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Information on EC 2.7.11.26 - tau-protein kinase and Organism(s) Saccharomyces cerevisiae and UniProt Accession P21965

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IUBMB Comments
Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
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Saccharomyces cerevisiae
UNIPROT: P21965
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Word Map
The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The enzyme appears in selected viruses and cellular organisms
Synonyms
amp-activated protein kinase, glycogen synthase kinase, protein kinase 1, gsk3b, extracellular-regulated kinase, gsk-3 beta, protein kinase-a, srpk2, gsk-3alpha, ttbk2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Gasket protein
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glycogen synthase kinase
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GSK-3 alpha
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GSK-3 beta
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protein tau kinase
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serine/threonine-protein kinase MDS1/RIM11
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serine/threonine-protein kinase MRK1
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tau factor protein kinase (phosphorylating)
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tau kinase
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tau protein kinase
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tau protein kinase I
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[tau-protein] O-phosphotransferase
Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
CAS REGISTRY NUMBER
COMMENTARY hide
111694-09-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + protein
ADP + phosphoprotein
show the reaction diagram
autophosphorylation at Tyr and Ser
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?
additional information
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
regulation of Rim11 by Tyr phosphorylation during sporulation. Rim11 is phosphorylated on Tyr199, and the Tyr phosphorylation is essential for its in vivo function
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Maurer, K.C.; Urbanus, J.H.; Planta, R.J.
Sequence analysis of a 30 kb DNA segment from yeast chromosome XIV carrying a ribosomal protein gene cluster, the genes encoding a plasma membrane protein and a subunit of replication factor C, and a novel putative serine/threonine protein kinase gene
Yeast
11
1303-1310
1995
Saccharomyces cerevisiae (P21965)
Manually annotated by BRENDA team
Maftahi, M.; Nicaud, J.M.; Levesque, H.; Gaillardin, C.
Sequencing analysis of a 24.7 kb fragment of yeast chromosome XIV identifies six known genes, a new member of the hexose transporter family and ten new open reading frames
Yeast
11
1077-1085
1995
Saccharomyces cerevisiae (P21965)
Manually annotated by BRENDA team
Shero, J.H.; Hieter, P.
A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1)
Genes Dev.
5
549-560
1991
Saccharomyces cerevisiae (P21965)
Manually annotated by BRENDA team
Neigeborn, L.; Mitchell, A.P.
The yeast MCK1 gene encodes a protein kinase homolog that activates early meiotic gene expression
Genes Dev.
5
533-548
1991
Saccharomyces cerevisiae (P21965)
Manually annotated by BRENDA team
Dailey, D.; Schieven, G.L.; Lim, M.Y.; Marquardt, H.; Gilmore, T.; Thorner, J.; Martin, G.S.
Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activity
Mol. Cell. Biol.
10
6244-6256
1990
Saccharomyces cerevisiae (P21965)
Manually annotated by BRENDA team
Zhan, X.L.; Hong, Y.; Zhu, T.; Mitchell, A.P.; Deschenes, R.J.; Guan, K.L.
Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation
Mol. Biol. Cell
11
663-676
2000
Saccharomyces cerevisiae (P38615)
Manually annotated by BRENDA team
Puziss, J.W.; Hardy, T.A.; Johnson, R.B.; Roach, P.J.; Hieter, P.
MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3
Mol. Cell. Biol.
14
831-839
1994
Saccharomyces cerevisiae (P38615)
Manually annotated by BRENDA team
Bowdish, K.S.; Yuan, H.E.; Mitchell, A.P.
Analysis of RIM11, a yeast protein kinase that phosphorylates the meiotic activator IME1
Mol. Cell. Biol.
14
7909-7919
1994
Saccharomyces cerevisiae (P38615)
Manually annotated by BRENDA team
Bianchi, M.W.; Plyte, S.E.; Kreis, M.; Woodgett, J.R.
A Saccharomyces cerevisiae protein-serine kinase related to mammalian glycogen synthase kinase-3 and the Drosophila melanogaster gene shaggy product
Gene
134
51-56
1993
Saccharomyces cerevisiae (P38615)
Manually annotated by BRENDA team
Hardy, T.A.; Wu, D.; Roach, P.J.
Novel Saccharomyces cerevisiae gene, MRK1, encoding a putative protein kinase with similarity to mammalian glycogen synthase kinase-3 and Drosophila Zeste-White3/Shaggy
Biochem. Biophys. Res. Commun.
208
728-734
1995
Saccharomyces cerevisiae (P50873)
Manually annotated by BRENDA team