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Information on EC 2.7.11.26 - tau-protein kinase and Organism(s) Drosophila melanogaster and UniProt Accession P18431

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IUBMB Comments
Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
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This record set is specific for:
Drosophila melanogaster
UNIPROT: P18431
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The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
amp-activated protein kinase, glycogen synthase kinase, protein kinase 1, gsk3b, extracellular-regulated kinase, gsk-3 beta, protein kinase-a, srpk2, gsk-3alpha, ttbk2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
protein kinase shaggy
-
Gasket protein
-
-
-
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glycogen synthase kinase
-
-
-
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glycogen synthase kinase-3beta
-
-
GSK-3 alpha
-
-
-
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GSK-3 beta
-
-
-
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protein tau kinase
-
-
-
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tau factor protein kinase (phosphorylating)
-
-
-
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tau kinase
-
-
-
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tau protein kinase
-
-
-
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tau protein kinase I
-
-
-
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Tau tubulin binding kinase1
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Tau tubulin binding kinase2
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[tau-protein] O-phosphotransferase
Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
CAS REGISTRY NUMBER
COMMENTARY hide
111694-09-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + protein tau
ADP + protein tau phosphate
show the reaction diagram
-
-
-
-
?
ATP + tau-protein
ADP + O-phospho-tau-protein
show the reaction diagram
-
phosphorylation at Ser-422
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + tau-protein
ADP + O-phospho-tau-protein
show the reaction diagram
-
phosphorylation at Ser-422
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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the tau-kinases MARK1, TTBK1, TTBK2 reduce lifespan of Drosophila melanogaster, and the effects are increased by co expression with human tau-protein
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SGG_DROME
514
0
53872
Swiss-Prot
-
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Adams, M.D.; Celniker, S.E.; Holt, R.A.; Evans, C.A.; Gocayne, J.D.; et al.
The genome sequence of Drosophila melanogaster
Science
287
2185-2195
2000
Drosophila melanogaster (P18431)
Manually annotated by BRENDA team
Benos, P.V.; Gatt, M.K.; Ashburner, M.; Murphy, L.; Harris, D.; et al.
From sequence to chromosome: the tip of the X chromosome of D. melanogaster
Science
287
2220-2222
2000
Drosophila melanogaster (P18431)
Manually annotated by BRENDA team
Bourouis, M.; Moore, P.; Ruel, L.; Grau, Y.; Heitzler, P.; Simpson, P.
An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily
EMBO J.
9
2877-2884
1990
Drosophila melanogaster (P18431)
Manually annotated by BRENDA team
Hughes, K.; Nikolakaki, E.; Plyte, S.E.; Totty, N.F.; Woodgett, J.R.
Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation
EMBO J.
12
803-808
1993
Rattus norvegicus (P18265), Rattus norvegicus (P18266), Drosophila melanogaster (P18431), Drosophila melanogaster
Manually annotated by BRENDA team
Peifer, M.; Pai, L.M.; Casey, M.
Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase
Dev. Biol.
166
543-556
1994
Drosophila melanogaster (P18431)
Manually annotated by BRENDA team
Ruel, L.; Pantesco, V.; Lutz, Y.; Simpson, P.; Bourouis, M.
Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila
EMBO J.
12
1657-1669
1993
Drosophila melanogaster (P18431)
Manually annotated by BRENDA team
Siegfried, E.; Perkins, L.A.; Capaci, T.M.; Perrimon, N.
Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3
Nature
345
825-829
1990
Drosophila melanogaster (P18431)
Manually annotated by BRENDA team
Siegfried, E.; Chou, T.B.; Perrimon, N.
wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate
Cell
71
1167-1179
1992
Drosophila melanogaster (P18431)
Manually annotated by BRENDA team
Chatterjee, S.; Sang, T.K.; Lawless, G.M.; Jackson, G.R.
Dissociation of tau toxicity and phosphorylation: Role of GSK-3beta, MARK, and Cdk5 in a Drosophila model
Hum. Mol. Genet.
18
164-177
2008
Drosophila melanogaster
Manually annotated by BRENDA team
Fernius, J.; Starkenberg, A.; Pokrzywa, M.; Thor, S.
Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau
Biol. Open
6
113-1023
2017
Drosophila melanogaster
Manually annotated by BRENDA team