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IUBMB CommentsThis enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) but requires MAPKKKK for activation. Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway . Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
Synonyms
b-raf, c-raf, mekk1, c-mos, apoptosis signal-regulating kinase 1, mixed lineage kinase, ste11, mekk3, map3k1, mapkkk,
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ATP + protein
ADP + phosphoprotein
ATP + Atf1
ADP + phosphorylated Atf1
MAPK kinase Atf1 activation
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-
?
ATP + protein
ADP + phosphoprotein
ATP + Sty1
ADP + phosphorylated Sty1
MAPK kinase Sty1 activation
-
-
?
ATP + Wis1
ADP + phosphorylated Wis1
ATP + protein
ADP + phosphoprotein
capable of partial suppression of the ras1 mutant phenotype
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-
?
ATP + protein
ADP + phosphoprotein
ste8 gene product functions in the signal transduction pathway
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-
?
ATP + protein
ADP + phosphoprotein
required for activation of the MAPK homologue Spc1, and integrity of the Wis1-Spc1 pathway is required for survival in extreme conditions of heat, osmolarity, oxidation or limited nutrition. Phosphorylates Wis1 in vitro and activates it in vivo
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-
?
ATP + protein
ADP + phosphoprotein
phosphorylates and activates Wis1 MAP kinase kinase in response to high osmolarity
-
-
?
ATP + protein
ADP + phosphoprotein
Mkh1 regulates cell morphology, cell wall integrity, salt resistance, cell cycle reentry from stationary-phase arrest, and filamentous growth in response to stress
-
-
?
ATP + Wis1
ADP + phosphorylated Wis1
-
-
-
?
ATP + Wis1
ADP + phosphorylated Wis1
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + protein
ADP + phosphoprotein
ATP + Atf1
ADP + phosphorylated Atf1
MAPK kinase Atf1 activation
-
-
?
ATP + protein
ADP + phosphoprotein
ATP + Sty1
ADP + phosphorylated Sty1
MAPK kinase Sty1 activation
-
-
?
ATP + protein
ADP + phosphoprotein
capable of partial suppression of the ras1 mutant phenotype
-
-
?
ATP + protein
ADP + phosphoprotein
ste8 gene product functions in the signal transduction pathway
-
-
?
ATP + protein
ADP + phosphoprotein
required for activation of the MAPK homologue Spc1, and integrity of the Wis1-Spc1 pathway is required for survival in extreme conditions of heat, osmolarity, oxidation or limited nutrition. Phosphorylates Wis1 in vitro and activates it in vivo
-
-
?
ATP + protein
ADP + phosphoprotein
phosphorylates and activates Wis1 MAP kinase kinase in response to high osmolarity
-
-
?
ATP + protein
ADP + phosphoprotein
Mkh1 regulates cell morphology, cell wall integrity, salt resistance, cell cycle reentry from stationary-phase arrest, and filamentous growth in response to stress
-
-
?
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17
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brenda