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Information on EC 2.7.11.26 - tau-protein kinase and Organism(s) Schizosaccharomyces pombe and UniProt Accession Q10452

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IUBMB Comments
Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
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Schizosaccharomyces pombe
UNIPROT: Q10452
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The taxonomic range for the selected organisms is: Schizosaccharomyces pombe
The enzyme appears in selected viruses and cellular organisms
Synonyms
amp-activated protein kinase, glycogen synthase kinase, protein kinase 1, gsk3b, extracellular-regulated kinase, gsk-3 beta, protein kinase-a, srpk2, gsk-3alpha, ttbk2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Gasket protein
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glycogen synthase kinase
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GSK-3 alpha
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GSK-3 beta
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protein tau kinase
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tau factor protein kinase (phosphorylating)
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tau kinase
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tau protein kinase
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tau protein kinase I
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[tau-protein] O-phosphotransferase
Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
CAS REGISTRY NUMBER
COMMENTARY hide
111694-09-8
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
autophosphorylation, phosphorylation on a conserved tyrosine residue is required for efficient activity. Phosphorylated at a Ser225 is likely to inhibit its function
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al.
The genome sequence of Schizosaccharomyces pombe
Nature
415
871-880
2002
Schizosaccharomyces pombe (Q10452)
Manually annotated by BRENDA team
Plyte, S.E.; Feoktistova, A.; Burke, J.D.; Woodgett, J.R.; Gould, K.L.
Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant
Mol. Cell. Biol.
16
179-191
1996
Schizosaccharomyces pombe (Q10452), Schizosaccharomyces pombe
Manually annotated by BRENDA team