
ACS Chem Neurosci
2018
Homo sapiens
Orbach, D; Sparber-Sauer, M; Laetsch, TW; Minard-Colin, V; Bielack, SS; Casanova, M; Corradini, N; Koscielniak, E; Scheer, M; Hettmer, S; Bisogno, G; Hawkins, DS; Ferrari, A
Spotlight on the treatment of infantile fibrosarcoma in the era of neurotrophic tropomyosin receptor kinase inhibitors: International consensus and remaining controversies.
Eur J Cancer
137
183-192
2020
Homo sapiens
Demetri, GD; Antonescu, CR; Bjerkehagen, B; Bovée, JVMG; Boye, K; Chacón, M; Dei Tos, AP; Desai, J; Fletcher, JA; Gelderblom, H; George, S; Gronchi, A; Haas, RL; Hindi, N; Hohenberger, P; Joensuu, H; Jones, RL; Judson, I; Kang, YK; Kawai, A; Lazar, AJ; Le Cesne, A; Maestro, R; Maki, RG; Martín, J; Patel, S; Penault-Llorca, F; Raut, CP; Rutkowski, P; Safwat, A; Sbaraglia, M; Schaefer, IM; Shen, L; Serrano, C; Schöffski, P; Stacchiotti, S; Hall, KS; Tap, WD; Thomas, DM; Trent, J; Valverde, C; van der Graaf, WTA; von Mehren, M; Wagner, A; Wardelmann, E; Naito, Y; Zalcberg, J; Blay, JY
Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network.
Ann Oncol
2020
Homo sapiens
Huang, Y; Song, YJ; Isaac, M; Miretzky, S; Patel, A; Geoffrey McAuliffe, W; Dreyfus, CF
Tropomyosin Receptor Kinase B Expressed in Oligodendrocyte Lineage Cells Functions to Promote Myelin Following a Demyelinating Lesion.
ASN Neuro
12
1759091420957464
0
Mus sp.
Italiano, A; Nanda, S; Briggs, A; Garcia-Foncillas, J; Lassen, U; Vassal, G; Kummar, S; van Tilburg, CM; Hong, DS; Laetsch, TW; Keating, K; Reeves, JA; Fellous, M; Childs, BH; Drilon, A; Hyman, DM
Larotrectinib versus Prior Therapies in Tropomyosin Receptor Kinase Fusion Cancer: An Intra-Patient Comparative Analysis.
Cancers (Basel)
12
2020
Homo sapiens
Zeng, Y; Yang, K
Sirtuin 1 participates in the process of age-related retinal degeneration.
Biochem Biophys Res Commun
468
167-72
0
Mus sp.
Radiske, A; Rossato, JI; Köhler, CA; Gonzalez, MC; Medina, JH; Cammarota, M
Requirement for BDNF in the reconsolidation of fear extinction.
J Neurosci
35
6570-4
2015
Hippocampus
Jiang, H; Chen, S; Li, C; Lu, N; Yue, Y; Yin, Y; Zhang, Y; Zhi, X; Zhang, D; Yuan, Y
The serum protein levels of the tPA-BDNF pathway are implicated in depression and antidepressant treatment.
Transl Psychiatry
7
e1079
2017
Homo sapiens
Mohammadi, A; Rashidi, E; Amooeian, VG
Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia.
Psychiatry Res
265
25-38
2018
Homo sapiens
Ullrich, M; Weber, M; Post, AM; Popp, S; Grein, J; Zechner, M; Guerrero González, H; Kreis, A; Schmitt, AG; Üçeyler, N; Lesch, KP; Schuh, K
OCD-like behavior is caused by dysfunction of thalamo-amygdala circuits and upregulated TrkB/ERK-MAPK signaling as a result of SPRED2 deficiency.
Mol Psychiatry
23
444-458
2018
Mus sp.
Lam, CT; Yang, ZF; Lau, CK; Tam, KH; Fan, ST; Poon, RT
Brain-Derived Neurotrophic Factor Promotes Tumorigenesis via Induction of Neovascularization: Implication in Hepatocellular Carcinoma.
Clin Cancer Res
2011
Homo sapiens
Moreau, JM; Ciriello, J
Chronic intermittent hypoxia induces changes in expression of synaptic proteins in the nucleus of the solitary tract.
Brain Res
1622
300-7
2015
animal
Fujita, Y; Endo, S; Takai, T; Yamashita, T
Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity.
EMBO J
30
1389-401
2011
Mus sp.
Chitranshi, N; Dheer, Y; Mirzaei, M; Wu, Y; Salekdeh, GH; Abbasi, M; Gupta, V; Vander Wall, R; You, Y; Graham, SL; Gupta, V
Loss of Shp2 Rescues BDNF/TrkB Signaling and Contributes to Improved Retinal Ganglion Cell Neuroprotection.
Mol Ther
27
424-441
2019
Homo sapiens, animal
Chan, SH; Wu, CW; Chang, AY; Hsu, KS; Chan, JY
Transcriptional upregulation of brain-derived neurotrophic factor in rostral ventrolateral medulla by angiotensin II: significance in superoxide homeostasis and neural regulation of arterial pressure.
Circ Res
107
1127-39
2010
Homo sapiens
Kim, HI; Lee, S; Lim, J; Chung, S; Koo, TS; Ji, YG; Suh, YG; Son, WS; Kim, SH; Choi, HJ
ERR? ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype.
Pharmacol Res
105423
2021
Homo sapiens
Zhang, X; Wang, J; Gao, JZ; Zhang, XN; Dou, KX; Shi, WD; Xie, AM
P2X4 receptor participates in autophagy regulation in Parkinson's disease.
Neural Regen Res
16
2505-2511
2021
Rattus
Canu, N; Pagano, I; La Rosa, LR; Pellegrino, M; Ciotti, MT; Mercanti, D; Moretti, F; Sposato, V; Triaca, V; Petrella, C; Maruyama, IN; Levi, A; Calissano, P
Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents.
Front Mol Neurosci
10
15
2017
Homo sapiens, Mus musculus, Rattus
Bernard-Gauthier, V; Mahringer, A; Vesnaver, M; Fricker, G; Schirrmacher, R
Design and synthesis of a fluorinated quinazoline-based type-II Trk inhibitor as a scaffold for PET radiotracer development.
Bioorg Med Chem Lett
27
2771-2775
2017
Homo sapiens
Rosenhauer, AM; Beach, LQ; Jeffress, EC; Thompson, BM; McCann, KE; Partrick, KA; Diaz, B; Norvelle, A; Choi, DC; Huhman, KL
Brain-derived neurotrophic factor signaling mitigates the impact of acute social stress.
Neuropharmacology
148
40-49
2018
Cricetinae, Mus sp.
Jin, W
Roles of TrkC Signaling in the Regulation of Tumorigenicity and Metastasis of Cancer.
Cancers (Basel)
12
2020
Homo sapiens
Giustini, NP; Jeong, AR; Buturla, J; Bazhenova, L
Advances in Treatment of Locally Advanced or Metastatic Non-Small Cell Lung Cancer: Targeted Therapy.
Clin Chest Med
41
223-235
2020
Homo sapiens
Caldwell, KJ; De La Cuesta, E; Morin, C; Pappo, A; Helmig, S
A newborn with a large NTRK fusion positive infantile fibrosarcoma successfully treated with larotrectinib.
Pediatr Blood Cancer
e28330
2020
Homo sapiens
Sholl, LM; Zheng, M; Nardi, V; Hornick, JL
Predictive 'biomarker piggybacking': an examination of reflexive pan-cancer screening with pan-TRK immunohistochemistry.
Histopathology
79
260-264
2021
Homo sapiens
Qi, D; Ouyang, C; Wang, Y; Zhang, S; Ma, X; Song, Y; Yu, H; Tang, J; Fu, W; Sheng, L; Yang, L; Wang, M; Zhang, W; Miao, L; Li, T; Huang, X; Dong, H
HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.
Brain Res
1577
69-76
2014
Rattus
Lin, Y; Lu, X; Dong, J; He, X; Yan, T; Liang, H; Sui, M; Zheng, X; Liu, H; Zhao, J; Lu, X
Involuntary, Forced and Voluntary Exercises Equally Attenuate Neurocognitive Deficits in Vascular Dementia by the BDNF-pCREB Mediated Pathway.
Neurochem Res
40
1839-48
2015
Hippocampus
Dong, E; Guidotti, A; Zhang, H; Pandey, SC
Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring.
Neuropharmacology
140
76-85
2018
Mus sp.
Zhu, JX; Hu, WQ; Dong, SQ; Yi, LT; Zeng, JX; Li, M
Hippocampal BDNF signaling is required for the antidepressant effects of perillaldehyde.
Pharmacol Rep
71
430-437
2019
Mus sp.
Zhang, ZC; Luan, F; Xie, CY; Geng, DD; Wang, YY; Ma, J
Low-frequency transcranial magnetic stimulation is beneficial for enhancing synaptic plasticity in the aging brain.
Neural Regen Res
10
916-24
2015
Mus sp., Hippocampus
Gruber-Olipitz, M; Ströbel, T; Chen, WQ; Grotzer, MA; Quehenberger, F; Slavc, I; Lubec, G
Synthesis, chaperoning, and metabolism of proteins are regulated by NT-3/TrkC signaling in the medulloblastoma cell line DAOY.
J Proteome Res
7
1932-44
2008
Homo sapiens
Mantyh, WG; Jimenez-Andrade, JM; Stake, JI; Bloom, AP; Kaczmarska, MJ; Taylor, RN; Freeman, KT; Ghilardi, JR; Kuskowski, MA; Mantyh, PW
Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain.
Neuroscience
2010
Mus musculus
Wong, J; Garner, B; Halliday, GM; Kwok, JB
Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease.
J Neurochem
123
159-71
2012
Hippocampus
English, AW; Liu, K; Nicolini, JM; Mulligan, AM; Ye, K
Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves.
Proc Natl Acad Sci U S A
110
16217-16222
2013
Mus sp.
Frank, P; Barrientos, G; Tirado-González, I; Cohen, M; Moschansky, P; Peters, EM; Klapp, BF; Rose, M; Tometten, M; Blois, SM
Balanced levels of nerve growth factor are required for normal pregnancy progression.
Reproduction
148
179-89
2014
Mus sp.
Schmauss, C
An HDAC-dependent epigenetic mechanism that enhances the efficacy of the antidepressant drug fluoxetine.
Sci Rep
5
8171
2015
Mus sp.
Dekeyster, E; Geeraerts, E; Buyens, T; Van den Haute, C; Baekelandt, V; De Groef, L; Salinas-Navarro, M; Moons, L
Tackling Glaucoma from within the Brain: An Unfortunate Interplay of BDNF and TrkB.
PLoS One
10
e0142067
2015
Mus musculus
Amadio, P; Baldassarre, D; Sandrini, L; Weksler, BB; Tremoli, E; Barbieri, SS
Effect of cigarette smoke on monocyte procoagulant activity: Focus on platelet-derived brain-derived neurotrophic factor (BDNF).
Platelets
1-6
2016
Homo sapiens
Fischer, DL; Kemp, CJ; Cole-Strauss, A; Polinski, NK; Paumier, KL; Lipton, JW; Steece-Collier, K; Collier, TJ; Buhlinger, DJ; Sortwell, CE
Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration.
J Neurosci
37
6786-6796
2017
Rattus, Compacta
Chiang, S; Cotzia, P; Hyman, DM; Drilon, A; Tap, WD; Zhang, L; Hechtman, JF; Frosina, D; Jungbluth, AA; Murali, R; Park, KJ; Soslow, RA; Oliva, E; Iafrate, AJ; Benayed, R; Ladanyi, M; Antonescu, CR
NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma.
Am J Surg Pathol
2018
Homo sapiens
Yan, L; Zhang, W
Precision medicine becomes reality-tumor type-agnostic therapy.
Cancer Commun (Lond)
38
6
2018
Homo sapiens
Yang, C; Kobayashi, S; Nakao, K; Dong, C; Han, M; Qu, Y; Ren, Q; Zhang, JC; Ma, M; Toki, H; Yamaguchi, JI; Chaki, S; Shirayama, Y; Nakazawa, K; Manabe, T; Hashimoto, K
AMPA Receptor Activation-Independent Antidepressant Actions of Ketamine Metabolite (S)-Norketamine.
Biol Psychiatry
84
591-600
2018
Mus sp.
Lin, PY; Kavalali, ET; Monteggia, LM
Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses.
Cell Rep
24
1550-1561
2018
Hippocampus
Iughetti, L; Lucaccioni, L; Fugetto, F; Predieri, B; Berardi, A; Ferrari, F
Brain-derived neurotrophic factor and epilepsy: a systematic review.
Neuropeptides
2018
Homo sapiens, Areas, animal
Yu, TH; Wu, YJ; Chien, ME; Hsu, KS
Transcranial direct current stimulation induces hippocampal metaplasticity mediated by brain-derived neurotrophic factor.
Neuropharmacology
144
358-367
2019
Rattus
Zhang, D; Zhu, HY; Bian, XB; Zhao, Y; Zang, P; Gao, YG; Zhang, LX
The antidepressant effect of 4-hydroxybenzyl alcohol 2-naphthoate through monoaminergic, GABAergic system and BDNF signaling pathway.
Nat Prod Res
1-4
2018
Mus sp.
Pedrinolla, A; Venturelli, M; Tamburin, S; Fonte, C; Stabile, AM; Galazzo, IB; Ghinassi, B; Venneri, MA; Pizzini, FB; Muti, E; Smania, N; Baldassarre, AD; Naro, F; Rende, M; Schena, F
Non-A?-Dependent Factors Associated with Global Cognitive and Physical Function in Alzheimer's Disease: A Pilot Multivariate Analysis.
J Clin Med
8
2019
Homo sapiens
Wong, HLX; Qin, HY; Tsang, SW; Zuo, X; Che, S; Chow, CFW; Li, X; Xiao, HT; Zhao, L; Huang, T; Lin, CY; Kwan, HY; Yang, T; Longo, FM; Lyu, A; Bian, ZX
Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling.
Nat Commun
10
1745
2019
Mus musculus, Mus sp.
Bailey, JJ; Kaiser, L; Lindner, S; Wüst, M; Thiel, A; Soucy, JP; Rosa-Neto, P; Scott, PJH; Unterrainer, M; Kaplan, DR; Wängler, C; Wängler, B; Bartenstein, P; Bernard-Gauthier, V; Schirrmacher, R
First-in-Human Brain Imaging of [18F]TRACK, a PET tracer for Tropomyosin Receptor Kinases.
ACS Chem Neurosci
10
2697-2702
2019
Homo sapiens
Sun, N; Chu, L; Yuan, L; Qi, Z
Inactivation of P2YR12 contributes to isoflurane-induced neuronal injury by altering TLR-4/BDNF/TNF-?.
Folia Neuropathol
57
161-169
2019
Rattus
Subramanian, G; Zhu, Y; Bowen, SJ; Roush, N; White, JA; Huczek, D; Zachary, T; Javens, C; Williams, T; Janssen, A; Gonzales, A
Lead identification and characterization of hTrkA type 2 inhibitors.
Bioorg Med Chem Lett
29
126680
2019
Homo sapiens, collection
Philippot, G; Forsberg, E; Tahan, C; Viberg, H; Fredriksson, R
A Single ?9-Tetrahydrocannabinol (THC) Dose During Brain Development Affects Markers of Neurotrophy, Oxidative Stress, and Apoptosis.
Front Pharmacol
10
1156
2019
Mus sp., Hippocampus
Moon, GJ; Kim, S; Jeon, MT; Lee, KJ; Jang, IS; Nakamura, M; Kim, SR
Therapeutic Potential of AAV1-Rheb(S16H) Transduction Against Alzheimer's Disease.
J Clin Med
8
2019
Mus sp.
Palasz, E; Wysocka, A; Gasiorowska, A; Chalimoniuk, M; Niewiadomski, W; Niewiadomska, G
BDNF as a Promising Therapeutic Agent in Parkinson's Disease.
Int J Mol Sci
21
2020
animal
Engeln, M; Song, Y; Chandra, R; La, A; Fox, ME; Evans, B; Turner, MD; Thomas, S; Francis, TC; Hertzano, R; Lobo, MK
Individual differences in stereotypy and neuron subtype translatome with TrkB deletion.
Mol Psychiatry
2020
Mus musculus, Metazoa
Sun, G; Miao, Z; Ye, Y; Zhao, P; Fan, L; Bao, Z; Tu, Y; Li, C; Chao, H; Xu, X; Ji, J
Curcumin alleviates neuroinflammation, enhances hippocampal neurogenesis, and improves spatial memory after traumatic brain injury.
Brain Res Bull
162
84-93
2020
Hippocampus
Forschner, A; Forchhammer, S; Bonzheim, I
NTRK gene fusions in melanoma: detection, prevalence and potential therapeutic implications.
J Dtsch Dermatol Ges
18
1387-1392
2020
Homo sapiens
Zou, W; Hu, X; Jiang, L
Advances in Regulating Tumorigenicity and Metastasis of Cancer through TrkB Signaling.
Curr Cancer Drug Targets
2020
Homo sapiens
He, YY; Wang, L; Zhang, T; Weng, SJ; Lu, J; Zhong, YM
Aerobic exercise delays retinal ganglion cell death after optic nerve injury.
Exp Eye Res
200
108240
2020
Rattus
Takemura, S; Isonishi, A; Tanaka, T; Okuda, H; Tatsumi, K; Yamano, M; Wanaka, A
Neural expression of sorting nexin 25 and its regulation of tyrosine receptor kinase B trafficking.
Brain Struct Funct
2020
Hippocampus
Haratake, N; Seto, T
NTRK Fusion-positive Non-small-cell Lung Cancer: The Diagnosis and Targeted Therapy.
Clin Lung Cancer
22
1-5
2021
Homo sapiens
Elfving, H; Broström, E; Moens, LNJ; Almlöf, J; Cerjan, D; Lauter, G; Nord, H; Mattsson, JSM; Ullenhag, GJ; Strell, C; Backman, M; La Fleur, L; Brunnström, H; Botling, J; Micke, P
Evaluation of NTRK immunohistochemistry as a screening method for NTRK gene fusion detection in non-small cell lung cancer.
Lung Cancer
151
53-59
2021
Homo sapiens
Percy, C; Schubert, T; Galant, C; Kirchgesner, T; Mazzeo, F
Larotrectinib in a NTRK-rearranged soft tissue sarcoma in the neoadjuvant setting: A case report.
Clin Case Rep
9
1694-1698
2021
Homo sapiens
Jaehne, EJ; Chong, EMS; Sbisa, A; Gillespie, B; Hill, R; Gogos, A; van den Buuse, M
TrkB agonist 7,8-dihydroxyflavone reverses an induced prepulse inhibition deficit selectively in maternal immune activation offspring: implications for schizophrenia.
Behav Pharmacol
32
404-412
2021
animal
Dieckmann, N; Schildhaus, HU; Bauer, S
Tropomyosin receptor kinases in sarcomas - of joy and despair.
Curr Opin Oncol
33
336-344
2021
Homo sapiens
Tsuchimochi, A; Endo, C; Motoyoshi, M; Tamura, M; Hitomi, S; Hayashi, Y; Shinoda, M
Effect of low-intensity pulsed ultrasound on orofacial sensory disturbance following inferior alveolar nerve injury: Role of neurotrophin-3 signaling.
Eur J Oral Sci
e12810
2021
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Franzese, O; Di Francesco, AM; Meco, D; Graziani, G; Cusano, G; Levati, L; Riccardi, R; Ruggiero, A
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612375
2021
Homo sapiens
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14875
2021
Homo sapiens
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