Information on EC 2.7.11.27 - [acetyl-CoA carboxylase] kinase

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The expected taxonomic range for this enzyme is: Euarchontoglires

EC NUMBER
COMMENTARY
2.7.11.27
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RECOMMENDED NAME
GeneOntology No.
[acetyl-CoA carboxylase] kinase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[acetyl-CoA carboxylase] phosphotransferase
Phosphorylates and inactivates EC 6.4.1.2, acetyl-CoA carboxylase, which can be dephosphorylated and reactivated by EC 3.1.3.17, [phosphorylase] phosphatase. The enzyme is more active towards the dimeric form of acetyl-CoA carboxylase than the polymeric form [5]. Phosphorylates serine residues.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5'-AMP activated protein kinase
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5'-AMP activated protein kinase
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alpha-2 isoform
acetyl coenzyme A carboxylase kinase (phosphorylating)
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acetyl-CoA carboxylase bound kinase
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acetyl-CoA carboxylase kinase
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acetyl-CoA carboxylase kinase (cAMP-independent)
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acetyl-CoA carboxylase kinase-2
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acetyl-CoA carboxylase kinase-3 (AMP-activated)
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acetyl-coenzyme A carboxylase kinase
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ACK2
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ACK3
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AMPK
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AMPK
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AMPKalpha
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AMPKalpha
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cAMP-activated protein kinase
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I-peptide kinase
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highly specific for acetyl-CoA carboxylase, binds selectively to the dimeric form
additional information
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cAMP-dependent protein kinase identified, that phosphorylates and inactivates acetyl-CoA carboxylase in vitro, but appears not to be involved in regulation in vivo
additional information
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phosphorylation by cAMP-dependent protein kinase has the same effect on acetyl-CoA carboxylase activity then phosphorylation with acetyl-CoA carboxylase kinase-2
additional information
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phosphorylation by cAMP-dependent protein kinase has the same effect on acetyl-CoA carboxylase activity then phosphorylation with acetyl-CoA carboxylase kinase-2; two other cAMP-independent kinases found, that phosphorylate but do not effect acetyl-CoA carboxylase kinase activity
CAS REGISTRY NUMBER
COMMENTARY
77000-06-7
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
lean and obese Wistar rats
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Manually annotated by BRENDA team
male Holtzman rats
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Manually annotated by BRENDA team
male sprague-dawley rats
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Manually annotated by BRENDA team
male Wistar Hannover rats
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Manually annotated by BRENDA team
response to 24 h starvation and high fat feeding
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Manually annotated by BRENDA team