Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.7.11.26 - tau-protein kinase and Organism(s) Mus musculus and UniProt Accession Q9WV60

for references in articles please use BRENDA:EC2.7.11.26
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Mus musculus
UNIPROT: Q9WV60
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
amp-activated protein kinase, glycogen synthase kinase, protein kinase 1, gsk3b, extracellular-regulated kinase, gsk-3 beta, protein kinase-a, srpk2, gsk-3alpha, ttbk2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycogen synthase kinase-3
-
glycogen synthase kinase-3beta
-
AMP-activated protein kinase
-
CDK5/p25
-
-
cyclin-dependent kinase 5
-
-
cyclin-dependent kinase 5/p39
-
-
cyclin-dependent kinase-5
-
-
Gasket protein
-
-
-
-
glycogen synthase kinase
-
-
-
-
glycogen synthase kinase 3
-
-
glycogen synthase kinase 3beta
-
-
glycogen synthase kinase-3
glycogen synthase kinase-3alphabeta
-
-
glycogen synthase kinase-3beta
-
-
GSK-3
-
-
GSK-3 alpha
-
-
-
-
GSK-3 beta
-
-
-
-
GSK-3alpha
-
isoform
GSK-3beta
GSK3alpha
GSK3beta
p-SAPK/JNK
-
-
protein kinase A
-
-
protein tau kinase
-
-
-
-
serine/threonine-protein kinase 2
-
-
SRPK2
-
-
stress activated kinase/c-jun N-terminal kinase
-
-
tau factor protein kinase (phosphorylating)
-
-
-
-
tau kinase
tau protein kinase
tau protein kinase I
tau tubulin kinase 2
-
tau-tubulin kinase
-
Tau-tubulin kinase 1
-
-
TPKI/GSK-3beta
-
-
TPKI/GSK3beta
-
-
TTBK1
TTBK2
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[tau-protein] O-phosphotransferase
Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
CAS REGISTRY NUMBER
COMMENTARY hide
111694-09-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + protein tau
ADP + protein tau phosphate
show the reaction diagram
the antagonist of GSK-3beta in protein tau phosphorylation is the phosphatase PP2A
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
ATP + beta-catenin
ADP + phosphorylated beta-catenin
show the reaction diagram
ATP + c-Jun
ADP + phosphorylated c-Jun
show the reaction diagram
-
substrate of isoform GSK-3alpha
-
-
?
ATP + CEP164
ADP + phospho-CEP164
show the reaction diagram
-
-
-
?
ATP + CEP97
ADP + phospho-CEP97
show the reaction diagram
-
-
-
?
ATP + eIF2B peptide
ADP + phosphorylated eIF2B peptide
show the reaction diagram
-
-
-
-
?
ATP + histone H1
ADP + histone H1 phosphate
show the reaction diagram
-
Cdk5 substrate
-
-
?
ATP + HLSNVSSTGSIDMVDSPQLATLADEVSASLAK
ADP + HLSNVSSTGSIDMVDpSPQLATLADEVSASLAK
show the reaction diagram
-
-
-
?
ATP + HSPB6
ADP + phosphorylated HSPB6
show the reaction diagram
-
phosphorylation at Ser16
-
-
?
ATP + phospho-glycogen synthase peptide-2
ADP + phosphorylated phospho-glycogen synthase peptide-2
show the reaction diagram
-
GSK3 substrate
-
-
?
ATP + protein tau
ADP + protein tau phosphate
show the reaction diagram
ATP + tau-protein
ADP + O-phospho-tau-protein
show the reaction diagram
ATP + TDP-43
ADP + phospho-TDP-43
show the reaction diagram
-
-
-
?
ATP + tubulin
ADP + phospho-tubulin
show the reaction diagram
-
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
ATP + protein tau
ADP + protein tau phosphate
show the reaction diagram
ATP + tau-protein
ADP + O-phospho-tau-protein
show the reaction diagram
ATP + tubulin
ADP + phospho-tubulin
show the reaction diagram
-
-
-
?
ATP + [tau-protein]
ADP + O-phospho-[tau-protein]
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
lithium chloride
15 mM
(2'Z,3'E)-6-bromoindirubin-3'-oxime
-
-
2-cyanoethyl alsterpaullone
-
-
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
-
-
6-bromo-indirubin-3'-oxime
-
-
6-bromoindirubin-3'-oxim
-
-
6-bromoindirubin-3'-oxime
-
-
alsterpaullone
-
-
AR-A014418
-
selective ATP-competitive inhibitor of GSK3
BIIB-TTBKi-284
-
-
compound C
inhibits tau protein phosphorylation by AMPK
CT99021
-
-
kenpaullone
-
-
p25
-
p25 overexpressing mice have reduced GSK3beta activity
-
roscovitine
-
Cdk5 inhibitor
SB 216763
SB-216763
-
selective ATP-competitive inhibitor of GSK3
SB-415286
-
-
trans-activating transcriptor-eIF2B
-
acts as a competitive inhibitor of GSK-3
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
AMP
AMP-activated protein kinase
cisplatin
-
GSK-3 is activated by cisplatin treatment of HEI-OC1 cells, 0.02 mM cisplatin induces phosphorylation of Tyr216 GSK-3beta in HEI-OC1 cells but reduces the phosphorylation of Ser9 GSK-3beta, the activity of GSK-3beta is regulated negatively by the phosphorylation of Ser9 and positively by the phosphorylation of Tyr216
CP-681301
-
CP-681301 treatment reverses the inhibition of GSK3beta activity
ether
-
dramatic increase in the phosphorylation level of Ser9 of TPKI/GSK3beta immediately and 10 min after ether administration, followed by rapid virtual reversion to baseline by 20 min, no significant changes in the protein level or Tyr216 phosphorylation level of the enzyme
GF-109203X
-
-
metformin
-
p25
-
cyclin activator, dependent on, over 10fold increase in activity of CDK5
-
p35
-
tightly bound neuronal activator of cdk5, required for activity with regulatory function, p39 activates to a greater extent compared to p35 in vitro
-
p39
-
tightly bound neuronal activator of cdk5, required for activity with regulatory function, p39 activates to a greater extent compared to p35 in vitro, p39 is the activator activator in vivo
-
soluble beta-amyloid oligomers
-
activate GSK-3beta mediated tau phosphorylation and increase toxicity, reduced content of soluble, not insoluble, amyloid oligomers reduces the tau phosphorylation activity, specific antibodies can inhibit the activation, overview
-
Wortmannin
-
-
additional information
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000095
BIIB-TTBKi-284
Mus musculus
isoform TTBK1, pH and temperature not specified in the publication
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
-
assay at
7.5
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
the active form of GSK-3beta is co-localized with the neurofibrillary tangles in the Alzheimer disease brains
Manually annotated by BRENDA team
-
entire amygdala or ventroposterior quadrant of cerebral hemisphere
Manually annotated by BRENDA team
-
immortilized embryonic brain cortex cell line
Manually annotated by BRENDA team
-
immortilized embryonic brain cortex cell line overexpressing the human tau protein
Manually annotated by BRENDA team
-
bone marrow-derived mesenchymal stem cell
Manually annotated by BRENDA team
weakest expression
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
mainly
Manually annotated by BRENDA team
-
GSK-3beta partially localizes within mitochondria
Manually annotated by BRENDA team
-
isoform GSK-3alpha
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
stimulation of GSK-3beta both in vitro and in vivo induces tau hyperphosphorylation with impairments of the cognitive functions, whereas inhibition of GSK-3beta improves tau pathologies and memory deficits. Stimulation of EphB2 upregulates PI3K and Akt with inhibition of GSK-3beta. Stimulation of EphB2 attenuates tau phosphorylation both in vitro and in hippocampus of human tau transgenic mice
evolution
TTBK2 is a serine/threonine protein kinase of the CK1 superfamily
malfunction
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GSK3B_MOUSE
420
0
46710
Swiss-Prot
Mitochondrion (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
-
immunoprecipitation, lysosomal degradation product of full-length TTBK1
36000
calculated from cDNA sequence
47000
-
SDS-PAGE
additional information
-
absence of a 230-kDa protein in the mouse cortex, suggests a very small quantity of full-length TTBK1
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
isoform TTBK2 kinase domain with ADP, using 0.1 M Tris pH 8.5, 10% (v/v) glycerol and 2 M Na/K phosphate
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Ni-Sepharose column chromatography
-
nickel resin column chromatography and Superdex 75 gel filtration
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta, by RT-PCR also found in rat and human brains, transient expression in COS-7 cells
-
His-tagged GSK3beta expressed in Escherichia coli BL21, into pEGFP vector and N18 cells transiently transfected
-
isoform TTBK1 is expressed in HEK-293T cells
mouse TTK cDNA isolated using amino acid sequences of purified bovine brain TTK
p25-induced Cdk5 over-activation of Cdk5 in young and old transgenic mice
-
the enzyme and human fetal tau-protein are coexpressed in Escherichia coli BL21(DE3) cells
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
5-azacytidine treatment (0.005 mM for 24 h) causes significant up-regulation of GSK-3beta whereas it stimulates GSK-3alpha expression only modestly
-
GSK-3beta levels are elevated by about 80% in APP transgenic neuronal cultures
-
knocking out miR-369 in Alzheimer's disease mice promotes hyperphosphorylation of tau and upregulates enzyme expression
-
LiCl and BIO also reduce the expression of GSK3beta
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
additional information
-
phosphorylation of T231 by GSK3beta may play an important role in tau’s hyperphosphorylation and functional regulation
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tomizawa, K.; Omori, A.; Ohtake, A.; Sato, K.; Takahashi, M.
tau-Tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau
FEBS Lett.
492
221-227
2001
Bos taurus, Mus musculus, Mus musculus (Q3UVR3), Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Mukai, F.; Ishiguro, K.; Sano, Y.; Fujita, S.C.
Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta
J. Neurochem.
81
1073-1083
2002
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Okawa, Y.; Ishiguro, K.; Fujita, S.C.
Stress-induced hyperphosphorylation of tau in the mouse brain
FEBS Lett.
535
183-189
2003
Mus musculus
Manually annotated by BRENDA team
Takahashi, S.; Saito, T.; Hisanaga, S.; Pant, H.C.; Kulkarni, A.B.
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules
J. Biol. Chem.
278
10506-10515
2003
Mus musculus
Manually annotated by BRENDA team
Harris, F.M.; Brecht, W.J.; Xu, Q.; Mahley, R.W.; Huang, Y.
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc
J. Biol. Chem.
279
44795-44801
2004
Mus musculus
Manually annotated by BRENDA team
Shelton, S.B.; Krishnamurthy, P.; Johnson, G.V.
Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells
J. Neurosci. Res.
76
110-120
2004
Mus musculus
Manually annotated by BRENDA team
Ma, Q.L.; Lim, G.P.; Harris-White, M.E.; Yang, F.; Ambegaokar, S.S.; Ubeda, O.J.; Glabe, C.G.; Teter, B.; Frautschy, S.A.; Cole, G.M.
Antibodies against beta-amyloid reduce abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro
J. Neurosci. Res.
83
374-384
2006
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Lambourne, S.L.; Sellers, L.A.; Bush, T.G.; Choudhury, S.K.; Emson, P.C.; Suh, Y.H.; Wilkinson, L.S.
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities
Mol. Cell. Biol.
25
278-293
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Ikeda, Y.; Ishiguro, K.; Fujita, S.C.
Ether stress-induced Alzheimer-like tau phosphorylation in the normal mouse brain
FEBS Lett.
581
891-897
2007
Mus musculus
Manually annotated by BRENDA team
Plattner, F.; Angelo, M.; Giese, K.P.
The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
J. Biol. Chem.
281
25457-25465
2006
Mus musculus
Manually annotated by BRENDA team
Lin, Y.T.; Cheng, J.T.; Liang, L.C.; Ko, C.Y.; Lo, Y.K.; Lu, P.J.
The binding and phosphorylation of Thr231 is critical for Taus hyperphosphorylation and functional regulation by glycogen synthase kinase 3beta
J. Neurochem.
103
802-813
2007
Mus musculus
Manually annotated by BRENDA team
Sato, S.; Cerny, R.L.; Buescher, J.L.; Ikezu, T.
Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation
J. Neurochem.
98
1573-1584
2006
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Fujio, J.; Hosono, H.; Ishiguro, K.; Ikegami, S.; Fujita, S.C.
Tau phosphorylation in the mouse brain during aversive conditioning
Neurochem. Int.
51
200-208
2007
Mus musculus, Mus musculus C57BL/6Njcl
Manually annotated by BRENDA team
Meske, V.; Albert, F.; Ohm, T.G.
Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3-dependent phosphorylation of Tau
J. Biol. Chem.
283
100-109
2008
Mus musculus (Q9WV60)
Manually annotated by BRENDA team
Shi, H.R.; Zhu, L.Q.; Wang, S.H.; Liu, X.A.; Tian, Q.; Zhang, Q.; Wang, Q.; Wang, J.Z.
17beta-Estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner
J. Neural Transm.
115
879-888
2008
Mus musculus
Manually annotated by BRENDA team
Wen, Y.; Planel, E.; Herman, M.; Figueroa, H.Y.; Wang, L.; Liu, L.; Lau, L.F.; Yu, W.H.; Duff, K.E.
Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
J. Neurosci.
28
2624-2632
2008
Mus musculus
Manually annotated by BRENDA team
Lomoio, S.; Scherini, E.; Necchi, D.
beta-Amyloid overload does not directly correlate with SAPK/JNK activation and tau protein phosphorylation in the cerebellar cortex of Ts65Dn mice
Brain Res.
1297
198-206
2009
Mus musculus
Manually annotated by BRENDA team
Sluchanko, N.N.; Seit-Nebi, A.S.; Gusev, N.B.
Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta
FEBS Lett.
583
2739-2742
2009
Mus musculus
Manually annotated by BRENDA team
Park, H.J.; Kim, H.J.; Bae, G.S.; Seo, S.W.; Kim, D.Y.; Jung, W.S.; Kim, M.S.; Song, M.Y.; Kim, E.K.; Kwon, K.B.; Hwang, S.Y.; Song, H.J.; Park, C.S.; Park, R.K.; Chong, M.S.; Park, S.J.
Selective GSK-3beta inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells
Hear. Res.
257
53-62
2009
Mus musculus
Manually annotated by BRENDA team
Crespo-Biel, N.; Camins, A.; Gutierrez-Cuesta, J.; Melchiorri, D.; Nicoletti, F.; Pallas, M.; Canudas, A.M.
Regulation of GSK-3beta by calpain in the 3-nitropropionic acid model
Hippocampus
20
962-970
2010
Mus musculus
Manually annotated by BRENDA team
Cho, J.; Rameshwar, P.; Sadoshima, J.
Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells
J. Biol. Chem.
284
36647-36658
2009
Mus musculus
Manually annotated by BRENDA team
Miao, Y.; Chen, J.; Zhang, Q.; Sun, A.
Deletion of tau attenuates heat shock-induced injury in cultured cortical neurons
J. Neurosci. Res.
88
102-110
2010
Mus musculus
Manually annotated by BRENDA team
Tackenberg, C.; Brandt, R.
Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau
J. Neurosci.
29
14439-14450
2009
Mus musculus
Manually annotated by BRENDA team
Takashima, A.
Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: role of GSK-3beta in adult brain
J. Pharmacol. Sci.
109
174-178
2009
Mus musculus
Manually annotated by BRENDA team
Wang, F.S.; Ko, J.Y.; Weng, L.H.; Yeh, D.W.; Ke, H.J.; Wu, S.L.
Inhibition of glycogen synthase kinase-3beta attenuates glucocorticoid-induced bone loss
Life Sci.
85
685-692
2009
Mus musculus
Manually annotated by BRENDA team
Manceur, A.P.; Driscoll, B.D.; Sun, W.; Audet, J.
Selective enhancement of the uptake and bioactivity of a TAT-conjugated peptide inhibitor of glycogen synthase kinase-3
Mol. Ther.
17
500-507
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Min, W.W.; Yuskaitis, C.J.; Yan, Q.; Sikorski, C.; Chen, S.; Jope, R.S.; Bauchwitz, R.P.
Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential
Neuropharmacology
56
463-472
2009
Mus musculus
Manually annotated by BRENDA team
Petit-Paitel, A.; Brau, F.; Cazareth, J.; Chabry, J.
Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neurons
PLoS ONE
4
e5491
2009
Mus musculus
Manually annotated by BRENDA team
Liao, J.C.; Yang, T.T.; Weng, R.R.; Kuo, C.T.; Chang, C.W.
TTBK2: a tau protein kinase beyond tau phosphorylation
BioMed Res. Int.
2015
575170
2015
Mus musculus (Q3UVR3), Homo sapiens (Q6IQ55)
Manually annotated by BRENDA team
Koehler, C.; Dinekov, M.; Goetz, J.
Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice
Neurobiol. Aging
34
1369-1379
2013
Mus musculus (Q2NL51), Mus musculus (Q9WV60), Mus musculus C57BL/6 (Q2NL51), Mus musculus C57BL/6 (Q9WV60)
Manually annotated by BRENDA team
Jiang, J.; Wang, Z.H.; Qu, M.; Gao, D.; Liu, X.P.; Zhu, L.Q.; Wang, J.Z.
Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3beta
Sci. Rep.
5
11765
2015
Homo sapiens (P49841), Homo sapiens, Mus musculus (Q9WV60), Mus musculus
Manually annotated by BRENDA team
Domise, M.; Didier, S.; Marinangeli, C.; Zhao, H.; Chandakkar, P.; Buee, L.; Viollet, B.; Davies, P.; Marambaud, P.; Vingtdeux, V.
AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo
Sci. Rep.
6
26758
2016
Mus musculus (Q5EG47), Mus musculus, Mus musculus C57BL6 (Q5EG47)
Manually annotated by BRENDA team
Bao, C.; Bajrami, B.; Marcotte, D.J.; Chodaparambil, J.V.; Kerns, H.M.; Henderson, J.; Wei, R.; Gao, B.; Dillon, G.M.
Mechanisms of regulation and diverse activities of tau-tubulin kinase (TTBK) isoforms
Cell. Mol. Neurobiol.
41
669-685
2021
Mus musculus (Q3UVR3), Mus musculus (Q6PCN3), Homo sapiens (Q5TCY1), Homo sapiens (Q6IQ55)
Manually annotated by BRENDA team
Yao, X.; Xian, X.; Fang, M.; Fan, S.; Li, W.
Loss of miR-369 promotes tau phosphorylation by targeting the Fyn and serine/threonine-protein kinase 2 signaling pathways in Alzheimer s disease mice
Front. Aging Neurosci.
11
365
2019
Mus musculus
Manually annotated by BRENDA team
Tugaeva, K.V.; Tsvetkov, P.O.; Sluchanko, N.N.
Bacterial co-expression of human Tau protein with protein kinase A and 14-3-3 for studies of 14-3-3/phospho-Tau interaction
PLoS ONE
12
e0178933
2017
Mus musculus
Manually annotated by BRENDA team